11,529 research outputs found
Journeys Through Jackson 2014 Vol.24 No.01
No full textJourneys Through Jackson is the official journal of the Jackson County Genealogical Society, Inc. The journal began as a monthly publication in July 1991, was published bimonthly from 1994 to 2003, and continues today as a quarterly publication. The journal issues in this digital collection are presented as annual compilations.c
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J o u r n e y s
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T h e Official J o u r n a l of t h e J a c k s o n C o u n t y G e n e a l o g i c a l Society, Inc.
Vol. X X I V , No. I W i n t e r 2 0 14
JACKSON COUNTY GENEALOGICAL SOCIETY, INC.
2014 Officers
President Kenneth E. Nicholson
Vice Presidents Timothy Osment, William L. Crawford
Secretary Karen C. Nicholson
Treasurer Teresa Deitz Manring
Librarian KimberlyS. Shuler
Office Manager Ruth C. Shuler
Web Master. Deanne G. Roles
Computer Technician Jason N. Gregory
Chair, Publications (Editor) Sanji Talley Watson
Journeys Through Jackson is the official publication of the Jackson County Genealogical Society. Members and non-members are invited to
submit genealogical materials for publication, with the understanding that the editor reserves the right to edit these materials for genealogical
content, clarity, or taste. The Society assumes no responsibility for errors of fact that may be contained in submissions, and except where noted,
the opinions expressed are not those of the editor or of the Jackson County Genealogical Society. The Society accepts no advertising for this
publication except for notices from other non-profit groups.
From the Editor
Well, winter has made it to the mountains, everything from rain to sleet to snow has been seen
here lately. But, on the bright side, it has given everyone an unexpected opportunity to work on
genealogy.
The Society is thriving so far this year with members renewing their memberships, people
coming by the office to use the resources that we have and new mysteries coming to light all the time. If
you haven't been by the office lately, I encourage you to drop by and see all the new materials that we
have. I also encourage you to come to the monthly meetings on the second Thursday of every month.
The meetings are always informative and interesting.
This fall, in October will be our Semi-annual fund-raiser, so keep that in mind. We will be
sending out further information in a few months regarding the activities that we will be having.
Journey Through Jackson Winter 2014
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T a b l e o f C o n t e n t s
Table of Contents, Announcements and Expression of Sympathy 1
JCGS Photo Album 2-6
Webster School Catalogue 7-14
Descendants of John Thomas Tatham 15-18
Genetic Genealogy: The Basics of Using DNA for Genealogy 19-24
People Helping Their Neighbors 25-27
Library Acquisitions 27
Treasurer's Report 28
1880 Jackson County Census 29-32
Ruth Bryson Mysteries « 33-36
1931 Jackson County Death Certificates..., 37-40
Book Review: Green River Graves: Hooper and Related Families 41
2014 JCGS Meeting Schedule 42
WWI Draft Cards 43-46
Index 47-48
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We offer our sincere sympathy and condolences to the family of JCGS member Eugene McGinnis. We
dedicate this issue of JTJ in his memory. We also offer our condolences to JCGS members Mary Jo
Hooper Cobb, Peggy Queen Mason , Barbara McCall Mathews, Lynn Allen Bryant and Elizabeth
Moss Wilson on the passing of their family members.
In the Holiday issue of JTJ, the address for Jean Hayes Cook was incorrect: The correct address is: 165
Grady Wiggins Drive, Otto, NC 27863.
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A w a r d W i n n e rs
In December at the annual meeting of JCGS the following awards were presented:
The Daniel Washington Deitz Award as presented'to William L. "Bill" Crawford.
The Robert Lee and Drusilla Holden Award was presented to Irene Bishop Hooper.
The Patron Award was presented to James and Jean Scott.
Plaques were presented to Dorris Dills Beck and Lawrence "Larry" Morton for their many years of
service and contributions to JCGS.
