2,220 research outputs found
Hoge (Dean R.) Zech (Charles E.) McNamara (Patrick H.) Donahue (Michael J.) Money Matters, Personal Giving in American Churches
No full textBrémond d'Ars Nicolas de. Hoge (Dean R.) Zech (Charles E.) McNamara (Patrick H.) Donahue (Michael J.) Money Matters, Personal Giving in American Churches. In: Archives de sciences sociales des religions, n°104, 1998. pp. 96-97
Ursachenforschung der DNA-strangbruchfreien Spermienselektion mittels Zech-Selector
No full textDiese Studie beschäftigt sich mit der Ursache der DNA-strangbruchfreien Spermienselektion mittels des Zech-Selectors. Durch die Veröffentlichung der Daten von Ebner et al. im Jahre 2011, ist bekannt, dass der Zech-Selector Spermien mit DNA-Strangbrüchen zu fast 100% von den übrigen Spermien trennt. Die Idee hinter dieser Studie war es, herauszufinden warum dieser Effekt zustande kommt. Ainsworth et al. veröffentlichte 2005 eine Arbeit in der er beschreibt, dass man durch elektrische Spannung Spermien mit DNA-Strangbrüchen trennen kann. Dieser Ansatz war richtungsweisend für unsere Hypothese. Bei dieser Studie handelt es sich um eine prospektive, randomisierte Studie, die in der privaten Kinderwunsch-Clinic Dr. J. Zech GmbH in Innsbruck durchgeführt wurde. Sie beruht auf der Hypothese, dass der Trennungseffekt des Zech-Selectors bezogen auf Spermien mit DNA-Strangbrüchen, auf seiner elektrostatischen Aufladung beruht. Um dies deutlich zu machen, wurde der Zech-Selector mit einer geerdeten Kupferplatte entladen, um somit den Trennungseffekt zu eliminieren. Es standen sich 2 Gruppen, die Kontrollgruppe und die Patientengruppe gegenüber. Als Voraussetzung für die Männer der Kontrollgruppe galt es eine Samenprobe mit einer Konzentration von ≥ 15 Mio/ml, einer progressiven Beweglichkeit von mind. 40% und einem Volumen von mind. 2ml abzugeben bzw. mussten sie bereits Väter sein. Für die Männer der Patientengruppe galt, was die Parameter Konzentration, progressive Beweglichkeit und Volumen angeht, dasselbe. Zusätzlich aber musste die Probe einen DFI (HALO-Wert) von ≥ 15% aufweisen. Für den Nachweis von Spermien mit DNA-Strangbrüchen wurde der Halosperm®-Test verwendet...This study deals with the DNA strandbreakfree selection of sperms using the Zech-selector. From the publication of Ebner’s data et al. 2011 it is known that the Zech-selector almost entirely seperates sperms with DNA strandbreaks from other sperms. The basic idea of the study was to find out why this effect is caused. In 2005 Ainsworth et al. published a study in which he explained that sperms with DNA strandbreaks can be separated with electric voltage. This approach was crucial for our hypothesis. This study is prospective and randomized and it was conducted at the private Kinderwunschclinic Dr. J. Zech in Innsbruck. It relies on the hypothesis that the separation effect of the Zech-selector of sperms with DNA strandbreaks is caused by its electrostatic charge. In order to prove this the Zech-selector was discharged with an earthed copper plate. Two groups, namely the control group and the patient group, were compared. Men of the control group had to give a sperm donation with a concentration of ≥ 15 Mill/ml, a progressive mobility of at least 40% and a volume of at least 2 ml and respectively be fathers. Those parameters also had to be met by men of the patient group but additionally their donation had to show a fragmentation index of ≥ 15%. In order to prove sperms with DNA strandbreaks the Halosperm test was used...eingereicht von Martin MalojerGraz, Univ., Masterarb., 201
Ursachenforschung der DNA-strangbruchfreien Spermienselektion mittels Zech-Selector
