937 research outputs found
Digitogorgia Zapata-Guardiola and Lopez-Gonzalez 2010
No full textGenus <i>Digitogorgia</i> Zapata-Guardiola and López-González, 2010 <p> <b>Diagnosis</b> <i>(modified from the original description, modifications in bold)</i>. Primnoidae with bottlebrush colonies and simple branchlets. Polyps elongated, cylindrical, markedly curved upwards to the branch, and arranged in whorls. Accessory operculars eight in number, stick shaped, close to eight operculars. Marginal scales without thorn or keel, eight in number, folding over operculars. Opercular and marginal scales, with pointed digitations distally, attenuated in body scales. Body scales in eight complete longitudinal rows. Coenenchyme with <b>two layers</b>: outer layer of oval shaped scales, <b>inner layer with irregular tuberculate sclerites.</b></p> <p> <b>Remarks on diagnosis.</b> During the study of <i>Digitogorgia brochi</i> <b>sp. nov.</b> we observed the presence of an additional inner layer of irregular tuberculate coenenchymal sclerites. Coenenchymal sclerites were described as a single layer of scales in the type species <i>D. kuekenthali</i> Zapata-Guardiola and López-González, 2010. After a re-examination of the coenenchyme of the holotype ZIZMH C11740 and paratype USNM 1128575 (2 fragments as BEIM-CRO- 30 in Zapata-Guardiola and López-González, 2010b: 317) of <i>D. kuekenthali</i>, an inner layer of irregular tuberculate sclerites (Figure 7) was also observed.</p>Published as part of <i>Zapata-Guardiola, Rebeca & López-González, Pablo J., 2010, Redescription of Thouarella brucei Thomson and Ritchie, 1906 (Cnidaria: Octocorallia: Primnoidae) and description of two new Antarctic primnoid species, pp. 48-68 in Zootaxa 2616</i> on pages 56-57, DOI: <a href="http://zenodo.org/record/197916">10.5281/zenodo.197916</a>
What comes after sovereignty?
No full textThis paper addresses the question of sovereignty from a perspective that connects the origins of public international law, with a series of onto-theological assumptions about the nature of place that were decisive in the emergence of modern colonialism. It will argue that insofar as sovereignty depends on some form of transcendence, external or internal, it is and has been ‘’impotent’’ from the very outset. However, contrary to the idea expressed in the well-known tale about the emperor’s new clothes, it is not the case that acknowledgement of this impotence would entail the end of sovereignty. Faced with the truth of its ultimate impotence, the sovereign supplements its role as decider with that of the intrigant. This new figure of sovereignty is embodied in the expert politician who announces the coming catastrophe in order to avert it, or contain it, through the use of ‘’limited’’ but ultimately borderless violence
Trans-acting element(s) operating across species barriers positively regulate expression of major histocompatibility complex class II genes.
No full textCorrection: Emilio Custodio: a pioneer in groundwater management and key reference for hydrogeologists worldwide
No full textThe article “Emilio Custodio: a pioneer in groundwater management and key reference for hydrogeologists worldwide”, written by Guardiola‑Albert, C., Bocanegra E., del Carmen Cabrera M., Candela L., Carrera J., Chambel A., Foster S., Jódar J., Herrera C., Manzano M., Molinero J., Vázquez‑Suñé E. and Vilanova E., was originally published under exclusive license to The Author(s), under exclusive licence to International Association of Hydrogeologists. As a result of the subsequent decision to publish the article under the open access model, the article’s copyright notice was changed on 17 December 2024 to © The Author(s) 2024 and the article is now distributed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0. The original article has been corrected.
Stable integration of mouse DNA into Ia-negative human B-lymphoma cells causes reexpression of the human Ia-positive phenotype.
No full textA novel autoregulatory loop between the Gcn2-Atf4 pathway and (L)-Proline [corrected] metabolism controls stem cell identity
No full textIncreasing evidence indicates that metabolism is implicated in the control of stem cell identity. Here, we demonstrate that embryonic stem cell (ESC) behaviour relies on a feedback loop that involves the non-essential amino acid L-Proline (L-Pro) in the modulation of the Gcn2-Eif2α-Atf4 amino acid starvation response (AAR) pathway that in turn regulates L-Pro biosynthesis. This regulatory loop generates a highly specific intrinsic shortage of L-Pro that restricts proliferation of tightly packed domed-like ESC colonies and safeguards ESC identity. Indeed, alleviation of this nutrient stress condition by exogenously provided L-Pro induces proliferation and modifies the ESC phenotypic and molecular identity towards that of mesenchymal-like, invasive pluripotent stem cells. Either pharmacological inhibition of the prolyl-tRNA synthetase by halofuginone or forced expression of Atf4 antagonises the effects of exogenous L-Pro. Our data provide unprecedented evidence that L-Pro metabolism and the nutrient stress response are functionally integrated to maintain ESC identity
aIr-1, a newly found locus on mouse chromosome 16 encoding a trans-acting activator factor for MHC class II gene expression.