Journey Through Jackson Winter 2014
J C G S P h o t o A l b u m W
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Fowler House and Cottages, Glenville, N. C
Altitude 3.500 ft. Modern Conveniences. Golf, Tennis, Swimming, Fishing, Hiking.
Not a Hotel, but a Home for Summer Quests.
Jean Scott bought this postcard on e-bay, and granted use of it for JTJ. According to Joann
Davis Suddreth, the Fowler House was on the point behind the old Glenville School that sat on
the lake shore. She remembers that it was still operating in 1965 when she was a senior at the
school. The picture below of Robert Lee Gunter and wife Martha Avaline "Mattie" Green
and their son Willie Clarence Gunter was also provided by Jean Scott.
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J C G S P h o t o A l b u m
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The above picture is of the David Mitchell and Caroline Owen Shelton family. Mitchell
Shelton is the tall young man in the middle and the girl in the back row with him is Abia
Shelton (never married). The young boy in the front is J. O. "Bud" Shelton and the young
girl is Elsie Shelton Phillips. This picture belongs to Carmaletta Gates and she granted
permission for it to be used in JTJ.
Journey Through Jackson Winter 2014
J C G S P h o t o A l b u m Kj
The following pictures belonged to the late Gwen McCall Ashe.
allowed us to use them in this issue of JTJ.
Her daughter, Kim Ashe graciously
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The gentleman to the above right is John
Harlin Mathis (21 Jan 1842 - 28 Nov
1901). The lady above is his wife Sarah
Haseltine Cathey (19 Oct 1848 - 15 Jun
1930).
The picture to the left is their daughter Dovie
Elizabeth Mathis (16 Apr 1868 - 28 May
1937) and her husband, James Milford
Owen (13 Jan 1865 - 4 Apr 1947).
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J C G S P h o t o A l b u m
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The picture above left is a son of John H.
and Sarah H. Cathey Mathis. Weston
Ulysses Mathis (22 Jun 1869 - 23 Feb
1939) and his wife, Martha Jane Owen
(25 Oct 1 8 7 3 - 6 May 1959).
The man above is Andrew Jackson
Owen (3 May 1831 - 18 Sep 1905). The
lady to the left is his wife Mary Ann
McCall (9 Jan 1832-20Mar 1915).
Journey Through Jackson Winter 2014
J C G S P h o t o A l b u m v _ y
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The picture above is of Andrew Jackson Wood
(6 Dec 1816 - 1 Jan 1908) and his wife, Jane
Henderson (1819-1915).
The picture to the upper right is of Melissa M.
Luker (26 Mar 1899 - 22 Nov 1918), the
daughter of Charles Benjamin Luker and
Sarah Ann McCall, and her husband Shelvin
Owen.
The couple to the right is John Lee Shook (27
Mar 1884 - 20 Aug 1965), and his wife, Mary
Elizabeth Galloway (14 Feb 1883 - 3 Jan 1964)
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Journey Through Jackson Winter 2014
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W e b s t e r S c h o o l C a t a l o g u e
The catalogue below was sent to the Society by Gary W. Hines of Louisville, KY. The catalogue predates a gift of
the 1916 catalogue shared by Betty Raby Rowland.
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Journey Through Jackson Winter 2014
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D e s c e n d a n t s o f J o h n T h o m a s T a t h am
ED: This was submitted by JCGS member, Mary Buchanan Smith. It will continue in following issues.
MACON AND JACKSON COUNTY LAND RECORDS:
Bk. A., Page 382,1836 ... '180 acres for 10.00 per 100 acres on waters of Savannah Creek.
Bk. A. Page 512, 3 Dec 1845. William Tatham to Warren Barker, for 300.00 pd by Wm. Tatham to Richard Wilson (Hs father-in-law) in year
1840 a parcel of land on Savannah Creek. 85 acres.
Bk. C , pg'1354, 27 Feb 1841. Jacob Sims of 1st part and John Wilson, (Brother-in-law) and William
Tatham of the second part for 10.00 sold unto Isaac Ashe a parcel of land on Savannah
Creek beginning at the mouth of the Hollow below the Ridge, by estimation 40 acres or more . . .
