346 research outputs found
Towards rational axillary treatment in relation to neoadjuvant therapy in breast cancer
No full textAbstract not availableM.E. Straver, E.J.Th. Rutgers, N.S. Russell, H.S.A. Oldenburg, S. Rodenhuis, J. Wesseling, A. Vincent, M.T.F.D. Vrancken Peeter
Using the t-distribution to improve the absolute structure assignment with likelihood calculations
No full textThe previously described method for absolute structure determination [Hooft, Straver & Spek (2008). J. Appl. Cryst. 41, 96–103] assumes a Gaussian error distribution. The method is now extended to make it robust against poor data with large systematic errors with the introduction of the Student t-distribution. It is shown that this modification makes very little difference for good data but dramatically improves results for data with a non-Gaussian error distribution
Corrigendum to “Sentinel node biopsy after primary systemic therapy in node positive breast cancer patients: Time trend, imaging staging power and nodal downstaging according to molecular subtype” (European Journal of Surgical Oncology (2019) 45(6) (969–975), (S0748798319302458), (10.1016/j.ejso.2019.01.219))
No full textThe authors regret that the author list in reference 27 was written incorrectly and should have been as follows: 27. M. Donker, M.E Straver, J. Wesseling, C.E. Loo, M. Schot, C.A Drukker et al. Marking axillary lymph nodes with radioactive iodine seeds for axillary staging after neoadjuvant systemic treatment in breast cancer patients: the MARI procedure. Ann Surg, 261 (2) (2015), pp. 378-382 The authors would like to apologise for any inconvenience caused
De extractie van munt-olie met sub- en superkritische kooldioxide: Ontwerpaspecten voor een productie plant
No full textDocument(en) uit de collectie Chemische ProcestechnologieDelftChemTechApplied Science
Schuilplaatsen gezocht voor de/het heilige. Gesprek met Peter Nissen
No full textItem does not contain fulltex
Heilige in een bepaalde context. Interview over pater Karel Houben
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39776.pdf (Publisher’s version ) (Open Access
Modern cryptography: the RSA system
No full textIn 1977 the RSA system was designed by Ron Rivest, Adi Shamir and Len Adleman. The RSA system is a part of modern cryptography. Modern cryptography makes sure that one can secure important information - like data, communication or banking accounts - on the computer. There are several attacks on the RSA system where the private key can be cracked. In this report two of such attacks are discussed
Detection of Fetal Copy Number Aberrations by Shallow Sequencing of Maternal Blood Samples
No full textMotivation: Numerous genetic disorders can be detected in prenatal diagnosis using Chorionic Villus Sampling. As this brings a 1:100 chance for miscarriage, this method is only applied when the fetus is suspected to have an increased chance at having an aberration. It is known that a small percentage of DNA in maternal plasma is of fetal origin and with the upswing of Next Generation Sequencing (NGS) it is now possible to diagnose trisomy 21 cases non-invasively using maternal blood samples. Other and smaller aberrations can be detected with this kind of blood samples using high coverage NGS, but this makes these methods more expensive. Our goal was to find a method to detect small aberrations using only shallow sequencing (low coverage NGS), keeping the costs per sample to a minimum. Methods: We developed an approach (called WISECONDOR) that determines whether a small region is aberrated by looking whether the read count within that region differs abnormally compared to the read counts of other similarly behaving regions within the same test sample. The other similarly behaving regions are considered to have similar NGS biases, such as GC-richness, and are found by comparing read count correlations over a set of healthy samples. Results: The developed script was able to correctly identify all tested T13, T18 and T21 cases. Aberrations such as del(13)(q12.3q14.3), i(12p10) and i(18q10) were also correctly called. The amount of false positives was minimal and even zero when the size of the aberrations was at least 20Mb, while the test samples varied from only 0.15 to 1.66 fold coverage. This shows that most fetal fetal copy number aberrations can be detected by shallow sequencing of maternal blood samples.Computer Science, MKE, Track BioinformaticsPattern Recognition & BioinformaticsElectrical Engineering, Mathematics and Computer Scienc
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