No full textRJ 2.2.5 is a human B cell line that has lost the capacity to express MHC class II genes. The human class II-positive phenotype is restored in somatic cell hybrids between RJ 2.2.5 and mouse spleen cells. By karyotype and molecular studies of an informative family of hybrids we have now shown that the reexpression of human class II gene products, as well as the maintenance of the mouse class II-positive phenotype, correlates with the presence of mouse chromosome 16. Thus, the existence on this mouse chromosome of a newly found locus, designated by us aIr-1, that determines a trans-acting activator function for class II gene expression, is established. Possible implications of this finding are discussed
Functional significance of polymorphism among MHC class II gene promoters.
No full textCited by the Following Articles in PubMed:
Dagan A. Loisel, Matthew V. Rockman, Gregory A. Wray, Jeanne Altmann, and Susan C. Alberts. Ancient polymorphism and functional variation in the primate MHC-DQA1 5′ cis-regulatory region. Proc Natl Acad Sci U S A. 2006 October 31; 103(44): 16331–16336. Published online 2006 October 19. doi: 10.1073/pnas.0607662103.
Dissection of the role of MHC class II A and E genes in autoimmune susceptibility in murine lupus models with intragenic recombination
Danqing Zhang, Keishi Fujio, Yi Jiang, Jingyuan Zhao, Norihiro Tada, Katsuko Sudo, Hiromichi Tsurui, Kazuhiro Nakamura, Kazuhiko Yamamoto, Hiroyuki Nishimura, Toshikazu Shira, and Sachiko Hirose. Proc Natl Acad Sci U S A. 2004 September 21; 101(38): 13838–13843. Published online 2004 September 10. doi: 10.1073/pnas.0405807101.
J V Taylor, L E Gordon, and H C Polk, Jr. Early decrease in surface expression of HLA-DQ predicts the development of infection in trauma patients. Clin Exp Immunol. 2000 December; 122(3): 308–311. doi: 10.1046/j.1365-2249.1999.00832.x.
Martin Baumgart, Verena Moos, Diana Schuhbauer, and Brigitte Müller. Differential expression of major histocompatibility complex class II genes on murine macrophages associated with T cell cytokine profile and protective/suppressive effects. Proc Natl Acad Sci U S A. 1998 June 9; 95(12): 6936–6940.
B Müller and A Mitchison. The importance of the back-signal from T cells into antigen-presenting cells in determining susceptibility to parasites. Philos Trans R Soc Lond B Biol Sci. 1997 September 29; 352(1359): 1327–1330.
Excited states of 4He droplets
No full textWe study low-lying excited states of 4He clusters up to a cluster size of 40 atoms in a variational framework. The ansatz wave function combines two- and three-body correlations, coming from a translationally invariant configuration interaction description, and Jastrow-type short-range correlation. We have previously used this scheme to determine the ground-state energies of 4He and 3He clusters. Here we present an extension of this ansatz wave function having a good quantum angular momentum L. The variational procedure is applied independently to the cases with L = 0,2,4, and upper bounds for the corresponding energies are thus obtained. Moreover, centroid energies for L excitations are calculated through the use of sum rules. A comparison with previous calculations is also made.Fil: Guardiola, R.. Facultad de Física / Dpto de Física Atómica y Nuclear; EspañaFil: Navarro, J.. Csic - Univ. de Valencia / Inst. de Física Corpuscular; EspañaFil: Portesi, Mariela Adelina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Física; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; Argentin
Combined Experimental and Modeling Methodology for Intake Line Evaluation in Turbocharged Diesel Engines