Bk. D., pg 1724 10 June 1844. James M. Tatham for sum of 30.00 on the waters of Savannah Creek, 100 acres with the exception of 10 acres marked off and
granted for the purpose 6f a mill site.
25 Jul 1848. Between William Tatham and George Bumgarner for the sum of fifty dollars a tract of
land on Savannah Creek in County of Macon containing 50 acres.
Bk. 1, pg 32, 1853. William Tatham - Methodist Church (By trans.) 10 Mar 1853 between William
Tatham, Isaac Ashe, Amos Ashe, Christenbury Webb, George Bumgarner and William Tatham,
Trustees for Church grounds and building and appurtenances there on known as the Weslannah Church or
Savannah Church for the use and benefit of the members and minitsers of the Methodist Epispocal
Church and their successors in office as they may be appt. by proper authorities of the Church as
inheritance forever... on waters of Savannah Creek on the North side of Tatham's Mill Race.
William Tatham and R. V. Welch
File 431, Grant 407, Entry 136, Bk 162, pg 293, 3 May 1853, 384 acres Savannah Creek
File 209, Grant 287, Entry 135, Bk 160, pg 559, 3 May 1853, 640 acres Savannah Creek near the head of
Sang Branch.
File 522", Grant 498, Entry 133, Bk 162, pg 572, 3 May 1853, 350 acres on Savannah Creek at J. L.
Tatham's Corner.
File 523, Grant 499, Entry 141, Bk 162, pg 573, 2 May 1853, 640 acres on Savannah Creek. (Tatham and
Welch) marker in Wilson's line . . . Hall's line . . . Wilson's Corner . . . Quilliams line . . . passing
Green's line.
File 524, Grant 500, Entry 134, Bk 162, pg 573, 3 May 1853, 640 acres on Savannah Creek.
File 525, Grant 501, Entry 142, Bk 162, pg 573, 3 May 1853, 640 acres on Savannah Creek.
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File 538, Grant 504, Entry 143, Bk 162, pg 575, 3 May 1853, 640 acres on Savannah Creek.
Bk. 1, pg 109, 1854. William Tatham sold to William H. Higdon, land on Savannah Creek for 2.00.
Bk. 1, pg 109, 1854. 18 Mar 1856. William Tatham, 1st part and Wm. F. Passmore 2nd part. William
Tatham for consideration of 12.00 to him in hand by the said Wm. F. Passmore, Jr. his interest in a
piece of land lying in Jackson County consisting of 1/3 of one undivided interest in same, which lands are
lying on the waters of Chattooga River. Certified 8 Apr 1856.
Pg 533, 24 Apr 1856. Whereas William Tatham has heretofore by entry obtained an interest in Entries
#862, 640 acres; #103, 350 acres; #134, 640 acres; #136, 384 acres; #137, 640 acres; #141, 640 acres;
#142, 640 acres; and #143, 640 acres lying in the County of Jackson for consideration of the sum of two
hundred dollars to William Tatham in hand paid has contracted and sold to James Tatham and F. Leach
off the County of Cherokee on the sixth of said entries on condition that they pay the said Tathm the sum
often cents per acre for one sixth part of the afore said entries and costs of surveying and contingent fees
there and then and the case Tatham obligtes (sic) himself to convey to John Tatham and Leach on
undivided sixth part of said entries.
Bk. 1, pg 494, 18 Mar 1856. William Tatham of State of NC and County of Macon for 30.00 paid by
Warren Barker a piece of land on the east side of Savannah Creek, in Dist. #8 being said Tatham's
interest in the land with John Wilson and Company. Entered 2 May 1836. Estimated 100 acres.
Bk. 2, pg 6, 12 Sep 1856. Between M. Francis, Wm. Tatham, N. Woodfin of Is' part and Wm. Passmore
Jamison of 2nd part for 85.00 paid in full. Sum paid above will be more or less than 10 cents per acre.
