98 research outputs found
The role of Class II major histocompatibility complex antigens in autoimmune diabetes: Animal models
No full textThe Role of Class II Major Histocompatibility Complex Antigens in Autoimmune Diabetes: Animal Models
No full textVascular catheter-related infection claims to health insurance company: often preventable
No full textAbstractUsing the main French health insurance company database over a 10-year period, the preventability of catheter-related infections of patients who claimed compensation after prosecution was reviewed by a panel expert. They occurred in 71 patients with few co-morbidities or risk factors for nosocomial infection and were mainly related to the use of a peripheral vascular catheter (42 cases) and due to Staphylococcus aureus (51 cases). Forty-two infections were considered to be preventable. Infections due to peripheral venous catheters were significantly more often preventable than those due to central ones (p < 0.05). We conclude that catheter-related infections perceived by patients and the justice system as not related to unforeseeable medical complications are mainly peripheral catheter infections due to S. aureus and might be an appropriate target for new preventive strategies
Surgical Management of Adrenocortical Carcinoma: Impact of Laparoscopic Approach, Lymphadenectomy, and Surgical Volume on Outcomes-A Systematic Review and Meta-analysis of the Current Literature
No full textContains fulltext :
200417.pdf (Publisher’s version ) (Open Access
PIN87 Non-Homogeneous Cost-Effectiveness Modeling of a New CHG-Dressing for Preventing Catheter-Related Bloodstream Infections for Patients in Intensive Care Units
No full textThe loaded surface profile: a new technique for the investigation of contact surfaces
No full textContact between rough surfaces produces a complex contact profile. The contact area is usually estimated according to roughness statistics in conjunction with surface models or by examining the surfaces before and after contact. Most of the existing literature on loaded surface profiles is theoretical or numerical in nature.This paper presents a methodology for a new system to measure the loaded surface profile, based on a non-contact 3D laser profiler. The system allows the measurement of contact area, deformation and contact resistance in terms of the contact force and plane displacement, all whilst the surfaces are actually in contact. This paper presents the initial study of the methodology and focuses on the method for determining the real contact area. The laser performs the scan through a transparent flat slide supported in a fixed position above the base. A test contact is mounted on a force sensor on an adjustable screw support such that this sub-assembly can move into contact with the fixed transparent surface. The main results are in the demonstration of the measurement method and in the initial study of contact force and contact area on a hemispherical Ag/SnO electrical contact surface
Inferior Thyroid Artery Injury After Attempts of Internal Jugular Venous Catheterization
No full text[No abstract available]Abbott G, 2001, BRIT J ANAESTH, V86, P143, DOI 10.1093-bja-86.1.143; Cuhaci B, 2000, AM J NEPHROL, V20, P476, DOI 10.1159-000046203; Jeganath V, 2001, BRIT J ANAESTH, V87, P302, DOI 10.1093-bja-87.2.302; MACGEE DC, 2003, NEW ENGL J MED, V348, P1123; Merrer J, 2001, JAMA-J AM MED ASSOC, V286, P700, DOI 10.1001-jama.286.6.700; Peces R, 1998, NEPHROL DIAL TRANSPL, V13, P1009, DOI 10.1093-ndt-13.4.1009; Randolph AG, 1996, CRIT CARE MED, V24, P2053, DOI 10.1097-00003246-199612000-00020; Ruesch S, 2002, CRIT CARE MED, V30, P454, DOI 10.1097-00003246-200202000-00031; Timsit JF, 1998, CHEST, V114, P207, DOI 10.1378-chest.114.1.20733
Correction to: Early EEG for Prognostication Under Venoarterial Extracorporeal Membrane Oxygenation (Neurocritical Care, (2020), 33, 3, (688-694), 10.1007/s12028-020-01066-3)
No full textThe original article was updated by replacing an incorrect institutional author to DINAMO study group towards the end of the author list. Table 1 was updated with modifications on the lines “History of acute brain injury” and “At ICU admission”. Acknowledgements section is corrected below to have the DINAMO study group information added towards the end
Normativity, Fundamental Rights and Legal Order in the EU
No full textTwo years ago, specifically on 23 May 2008, the European Public Law Organization (EPLO) Branch in Bucharest was established in the presence of Prof.Dr. Spyridon Flogaitis, Director, President of the Board of Directors and important Romanian and Hellenic officials. Hosted by the National School of Political Studies and Public Administration (NSPSPA) through the Faculty of Public Administration, the EPLO Branch in Bucharest has marked an important moment in view of extending and developing EPLO specific activities and has encompassed an activity of collaboration of over a decade between the two institutions. The forms of collaboration, already traditional: joint European programmes, participation in the European Public Law Academy, mobility of students, doctoral students and teaching staff will be diversified. The start of a cycle of conferences on actual topics of the European Union construction, legal, administrative and managerial substantiation of the important processes represents such a form. Conducted under the aegis "The Dialogues of EPLO at NSPSPA", the conferences have enjoyed the participation of recognized academic personalities from prestigious European universities. The conferences have carried forth scientific events for the Romanian academia, in view to increase EPLO prestige, to acquire knowledge and disseminate its activities. The current volume gathers the content of the first conferences, circumscribing to important concepts of the theory and practice of the EU construction: normativity, fundamental rights or legal order. Of course the reader's thorough analysis when studying the current volume will get us close or far away from the three concepts, already stated. Thus, the first topic "La Regulation, une forme moderne de la normativite?" of Professor Gérard Timsit debates, from doctrine view, the specific difference between "regulation" and "reglementation", taking into consideration "the crisis of traditional normativity" developing towards "a new social normativity". Considering the societies' complexity, the author identifies another crisis of "the deficit of legitimacy", leading to "the deficit of societies' complexity and their governance systems". Professor Timsit, whose work substantiates the programmes on theory and science of administration within the framework of NSPSPA, reveals the necessity of new changes in view of better understanding the complexity: transforming