No full textDiese Studie beschäftigt sich mit der Ursache der DNA-strangbruchfreien Spermienselektion mittels des Zech-Selectors. Durch die Veröffentlichung der Daten von Ebner et al. im Jahre 2011, ist bekannt, dass der Zech-Selector Spermien mit DNA-Strangbrüchen zu fast 100% von den übrigen Spermien trennt. Die Idee hinter dieser Studie war es, herauszufinden warum dieser Effekt zustande kommt. Ainsworth et al. veröffentlichte 2005 eine Arbeit in der er beschreibt, dass man durch elektrische Spannung Spermien mit DNA-Strangbrüchen trennen kann. Dieser Ansatz war richtungsweisend für unsere Hypothese. Bei dieser Studie handelt es sich um eine prospektive, randomisierte Studie, die in der privaten Kinderwunsch-Clinic Dr. J. Zech GmbH in Innsbruck durchgeführt wurde. Sie beruht auf der Hypothese, dass der Trennungseffekt des Zech-Selectors bezogen auf Spermien mit DNA-Strangbrüchen, auf seiner elektrostatischen Aufladung beruht. Um dies deutlich zu machen, wurde der Zech-Selector mit einer geerdeten Kupferplatte entladen, um somit den Trennungseffekt zu eliminieren. Es standen sich 2 Gruppen, die Kontrollgruppe und die Patientengruppe gegenüber. Als Voraussetzung für die Männer der Kontrollgruppe galt es eine Samenprobe mit einer Konzentration von ≥ 15 Mio/ml, einer progressiven Beweglichkeit von mind. 40% und einem Volumen von mind. 2ml abzugeben bzw. mussten sie bereits Väter sein. Für die Männer der Patientengruppe galt, was die Parameter Konzentration, progressive Beweglichkeit und Volumen angeht, dasselbe. Zusätzlich aber musste die Probe einen DFI (HALO-Wert) von ≥ 15% aufweisen. Für den Nachweis von Spermien mit DNA-Strangbrüchen wurde der Halosperm®-Test verwendet...This study deals with the DNA strandbreakfree selection of sperms using the Zech-selector. From the publication of Ebner’s data et al. 2011 it is known that the Zech-selector almost entirely seperates sperms with DNA strandbreaks from other sperms. The basic idea of the study was to find out why this effect is caused. In 2005 Ainsworth et al. published a study in which he explained that sperms with DNA strandbreaks can be separated with electric voltage. This approach was crucial for our hypothesis. This study is prospective and randomized and it was conducted at the private Kinderwunschclinic Dr. J. Zech in Innsbruck. It relies on the hypothesis that the separation effect of the Zech-selector of sperms with DNA strandbreaks is caused by its electrostatic charge. In order to prove this the Zech-selector was discharged with an earthed copper plate. Two groups, namely the control group and the patient group, were compared. Men of the control group had to give a sperm donation with a concentration of ≥ 15 Mill/ml, a progressive mobility of at least 40% and a volume of at least 2 ml and respectively be fathers. Those parameters also had to be met by men of the patient group but additionally their donation had to show a fragmentation index of ≥ 15%. In order to prove sperms with DNA strandbreaks the Halosperm test was used...eingereicht von Martin MalojerGraz, Univ., Masterarb., 201
Rigor Moderatus doctrinae pontificiae circa usuras a SS. D. N. Benedicto XIV. per epistolam encylicam episcopis Italiae traditus
No full text... Præside Francisco Zech, S. J. SS. Theologiæ, & SS. Canonum Doctore, horúmque Professore Publico & Juris Primario...Bd. 3 im Verl. Gräz & Summer, Ingolstadii, erschienenErschienen: 1 (1747) - 3 (1751)Ingolstadt, Univ., Jur. Diss
Correction: A case of novel DYT6 dystonia variant with serious complications after deep brain stimulation therapy: a case report
No full textFollowing publication of the original article [1], the authors reported an error in author group. Author M. Zech should be affiliated to affiliations 6 and 7. The original article [1] has been updated
Reconstructing lake evaporation history and the isotopic composition of precipitation by a coupled delta<sup>18</sup>O–delta<sup>2</sup>H biomarker approach
