745 research outputs found
The unexplained nature of reading.
No full textThe effects of properties of words on their reading aloud response times (RTs) are 1 major source of evidence about the reading process. The precision with which such RTs could potentially be predicted by word properties is critical to evaluate our understanding of reading but is often underestimated due to contamination from individual differences. We estimated this precision without such contamination individually for 4 people who each read 2,820 words 50 times each. These estimates were compared to the precision achieved by a 31-variable regression model that outperforms current cognitive models on variance-explained criteria. Most (around 2/3) of the meaningful (non-first-phoneme, non-noise) word-level variance remained unexplained by this model. Considerable empirical and theoretical-computational effort has been expended on this area of psychology, but the high level of systematic variance remaining unexplained suggests doubts regarding contemporary accounts of the details of the mechanisms of reading at the level of the word. Future assessment of models can take advantage of the availability of our precise participant-level database
Miscellaneous essays : Impressions of Theophrastus Such : The veil lifted : Brother Jacob /
No full textMode of access: Internet
REGIONAL AND NATIONAL IMPACTS OF EXPANDED PACIFIC NORTHWEST POTATO PRODUCTION
No full textA 46-equation econometric model of the U.S. potato market was developed. The model examines the determination of planted acreage, yield, production, and farm prices in the Pacific Northwest and in five other producing regions which compete with Northwest production. National demand relationships for potatoes used in processing, fresh consumption and livestock feed are also specified. These estimated relationships are used to simulate future scenarios which assume alternative rates of expansion for Northwest potato production. Results suggest that opportunities for considerable expansion of Northwest potato production exist if the secular shift in potato demand continues and increases in acreage are not excessive or expansion does not occur too quickly.Crop Production/Industries,
Visualizing the Immune System: Providing Key Insights into HIV/SIV Infections
No full textImmunological inductive tissues, such as secondary lymphoid organs, are composed of distinct anatomical microenvironments for the generation of immune responses to pathogens and immunogens. These microenvironments are characterized by the compartmentalization of highly specialized immune and stromal cell populations, as well as the presence of a complex network of soluble factors and chemokines that direct the intra-tissue trafficking of naïve and effector cell populations. Imaging platforms have provided critical contextual information regarding the molecular and cellular interactions that orchestrate the spatial microanatomy of relevant cells and the development of immune responses against pathogens. Particularly in HIV/SIV disease, imaging technologies are of great importance in the investigation of the local interplay between the virus and host cells, with respect to understanding viral dynamics and persistence, immune responses (i.e., adaptive and innate inflammatory responses), tissue structure and pathologies, and changes to the surrounding milieu and function of immune cells. Merging imaging platforms with other cutting-edge technologies could lead to novel findings regarding the phenotype, function, and molecular signatures of particular immune cell targets, further promoting the development of new antiviral treatments and vaccination strategies
HIV in The Immune System: The Role of Specialized Follicular Dendritic Cells in Promoting Viral Disease
No full textHuman Immunodeficiency Virus (HIV) has become a world wild epidemic affecting millions of people across the globe. Even in the face of potent antiviral drugs which are only available in first world countries, HIV continues to evade intervention strategies and eventually destroy the body’s immune system. During the longest stage of HIV disease, clinical latency, much of active infection is confined to the germinal centers of secondary lymphoid tissue (1). Here HIV is trapped on the surface of follicular dendritic cells (FDC) which reside in this region of all secondary lymphoid organs (2). Large amounts of HIV localize on FDC in the form of immune complexes and even in the presence of high concentrations of neutralizing antibody remain highly infectious (3). Our lab has obtained preliminary data further supporting the importance of FDC in HIV infection. These findings suggest that FDC increase HIV infection/replication in T-cells some 200-fold. However, little is known about the interactions between FDC and T-lymphocytes in viral infection. We hypothesize that FDC increase HIV co-receptor expression on T-cells, thus, potentiating infection. This along with other viral factors may enhance the T-cell’s chances of infection. Our research seeks to determine if FDC increase CXCR4 expression on CD4+ T-cells
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