No full textThis paper presents a methodology for diesel engine intake line analysis that combines specific element tests and modeling. The purpose of this methodology is to determine the impact of intake lines, or newly designed intake elements, on the volumetric efficiency of internal combustion engines while avoiding expensive on-engine tests. For this research, the intake system is divided into several elements which are individually characterized using flow and impulse test rigs. Next, individual systems are modeled using a one-dimensional code. Finally, these component models are coordinated to provide an evaluation of the volumetric efficiency. Intake lines coming from two turbocharged diesel engines are used to illustrate the method. The model is validated by comparing the model results with the actual system performance evaluated in engine test cells. Discussions of the feasibility of the technique and on the impact of element model inaccuracies on the overall system model are provided.The authors wish to thank the economical support of this work to Spanish Project TRA2007-65433 from Ministerio de Ciencia e Innovacion. Olivier Varnier is indebted to the Ministerio de Ciencia e Innovacion for its support through Grant AP2007-02868. The authors thank D. Moreno for his valuable contribution in the experimental tests and Prof. A. Broatch.Torregrosa, AJ.; Galindo, J.; Guardiola, C.; Varnier ., ON. (2011). Combined Experimental and Modeling Methodology for Intake Line Evaluation in Turbocharged Diesel Engines. International Journal of Automotive Technology. 12(3):359-367. https://doi.org/10.1007/s12239-011-0042-8S359367123Abom, M. and Knutsson, M. (2007). Acoustic analysis of charge air coolers. SAE Paper No. 2007-01-2208.Bozza, F., Gimelli, A., Pianese, V., De Martino, S. and Curion, R. (2004). An acoustic design procedure for intake systems: 1D analysis and experimental validation. SAE Paper No. 2004-01-0412.Bromnick, P. A., Pearson, R. J. and Winterbone, D. E. (1998). Intercooler model for unsteady flow in engine manifolds. Proc. IMechE. Part D: J. Automob. Eng. 212,2, 119–132.Desantes, J. M., Torregrosa, A. J., Broatch, A. and Climent, H. (2006). Silencing capabilities of non-silencer elements: an underused potential? Proc. 4th Styrian Noise, Vibration and Harshness Cong., Graz, Austria, 105–122.Galindo, J., Climent, H., Guardiola, C. and Domenech, J. (2009a). Strategies for improving the mode transition in a sequential parallel turbocharged automotive Diesel engine. Int. J. Automotive Technology 10,2, 141–149.Galindo, J., Serrano, J. R., Arnau, F. J. and Piqueras, P. (2009b). Description of a semi-Independent time discretization methodology for a one-dimensional gas dynamics model. J. Engineering for Gas Turbines and Power Trans. ASME 131,3, Papers No. 034504.Galindo, J., Serrano, J. R., Climent, H. and Tiseira, A. (2007). Analysis of gas-dynamic effects in compact exhaust systems of small two-stroke engines. Int. J. Automotive Technology 8,4, 403–411.Galindo, J., Serrano, J. R., Guardiola, C. and Cervelló, C. (2006). Surge limit definition in a specific test bench for the characterization of automotive turbochargers with pulsating and continuous flow. Experimental Thermal and Fluid Science 30,5, 449–462.Gamba, F., Pilo, L. and Turino, G. (1995). Optimized air intake systems. SAE Paper No. 951264.Heywood, J. B. (1988). Internal Combustion Engine Fundamentals. McGraw-Hill, Inc. New York.Kegl, B., Pehan, S. and Kegl, M. (2007). Improvement of engine performance using an optimization procedure. Proc. IMechE. Part D: J. Automob. Eng. 221,8, 1001–1014.Knutsson, M. and Abom, M. (2009). Sound propagation in narrow tubes including effects of viscothermal and turbulent damping with application to charge air coolers. J. Sound and Vibration, 320, 289–321.Payri, F., Galindo, J., Serrano, J. R. and Arnau, F. J. (2004). Analysis of numerical methods to solve one-dimensional fluid-dynamic governing equations under impulsive flow in tapered ducts. Int. J. Mechanical Science, 46, 981–1004.Payri, F., Desantes, J. M. and Broatch, A. (2000). Modified impulse method for the measurement of the frequency response of acoustic filters to weakly nonlinear transient excitations. J. Acoustical Society of America 107,2, 731–738.Serrano, J. R., Arnau, F. J., Dolz, V., Tiseira, A., Lejeune, M. and Auffret, N. (2008). Analysis of the capabilities of a two-stage turbocharging system to fulfill the US2007 anti-pollution directive for heavy duty diesel engines. Int. J. Automotive Technology 9,3, 277–288.Trochon, E. (2001). A new type of silencers for turbocharger noise control. SAE Paper No. 2001-01-1436.Watson, N. and Janota, M. S. (1982). Turbocharging the Internal Combustion Engine. Macmillan. London
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