50 research outputs found
High-resolution X-ray structure of the trimeric Scar/WAVE-complex precursor Brk1.
No full textThe Scar/WAVE-complex links upstream Rho-GTPase signaling to the activation of the conserved Arp2/3-complex. Scar/WAVE-induced and Arp2/3-complex-mediated actin nucleation is crucial for actin assembly in protruding lamellipodia to drive cell migration. The heteropentameric Scar/WAVE-complex is composed of Scar/WAVE, Abi, Nap, Pir and a small polypeptide Brk1/HSPC300, and recent work suggested that free Brk1 serves as a homooligomeric precursor in the assembly of this complex. Here we characterized the Brk1 trimer from Dictyostelium by analytical ultracentrifugation and gelfiltration. We show for the first time its dissociation at concentrations in the nanomolar range as well as an exchange of subunits within different DdBrk1 containing complexes. Moreover, we determined the three-dimensional structure of DdBrk1 at 1.5 Å resolution by X-ray crystallography. Three chains of DdBrk1 are associated with each other forming a parallel triple coiled-coil bundle. Notably, this structure is highly similar to the heterotrimeric α-helical bundle of HSPC300/WAVE1/Abi2 within the human Scar/WAVE-complex. This finding, together with the fact that Brk1 is collectively sandwiched by the remaining subunits and also constitutes the main subunit connecting the triple-coil domain of the HSPC300/WAVE1/Abi2/ heterotrimer to Sra1(Pir1), implies a critical function of this subunit in the assembly process of the entire Scar/WAVE-complex
On a contemporary poet’s output from the Baroque perspective
No full textStanisław Gostkowski, współczesny poeta, autor siedmiu tomików, zmarł w roku 2000. Nie należał do Nowej Fali ani do Nowej Prywatności. Cenił wiersze Tymoteusza Karpowicza. W artykule piszę o pierwszym tomiku Nie chowajcie mnie żyjącego i czwartym Śmierć ma słodki zapach. Gostkowski pisał o śmierci, ale dla życia. W swojej poezji bardzo często eksponował barokową ideę vanitas. W szkicu zaprezentowano interpretację z perspektywy baroku.Stanisław Gostkowski, a contemporary poet, author of seven volumes, died in 2000. He did not belong to the New Wave and New Privacy. His literary patron was Tymoteusz Karpowicz. I am writing about the first volume, Don’t bury me alive, and the fourth one, titled Death has a sweet smell. Gostkowski wrote about death, nevertheless just for life. He often emphasises vanitas in his poetry. Here is an interpretation of his output from the Baroque perspective
Gdańskie sonety sprzed półtora wieku
No full textRev. S. Tomicki is an author of the poetic collection entitled Kwiaty więzienia (The flowers of Prison). He wrote this volume during his confinement in jails in Berlin and Wisloujscie Fortress. The Wisloujscie Sonnets are most important part of his poetry. They are dedicated to Gdansk landscape that has been seen from the Fortress in 1863-1866. Before him no one has written it poetically.</jats:p
Wojenne reportaże Micińskiego z roku 1917
No full textMyciński’s wartime reportage from 1917We know very little about the last few years of Tadeusz Miciński’s life and work. This is a consequence of the turbulent time of the First Wold War, to which the poet by no means remained indifferent.Miciński spent that time in the Polesie region and in Moscow, serving as a political officer in Józef Dowbor Muśnicki’s 1st Corps, where his tasks included writing for frontline newspapers. In the second half of 1917 he reported from the frontline and his reports were published in Polskie Siły Zbrojne [Polish Armed Forces]. And this is what the article is all about. It contains information about reportage published in the paper as well as the article “Belshazzarian phantom of Russia”. Although this is typical soldier reportage, there are clear historiosophical ideas by Miciński. It concludes with the Poem Z obozu [From the camp], one of the writer’s last pieces.Myciński’s wartime reportage from 1917We know very little about the last few years of Tadeusz Miciński’s life and work. This is a consequence of the turbulent time of the First Wold War, to which the poet by no means remained indifferent.Miciński spent that time in the Polesie region and in Moscow, serving as a political officer in Józef Dowbor Muśnicki’s 1st Corps, where his tasks included writing for frontline newspapers. In the second half of 1917 he reported from the frontline and his reports were published in Polskie Siły Zbrojne [Polish Armed Forces]. And this is what the article is all about. It contains information about reportage published in the paper as well as the article “Belshazzarian phantom of Russia”. Although this is typical soldier reportage, there are clear historiosophical ideas by Miciński. It concludes with the Poem Z obozu [From the camp], one of the writer’s last pieces