No full textOver the past decades, delta O-18 and delta H-2 analyses of lacustrine sediments became an invaluable tool in paleohydrology and paleolimnology for reconstructing the isotopic composition of past lake water and precipitation. However, based on delta O-18 or delta H-2 records alone, it can be challenging to distinguish between changes of the precipitation signal and changes caused by evaporation. Here we propose a coupled, delta O-18-delta H-2 biomarker approach that provides the possibility to disentangle between these two factors. The isotopic composition of long chain n-alkanes (n-C-33, n-C-27, n-C-31) were analyzed in order to establish a 16 ka Late Glacial and Holocene delta H-2 record for the sediment archive of Lake Panch Pokhari in High Himalaya, Nepal. The delta H-2(n-alkane) record generally corroborates a previously established delta O-18(sugar) record reporting on high values characterizing the deglaciation and the Older and the Younger Dryas, and low values characterizing the Bolling and the Allerod periods. Since the investigated n-alkane and sugar biomarkers are considered to be primarily of aquatic origin, they were used to reconstruct the isotopic composition of lake water. The reconstructed deuterium excess of lake water ranges from +57 parts per thousand to -85 parts per thousand and is shown to serve as proxy for the evaporation history of Lake Panch Pokhari. Lake desiccation during the deglaciation, the Older Dryas and the Younger Dryas is affirmed by a multi-proxy approach using the Hydrogen Index (HI) and the carbon to nitrogen ratio (C/N) as additional proxies for lake sediment organic matter mineralization. Furthermore, the coupled delta O-18 and delta H-2 approach allows disentangling the lake water isotopic enrichment from variations of the isotopic composition of precipitation. The reconstructed 16 delta O-18(precipitation) record of Lake Panch Pokhari is well in agreement with the delta O-18 records of Chinese speleothems and presumably reflects the Indian Summer Monsoon variability. (C) 2014 Elsevier B.V. All rights reserved.German Research Foundation [ZE 844/1-2
Do n-alkane biomarkers in soils/sediments reflect the δ 2-H isotopic composition of precipitation? A case study from Mt. Kilimanjaro and implications for paleoaltimetry and paleoclimate research
No full textDuring the last decade compound-specific deuterium (2H) analysis of plant leaf wax-derived n-alkanes has become a promising and popular tool in paleoclimate research. This is based on the widely accepted assumption that n-alkanes in soils and sediments generally reflect δ2H of precipitation (δ2Hprec). Recently, several authors suggested that δ2H of n-alkanes (δ2Hn-alkanes) can also be used as a proxy in paleoaltimetry studies. Here, we present results from a δ2H transect study (∼1500 to 4000 m above sea level [a.s.l.]) carried out on precipitation and soil samples taken from the humid southern slopes of Mt. Kilimanjaro. Contrary to earlier suggestions, a distinct altitude effect in δ2Hprec is present above ∼2000 m a.s.l., that is, δ2Hprec values become more negative with increasing altitude. The compound-specific δ2H values of nC27 and nC29 do not confirm this altitudinal trend, but rather become more positive both in the O-layers (organic layers) and the Ah-horizons (mineral topsoils). Although our δ2Hn-alkane results are in agreement with previously published results from the southern slopes of Mt. Kilimanjaro [Peterse F, van der Meer M, Schouten S, Jia G, Ossebaar J, Blokker J, Sinninghe Damsté J. Assessment of soil n-alkane δD and branched tetraether membrane lipid distributions as tools for paleoelevation reconstruction. Biogeosciences. 