331 research outputs found
Denis Sargan: Some Perspectives
No full textWe attempt to present Denis Sargan's work in some kind of historical perspective, in two ways. First, we discuss some previous members of the Tooke Chair of Economic Science and Statistics, which was founded in 1859 and which Sargan held. Second, we discuss one of his artices 'Asymptotic Theory and Large Models' in relation to modern preoccupations with semiparametric econometrics.Denis Sargan, Tooke Chair of Economic Science and Statistics, asymptotic theory and large models, semiparametric econometrics.
Skin microvascular vasodilatory capacity in offspring of two parents with Type 2 diabetes
No full textAims<br/> Microvascular dysfunction occurs in Type 2 diabetes and in subjects with fasting hyperglycaemia. It is unclear whether this dysfunction relates to dysglycaemia. This study investigated in normogylcaemic individuals whether a genetic predisposition to diabetes, or indices of insulin resistance including endothelial markers, were associated with impaired microvascular function.<br/> Methods<br/> Maximum microvascular hyperaemia to local heating of the skin was measured using laser Doppler flowmetry in 21 normoglycaemic subjects with no family history of diabetes (Group 1) and 21 normoglycaemic age, sex and body mass index-matched offspring of two parents with Type 2 diabetes (Group 2). <br/>Results<br/> Although Group 2 had normal fasting plasma glucose and glucose tolerance tests, the 120-min glucose values were significantly higher at 6.4 (5.3-6.6) mmol/l (median (25th-75th centile)) than the control group at 4.9 (4.6-5.9) mmol/l (P=0.005) and the insulinogenic index was lower at 97.1 (60.9-130.8) vs. 124.0 (97.2-177.7) (P=0.027). Skin maximum microvascular hyperaemia (Group 1: 1.56 (1.39- 1.80) vs. Group 2: 1.53 (1.30-1.98) V, P=0.99) and minimum microvascular resistance which normalizes the hyperaemia data for blood pressure (Group 1: 52.0 (43.2-67.4) vs. Group 2: 56.0 (43.7-69.6) mmHgN, P=0.70) did not differ in the two groups. Significant positive associations occurred between minimum microvascular resistance and indices of the insulin resistance syndrome; plasminogen activator inhibitor type 1 (R-s=0.46, P=0.003), t-PA (R-s=0.36, P=0.03), total cholesterol (R-s=0.35, P=0.02), and triglyceride concentration (R-s=0.35, P=0.02), and an inverse association with insulin sensitivity (R-s=-0.33, P=0.03).<br/> Conclusions<br/> In normoglycaemic adults cutaneous microvascular vasodilatory capacity is associated with features of insulin resistance syndrome, particularly with plasminogen activator inhibitor type 1. A strong family history of Type 2 diabetes alone does not result in impairment in the maximum hyperaemic response
Reconciling global tipping point theories: insight from magnetic experiments
No full textDriven by a combination of global warming and unsustainable resource management, global tipping elements represent existential threats to Earth’s systems and communities. However, the tipping point theory is still developing. Here, we reconcile alternative theories through a comparison of mathematical tipping point models and empirical experiments on micromagnet systems. We show how discontinuous change in spatially complex ecosystem models and multidomain magnetic materials represents common generic stress-response behavior in systems that organize spatially when placed under stress. Such systems show “soft,” incremental rather than “hard,” abrupt change and may represent the majority of ecological, landscape, and social-ecological systems. The findings emphasize how the classic fold bifurcation model should be restricted to describing simple systems. We explore the effects of stress magnitude and rate on soft and hard systems and draw insight for global tipping elements: scale dependence, abrupt versus incremental change, reversibility, early warning signals, and positive socioeconomic tipping points
A. A. Co. Newcastle Heights [cartographic material] : magnificent, 17 residential areas : within a few minutes of Merewether Beach Tram : commanding views of ocean and district : for auction sale on the ground at 3 p.m. on Saturday, July 3rd, 1937 /
No full textSales plan for land in the suburb of Bar Beach in Newcastle, bounded by Brooks Street, Tooke Street, and Light Street.; "Terms: 15% deposit, balance at 1, 2, 3, 4 and 5 years. Interest 5% per annum."; "E. J. Davis, surveyor, A.A. Co."; Also available in an electronic version via the internet at: http://nla.gov.au/nla.map-lfsp1793.Newcastle Height
Structure-Function Analysis of the Anti-proliferative Effect of the Human Guanylate Binding Protein-1 (GBP-1) in Endothelial Cells.