Gdańskie sonety sprzed półtora wieku
No full textRev. S. Tomicki is an author of the poetic collection entitled Kwiaty więzienia (The flowers of Prison). He wrote this volume during his confinement in jails in Berlin and Wisloujscie Fortress. The Wisloujscie Sonnets are most important part of his poetry. They are dedicated to Gdansk landscape that has been seen from the Fortress in 1863–1866. Before him no one has written it poetically.Ks. Symforian Tomicki jest autorem tomiku wierszy pt. Kwiaty więzienia. Wiersze napisał podczas niewoli w Berlinie i gdańskiej Twierdzy Wisłoujście. Właśnie Sonety Wisłuskie stanowią najważniejsza i najbardziej oryginalną część jego dorobku poetyckiego. Poświęcone są one krajobrazowi gdańskiemu widzianemu z twierdzy, w której przebywał w latach 1863–1866. Nikt przed nim nie zobrazował Twierdzy Wisłoujście w sposób poetycki
One hundred and fifty-year-old sonnets from Gdansk
No full textRev. S. Tomicki is an author of the poetic collection entitled Kwiaty więzienia (The flowers of Prison). He wrote this volume during his confinement in jails in Berlin and Wisloujscie Fortress. The Wisloujscie Sonnets are most important part of his poetry. They are dedicated to Gdansk landscape that has been seen from the Fortress in 1863–1866. Before him no one has written it poetically.Ks. Symforian Tomicki jest autorem tomiku wierszy pt. Kwiaty więzienia. Wiersze napisał podczas niewoli w Berlinie i gdańskiej Twierdzy Wisłoujście. Właśnie Sonety Wisłuskie stanowią najważniejsza i najbardziej oryginalną część jego dorobku poetyckiego. Poświęcone są one krajobrazowi gdańskiemu widzianemu z twierdzy, w której przebywał w latach 1863–1866. Nikt przed nim nie zobrazował Twierdzy Wisłoujście w sposób poetycki
CDC42 switches IRSp53 from inhibition of actin growth to elongation by clustering of VASP
No full textFilopodia explore the environment, sensing soluble and mechanical cues during directional motility and tissue morphogenesis. How filopodia are initiated and spatially restricted to specific sites on the plasma membrane is still unclear. Here, we show that the membrane deforming and curvature sensing IRSp53 (Insulin Receptor Substrate of 53 kDa) protein slows down actin filament barbed end growth. This inhibition is relieved by CDC42 and counteracted by VASP, which also binds to IRSp53. The VASP: IRSp53 interaction is regulated by activated CDC42 and promotes high-density clustering of VASP, which is required for processive actin filament elongation. The interaction also mediates VASP recruitment to liposomes. In cells, IRSp53 and VASP accumulate at discrete foci at the leading edge, where filopodia are initiated. Genetic removal of IRSp53 impairs the formation of VASP foci, filopodia and chemotactic motility, while IRSp53 null mice display defective wound healing. Thus, IRSp53 dampens barbed end growth. CDC42 activation inhibits this activity and promotes IRSp53-dependent recruitment and clustering of VASP to drive actin assembly. These events result in spatial restriction of VASP filament elongation for initiation of filopodia during cell migration, invasion, and tissue repair
The presented world of "Mené-Mené-Thekel-Upharisim!... Quasi una phantasia" by Tadeusz Miciński
No full textAnother - after e.g. Cz. Latawiec, E. Rzewuska, M. Podraza-Kwiatkowska, T. Linkner, M. Bajko - discussion of the unfinished novel "Mené-Mené-Thekel-Upharisim!... Quasi una phantasia" (ed. 1931). by examining the structural skeleton of the novel, the author reflects on its main structural elements: the narrative and its subject - the world presented. The narrative of the novel, containing within itself all the dialogues of the charakters, organizes the world presented, and its charakter depends largely on the distance to the world. It shows the course of events in the novel, which is associated with the environment and the participating characters of the unfolding text. It is an essential means of expression in the novel-like text
