3,207 research outputs found
Corticotropin-releasing hormone neurons in the hypothalamic paraventricular nucleus: Morphological and functional aspects
No full textItem does not contain fulltextK.U. Nijmegen, 14 mei 1997Promotores : Cools, A.R., Meek, J.129 p
Corticotropin-releasing hormone neurons in the hypothalamic paraventricular nucleus: morphological and functional aspects
No full textContains fulltext :
mmubn000001_242542980.pdf (Publisher’s version ) (Open Access)Promotores : A. Cools en J. Meek129 p
Individual differences in the acute effects of cannabis and cocaine on cognitive control
No full textContains fulltext :
155627.pdf (Publisher’s version ) (Open Access)Radboud Universiteit Nijmegen, 09 maart 2016Promotores : Cools, R., Raemakers, J. Co-promotores : Verkes, R.J., Bruijn, E.R.A. d
A tropical interpretation of m-dissimilarity maps
No full textLet T be a weighted tree with n numbered leaves and let D = (D (i, j))i, j be its distance matrix, so D (i, j) is the distance between the leaves i and j. If m is an integer satisfying 2 ≤ m ≤ n, we prove a tropical formula to compute the m-dissimilarity map of T (i.e. the weights of the subtrees of T with m leaves), given D. For m = 3, we present a tropical description of the set of m-dissimilarity maps of trees. For m = 4, a partial result is given
Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia
No full textT-cell acute lymphoblastic leukemia (T-ALL) is caused by the cooperation of multiple oncogenic lesions. We used exome sequencing on 67 T-ALLs to gain insight into the mutational spectrum in these leukemias. We detected protein-altering mutations in 508 genes, with an average of 8.2 mutations in pediatric and 21.0 mutations in adult T-ALL. Using stringent filtering, we predict seven new oncogenic driver genes in T-ALL. We identify CNOT3 as a tumor suppressor mutated in 7 of 89 (7.9%) adult T-ALLs, and its knockdown causes tumors in a sensitized Drosophila melanogaster model. In addition, we identify mutations affecting the ribosomal proteins RPL5 and RPL10 in 12 of 122 (9.8%) pediatric T-ALLs, with recurrent alterations of Arg98 in RPL10. Yeast and lymphoid cells expressing the RPL10 Arg98Ser mutant showed a ribosome biogenesis defect. Our data provide insights into the mutational landscape of pediatric versus adult T-ALL and identify the ribosome as a potential oncogenic factor.sponsorship: This work was supported by grants from KU Leuven (concerted action grant to J. Cools and P.V. and PF/10/016 SymBioSys to J. Cools and S.A.), FWO-Vlaanderen (G.0546.11 to J. Cools, P.V., S.A. and A.U. and G.0704.11N to S.A.), the Foundation against Cancer (SCIE2006-34 to J. Cools and 2010-154 to S.A.), a European Research Council (ERC) starting grant (J. Cools), the Interuniversity Attraction Poles (IAP) granted by the Federal Office for Scientific, Technical and Cultural Affairs, Belgium (J. Cools and P.V.), a grant from the Ministry of Health, Cancer Plan (J. Cools, P.V. and S.A.), a grant from the French program Carte d'Identite des Tumeurs (CIT, Ligue Contre le Cancer) and from Canceropole d'Ile de France (J.S.), and a grant from the US National Institutes of Health (NIH; GM53655 to A.W.J. and SE). K.D.K. is a postdoctoral researcher, and P.V. is a senior clinical investigator of FWO-Vlaanderen. (KU Leuven|PF/10/016 SymBioSys, FWO-Vlaanderen|G.0546.11, FWO-Vlaanderen|G.0704.11N, Foundation against Cancer|SCIE2006-34, Foundation against Cancer|2010-154, European Research Council (ERC), Federal Office for Scientific, Technical and Cultural Affairs, Belgium, Ministry of Health, Cancer Plan, French program Carte d'Identite des Tumeurs (CIT, Ligue Contre le Cancer), Canceropole d'Ile de France, US National Institutes of Health (NIH)|GM53655)status: Publishe
Are azole fungicides losing ground against Septoria wheat disease? Resistance mechanisms in Mycosphaerella graminicola
No full textThere has been a recent rapid decline in the efficacy of some, but not all, azole fungicides in controlling the Septoria leaf blotch pathogen of wheat, Mycosphaerella graminicola. Hans J. Cools and Bart A. Fraaije ask the question: can widespread resistance to all azoles develop in this pathogen
Large Time Step and DC Stable TD-EFIE Discretized with Implicit Runge-Kutta Methods
No full textThe time domain-electric field integral equation (TD-EFIE) and its differentiated version are widely used to simulate the transient scattering of a time dependent electromagnetic field by a perfect electric conductor (PEC). The time discretization of the TD-EFIE can be achieved by a space-time Galerkin approach or, as it is considered in this contribution, by a convolution quadrature using implicit Runge-Kutta methods. The solution is then computed using the marching-on-in-time (MOT) algorithm. The differentiated TD-EFIE has two problems: 1) the system matrix suffers from ill-conditioning when the time step increases (low frequency breakdown) and 2) it suffers from the DC instability, i.e., the formulation allows for the existence of spurious solenoidal currents that grow slowly in the solution. In this article, we show that 1) and 2) can be alleviated by leveraging quasi-Helmholtz projectors to separate the Helmholtz components of the induced current and rescale them independently. The efficacy of the approach is demonstrated by numerical examples including benchmarks and real-life applications.Numerical Analysi
Psychotherapie in Vlaanderen : een overzicht aan de hand van terugkerende discussiepunten
No full textData for "Wildfire smoke cools summer river and stream water temperatures"
No full textThese data were used in an analysis of the effects of wildfire smoke on river and stream water temperatures, air temperatures, and solar radiation in the lower Klamath River Basin, California, USA. These data were assembled and analyzed by Aaron T. David, J. Eli Asarian, and Frank K. Lake. The publication describing these data and the results and interpretation of our analysis is titled: "Wildfire smoke cools summer river and stream water temperatures." For questions about these data or the publication, please contact Aaron David ([email protected])
Gifford-McMahon/Joule-Thomson Refrigerator Cools to 2.5 K
No full textA compact refrigerator designed specifically for cooling a microwave maser low-noise amplifier is capable of removing heat at a continuous rate of 180 mW at a temperature of 2.5 K. This refrigerator is a combination of (1) a commercial Gifford-McMahon (GM) refrigerator nominally rated for cooling to 4 K and (2) a Joule-Thomson (J-T) circuit. The GM refrigerator pre-cools the J-T circuit, which provides the final stage of cooling. The refrigerator is compact and capable of operating in any orientation. Moreover, in comparison with a typical refrigerator heretofore used to cool a maser to 4.5 K, this refrigerator is simpler and can be built at less than half the cost
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