No full textIn vitro antitumor activity and interaction with DNA model bases of cis-[PtCl2(iPram)(azole)] complexes and comparison with their trans analogues
No full textAsymmetric cis-platinum(II) complexes with isopropylamine and two different azole ligands were synthesized and characterized with different techniques. In addition, for one of the complexes the X-ray structure was determined. Cytotoxicity tests using several human tumor cell lines, including the cisplatin-sensitive cell line A2780 and its cisplatin-resistant analogue. These results were compared with the results obtained for the trans isomers of the presented complexes and a relation between the structure and the activity was established. It was found that complexes with cis geometry are less active than their trans analogues, in particular in the resistant cell line A2780R.
However, complex 1 can overcome cisplatin resistance to a certain extent. In the interaction with GMP, the asymmetric cis-Pt(II) complexes react with similar rates as their trans analogues and they behave as bifunctional species
The pantheon, representing the fabulous histories of the heathen Gods and most illustrious heroes, in a short, plain, and familiar method by way of dialogue. [electronic resource] : Illustrated and adorned with elegant copper cutts of the several deities. Written by Fra. Pomey, of the Society of Jesus, author of the French and Latin dictionary; for the use of the dauphin. The eighth edition. In which the whole translation is revised, and much amended: whereby it is now made more fit than any of the former impressions. For the use of schools. By Andrew Tooke, A.M.
No full textA translation by Andrew Tooke of Francois Antoine Pomey's 'Pantheum mythicum'.Electronic reproduction.English Short Title Catalog,Reproduction of original from National Library of Ireland
'Because even the placement of a comma might be important': Expertise, filtered embodiment and social capital in online sexual health promotion
No full textThe Terrence Higgins Trust (THT) is a leading UK HIV and sexual health organization, and community outreach and support remain a key tenet of the charity’s philosophy. Outreach work includes campaign drives in bars, clubs and saunas, peer-led workshops, support groups, condom distribution in community venues and one-to-one intervention programmes to help raise HIV/AIDS awareness. But what happens to community activism and outreach when the community one seeks to engage moves online? In this article, we report on a study capturing the experiences of workers engaged in THT’s digital outreach service, Netreach. Using ethnographic and other qualitative methods, we identify the shifting nature of health promotion outreach work and the changes in expert–client relationship that occur when community outreach takes place on digital platforms. We identify how issues of (dis)embodiment, expertise and cultural capital play a role in determining the success – or failure – of online outreach work
Three new asymmetric trans-amine(azole)dichloridoplatinum complexes that overcome cisplatin resistance and their reactions with 5'-GMP
No full textThree new asymmetric platinum(II) complexes comprising an isopropylamine ligand trans to an azole ligand were synthesized and
fully characterized by 1H NMR, 195Pt NMR, IR and elemental analysis. In addition the X-ray crystal structure of all three complexes
was determined. The reaction kinetics of the complexes with DNA model base guanosine-5'-monophosphate (GMP) was studied, revealing
reaction kinetics comparable to cisplatin. To gain insight in the complexes as potential antitumor agents, cytotoxicity assays were performed on a variety of human tumor cell lines. These assays showed the complexes all to possess cytotoxicity profiles comparable
to cisplatin. Furthermore, the complexes largely retain their activity in a human ovarian carcinoma cell line resistant to cisplatin, A2780R, compared to the cisplatin sensitive parent cell line A2780. These results are of fundamental importance, illustrating how platinum
complexes of trans geometry can show improved activity compared to cisplatin in both cisplatin sensitive and cisplatin resistant cell lines
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