237 research outputs found
A randomized controlled trial of imipramine in patients with irritable bowel syndrome
No full textAim: To study the efficacy of low-dose imipramine in relieving symptoms associated with the irritable bowel syndrome (IBS). Methods: A randomized, double-blind trial of 25 mg imipramine vs matched placebo for 12 wk was performed. Doubling the dose was allowed once at week 2 in case of an unsatisfactory early response. Primary efficacy variables were subjective global symptom relief and quality of life (QoL) using SF-36 at week 12. Results: One hundred and seven patients were enrolled by advertisement or referral by general practitioners and 56 (31 imipramine: 25 placebo) completed the 16-wk study. Baseline characteristics were comparable. A high overall dropout rate was noted in the imipramine and placebo arms (47.5percent vs 47.9percent, P 0.05), a mean of 25.0 and 37.4 d from enrollment, respectively (P 0.05). At the end of 12 wk, there was a significant difference in global symptom relief with imipramine over placebo (per-protocol: 80.6percent vs 48.0percent, P = 0.01) and a trend on intent-to-treat (ITT) analysis (42.4percent vs 25.0percent, P = 0.06). This improvement was evident early and persisted to week 16 (P = 0.024 and 0.053 by per-protocol and ITT analyses, respectively). Mean cumulative and componentspecific SF-36 scores improved in the imipramine group only (per-protocol, P 0.01). Drug-related adverse events leading to patient dropout were more common in the imipramine group (25.4percent vs 12.5percent, P 0.05). Conclusion: Imipramine may be effective in the treatment of IBS patients and is associated with improved QoL. Careful patient selection, initiation of a low dose with gradual escalation and monitoring for side effects may result in an improved therapeutic response. © 2009 The WJG Press and Baishideng. All rights reserved.Brandt LJ, 2002, AM J GASTROENTEROL, V97, pS7; Camilleri M, 2000, LANCET, V355, P1035, DOI 10.1016-S0140-6736(00)02033-X; Camilleri M, 2003, CLIN GASTROENTEROL H, V1, P111, DOI 10.1053-jcgh.2003.50019; Chang L, 2004, ALIMENT PHARM THERAP, V20, P31, DOI 10.1111-j.1365-2036.2004.02183.x; Choi S, 2006, LIFE SCI, V78, P2322, DOI 10.1016-j.lfs.2005.09.032; CLOUSE RE, 1994, ALIMENT PHARM THERAP, V8, P409; Clouse RE, 2005, GUT, V54, P1332, DOI 10.1136-gut.2004.048884; Drossman DA, 2003, GASTROENTEROLOGY, V125, P19, DOI 10.1016-S0016-5085(03)00669-3; Drossman DA, 2002, GASTROENTEROLOGY, V123, P2108, DOI 10.1053-gast.2002.37095; GARRATT AM, 1993, BRIT MED J, V306, P1440; GORARD DA, 1995, DIGEST DIS SCI, V40, P86, DOI 10.1007-BF02063948; GREENBAUM DS, 1987, DIGEST DIS SCI, V32, P257, DOI 10.1007-BF01297051; Hahn BA, 1997, ALIMENT PHARM THERAP, V11, P553, DOI 10.1046-j.1365-2036.1997.00160.x; HEEFNER JD, 1978, PSYCHOSOMATICS, V19, P540; LANCASTERSMITH MJ, 1982, ACTA PSYCHIAT SCAND, V66, P33, DOI 10.1111-j.1600-0447.1982.tb00912.x; Linner L, 1999, BIOL PSYCHIAT, V46, P766, DOI 10.1016-S0006-3223(99)00126-2; McQuay HJ, 1997, BRIT MED J, V314, P763; Morgan V, 2005, GUT, V54, P601, DOI 10.1136-gut.2004.047423; MYREN J, 1982, SCAND J GASTROENTERO, V17, P871; Novick J, 2002, ALIMENT PHARM THERAP, V16, P1877, DOI 10.1046-j.0269-2813.2002.01372.x; Rajagopalan M, 1998, J GASTROEN HEPATOL, V13, P738, DOI 10.1111-j.1440-1746.1998.tb00723.x; Spiegel BMR, 2004, ARCH INTERN MED, V164, P1773, DOI 10.1001-archinte.164.16.1773; STEINHART MJ, 1981, INT J PSYCHIAT MED, V11, P45; STEWART AL, 1989, JAMA-J AM MED ASSOC, V262, P907, DOI 10.1001-jama.262.7.907; STEWART AL, 1988, MED CARE, V26, P724, DOI 10.1097-00005650-198807000-00007; SVENSSON TH, 1978, SCIENCE, V202, P1089, DOI 10.1126-science.213833; Talley NJ, 2008, DIGEST DIS SCI, V53, P108, DOI 10.1007-s10620-007-9830-4; Talley NJ, 2004, AM J GASTROENTEROL, V99, P921, DOI 10.1111-j.1572-0241.2004.04128.x; Tanum L, 1996, SCAND J GASTROENTERO, V31, P318, DOI 10.3109-00365529609006404; Tripathi B M, 1983, J Assoc Physicians India, V31, P201; Vahedi H, 2008, ALIMENT PHARM THERAP, V27, P678, DOI 10.1111-j.1365-2036.2008.03633.x; van Zanten SJOV, 1999, GUT, V45, P69; Whitehead WE, 2006, AM J GASTROENTEROL, V101, P1057, DOI 10.1111-j.1572-0241.2006.00535.x; 2002, AM J GASTROENTEROL, V97, pS113121