William Tatham died in 1858 without a will. His estate had to be settled in federal court in Morganton,
Burke County, NC.
Jackson County Register of Deeds
This indenture made this the 10* day of May in the year of our Lord, 1860, between E. D. Davis Esq.
High Sheriff of the County of Jackson and State of NC of the one part and John Wilson of Jackson Co.
NC of the other, part witnessed by virtue of two executions issuing from the county Court of Jackson
against Joseph Keener and William Tatham for the sum of 263.58 to satisfy the said Execution
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with the cost thereon and the said E. D. Davis Sheriff did seize and take into his hands and custody no
goods nor chatties to be found a certain piece or parcel of land in the County of Jackson bounded as
follows beginning on a Black Oak N. E. corner of No. 158 and runs North seventy Five West 105 pole to
a Black Walnut thence south Twelve west sixty three poles to a White Oak thence South forty poles to a
stake on Savannah Creek at Bumgarner's N. W. Corner thence down the meanders of Savannah Creek
ninety five poles to a Beach Bumgarner's N. E. Corner thence south Twenty five west twenty one poles to
a dogwood thence east twenty five poles to a Hickory thence South forty poles to a Chestnut thence East
fifty eight poles to a Red Oak thence North seventy poles to a Hickory thence seventy eight poles to a
Black Oak thence North five East one hundred poles to a Lynn (sic) at the Stillhouse Branch thence West
down said Branch fifty poles to a Maple on bank of Savannah Creek then North west eighteen poles to a
Stake at a Bridge on the State Road adjoining the Wilson old tract then south seventy two sixteen poles to
stake thence N. fifty five w e s t . . . containing one hundred and seventy nine acres the lands on which the
Widow Tatham now lives and the sheriff after due advertisement according tq,law did cause the piece of
land with all appurtenances be put up at public sale to the highest bidder on the 20th day of March in 1860
at which time John Wilson (Brother to Isabella Tatham) became the last and highest bidder at the sum
of twenty dollars for the lands with appurtenances belonging to William Tatham deed.
Isabella Wilson is the daughter of Richard Wilson and Racheal Strain. She was born on 1 Jun 1802 in
Buncombe Co., NC. She died on 3 Oct 1889, in Jackson Co., NC. Burial in Wesleyanna Cemetery,
Jackson Co., NC.
Notes for Isabella Wilson
1860 Census, Jackson County, North Carolina
I. Tatham
J . L .
T.N.
J.M.
D.J.
55
22
20
18
18
female Farmer
male
male
male
male
William Henry Tatham .and Isabella Wilson were married on 12 Jan 1826, (Ref. Bible of John & Ann
Tatham.)
15. i. Elizabeth Araline Tatham. She was born on 2 Apr 1827 in Haywood Co., NC. She
married George Bumgarner on 27 Feb 1847 in Macon Co., NC. She died on 24 Aug 1903 in Jackson
Co., NC. Burial in Fairyiew Memorial Gardens, Jackson Co., NC.
16. ii. Lucinda Tatham. She was bprn on 1 Aug 1828 in Savannah Jackson Co., NC. She died
5 Jul 1892 in Savannah, Jackson Co., NC. Burial in Weslyanna Methodist Church Cemetery, Jackson
Co., NC.
17. iii. Clarinda Tatham. She was born on 16 Feb 1830. She married Robert A. Phillips on
13 Oct 1853 in Jackson Co., NC. She died on 3 Oct 1920 in Macon Co., NC.
iv. Alpheus L. Tatham. He was born 22 Nov 1832 in Macon Co., NC. He died in 1854.
Notes for Alpheus L. Tatham
Macon County Land Records
Grant 1144, 23 Dec 1843, Issued 11 Feb 1853, District 11, Section 158 (Jackson County,
NC) on Tatham's Creek, on the waters of Savannah Creek, adjoining William Tatham.
