1,054 research outputs found
Battistini (R.), Hoerner (J.-M.).- Géographie de Madagascar. 1986
No full textSalomon Jean-Noël. Battistini (R.), Hoerner (J.-M.).- Géographie de Madagascar. 1986. In: Cahiers d'outre-mer. N° 160 - 40e année, Octobre-décembre 1987. pp. 405-406
R. Battistini, J.-M. Hoerner, Géographie de Madagascar
No full textGeorge Pierre. R. Battistini, J.-M. Hoerner, Géographie de Madagascar. In: Annales de Géographie, t. 96, n°533, 1987. p. 134
Hoerner\u27s Market Interior
No full textImage shows various carcasses hanging from the walls inside the Hoerner\u27s Meat Market
The rise of engineers in Russia
No full textAlfred J. Rieber, The rise of engineers in Russia.
The Russian engineering profession owes much of its professional ethos and ideology to the tradition of les grandes écoles as transmitted by French engineers imbued with St. Simonian ideals who staffed the Institute of Transportation Engineers in the early nineteenth century. Until then, Peter I's vision of a technological society had encountered resistance of the nobility to technical education, competing demands of the army for engineers and changing economic policies of the state. By the mid-nineteenth century Russian engineers controlled the Ministry of Transportation and firmly established a statist policy of economic development.Alfred J. Rieber, L'ascension des ingénieurs en Russie.
La profession d'ingénieur en Russie doit beaucoup de son code de valeurs et de son idéologie professionnelle à la tradition des « grandes écoles », telle qu'elle a été transmise par les ingénieurs français, pénétrés d'idéaux saint-simoniens, qui constituaient le personnel d'encadrement de l'Institut d'ingénieurs des transports, au début du XIXe siècle. Jusque-là la société technologique conçue par Pierre Ier s'était heurtée à la résistance de la noblesse à l'éducation technique, aux besoins concurrentiels de l'armée en ingénieurs et aux politiques économiques changeantes de l'État. Au milieu du XIXe siècle, les ingénieurs russes étaient à la tête du ministère des Transports et ils instaurèrent résolument une politique étatique de développement économique.Rieber Alfred J. The rise of engineers in Russia. In: Cahiers du monde russe et soviétique, vol. 31, n°4, Octobre-Décembre 1990. pp. 539-568
EP-1207: Outcomes and prognostic factors in solitary brain metastasis from small cell lung cancer
No full textPO-172 Carbon ion radiotherapy in active raster- scanned technique for malignant lacrimal gland tumors
No full textStrategisk regnskapsanalyse og verdsettelse av Rieber & Søn ASA
No full textJeg har i denne utredningen foretatt en strategisk regnskapsanalyse og verdsettelse av Rieber & Søn ASA. Verdsettelsestidspunkt er 30.06.09.
I den første delen av utredningen presenteres konsernet og den tilhørende bransjen. Deretter presenteres ulike verdsettelsesteknikker og det argumenteres for å velge en fundamental verdsettelsesteknikk. Gjennom strategisk analyse kartlegges konsernets strategiske posisjon. Jeg gjennomgår deretter en regnskapsanalyse der regnskapet omgrupperes og justeres for å tilpasses investororientert analyse. Regnskapet analyseres så i forhold til risiko, lønnsomhet og vekst, og historiske avkastningskrav utarbeides.
Den strategiske regnskapsanalysen danner så grunnlaget for utarbeidelse av et framtidsregnskap og fremtidskrav. På basis av dette verdsettes så egenkapitalen ved hjelp av tre verdsettelsesmetoder. Vektene i avkastningskravene oppdateres deretter sekvensielt for å komme frem til ett felles verdiestimat. Dette gir et verdiestimat på 43,03 NOK per aksje. Etter en analyse av usikkerheten i verdiestimatet konkluderer jeg med en anbefaling om å holde på Rieber & Søn-aksjen
Abstract 1107: Mutant p53 increases epithelial mesenchymal transition, estrogen receptor alpha and erbB2/Her2/neu
No full textAbstract
OBJECTIVES.- Progression of carcinomas involves transition from an epithelial cobblestone-like cytoarchitecture to an elongated, mesenchymal phenotype., leading to an epithelial to mesenchymal transdifferentiation (EMT) (1). Since the p53 tumor suppressor pathway is inactivated in most human cancers due to gene mutations or dysfunction, we now investigated in human wt p53 breast carcinoma cells, whether EMT and cell proliferation are influenced by introducing a dominant-negative (DN) R175H mutant p53 (2). This mutation occurring in the p53 zinc-binding domain, is common to breast cancer patients poorly responsive to therapy (2) METHODS.- .- Fluorescence microscopy was used to determine EMT-linked decreases in E-cadherin and cytokeratin 18. These changes and others associated with EMT, were verified by immune blotting. Laser scanning cytometry was used to measure expression of ErbB2 and estrogen receptor alpha, cell cycle profile and proliferation (2). RESULTS.- Cells transduced with the DN-R175H mutant p53, increased expression of the mesenchymal marker vimentin and proliferation-associated cyclin A, also showing a greater G2 population which correlated with increased c-neu/Her2/ErbB2. Joint cytometric analysis of the Ki67proliferation marker and estrogen receptor alpha revealed a greater number of estrogen receptor-positive proliferating cells (3) among the mesenchymal population harbouring the DN-R175H mutant p53 .CONCLUSIONS.- These results suggest that EMT induced by the DN-R175H mutant p53 promotes a gain of pro-oncogenic function by increasing the % of proliferating cells expressing estrogen receptor alpha (3) and the expression of erbB2 (4)
REFERENCES
1.-Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Invest. 2009 119: 1420-8.
2.- Rieber M, Strasberg Rieber M. DN-R175H p53 mutation is more effective than p53 interference in inducing epithelial disorganization and activation of proliferation signals in human carcinoma cells : role of E-cadherin. Int J Cancer. 2009; 125:1604-12.
3.- Shoker BS, Jarvis C, Clarke RB, Anderson E, Hewlett J, Davies MP, Sibson DR, Sloane JP. Estrogen receptor-positive proliferating cells in the normal and precancerous breast. Am J Pathol 1999, 155:1811-1815.
4.- Cicalese A, Bonizzi G, Pasi CE, Faretta M, Ronzoni S, Giulini B, Brisken C, Minucci S, Di Fiore PP, Pelicci PG. The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells. Cell. 2009; 138:1083-95.
Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1107.</jats:p
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