237 research outputs found
Supporting Data for Salt-Dependent Structure in Methylcellulose Fibrillar Gels
No full textData files used to generate all figures in the manuscript "Salt-Dependent Structure in Methylcellulose Fibrillar Gels" and its supplementary information.The collection of this data was supported primarily by the National Science Foundation through University of Minnesota MRSEC under award number DMR-1420013 and DMR-2011401.Liberman, Lucy; Schmidt, Peter W; Coughlin, McKenzie L; Matatyaho Ya'akobi, Asia; Davidovich, Irina; Edmund, Jerrick; Ertem, Sedef P; Morozova, Svetlana; Talmon, Yeshayahu; Bates, Frank S; Lodge, Timothy P. (2022). Supporting Data for Salt-Dependent Structure in Methylcellulose Fibrillar Gels. Retrieved from the University Digital Conservancy, https://doi.org/10.13020/dc5t-te76
Leituras contemporâneas de Rousseau:: Constant, Vaughan, Talmon ou Berlin: de que lado estará o verdadeiro pensamento do Genebrino?
No full textO Do contrato social, livro publicado por Rousseau em Paris em abril de 1762 é o trabalho que lhe notabiliza no campo do pensamento político. Nele imprimindo uma forma abstrata, metafísica, o filósofo põe-se a enfrentar o problema da relação entre liberdade e autoridade, essa uma questão bastante espinhosa que suscita polêmicas e controvérsias fazendo às vezes perder-se a orientação verdadeira de seu pensamento. De um lado, aparecem aqueles que, tocados pela perspectiva liberal, contestam a essência de suas ideias, tendo-o enquanto ditador e totalitário. B. Constant, vendo-o inspirado nos antigos, em especial os gregos, no seio da pólis, entende que, embora comece orientando-se pelas ideias de Locke, tal como lhe interpreta também C.E. Vaughan, Rousseau acaba defendendo um modelo de Estado que absolutiza a vontade geral, vindo sufocar o indivíduo. Por essa linha teórica, avançam, guardados seus traços próprios, J. L. Talmon e I. Berlin, sendo que o primeiro julga que Rousseau termina fazendo-se preconizador daquilo que chama “democracia totalitária”, enquanto o segundo acredita que o genebrino peca por mitificar a figura do “eu verdadeiro” que se apresentaria como verdade única autorizando qualquer arbítrio. Penso ser possível divergir-se dessa perspectiva entendendo que a essência da doutrina política de nosso autor não é autocrática e totalitária e busca consumar um gênero elevado de liberdade. Visamos aqui, neste artigo, apoiarmo-nos neste conceito convencido de que nele está fundado o verdadeiro pensamento de Rousseau que não raro é muito mal lido, embora contenha ideias alvissareiras no sentido moral e político
Brain metastases-derived extracellular vesicles induce binding and aggregation of low-density lipoprotein
No full textBackground: Cancer cell-derived extracellular vesicles (EVs) have previously been shown to contribute to pre-metastatic niche formation. Specifically, aggressive tumors secrete pro-metastatic EVs that travel in the circulation to distant organs to modulate the microenvironment for future metastatic spread. Previous studies have focused on the interface between pro-metastatic EVs and epithelial/endothelial cells in the pre-metastatic niche. However, EV interactions with circulating components such as low-density lipoprotein (LDL) have been overlooked. Results: This study demonstrates that EVs derived from brain metastases cells (Br-EVs) and corresponding regular cancer cells (Reg-EVs) display different interactions with LDL. Specifically, Br-EVs trigger LDL aggregation, and the presence of LDL accelerates Br-EV uptake by monocytes, which are key components in the brain metastatic niche. Conclusions: Collectively, these data are the first to demonstrate that pro-metastatic EVs display distinct interactions with LDL, which impacts monocyte internalization of EVs. [Figure not available: see fulltext.