Grant 1145, 12 May 1847, Issued 11 Feb 1853, 100 acres on Savannah Creek (probably
same as Bk. G, pg 52.)
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Journey Through Jackson Winter 2014
Bk. G, pg 52, 1853. Altheous Tatham, 100 acres on the waters of Savannah Creek v-^->'
beginning at a popular (sic) tree . . . runs by Luke Wilson's corner.
Jackson County Minute Docket - March Term 1856
Invoice of Estate of A. L. Tatham by William Tatham, Administrator.
Trivit (?) on Stephen Munday, 53.00
2 Watches 108.00
1 bolts refroster (?) 30.00
John B. Allison debt for 150.00
William E. Enloe 50.00
Benjamin Allison 10.00
J. B. Love
1 shot gun
140 acres of land
William Tatham, Administer - Certified by D. Rogers, Clk.
"Family History" said that Lee Tatham was arrested for forcibly taking mail from letter
carrier between Dillsboro and Franklin because he was expecting a letter from a woman.
He was arrested and jailed in Macon County, NC Jail and there died of the "Bloody
Flux". (Told by Mattie Buchanan Cabe, daughter of Lillie Tatham Buchanan.)
18. v. Racheal Minerva Tatham. She was born on 24 Jul 1834 in Macon Co., NC. She
married Jesse Jones in 1856. She died before 1875 in Jackson Co., NC
19. vi. James Lafayette Tatham. He was born on 18 Jul 1837 in Macon Co. NC. He married •^^J
Catherine Boyd on 9 Jun 1861 in Jackson Co., NC. He died on 14 Mar 1919 in Jackson Co., NC. Burial
in Wesleyanna Methodist Church Cemetery, Jackson Co., NC.
20. vii. Thomas Nathaniel Tatham. He was born on 4 Jun 1839 in Jackson Co., NC. He
married Artie Mae Bryson on 15 Feb 1865 in Jackson Co., NC. He died Sep 1919 in Young Harris,
Georgia. Military Service: CSA, CO. A. Infantry Regiment, Thomas Legion. He is buried in Young
Harris, Gerogia.
21. viii. David Jasper Tatham. He was born 15 Apr 1842 in Jackson Co., NC. He married
Mary Collins Pilky on 22 Mar 1866 in Jackson Co., NC. He died 17 Oct 1891 in Jackson Co., NC.
Burial in Wesleyanna Methodist Cemetery, Jackson Co., NC.
22. ix. John M. Tatham. He was bom
Richard Jackson Jr. letter to Thomas Rotch, Providence, March 13th 1793
No full textA statement for Thomas Rotch's account with Richard Jackson Jr. Jackson's bill includes shipments of candles and butter with shipping and commission changes attached that he received from Rotch in New Bedford. Pd 67.8 1/2 To credit, the bill was paid for the same amount with errors accepted which meant that Rotch or Jackson could contest the bill if either party thought it was inaccurate. 7.7" x 6.25" (19.6cm by 16cm)
Accompanied letter of same date. (A-226-4
Implications of the Improvement of Teaching Quality for Professional Development (PD) of Academics at the Colleges of Applied Sciences (CASs) in the Sultanate of Oman
No full textThe Oman Accreditation Council (OAC), which is called later the Oman Academic Accreditation Authority (OAAA), designed a higher education institution (HEI) Quality Assurance (QA) framework for Omani public and private Higher Education Institutions (HEIs), starting with a quality audit process in 2008. The Colleges of Applied Sciences (CASs), as a public HEI, are required to ensure the quality of all services and activities to meet particular national standards (specified in the framework) in order to gain a HEI and programme certificate. In line with a quality audit scope, the quality of the fields of PD and related teaching quality should be ensured and enhanced by the promotion and contribution of the former field to the maintenance and improvement of the latter one.
