142 research outputs found
InTouch Week of December 6, 2022
No full textGiving Tuesday Raises Money for Clinical Skills and Simulation Center Wen-Hui Wang, M.D., Awarded $2.7 Million NIH Grant for New Options for Hypertension NYMC and TU to Host 23rd COVID-19 Symposium on December 8 M.D./Ph.D. Candidate Jacob Hehir Seeks Therapy for Tinnitus and Treatment-Resistant Epilepsyhttps://touroscholar.touro.edu/in_touch/1044/thumbnail.jp
Management of patients with generalised myasthenia gravis and COVID-19 : four case reports
No full textComment on : International MG/COVID-19 Working Group; Jacob S, Muppidi S, Guidon A, Guptill J, Hehir M, Howard JF Jr, Illa I, Mantegazza R, Murai H, Utsugisawa K, Vissing J, Wiendl H, Nowak RJ. Guidance for the management of myasthenia gravis (MG) and Lambert-Eaton myasthenic syndrome (LEMS) during the COVID-19 pandemic. J Neurol Sci. 2020 May 15;412:116803. doi: 10.1016/j.jns.2020.116803. Epub 2020 Mar 25. PMID: 32247193; PMCID: PMC7105910
Spring 2023 GSBMS Alumni Connections
No full textNYMC Annual Days of Giving Set for March 28 and 29 Department of Pathology, Microbiology and Immunology Hosts Inaugural Research Symposium Film Screening and Discussion Helps Celebrate Black History Month 2.9 Million NIH Grant for Preventing Strep A Infection Sachin Gupte, M.D., Ph.D., Awarded $2.7 Million NIH Grant to Develop Treatments for Vascular Diseasehttps://touroscholar.touro.edu/nymc_gsbms_book/1018/thumbnail.jp
Neuromodulation of Mouse Auditory Cortex Using Focused Ultrasound
No full textNeurological diseases impose a large health and financial burden for nations worldwide. Current treatments for many conditions are limited to pharmacological or invasive surgical approaches. Neuromodulation is an alternative therapy wherein electrical currents, magnetic fields, or electromagnetic waves are used to noninvasively modify brain function. Focused ultrasound (FUS) has been shown to alter neural activity, theoretically with much higher spatial resolution than other neuromodulation techniques. However, these predictions assume that neuromodulatory effects are constrained to the acoustic focus. Given that the architecture of neural circuitry in the cerebral cortex supports delicately balanced lateral processing on spatial scales that may exceed the acoustic spot size, it is critical to probe spatial effects in vivo.
Here, we used a novel approach that combines wide-field Ca2+ imaging with targeted, random-access sonication to examine the effects of focal neuromodulation in the auditory cortex of transgenic mice expressing the Ca2+ sensor GCaMP6s. We visualized auditory-evoked cortical activity and quantified the effects of low-intensity FUS on the magnitude and spatiotemporal evolution of these sensory responses. We performed immunohistochemical analysis of brain slices as well as in vivo optical coherence tomography-angiography imaging to assess gross changes in microvascular integrity.
Our work provides a preclinical exploration of a promising neuromodulation modality with insight into the acute and persistent effects of targeted sonication in the cerebral cortex. While our results support the assertion that neuromodulatory effects can be localized, they also find evidence in some cases of off-target effects such as altered spatial propagation of sensory evoked responses
Curing Cholera: Pathogens, Places and Poverty in South Asia
No full textIn this paper I will seek to provide a new understanding of endemicity of disease in India. Through a study of cholera research in the twentieth century I will argue that disease and its endemicity has to be understood in biological factors as well as within a wider social and economic context. I will discuss the medical efforts at locating the causality of cholera from the nineteenth century in Indian climate, water bodies and human anatomy to show that cholera is no more a biological phenomena than water is an ecological or environmental problem. Both are essentially political and economic questions
Age, growth and reproductive biology of whiting Merlangius merlangus (Linnaeus 1758) in the Celtic Sea
No full textAge, growth and reproductive biology were investigated for whiting (Merlangius merlangus) captured from the Celtic Sea (ICES division Vllg), for the period January 2001 to January 2002. Females dominated the sex ratio of 1: 2.25. The relative abundance of females exceeded the number of males in all length classes. The relationship between weight (g) and total length (cm) was the same for male and female whiting. A total of 973 fish were aged and the maximum age recorded was 11 years. Results from an intercalibration exercise showed 87% agreement in age readings between the author and an expert in ageing whiting at the Marine Institute. Females were dominated by 2 year olds, while males were dominated by 3 year olds. Lx was estimated as 38cm and a growth rate was calculated K = 0.3769 year'1. Females were fully recruited to the fishery at 3 years of age, while the age at full recruitment (tr) for males was 4 years. Female whiting spawned from late February to June 2001 and matured at a total length of 23 cm in their first year. Female whiting reached L5o at a total length of 28 cm and 2.7 years of age. Male whiting spawned from February to June 2001. They matured at a total length of 21 cm and in their first year. Male whiting reached L50 at a total length of 30.4 cm and 3.6 years of age. The following critical points should be taken into account in the management of the Celtic Sea whiting stock: An Fpa should be established in order to assess the current level of fishing mortality; The maturity ogives need further study; The extent of gutting of large fish before landing by fishers in the fleet should be investigated and the apparent decline in size of 4 - 7 year old fish in the Celtic Sea between 1996 and 2001 needs to be assessed