2009;6:2799–2807], a re-interpretation is required given that the δ2Hn-alkane results do not reflect the δ2Hprec results. The theoretical framework for this re-interpretation is based on the evaporative isotopic enrichment of leaf water associated with the transpiration process. Modelling results show that relative humidity, decreasing considerably along the southern slopes of Mt. Kilimanjaro (from 78 % in ∼2000 m a.s.l. to 51 % in 4000 m a.s.l.), strongly controls δ2Hleaf water. The modelled 2H leaf water enrichment along the altitudinal transect matches well the measured 2H leaf water enrichment as assessed by using the δ2Hprec and δ2Hn-alkane results and biosynthetic fractionation during n-alkane biosynthesis in leaves. Given that our results clearly demonstrate that n-alkanes in soils do not simply reflect δ2Hprec but rather δ2Hleaf water, we conclude that care has to be taken not to over-interpret δ2Hn-alkane records from soils and sediments when reconstructing δ2H of paleoprecipitation. Both in paleoaltimetry and in paleoclimate studies changes in relative humidity and consequently in δ2Hn-alkane values can completely mask altitudinally or climatically controlled changes in δ2Hprec
Modeling promoter search by E. coli RNA polymerase: One-dimensional diffusion in a sequence-dependent energy landscape
No full textWe present a biophysical model of promoter search by Escherichia coli RNA polymerase. We use an unconventional weight matrix derived from promoter strength data to extract the energy landscape common to a large set of known promoters. This exhibits a continuous strengthening of the binding energy when approaching the transcription start site from either side. During promoter search, the RNA polymerase slides along the DNA double helix (one-dimensional diffusion) after randomly binding to it. We discuss the possibility that the sliding has a sequence-dependent component, which implies that the energy landscape influences the movement with respect to speed, direction and efficiency. Based on this assumption, we relate the obtained energy landscape around the promoters to the one-dimensional diffusion of the RNA polymerase. Our analytical results suggest that the sequence-dependent random walk slows down and gets directed upon entering a region of 500 bp around the transcription start site, which significantly increases the efficiency of promoter search. These results may explain how the RNA polymerase is able to find the promoter in biologically relevant times out of a vast excess of non-target sites. Moreover, they provide evidence for a sequence-dependent component of one-dimensional diffusion. © 2009 Elsevier Ltd. All rights reserved.Barbi M, 2004, PHYS REV E, V70, DOI 10.1103-PhysRevE.70.041901; Barbi M, 2004, J BIOL PHYS, V30, P203, DOI 10.1023-B:JOBP.0000046728.51620.14; BERG OG, 1981, BIOCHEMISTRY-US, V20, P6929, DOI 10.1021-bi00527a028; Blainey PC, 2006, P NATL ACAD SCI USA, V103, P5752, DOI 10.1073-pnas.0509723103; Bruinsma RF, 2002, PHYSICA A, V313, P211, DOI 10.1016-S0378-4371(02)01038-5; Bustamante C, 1999, J BIOL CHEM, V274, P16665, DOI 10.1074-jbc.274.24.16665; Dombroski AJ, 1996, P NATL ACAD SCI USA, V93, P8858, DOI 10.1073-pnas.93.17.8858; ERIE DA, 1994, SCIENCE, V266, P1562, DOI 10.1126-science.7985026; Flyvbjerg H, 2006, NUCLEIC ACIDS RES, V34, P2550, DOI 10.1093-nar-gkl271; Gowers DM, 2005, P NATL ACAD SCI USA, V102, P15883, DOI 10.1073-pnas.0505378102; Gruber TM, 2003, ANNU REV MICROBIOL, V57, P441, DOI 10.1146-annurev.micro.57.030502.090913; Guthold M, 1999, BIOPHYS J, V77, P2284; Halford SE, 2004, NUCLEIC ACIDS RES, V32, P3040, DOI 10.1093-nar-gkh624; Harada Y, 1999, BIOPHYS J, V76, P709, DOI 10.1016-S0006-3495(99)77237-1; Hosid S, 2004, BMC MOL BIOL, V5, DOI 10.1186-1471-2199-5-14; HU L, 2007, ARXIV07091495V1CONDM; JELTSCH A, 