The chief purpose of this study was to identify the uptake and implications of the growing requirement to improve teaching quality and the PD of academics at the CASs in the Sultanate of Oman especially in the context of the application of the QA framework. The study focused on examining the academics’ participation in professional development programmes (PDPs) and current perceptions of PD with respect to the improvement of teaching quality improvement at these colleges. The current study also dealt with a reorganization and prioritization of academics’ PD needs, barriers to effective PD, and factors to enhance PD of academics regarding teaching quality improvement in the colleges.
Based on the purpose and research objectives, the current study adopted both positivist (quantitative) and interpretive (qualitative) research paradigms. Because the study perused quantitative and qualitative data regarding certain variables, it chose a mixed-research design. The researcher designed survey questionnaire to collect quantitative data and a semi-structured interview and a focus group discussion to probe and interpret quantitative findings. After fulfillment of the validity and reliability measurements, a self-completion questionnaire was distributed to a stratified random sample of academics (170) over the six CASs. A total of 150 questionnaires (out of 170) were completed and returned and the response-rate reached 88.2%. The quantitative data was analyzed by appropriate analysis using the Statistical Package for Social sciences (SPSS), while the qualitative data was analyzed by appropriate qualitative analysis.
The findings of the study showed that the level of academics’ participation in PDPs to improve teaching quality in the last two years in the CASs seems to be unsatisfactorily low. The current perceptions of the PD situations in the colleges, relating to teaching quality improvement, signified a shortage in the number of available PDPs and/or a discouragement of academics’ participation in these programmes in the last two years. The study also revealed all the 22 PD needs of academics regarding the improvement of teaching quality are significantly demanded by participants; the higher rated needs focused on a development of ‘student centred’ skills, such as critical thinking and problem-solving skills.
Furthermore, the study illustrated that the highest significant perceived barriers to effective PD in the CASs, as related to teaching quality improvement, focus on a lack of a clear institutional PD policy and a lack of appropriately systematic PD plans. The study also revealed all 10 perceived factors to enhance PD regarding teaching quality improvement are very important. The most significant factors represented and stressed particular problematic issues (the high rated barriers) and a reduction of a heavy workload to enhance academics’ participation in PD regarding the improvement of teaching quality.
Conclusions drawn from the discussion of the findings of study include a lack of a clear PD policy at national and institutional levels and absence of a particular authority/unit concerning PD issues in Omani HEIs. The two problematic issues resulted in a lack of systematic and realistic PD plans in the CASs, involving a lack of academics’ involvement in PD plans, a misconnection of academics’ PD needs to PD, inappropriate facilities and resources allocation, and inappropriate evaluation processes of PD. In addition, the conclusions also include that PD of academics regarding the improvement of teaching quality in the colleges requires more attention and focus to manage particular significant issues perceived by participants as both barriers and potential facilitators relating to PD of academics.
Based on identified conclusions, particular implications for policy and practice to enhance PD to improve teaching quality were set at three levels: governmental, institutional, and individual. Moreover, achievements of the current study according to the research questions were identified and contributions of the study to the fields of PD, teaching quality, and the context of QA and quality audit in HE were addressed. Based on the findings and conclusions, particular directions and recommended issues were suggested to be studied by further research to benefit the enhancement of PD and related teaching quality improvement
Developing partnership through Third Space activity