Age, growth and reproductive biology of whiting Merlangius merlangus (Linnaeus 1758) in the Celtic Sea
No full textAge, growth and reproductive biology were investigated for whiting (Merlangius merlangus) captured from the Celtic Sea (ICES division Vllg), for the period January 2001 to January 2002. Females dominated the sex ratio of 1: 2.25. The relative abundance of females exceeded the number of males in all length classes. The relationship between weight (g) and total length (cm) was the same for male and female whiting. A total of 973 fish were aged and the maximum age recorded was 11 years. Results from an intercalibration exercise showed 87% agreement in age readings between the author and an expert in ageing whiting at the Marine Institute. Females were dominated by 2 year olds, while males were dominated by 3 year olds. Lx was estimated as 38cm and a growth rate was calculated K = 0.3769 year'1. Females were fully recruited to the fishery at 3 years of age, while the age at full recruitment (tr) for males was 4 years. Female whiting spawned from late February to June 2001 and matured at a total length of 23 cm in their first year. Female whiting reached L5o at a total length of 28 cm and 2.7 years of age. Male whiting spawned from February to June 2001. They matured at a total length of 21 cm and in their first year. Male whiting reached L50 at a total length of 30.4 cm and 3.6 years of age. The following critical points should be taken into account in the management of the Celtic Sea whiting stock: An Fpa should be established in order to assess the current level of fishing mortality; The maturity ogives need further study; The extent of gutting of large fish before landing by fishers in the fleet should be investigated and the apparent decline in size of 4 - 7 year old fish in the Celtic Sea between 1996 and 2001 needs to be assessed
Differences in Vestibulo-Ocular Reflex Time Constants in Patients With Vestibular Migraine versus Vestibular Neuritis/Labyrinthitis
No full textOBJECTIVE: Recurrent dizziness, vertigo, and imbalance, as well as nausea or vomiting, can be induced by central or peripheral vestibular pathology. Vestibular migraine (VM) is a central pathology in which migraines reciprocally interact with vestibular nuclei. Vestibular neuritis and labyrinthitis (VN/L) are peripheral diseases involving inflammation of structures in the vestibular nerve or labyrinth. Because VM and VN/L in early stages can produce similar symptoms, diagnosis may require prolonged clinical evaluation. It has been suggested that differences in a patient\u27s Vestibulo-Ocular Reflex (VOR) measured during the rotary chair step rotation test (RCS Test) can differentiate VM from peripheral pathologies, allowing for faster diagnosis. We sought to compare VOR time constants (VORTs) in patients with VM versus VN/L, with the goal of exploring potential diagnostic value. STUDY DESIGN: Retrospective chart review of patients seen at a hospital balance center between January 2010 and June 2019. SETTING: Tertiary referral center. PATIENTS: 68 patients (mean age = 58.15, 65 % female, 35 % male) were placed into two groups based on clinical diagnosis codes: 1) VM or 2) VN/L. MAIN OUTCOME MEASURE(S): Primary variable of VORT, evoked by rotational step testing. RESULTS: Patients in the VM group demonstrated statistically significant elevated VOR Ts outside the normed range of 10-19.5 compared to those in the VN/L group (p = 0.0003) while patients in the VN/L group demonstrated statistically significant shortened VOR Ts (p = 0.0443) with the two populations having distinctly different VOR T profiles. CONCLUSIONS: Our results support the conclusion that elevated VOR Ts are a sign of central vestibular pathology and highlight the benefit of utilizing rotary chair testing early in the diagnostic process as a powerful diagnostic tool when evaluating dizzy patients for central versus peripheral vestibular dysfunction. Our results suggest more particularly that elevated VOR Ts can be utilized to identify patients with vestibular migraine, thus offering differentiation from patients with peripheral vestibular dysfunction earlier in the process of diagnosis, with an opportunity for earlier intervention
Is Religious Liberty Under Threat in America?:
No full textA panel of experts in theology and constitutional law examined threats to religious liberty in America at a campus forum moderated by Vatican expert and author John L. Allen, Jr. of National Catholic Reporter and sponsored by the Church in the 21st Century Center, BC Law School and the School of Theology and Ministry
Towards a European consensus for reporting incidental findings during clinical NGS testing
No full textIn 2013, the American College of Medical Genetics (ACMG) examined the issue of incidental findings in whole exome and whole genome sequencing, and introduced recommendations to search for, evaluate and report medically actionable variants in a set of 56 genes. At a debate held during the 2014 European Society for Human Genetics Conference (ESHG) in Milan, Italy, the first author of that paper presented this view in a debate session that did not end with a conclusive vote from the mainly European audience for or against reporting back actionable incidental findings. In this meeting report, we elaborate on the discussions held during a special meeting hosted at the ESHG in 2013 from posing the question 'How to reach a (European) consensus on reporting incidental findings and unclassified variants in diagnostic next generation sequencing'. We ask whether an European consensus exists on the reporting of incidental findings in genome diagnostics, and present a series of key issues that require discussion at both a national and European level in order to develop recommendations for handling incidental findings and unclassified variants in line with the legal and cultural particularities of individual European member states
- …