The Grizzly, February 6, 1987
No full textResidential Village Saluted: Ursinus Recipient of County Planning Award • Art Critic Kuspit Condemns Ursinus\u27 Acquisitions • Biology Dept. Offers Field Study • Letters: Pro Abortion Bias Suggested; Art Critic Elitist; Hoopsters Accomplish Goals Despite Poor Press; Kane Commends McCullough • News Notes: Weaver to Play on Heefner Organ Again; Board Member Jeffers Dies at 79; Health Promotion Project; Lorelei, a U.C. Tradition • The Coddling of College Students • Connolly Finds Berry Piece Arrogant, Rash and True • Grappling Bears Stun Opponents in Streaking to 9-2 • Ursinus Roars Back to Thrash Hopkins • Men\u27s Track Impressive Early in Season • Mer Men Waiting for Loyola • Lady Hoopsters Capture First Home Win • Sophomore Wrestler Seislove on a Roll • A Baby and the Ball - Two Plays Called at Once • Japanese Program Offered Again • Fishing Club Factshttps://digitalcommons.ursinus.edu/grizzlynews/1180/thumbnail.jp
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Gyrotron anode modulation of the Electron Cyclotron Resonant Heating (ECRH) from dc to 50 kHz on the Tandem Mirror Experiment-Upgrade (TMX-U)
No full textThis paper describes control of gyrotron microwave energy output by modulation of gyrotron anode voltage. At present, Electron Cyclotron Resonant Heating (ECRH) uses five gyrotrons on the Tandem Mirror Experiment-Upgrade (TMX-U) for plasma heating. One is in the 10 kG region of each end plug, one at the 5 kG region of each end plug, and one is used for central-cell heating. Also described are the design and operation of the anode modulation system. The operating advantages of gyrotron anode modulation include power balance, independent control of each gyrotron, an ability to modulate microwave output power up to 50 kHz, and gyrotron tuning. The performance results of anode modulation will be discussed. 9 figs
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Quality assurance for Electron Cyclotron Resonant Heating (ECRH)
No full textDue to the complexity of the Tandem Mirror Experiment-Upgrade (TMX-U) and the importance of operating time, all the subsystems must be made as reliable as possible. ECRH is such a subsystem. In order to accomplish this task with ECRH, two things were needed: (1) training in proper operation and maintenance of the system; (2) a quality control assurance program. This paper will explain how these things were implemented
A gravitational wave observatory operating beyond the quantum shot-noise limit
No full textAround the globe several observatories are seeking the first direct detection of gravitational waves (GWs). These waves are predicted by Einstein’s general theory of relativity and are generated, for example, by black-hole binary systems. Present GW detectors are Michelson-type kilometre-scale laser interferometers measuring the distance changes between mirrors suspended in vacuum. The sensitivity of these detectors at frequencies above several hundred hertz is limited by the vacuum (zero-point) fluctuations of the electromagnetic field. A quantum technology—the injection of squeezed light—offers a solution to this problem. Here we demonstrate the squeezed-light enhancement of GEO600, which will be the GWobservatory operated by the LIGO Scientific Collaboration in its search for GWs for the next 3–4 years. GEO600 now operates with its best ever sensitivity, which proves the usefulness of quantum entanglement and the qualification of squeezed light as a key technology for future GW astronomy.J. Abadie... M.R. Ganija... D.J. Hosken... J. Munch... D.J. Ottaway... P.J. Veitch... et al. J. Abadie... M. R. Ganija...D. J. Hosken... J. Munch... D. J. Ottaway... P. J. Veitch... et al., (LIGO Scientific Collaboration
Erratum: All-sky search for gravitational-wave bursts in the first joint LIGO-GEO-Virgo run (Physical Review D - Particles, Fields, Gravitation and Cosmology (2010) 81 (102001))
No full textThis paper was published online on 5 May 2010 with an omission in the Collaboration author list. S. Dwyer has been
added as of 12 April 2012. The Collaboration author list is incorrect in the printed version of the journal
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