1,145 research outputs found

    cem: Software for Coarsened Exact Matching

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    This program is designed to improve causal inference via a method of matching that is widely applicable in observational data and easy to understand and use (if you understand how to draw a histogram, you will understand this method). The program implements the coarsened exact matching (CEM) algorithm, described below. CEM may be used alone or in combination with any existing matching method. This algorithm, and its statistical properties, are described in Iacus, King, and Porro (2008).

    Biologic targeting in the treatment of inflammatory bowel diseases [Retraction]

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    Bosani M, Ardizzone S, Porro GB. Biologics: Targets and Therapy. 2009;3:77–97.This paper has been retracted after we were made aware that it contains a large amount of reused, and uncited material that was not placed within quotation marks.The following statement has been supplied by Dr Sandro Ardizzone:The review entitled "Biologic targeting in the treatment of inflammatory bowel disease" has been commissioned by this journal and published in 2009 (Matteo Bosani, Sandro Ardizzone, Gabriele Bianchi Porro. Biologics: Targets & Therapy 2009;3:77–97). The paper was written by our young coworker (Dr M Bosani). He has consulted many papers, including our previous reviews published years before. The not perfect knowledge of English language has greatly influenced the writing of the paper itself. So he saved in word file several parts of our previous papers (Ardizzone S, Bianchi Porro G. Inflammatory bowel disease: new insights into pathogenesis and treatment. J Intern Med 2002;252:475–496 – Ardizzone S, Bianchi Porro G. Biologic therapy for inflammatory bowel disease. Drugs 2005:2253–2286), and then transferred to the final paper. He was unaware as we are, of the fact that he could not reuse previously published material in other journals. The reuse of this material was made in good faith.Taking our responsibility for what happened, we intend to apologize for this inconvenience to the Editor (Dr Doris Benbrook) and Publisher (Dr Tim Hill). Moreover, for the reasons mentioned above, I consider appropriate to retract the paper itself.This retraction relates to this paper

    The PPT-module: High-performance readout for the DSSC detector at XFEL

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    DSSC is one of several 2D megapixel detectors currently being built for the European XFEL at DESY, Hamburg. DSSC acquires 8-bit digitized image-series of 700 frames at a sample rate of 4.5MHz. Repetition rate is 10Hz. Non-linear sensor characteristics improves the low-energy resolution. DSSC readout operation involves several subsystems: overall clock and timing control distributed from the XFEL machine via a few dedicated signals. Slow- control and back-end data acquisition controlled via a control Ethernet network. Back-end data acquisition is composed of a computing farm and a train-builder unit, which collects data in detector-specific formats and provides frames in a common format to the back-end. The PPT module is located at the external boundary of the detector, interfacing to both the external subsystems and the on-detector readout module (IOB). The IOB controls the primary readout ASICs and combines the parallel input channels into fewer high-speed serial links towards the PPT. The PPT has to provide the intelligent control of the DSSC instrument. At the same time it handles the readout data from four IOBs: receiving over twelve 3Gbit/s links, reformatting and buffering into a DDR3-memory buffer and transmitting UDP packets over four 10Gbit/s links towards the train-builder. The nominal payload bandwidth is in the order of 4*9Gbit/s. The implementation is based upon state-of-the art FPGA technology using a Xilinx Kintex-7 device. The control portion of the design executes on an embedded Linux system running on a Microblaze processor inside the FPGA. The data-path portion is implemented by a number of VHDL-modules. The UDP output is driven by a complex multi-channel DMA engine under control of the processor. We present the first measurements from the data handling performance, the operation of the interface to the external timing and control system and the control software

    Severe abdominal pain in patients with AIDS: Frequency, clinical aspects, causes, and outcome