1994, BIOCHEMISTRY-US, V33, P10215, DOI 10.1021-bi00200a001; KABATA H, 1993, SCIENCE, V262, P1561, DOI 10.1126-science.8248804; Kalodimos CG, 2004, SCIENCE, V305, P386, DOI 10.1126-science.1097064; Kiryu H, 2005, BIOINFORMATICS, V21, P1062, DOI 10.1093-bioinformatics-bti094; KOBAYASHI M, 1990, NUCLEIC ACIDS RES, V18, P7367, DOI 10.1093-nar-18.24.7367; MULLIGAN ME, 1985, J BIOL CHEM, V260, P3529; MURTHY KPN, 1989, PHYS REV A, V40, P2082, DOI 10.1103-PhysRevA.40.2082; PAGET MSB, 2003, GENOME BIOL, V4, P230; RICCHETTI M, 1988, P NATL ACAD SCI USA, V85, P4610, DOI 10.1073-pnas.85.13.4610; RIGGS AD, 1970, J MOL BIOL, V53, P401, DOI 10.1016-0022-2836(70)90074-4; Sakata-Sogawa K, 2004, P NATL ACAD SCI USA, V101, P14731, DOI 10.1073-pnas.0406441101; Salgado H, 2006, NUCLEIC ACIDS RES, V34, pD394, DOI 10.1093-nar-gkj156; Saxton MJ, 2007, BIOPHYS J, V92, P1178, DOI 10.1529-biophysj.106.092619; Sengupta AM, 2002, P NATL ACAD SCI USA, V99, P2072, DOI 10.1073-pnas.022388499; Shimamoto N, 1999, J BIOL CHEM, V274, P15293, DOI 10.1074-jbc.274.22.15293; Slutsky M, 2004, BIOPHYS J, V87, P4021, DOI 10.1529-biophysj.104.050765; Slutsky M, 2004, PHYS REV E, V69, DOI 10.1103-PhysRevE.69.061903; VONHIPPEL PH, 1989, J BIOL CHEM, V264, P675; VONHIPPEL PH, 1986, P NATL ACAD SCI USA, V83, P1608; Weindl J, 2007, NUCLEIC ACIDS RES, V35, P7003, DOI 10.1093-nar-gkm720; WEINDL J, 2007, P IEEE INT C COMM IC, P833; Widom J, 2005, P NATL ACAD SCI USA, V102, P16909, DOI 10.1073-pnas.0508686102; WINTER RB, 1981, BIOCHEMISTRY-US, V20, P6961, DOI 10.1021-bi00527a03021
An exile in Buenos Aires: The stroll in the Argentinean works of Paul Zech (1933-1946)
No full textEn 1933 el escritor alemán Paul Zech debe huir de Alemania y refugiarse en Buenos Aires, donde vivirá hasta su muerte en 1946. Allí tendrá una intensa actividad literaria, llevada adelante en difíciles condiciones de vida, tanto en cuanto a su condición misma de exiliado, como por sus cambiantes y conflictivos vínculos al interior de la colectividad alemana. En esta obra, una inclinación a la caminata por la ciudad nos muestra una imagen de la Argentina de la década de 1930 desde el novedoso punto de vista de un autor exiliado en estas tierras.En este trabajo nos preguntamos cómo se constituye en la obra argentina de Zech el paseo en el exilio (si acaso es posible el paseo en el exilio) y cómo se recorta, por sus particularidades, de los otros registros urbanos escritos «a pie» en su misma época (Benjamin, Kracauer).In 1933 the German writer Paul Zech had to flee from Germany and go into exile in Buenos Aires, where he would live until his death in 1946. There, he would have an intense literary activity, carried out under difficult living conditions, both because of his condition as an exile and because of his changing and con-flictive links within the German community. Within Zech’s works during these years, an inclination to walk around the city shows us an image of Argentina in the 1930s from the novel point of view of an author exiled in these lands.In this work we inquire how the strollin exile (whether it is possible to stroll in exile) is constituted in Zech’s Argentinean work and how it is cut out, due to its particularities, from the other urban records written «by foot» in his same period (Benjamin, Kracauer).Fil: Sufotinsky Reynoso, Eric Tomás. Universidad Nacional de Rosario. Facultad de Humanidades y Artes. Instituto de Estudios Críticos en Humanidades. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Estudios Críticos en Humanidades; Argentin
Patients with coronary artery disease (CAD) homozygous for the B-Allele of high density lipoprotein (HDL) paraoxonase (PON1) exhibit reduced HDL-PON1 arylesterase activities of HDL subtractions HDL2 and HDL3
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