1,723,345 research outputs found
Creighton Alumni Hawaii Trip, Bernard J. Conway
No full textCreighton Alumni Hawaii Trip, Bernard J. Conway, director of alumni relation
Creighton Alumni Hawaii Trip, Bernard J. Conway
No full textCreighton Alumni Hawaii Trip, Bernard J. Conway, director of alumni relation
Studies presented to Sir Hilary Jenkinson. Edited by J. Conway Davies
No full textSilvestre H. Studies presented to Sir Hilary Jenkinson. Edited by J. Conway Davies. In: Scriptorium, Tome 12 n°1, 1958. p. 155
From epigenetics to lipid metabolism: different approaches to fight cancer
Full text linkDuring my Phd I have been working on the developement of small molecules as modulators of epigenetic and non-epigenetic targets involved in cancer development ad progression. Mainly my work have been focused on the development of inhibitors (dimethylpyridone containing pyrrole- and pyrazole-based) of the lysine methyltransferase EZH2 as the catalytically active member of the Polycomb complex PRC2. These studies yielded the identification of novel EZH2is, also revealing nice SAR data. Some of the novel compounds showed promising activity in cancer cells having antiproliferative effects, reducing the H3K27 methylation, inducing apoptosis and autophagy. One of the novel compounds proved active also in a mouse model of medulloblastoma. Additionally, a Medicinal Chemistry study on Astemizole, as potential PRC2 disruptor, have been performed. For this project no biological data are jet available. In addition, a guest research stay at the University of Oxford (with S. Conway) resulted in a study on the design, synthesis and preliminary assays of photoaffinity probes for BET bromodomains. Finally, I worked on a new target from the field of lipid signalling, alkylglycerone phosphate synthase (AGPS) by developing SAR studied on the first in class AGPS inhibitor published in 2015 by the group of Prof. Mai
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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