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    Parente F, Cernuschi M, Antinori S, Lazzarin A, Moroni M, Fasan M, Rizzardini G, Rovati V, Morandi E, Molteni P, Bianchi Porro G. Severe abdominal pain in patients with AIDS: frequency, clinical aspects, causes, and outcome. Scand J Gastroenterol 1994;29:511-515. Background: The exact prevalence of abdominal pain in AIDS patients, as well as the entire spectrum of causative disorders, has not yet been well defined. In addition, the existing data derive almost exclusively from surgical series describing only those patients who have undergone emergency surgical procedures. Methods: We reviewed our experience with patients presenting with severe abdominal pain from a large series of non-selected consecutive AIDS patients seen at our institution over a period of 4 years. Results: Of 458 patients, 71 (15% had severe abdominal pain, and its occurrence was associated with a reduced patient survival. Specific diagnoses were made premortem in 42 patients (59% potential causes of pain were identified at postmortem examination in 23 patients (33% whereas no specific causes were found in 6 patients (8% Most of the causative disorders (65% were AIDS-related, whereas HIV-independent pathologic conditions were found in only 18% of the patients. The predominant site of pain, combined with a few key symptoms, had a high predictive diagnostic value in nearly half of the patients. The indications for emergency laparotomy were limited and substantially similar to those of the non-HIV population. Conclusions: Severe abdominal pain frequently complicates the course of AIDS, and its occurrence is associated with reduced survival. In most patients it is due to disorders closely associated with the HIV infection. Specific causes of pain may be identified in most of the cases by an appropriate diagnostic evaluation. © 1994 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted

    Kerr microscopy study of magnetization reversal in uniaxial Co-films

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    We have studied the magnetization reversal of uniaxial Co(1 0 1 0) films as a function of the applied field orientation by means of magneto-optical Kerr effect microscopy. Hereby, we find that while stable intermediate domain states exist for most field directions, their occurrence is suppressed for field orientations along the easy axis of magnetization. To facilitate this study, we have developed a data extraction methodology that allows for the quantitative analysis and compact display of entire magnetization distribution field-sequences in a single picture. It furthermore allows for the automated data analysis to unambiguously distinguish magnetization rotation processes from field-induced domain formation

    Multi-fractal cancer risk assessment

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    From fractal point of view, there exist two types of cancer tissues. Those having multifractal (or fractal) structure, and the rest, for example, Wilms tumors. To support the diagnostics, we shall be aware of this differentiation and we shall use robust methods for measuring of multifractality. The main reason a robust discrimination is needed is the simple fact that histopathological discrimination between mastopathy and cancer is difficult in many cases. As we show in this article, using spectra or energy for multifractal model can be of help. However, it needs robustness since many mastopathic tissues are mimicking cancer ones. This article tackles this multidisciplinary topic. In particular, we provide diffusion model for metabolic heat for both cancer and mastopathy related tissues and novel concept of metabolism related energy

    Traditional communities as "Subjects of Rights" and the commoditization of knowledge in Brazil.

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    The International Labor Organization (ILO) Convention 169 and the Convention of Biological Diversity (CBD) led signatory state-members to recognize traditional communities as subjects of rights, and no longer as objects of tutelage. However, their implementation may bring new challenges in states adopting market-based decision-making to rule social life. In pluri-ethnic societies in which power differentials are structurally embedded, traditional communities and companies exploring their resources and knowledge have been, historically, unequal and opposed parties. In processes of benefit sharing, these unequal social actors are wrongfully considered equally free subjects of rights in negotiating contracts in supposedly free markets. Erasing historical and structural differences, and assuming equality in an unequal world will only reproduce the inequality that CBD has aimed to address

    Habitat loss, extinction debt and climate change threaten terricolous lichens in lowland open dry habitats

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    Habitat loss is the main driver of biodiversity decline worldwide. An immediate consequence can be extinction debt, i.e. time-delayed extinction of species following habitat loss. We tested extinction debt in terricolous lichen communities in 45 patches of lowland open dry habitats in the western Po Plain (northern Italy) considering richness of four species groups: total, red-listed, rare, and common species. The distance from the currently nearest patch and the annual precipitation correlated – negatively and positively, respectively – with all the groups. Total, red-listed, and rare species were positively related to the oldest available patch extent (1954). Common species were positively related to the current (2020) patch extent. Total and red-listed species were negatively related to the extent difference (1954–2020). Results reveal an extinction debt which has not yet been completely paid and that could be exacerbated by climate change. To counteract this trend, management should conserve habitat patches with the highest species richness, improve connectivity between habitat patches, and provide suitable microrefugia for species with different ecological requirements
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