Towards improving predictions of non-Newtonian settling slurries with Delft3D: theoretical development and validation in 1DV
No full textTo date there is limited knowledge about the flow behaviour of non-Newtonian slurry and tailings flows. In hydraulic engineering and the mining industry numerous questions and uncertainties still exist. Different numerical and analytical models have been developed attempting to meet this demand. For the larger part they describe the rheological properties of the flow and are commonly developed for the mining industry. Delft3D is a widely used and proven numerical modelling suite to predict flow behaviour of different water bodies including physical processes e.g. the transport of sediments and stratifications. This thesis contributes to embedding the rheological characterizations for mud-sand-water mixtures and settling of granular material in Delft3D. This thesis includes: - An analysis of three different formulas that describe the rheological properties of mud-sand flows. - A theoretical description of a settling model that accounts for shear induced hindered settling of granular material in a Non-Newtonian flow. - The implementation of the three rheological models and the segregation model into Delft3D, completed by model verification on theoretical relations, and simple validation. The present model is able to simulate non-Newtonian laminar flows and the segregation of granular material in the carrier fluid in 1DV.Civil Engineering and GeosciencesHydraulic Engineerin
Drug loaded fluorescent cubosomes:versatile nanoparticles for potential theranostic applications
No full textIn this work, monoolein-based cubosomes were doped with two fluorescent probes, namely, fluorescein and dansyl, properly modified with a hydrocarbon chain to increase
their encapsulation efficiency within the monoolein palisade. The
same nanocarriers were also loaded with quercetin, a hydrophobic
molecule with potential anticancer activity. Particularly,
the cubosomes doped with the modified fluorescein probe were successfully exploited for single living cell imaging. The physicochemical and photophysical characterizations reported
here, along with the well-known ability of cubosomes in hosting
molecules with pharmaceutical interest, strongly encourage the use of these innovative fluorescent nanocarriers for theranostic
purposes
Development of a numerical for dynamic depositioning of non-Newtonian slurries
No full textThis study aims to improve the predictive capabilities of flow pattern and depositional behaviour of non-Newtonian, high concentration sand and fines mixtures. The depositional behaviour influences the geometry of the deposit and the distribution of sand and fines particles, which in turn influence the strength and consolidation performance of the deposit. Ultimately this affects the area reclamation targets from the mining industry. In this study an existing numerical model, Delft3D (a three-dimensional, open source flow model from Deltares utilized world-wide in various hydrodynamic and sediment transport studies), is extended with the physics that describe non-Newtonian rheology and sand settling in shear flow. The rheology determines the yield stress and viscosity of a fluid. Shear induced sand settling occurs for fluids with a yield stress. Sand settles under shear whereas smaller particles stay suspended, producing segregation. Segregation leads to non-uniformity in deposit composition (e.g sand and fines dominated areas). Rheology and sand settling mutually interact, directly influencing deposition patterns. This study is a continuation of the work of [Hanssen, 2016], who included specific rheology and sand settling formulation in a one-dimensional version of Delft3D (i.e. 1DV). As part of this work, further verification of this one-dimensional model has been performed and the model has been extended to two-dimensional vertical (i.e. 2DV in a longitudinal cross section). The extended model has been tested in 2DV with deposition over a 400 meters slope. A sensitivity analysis is performed to consider the effect of different solid contents and rheological properties. The model is also tested on specific oil sand applications and data, such as tailings deposition down a beach, mutual interaction of tailings with different rheology or strength and a characterization of fines capture compared with data. This study proved that the extended version of Delft3D can simulate a 2DV non-Newtonian high density flow including sand settling. However there are still some physical processes where the model needs improvements or further research is needed, such as laminar-turbulence regime; transition to 3D and the motion of sand layers. Further model verification and development goes hands in hands with a good data set. Specifically important are flume/field tests with rheology data and its variation with time, especially for polymer added tailings, to verify the model.Mechanical, Maritime and Materials EngineeringOffshore and Dredging EngineeringDredging Engineerin
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