No full textThis paper reports on a small-scale research investigation into developing partnerships between a Higher Education Institution (HEI) in England and schools based on a collaborative, rather than a cooperative model. Here, a deeper’ interpretation of collaboration, that is to say ‘working together’ rather than ‘working with’ is facilitated through Third Space activity. In essence 'Third Space’ suggests coming out of our normal working environment at school or university) and into a neutral ‘third space’ to design, develop and deliver teacher education with jointly shared understanding and vision. The research was carried out during 2012 and consisted of non-participant observation of meetings between HEI and school staff involved in the partnership and semi-structure interviews with a sample of these staff. The university programme involved was the PGCE secondary programme, however it is important to note that the research suggested that the philosophy of Third Space activity to develop partnership transcends limitations of context. Findings suggest that, despite the ambitious nature of this philosophy, this kind of partnership working has the potential to be transformative for all concerned: HEI tutors, school mentors and student teachers. This in turn benefits pupils in school. As School Direct becomes more widespread in England, it is suggested that the benefits of this kind of working could add significantly to the evolution of effective partnership practice not only in the English context but also in teacher education world-wide
Fullerene-like WS<sub>2</sub> supported Pd catalyst for hydrogen evolution reaction
No full textHydrogen is the most desirable green energy carrier and electrocatalytic hydrogen evolution reaction (HER) from water is a promising route for hydrogen production. The search for efficient, low-cost HER catalysts is a challenging and attracting topic. In this work, we report that inorganic fullerene-like WS2 supported Pd nanoparticles (Pd/WS2), with Pd loading of 0.76 wt%, are active for electrocatalytic HER conducted in 0.5 M H2SO4 solution, with overpotential at 10 mA cm−2 current density of ~130 mV and Tafel slope of 82.4 mV dec−1, which is comparable to that of Pt/WS2 (0.88 wt% Pt loading) with higher costs. Characteristic results indicate that WO3 impurities were in-situ produced on the WS2 surface and the Pd NPs are primarily located inside the WS2 nanocages. Contrasting experiments suggest that the WO3 impurities play a crucial role in generating Hads intermediate and the Pd NPs are active sites of H2 production, and a reaction mechanism is proposed. The Pd/WS2 catalyst also shows good long-term stability owing to the location of Pd NPs inside the WS2 cages. The high HER activity, low costs and good stability make the Pd catalyst a potential alternative to Pt catalyst for HER.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Micro and Nano Engineerin
Enhanced T-Cell Immunity to Osteosarcoma Through Antibody Blockade of PD-1/PD-L1 Interactions
No full textabstract: Osteosarcoma is the most common bone cancer in children and adolescents. Although 70% of patients with localized disease are cured with chemotherapy and surgical resection, patients with metastatic osteosarcoma are typically refractory to treatment. Numerous lines of evidence suggest that cytotoxic T lymphocytes (CTLs) limit the development of metastatic osteosarcoma. We have investigated the role of PD-1, an inhibitory TNFR family protein expressed on CTLs, in limiting the efficacy of immune-mediated control of metastatic osteosarcoma. We show that human metastatic, but not primary, osteosarcoma tumors express a ligand for PD-1 (PD-L1) and that tumor-infiltrating CTLs express PD-1, suggesting this pathway may limit CTLs control of metastatic osteosarcoma in patients. PD-L1 is also expressed on the K7M2 osteosarcoma tumor cell line that establishes metastases in mice, and PD-1 is expressed on tumor-infiltrating CTLs during disease progression. Blockade of PD-1/PD-L1 interactions dramatically improves the function of osteosarcoma-reactive CTLs in vitro and in vivo, and results in decreased tumor burden and increased survival in the K7M2 mouse model of metastatic osteosarcoma. Our results suggest that blockade of PD-1/PD-L1 interactions in patients with metastatic osteosarcoma should be pursued as a therapeutic strategy.This is a non-final version of an article published in final form as Lussier, Danielle M., O'Neill, Lauren, Nieves, Lizbeth M., McAfee, Megan S., Holechek, Susan A., Collins, Andrea W., Dickman, Paul, Jacobsen, Jeffrey, Hingorani, Pooja, & Blattman, Joseph N. (2015). Enhanced T-Cell Immunity to Osteosarcoma Through Antibody Blockade of PD-1/PD-L1 Interactions. JOURNAL OF IMMUNOTHERAPY, 38(3), 96-106. http://dx.doi.org/10.1097/CJI.000000000000006