Tadeusz Miciński’s Journalistic Works During The Great War
No full textZdigitalizowano i udostępniono w ramach projektu pn. Rozbudowa otwartych zasobów naukowych Repozytorium Uniwersytetu w Białymstoku – kontynuacja, dofinansowanego z programu „Społeczna odpowiedzialność nauki” Ministra Edukacji i Nauki na podstawie umowy BIBL/SP/0040/2023/01.The author of the article discusses the literary activity of Tadeusz Miciński from the First World War. It boils down largely to journalistic texts: articles, manifestos, open letters, travel reports from the front and from the life of Polish soldiers fighting on the eastern front. In 1917, the writer becomes an educational officer in the The Polish First Army Corps, commanded by general Józef Dowbor-Muśnicki, getting actively involved with his pen in the struggle for the “Polish cause.” Miciński is an unusual soldier: an educational officer, not avoiding the dangers of the front, a war correspondent, a reporter, and at the same time the tribune of the people and the conscience
of the nation. A poet in the war, although now mainly a publicist, a social activist; finally, a spokesman for the Polish cause, with a decidedly anti-German orientation, pro-Russian out of necessity; he is a poet whose poetry takes on an ad hoc political, and journalistic character. Miciński’s journalistic writings are devoid of affairs which could seem too trivial to be discussed in the wartime. They have been subordinated to a well-defined purpose: raising awareness, teaching, influencing attitudes, comforting, warming up to battle, informing about the issues and events important for the Polish community, and doing it as far as possible intelligibly and to date.Katedra Badań Filologicznych „Wschód – Zachód”, Uniwersytet w BiałymstokuMARCIN BAJKO, dr, adiunkt Katedry Badań Filologicznych „Wschód – Zachód” w Instytucie Filologii Polskiej Uniwersytetu w Białymstoku. Zainteresowania badawcze: pisarstwo Tadeusza Micińskiego w kontekście literatury romantycznej i młodopolskiej; twórczość Juliusza Słowackiego, Seweryna Goszczyńskiego, „czarny romantyzm”; Wschód i Zachód w literaturze modernizmu, mitologie, religie. Napisał doktorat o twórczości Tadeusza Micińskiego. Edytor jego polemicznego pisma Walka o Chrystusa (1911), wydanego po stu latach (Białystok 2011). Autor monografii: Heroiczna Apokalipsa. W kręgu idei i wyobraźni Tadeusza Micińskiego (Białystok 2012). Ostatnio wydał książkę: „Sny niezwykłe o Polsce i o Europie”. Diagnoza kultury w pismach Tadeusza Micińskiego u progu Pierwszej Wojny Światowej (Kraków 2015).Bajko M., „Sny niezwykłe o Polsce i o Europie”. Diagnoza kultury w pismach Tadeusza Micińskiego w progu Pierwszej Wojny Światowej, Kraków 2015.Flis-Czerniak E., „Polskość jest wyznaniem” – Miciński w przededniu i w dobie wielkiej wojny, w: Pierwsza wojna światowa w literaturze polskiej i obcej. Wybrane zagadnienia, red. E. Łoch
i K. Stępnik, Lublin 1999.Jagła D., Tadeusza Micińskiego droga do Polski, „Didaskalia” 1997, nr 19/20.Kwiatkowski J., Od katastrofizmu solarnego do synów słońca, w: Młodopolski świat wyobraźni, pod red. M. Podrazy-Kwiatkowskiej, Kraków 1977.Linkner T., Wojenne reportaże Micińskiego z roku 1917 („Prace Literackie” LV, Wrocław 2015.Linkner T., Zanim skończyło się maskaradą. Ze studiów nad twórczością Tadeusza Micińskiego, Gdańsk 2003, s. 389.Ławski J., „Pszenica i kąkol”. Wyobraźnia poetycka Tadeusza Micińskiego w latach „Wielkiej Wojny”, w: Poezja Tadeusza Micińskiego. Interpretacje, red. A. Czabanowskiej-Wróbel, P. Próchniaka, M. Stali, Kraków 2004.Ławski J., Nieznany rosyjski artykuł Tadeusza Micińskiego o Henryku Sienkiewiczu, „Bibliotekarz Podlaski” nr 1/2016 (XXXII).Maciejewska I., Rewolucja i niepodległość. Z dziejów literatury polskiej lat 1905-1920, Kielce 1991.Niciński K., Kwestia słowiańska w publicystyce Tadeusza Micińskiego podczas I wojny światowej i w latach ją poprzedzających, w: Nacjonalizm polski do roku 1939. Wizje kultury polskiej
i europejskiej, red. K. Stępnik i M. Gabryś, Lublin 2011.Tynecki J., Inicjacje mistyka. Rzecz o Tadeuszu Micińskim, Łódź 1976.Wydrycka A., Zapomniane teksty Micińskiego, „Ruch Literacki” 1989, z. 4-5.2612916
