442 research outputs found
J.-J. Rager, Les Musulmans algériens en France et dans les pays islamiques
No full textÉmerit Marcel. J.-J. Rager, Les Musulmans algériens en France et dans les pays islamiques. In: Annales. Economies, sociétés, civilisations. 5ᵉ année, N. 3, 1950. pp. 350-353
Betriebswirtschaftliche Analyse und informationstechnische Umsetzung virtueller Produktionsnetzwerke
No full textBetriebswirtschaftliche Analyse und informationstechnische Umsetzung virtueller Produktionsnetzwerke / J. Friedl, A. Tuma, M. Rager. - In: Logistik Management / Thomas Spengler ... Hrsg. - Heidelberg : Physica-Verl., 2004. - S. 271-28
An Exploration of the Training Needs for End-of-Life Doulas in Alzheimer\u27s Disease and Related Dementias
No full textThe end-of-life doula movement originated from the birth doula movement during the 21st century to serve as companions, mentors, and advocates for the dying. The end-of-life doula role is relatively new, and there are no standardized practices for overseeing training programs. This project sought to describe the experience of trained end-of-life doulas working with persons living with dementia and to identify the educational need to improve dementia training. This project used a qualitative descriptive design. Eight doulas were recruited through a purposive sampling method and completed in-depth interviews. These interviews were then analyzed in two cycles of coding: descriptive and pattern coding. Five themes were identified: three describing doula experiences (working with people living with dementia, impact on families, techniques for working with people living with dementia) and two describing educational needs relating to ADRD (doula attributes, what should be taught to doulas). Participants described the experience of working with people living with dementia as unique when compared to other disease processes. They emphasized the lack of and need for training in caring for persons living with dementia at end-of-life. Results were mapped to the principles of adult learning theory, and recommendations were made for future efforts to improve dementia training for end-of-life doulas
Synthesis and Evaluation of [<sup>18</sup>F]RAGER: A First Generation Small-Molecule PET Radioligand Targeting the Receptor for Advanced Glycation Endproducts
No full textThe
receptor for advanced glycation endproducts (RAGE) is a 35
kDa transmembrane receptor that belongs to the immunoglobulin superfamily
of cell surface molecules. Its role in Alzheimer’s disease
(AD) is complex, but it is thought to mediate influx of circulating
amyloid-β into the brain as well as amplify Aβ-induced
pathogenic responses. RAGE is therefore of considerable interest as
both a diagnostic and a therapeutic target in AD. Herein we report
the synthesis and preliminary preclinical evaluation of [<sup>18</sup>F]RAGER, the first small molecule PET radiotracer for RAGE (<i>K</i><sub>d</sub> = 15 nM). Docking studies proposed a likely
binding interaction between RAGE and RAGER, [<sup>18</sup>F]RAGER
autoradiography showed colocalization with RAGE identified by immunohistochemistry
in AD brain samples, and [<sup>18</sup>F]RAGER microPET confirmed
CNS penetration and increased uptake in areas of the brain known to
express RAGE. This first generation radiotracer represents initial
proof-of-concept and a promising first step toward quantifying CNS
RAGE activity using PET. However, there were high levels of nonspecific
[<sup>18</sup>F]RAGER binding <i>in vitro</i>, likely due
to its high log <i>P</i> (experimental log <i>P</i> = 3.5), and rapid metabolism of [<sup>18</sup>F]RAGER in rat liver
microsome studies. Therefore, development of second generation ligands
with improved imaging properties would be advantageous prior to anticipated
translation into clinical PET imaging studies
Improved calibration of DD neutron counters by activation of two indium disks in the Frascati 1-MJ plasma focus
No full textSupplemental Material, DS2_TPX_10.1177_0192623319873882 - Comparison of Gene Expression Responses in the Small Intestine of Mice Following Exposure to 3 Carcinogens Using the S1500+ Gene Set Informs a Potential Common Adverse Outcome Pathway
No full textSupplemental Material, DS2_TPX_10.1177_0192623319873882 for Comparison of Gene Expression Responses in the Small Intestine of Mice Following Exposure to 3 Carcinogens Using the S1500+ Gene Set Informs a Potential Common Adverse Outcome Pathway by Grace A. Chappell, Julia E. Rager, Jeffrey Wolf, Milos Babic, Kyle J. LeBlanc, Caroline L. Ring, Mark A. Harris and Chad M. Thompson in Toxicologic Pathology</p
Supplemental Material, Supplemental_Tables_091019 - Comparison of Gene Expression Responses in the Small Intestine of Mice Following Exposure to 3 Carcinogens Using the S1500+ Gene Set Informs a Potential Common Adverse Outcome Pathway
No full textSupplemental Material, Supplemental_Tables_091019 for Comparison of Gene Expression Responses in the Small Intestine of Mice Following Exposure to 3 Carcinogens Using the S1500+ Gene Set Informs a Potential Common Adverse Outcome Pathway by Grace A. Chappell, Julia E. Rager, Jeffrey Wolf, Milos Babic, Kyle J. LeBlanc, Caroline L. Ring, Mark A. Harris and Chad M. Thompson in Toxicologic Pathology</p
Supplemental Material, DS1_TPX_10.1177_0192623319873882 - Comparison of Gene Expression Responses in the Small Intestine of Mice Following Exposure to 3 Carcinogens Using the S1500+ Gene Set Informs a Potential Common Adverse Outcome Pathway
No full textSupplemental Material, DS1_TPX_10.1177_0192623319873882 for Comparison of Gene Expression Responses in the Small Intestine of Mice Following Exposure to 3 Carcinogens Using the S1500+ Gene Set Informs a Potential Common Adverse Outcome Pathway by Grace A. Chappell, Julia E. Rager, Jeffrey Wolf, Milos Babic, Kyle J. LeBlanc, Caroline L. Ring, Mark A. Harris and Chad M. Thompson in Toxicologic Pathology</p
Supplemental Material, DS3_TPX_10.1177_0192623319873882 - Comparison of Gene Expression Responses in the Small Intestine of Mice Following Exposure to 3 Carcinogens Using the S1500+ Gene Set Informs a Potential Common Adverse Outcome Pathway
No full textSupplemental Material, DS3_TPX_10.1177_0192623319873882 for Comparison of Gene Expression Responses in the Small Intestine of Mice Following Exposure to 3 Carcinogens Using the S1500+ Gene Set Informs a Potential Common Adverse Outcome Pathway by Grace A. Chappell, Julia E. Rager, Jeffrey Wolf, Milos Babic, Kyle J. LeBlanc, Caroline L. Ring, Mark A. Harris and Chad M. Thompson in Toxicologic Pathology</p
- …