Modeling of Surface Segregation for Binary Alloys in Vacuum and Gas Environments: Applied to Pd-alloys
No full textComputational modeling offers the possibility to design alloys in a cheaper and faster way. A model for surface segregation for binary alloys in vacuum and by adsorption and absorption of gases was developed and applied. The proposed model was used in conjunction with the Miedema semi-empirical model for the calculation of enthalpies of solution and formation of binary alloys and with the cluster variation method (CVM) for the calculation of the ? and ? phase boundaries in the ternary Pd-M-H systems. The models for segregation were applied in a temperature range from 298K to 600K, considering the surface plane (111) of the FCC crystal structure. The model for segregation in vacuum was applied to Pd-Au, Pd-Ag, Pd-Cu, Pd-Ni and Pd-Pt. For this case Pd is segregated for the Pd-Pt alloys only. By increasing the temperature from 298K to 600K, the surface concentrations of Pd decreased for all of the alloys. By varying the plane from (111) to (100) few changes were observed. The calculated results compared to experiments were found to be in good agreement for Pd-Au and Pd-Ag. For the model of surface segregation by adsorption and chemisorption, H2, CO and O2 gases on Pd-Ag, Pd-Cu, Pd-Ni and Pd-Pt were considered. In the presence of adsorbed or chemisorbed hydrogen, segregation of Pd was found for Pd-Ag, Pd-Cu and Pd-Pt alloys. For adsorbed O2 and CO on Pd-Ag and Pd-Cu alloys gases, segregation of Pd was enhanced. The model for segregation by absorption of hydrogen was applied for Pd-Ag, Pd-Cu, Pd-Ni and Pd-Pt alloys, using a hydrogen (bulk) concentration of 0.50 H/M. No Pd segregation was found for Pd-Ag alloys. For Pd-Pt alloys, Pd segregation was observed. For Pd-Cu alloys with large concentrations of Pd, a surface enrichment of Pd was calculated, while for alloys with low concentration of Pd a slight Cu surface enrichment was observed. Enhanced segregation of Ni was found for Pd-Ni alloys. The H/M fractions at the boundaries of the ? and ? phase obtained with the CVM for the Pd85Ag15H system were used as input values to calculate the surface concentration of Ag. As the hydrogen concentration was increased, the surface segregation of Pd also increased. For the surface segregation by adsorption and absorption combined, segregation of Pd was observed for Pd-Ag, Pd-Cu and Pd-Pt alloys. Surface enrichment of Ni was found for Pd-Ni alloys. The proposed model enables to predict surface segregation under various conditions and the results show that it is affected by many parameters.Master Materials Science and EngineeringDepartment of Materials Science and EngineeringMechanical, Maritime and Materials Engineerin
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Novel fuzzy logic controllers with self-tuning capability
No full textTwo controllers which extend the PD+I fuzzy logic controller to deal with the plant having time varying nonlinear dynamics are proposed. The adaptation ability of the first self tuning PD+I fuzzy logic controller (STPD+I_31) is achieved by adjusting the output scaling factor automatically thereby contributing to significant improvement in performance. Second controller (STPD+I_9) is the simplified version of STPD+I_31 which is designed under the imposed constraint that allows only minimum number of rules in the rule bases. The proposed controllers are compared with two classical nonlinear controllers: the pole placement self tuning PID controller and sliding mode controller. All the controllers are applied to the two-links revolute robot for the tracking control. The tracking performance of STPD+I_31 and STPD+I_9 are much better than the pole placement self tuning PID controller during high speed motions while the performance are comparable at low and medium speed. In addition, STPD+I_31 and STPD+I_9 outperform sliding mode controller using same method of comparison study
Prosperity without growth? : the transition to a sustainable economy
No full textThis report is summarised by the documents 'Prosperity without growth? : summary' and 'Ffyniant heb dwf? : crynodeb'Prosperity without Growth? analyses the complex relationships between growth, environmental crises and social recession.Publisher PD
Personal Papers (MS 80-0002)
No full textInvoice for items sold to Daniel Webster Kempner by O. P. Jackson Seed Co., including the cost of Chives Seed. Handwritten note " pd 6/3/49.
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