1,759,631 research outputs found
JN-01 docked into the KAT-II active site.
No full textThe amino acids within 5.0 Å of JN-01 (green) were chosen for display. Residues Ser-143, Gly-144, and Gln-289 were removed for clarity. The oxygen atoms in the sulfonamide form hydrogen bonds (yellow dashes) with Asn-202 and Lys-263, and the aromatic ring has pi-pi interactions (green dashes) with Tyr-74. Image generated with PyMOL [29].</p
JN-02 docked into the KAT-II active site.
No full textThe amino acids within 5.0 Å of JN-02 (green) were chosen for display. Residues Ser-143, Gly-144, and Gln-289 were removed for clarity. The amine in the sulfonamide forms hydrogen bonds (yellow dashes) with Gln-118, and the carbonyl in the phthalimide rings forms a hydrogen bond with Tyr-142. The aromatic ring has pi-pi interactions (green dashes) with Tyr-142 and pi-cation interactions (blue dashes) with Lys-263. Image generated with PyMOL [29].</p
JN-03 docked into the KAT-II active site.
No full textThe amino acids within 5.0 Å of JN-03 (green) were chosen for display. Residues Ser-143, Gly-144, and Gln-289 were removed for clarity. The sulfate forms hydrogen bonds with Tyr-74, Gln-118, Lys-263, and Arg-270, and the carboxyl moiety forms hydrogen bonds with Asn-202 and Arg-399. The aromatic ring has pi-cation interactions (blue dashes) with Lys-263. Image generated with PyMOL [29].</p
Geistreiches Gesang-Buch, Den Kern alter und neuer Lieder, in sich haltend : Jn gegenwärtiger beqvemer Ordnung und Form/ Nach denen unter diesen Namen alhier schon edirten Gesang-Büchern eingerichtet / Herausgegeben von Joh. Anastasio Freylinghausen/ Past. Adiuncto zu St. Ullrich.
No full textTitelblatt in Rot- und SchwarzdruckDie Rückseite des Titelblatts ist unbedrucktVorlageform der Veröffentlichungsangabe: Halle, Jn Verlegung des Wäysenhauses, A. 1725
The dynamics of single spike-evoked adenosine release in the cerebellum
Full text linkThe purine adenosine is a potent neuromodulator in the brain, with roles in a number
of diverse physiological and pathological processes. Modulators such as adenosine are difficult
to study as once released they have a diffuse action (which can affect many neurones) and,
unlike classical neurotransmitters, have no inotropic receptors. Thus rapid postsynaptic currents
(PSCs) mediated by adenosine (equivalent to mPSCs) are not available for study. As a result
the mechanisms and properties of adenosine release still remain relatively unclear. We have
studied adenosine release evoked by stimulating the parallel fibres in the cerebellum. Using
adenosine biosensors combined with deconvolution analysis and mathematical modelling, we
have characterised the release dynamics and diffusion of adenosine in unprecedented detail.
By partially blocking K+ channels, we were able to release adenosine in response to a single
stimulus rather than a train of stimuli. This allowed reliable sub-second release of reproducible
quantities of adenosine with stereotypic concentration waveforms that agreed well with predictions
of a mathematical model of purine diffusion. We found no evidence for ATP release
and thus suggest that adenosine is directly released in response to parallel fibre firing and does
not arise from extracellular ATP metabolism. Adenosine release events showed novel short-term
dynamics, including facilitated release with paired stimuli at millisecond stimulation intervals
but depletion-recovery dynamics with paired stimuli delivered over minute time scales. These
results demonstrate rich dynamics for adenosine release that are placed, for the first time, on a
quantitative footing and show strong similarity with vesicular exocytosis
On the zeros of Jn(z)±iJn+1(z) and [Jn+1(z)]2−Jn(z)Jn+2(z)
No full textAbstractThe zeros of Jn(z)±iJn+1(z) and [Jn+1(z)]2−Jn(z)Jn+2(z) play an important role in certain physical applications. At the origin these functions have a zero of multiplicity n (if n⩾1) and 2n+2, respectively. We prove that all the zeros that lie in C0 are simple. zebec (Kravanja et al., Comput. Phys. Commun. 113(2–3) (1998) 220–238) is a reliable software package for calculating zeros of Bessel functions of the first, the second, or the third kind, or their first derivatives. It can be easily extended to calculate zeros of any analytic function, provided that the zeros are known to be simple. Thus, zebec is the package of choice to calculate the zeros of Jn(z)±iJn+1(z) or [Jn+1(z)]2−Jn(z)Jn+2(z). We tabulate the first 30 zeros of J5(z)−iJ6(z) and J10(z)−iJ11(z) that lie in the fourth quadrant as computed by zebec
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Franz Liszt's Gesammelte Lieder. Jn sechs Heften
Full text linkFRANZ LISZT'S GESAMMELTE LIEDER. JN SECHS HEFTEN
Franz Liszt's Gesammelte Lieder. Jn sechs Heften
Franz Liszt's Gesammelte Lieder. Jn sechs Heften ; Heft 1 (H. 1) (1)
Franz Liszt's Gesammelte Lieder. Jn sechs Heften ; Heft 2 (H. 2) (1)
Franz Liszt's Gesammelte Lieder. Jn sechs Heften ; Heft 3 (H. 3) (1)
Franz Liszt's Gesammelte Lieder. Jn sechs Heften ; Heft 4 (H. 4) (1)
Franz Liszt's Gesammelte Lieder. Jn sechs Heften ; Heft 5 (H. 5) (1)
Franz Liszt's Gesammelte Lieder. Jn sechs Heften ; Heft 6 (H. 6) (1
Curtiss JN-4Can
No full text1/4 right hand side view of multiple Curtiss JN-4s, civilian aircraft, on the ground. Note on back JN-4 (Canadian) \u27Canucks\u27 and personnel of Service Aviation Training and Transportation Company of Wabash, IN.https://corescholar.libraries.wright.edu/special_ms223_photographs/1093/thumbnail.jp
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