the bureaucratic state into a strategic state, thus triggering a reshaped administration, able to deal the society's empirical realities in times of crisis or disaster. The issues specific for the transformations of the European institutions after the Lisbon Treaty are approached by Professor Jean Paul Jacque, who insists on "strengthening the effectiveness of the EU institutional system" through the democratisation of law-making within the Council, enlargement of the scope of the co-decision procedure etc. The comparative analysis between the provisions of the former EU Constitution and those of Lisbon Treaty emphasises the necessity of national parliaments' participation and promotion of participative democracy in view of democratization of law-making within the Council. In the conclusions of the conference, the author presents "the open democratic space that has to be occupied by political actors and citizens", which should abandon the traditional behaviour in the European elections, insisting on relevant matters concerning the competences and contents of the EU policies. The perspective opened by Lisbon Treaty on fundamental rights protection in the European Union provides for the first time a mandatory set of fundamental rights. Corroborating this fact with the provisions of the EU Charter of Fundamental Rights, common questions emerge, finding an answer in Professor Helena Raulus's conference. The questions refer to the meaning of that new fundamental rights system for the Union or Member States as well as to the EU role in strengthening the fundamental human rights and creating a new mechanism for monitoring the human rights infringement by the Member States. A final conclusion, quite interesting for the debated topic refers to the fact that in the emphasised context, the Union does not gain any new competences or tasks on human rights protection and the provisions of the Charter are mainly directed to the Union institutions and to the Member States only when they are acting within the scope of the Union law. Matteo Gnes's conference tries to address other question: "European legal integration: new possibilities for EU and non-EU citizens?" Based on a broad range of relevant cases, Centros, Akrich or Polish plumber, the conclusion of the conference refers to the phenomena due to the convergence of market forces and legal principles embodied in the principles of free movement. Even if some of those phenomena may foster Euro sceptic attitudes, the final conclusion is: "European integration is an extremely positive central aspect of everyday life of every European citizen". In addition to the topics on fundamental rights and freedoms, it emerges the issue of the public contracts in the European law. The debate with legal and economic features, presented by Professor Pierre Nihoul is structured on the principles of competition, transparency and neutrality and it highlights the necessity to take into consideration the social, environmental, ethic and fair concerns on the public markets. In this context, however, it is worth to mention a conclusion. It refers, on one hand, to the fact that the opportunities provided by the legal texts remain limited and, on the other hand, the exercise of public powers does not sufficiently reflect the development of the legal debate. The contents of the other two conferences are complementary, being focused on the EU democratic legal order, respectively the European judiciary. The most important issues addressed by Professor Bertrand Mathiew in his conference refer to the legitimacy of the European legal order and to the interrogation on: "European Parliament, a representation of the European citizens?" We also find the response to those topics or questions in the second part of the presentation concerning the European Parliament which is considered an institution participating in the democratic functioning of the European Union; thus it becomes "an instrument of embryo for separation of powers", and its representative function is challenged by other forms of democratic expression. Professor Thomas Oppermann presents his arguments and the structures triggering the European judiciary. As a cross-national democracy observing the rule of law, the EU needs an independent judiciary system – the third power, the constitutive Treaties legitimate the fact that the EU is a "Union of law", interpreting and enforcing the European law. The European legislation is mandatory in all Member States
Distribution of pathogens and antimicrobial resistance in bacteremia according to hospitalization duration: A nationwide surveillance study in Switzerland.
No full textOBJECTIVES
Changing microorganism distributions and decreasing antibiotic susceptibility with increasing length of hospital stay have been demonstrated for the colonization or infection of selected organ systems. We wanted to describe microorganism distribution or antibiotic resistance in bacteremia according to duration of the hospitalization using a large national epidemiological/microbiological database (ANRESIS) in Switzerland.
METHODS
We conducted a nationwide, observational study on bacteremia using ANRESIS data from 1st January 2008 to 31st December 2017. We analyzed data on bacteremia from those Swiss hospitals that sent information on a regular basis during the entire study period. We described the pathogen distribution and specific trends of resistance during the hospitalization for E. coli, K. pneumoniae, P. aeruginosa, S. marcescens and S. aureus.
RESULTS
We included 28,318 bacteremia isolates from 90 Swiss hospitals. The most common etiology was E. coli (33.4%, 9,459), followed by S. aureus (16.7%, 4,721), K. pneumoniae (7.1%, 2,005), E. faecalis (5.2%, 1,473), P. aeruginosa (4.3%, 1,228), S. pneumoniae (4.3%, 1,208) and E. faecium (3.9%, 1,101). We observed 489 (1.73%) Serratia marcescens isolates. We observed an increasing trend for Enterococcus faecium (from 1.5% at day 0 to 13.7% at day 30; p<0.001), K. pneumoniae (from 6.1% to 7.8%, p<0.001) and P. aeruginosa (from 2.9% to 13.7%, p<0.001) with increasing duration of hospitalization; and a decreasing trends for E. coli (from 41.6% at day 0 to 21.6% at day 30; p<0.001) and S. aureus (from 14.4% to 14.7%; p<0.001). Ceftriaxone resistance among E. coli remained stable for the first 15 days of hospitalization and then increased. Ceftriaxone resistance among K. pneumoniae and S. marcescens and oxacillin resistance among S. aureus increased linearly during the hospitalization. Cefepime resistance among P. aeruginosa remained stable during the hospitalization.
CONCLUSIONS
We showed that hospitalization duration is associated with a species- and antibiotic class-dependent pattern of antimicrobial resistance
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