918 research outputs found

    Personal Papers (MS 80-0002)

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    Letter from I. H. Kempner to J. B. Pattison discussing the prospect of their mutual friend Senterfit willing the speakership race because his opponent, Representative McDaniel of Wichita Falls, withdrew from the race

    Lake Powell Research Project Bulletin, Number 45, May 1977

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    Scanned copy of "Lake Powell Research Project Bulletin," Number 45, May 1977, containing the report, "Prehistoric and historic steps and trails of Glen Canyon - Lake Powell," by Natalie B. Pattison and Loren D. Potte

    Accurately determining intermediate and terminal plan states using bayesian goal recognition

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    Goal Recognition concerns the problem of determining an agent's final goal, deduced from the plan they are currently executing (and subsequently being observed). The set of possible goals or plans to be considered are commonly stored in a library, which is then used to propose possible candidate goals for the agent's behaviour. Previously, we presented AUTOGRAPH - a system which removed the need for a goal or plan library, thus making any problem solvable without the need to construct such a structure. In this paper, we discuss IGRAPH, which improves upon its predecessor by utilising Bayesian inference to determine both terminal and intermediate goals/states which the agent being observed is likely to pass through

    Impact hammer-based analysis of nonlinear effects in bolted lap joint

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    This work presents an experimental investigation into the dynamic behavior of a bolted joint beam configuration. The impact hammer is chosen as an alternative to classical harmonic excitation methods. The structural responses are explored for a range of the joint tightening toques and various levels of impulse hammer excitations. A symmetric beam assembly made of two nominally identical steel beams is studied. Symmetric modes are found to be sensitive to the test parameters. For given torque, impact-based varying joint loading conditions are used to induce the nonlinear joint effects. A linear data processing strategy is used to observe the nonlinear behavior indirectly. The dynamic joint behavior is described in the form of the modal frequency-damping ratio performance maps represented by the two-parametric approximating quadratic response surface models. This model maps the joint conditions on the corresponding dynamic characteristics of interest and it will serve as a basis for the parametric linear joint model development.</p

    ‘Qui Docet Discet’ (Those who teach learn) – how peer teaching can help prepare student teachers for the classroom

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    This study in reciprocal peer teaching (RPT), in an English Higher Education Institution (HEI), enabled PGCE students teaching English and Modern Languages at secondary level to develop their confidence in interactive teaching methods. Students focussed on developing drama techniques, an area for improvement in both cohorts. Research centred on whether student teachers found RPT beneficial in fostering classroom skills and confidence, which was evaluated through assessing students’ self-efficacy in particular tasks. In a mixed methods study, self-efficacy for using drama techniques was measured via questionnaires based on the Teaching Confidence scale and a focus group elicited RPT data. Findings demonstrated increased confidence levels post to pre-test in using drama techniques; students highlighted the positive benefits of collaboration, application and adaptation of pedagogy. The emotional impact of the RPT process was an unexpected finding however, reinforced by the focus group, although with greater emphasis on the cognitive benefits of the process. Findings demonstrated increased self-efficacy through acknowledgment of mastery and vicarious experiences. Whilst there were limitations in view of the small scale of the project, short-term benefits were derived by students and the project will continue to be used at the HEI as an effective method of skills sharing

    The Spirit : the relation of God and man, considered from the standpoint of philosophy, psychology and art /

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    Includes bibliographical references and indexes.Introduction.--Seth Pringle-Pattison, A. Immanence and transcendence.--Dougall, L. God in action.--Hadfield, J. A. The psychology of power.--Scott, C. A. A. What happened at Pentecost.--Emmet, C. W. The psychology of grace: how God helps.--Emmet, C. W. The psychology of inspiration: how God teaches.--Dougall, L. The language of the soul: some reflections on the Christian sacraments.--Clutton-Brock, A. Spiritual experience.--Clutton-Brock, A. Spirit and matter.--Streeter, B. H. Christ the constructive revolutionary.Mode of access: Internet

    The Twelfth International Symposium on Very High Energy Cosmic Ray Interactions took place at CERN from 15 to 20 July 2002.

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    Photo 01: Symposium participants outside building 500. Photo 02: B. Pattison (CERN) welcomes participants to the symposium. Photo 05: CERN Director-General Luciano Maiani delivers a message from the CERN Directorate. Photos 06, 07, 08: J. Ellis (CERN) delivers his invited lecture: "High-energy astrophysics and relation to cosmology"

    Modelling the effects of the weather on admissions to UK trauma units : a cross-sectional study

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    Objective To assess the relationship between daily trauma admissions and observed weather variables, using data from the Trauma Audit and Research Network of England and Wales and the UK Meteorological Office. Design A cross-sectional study. Setting Twenty-one accident and emergency departments (ED) located across England. Participants All patients arriving at one of the selected ED, with a subsequent death, inpatient stay of greater than 3 days, interhospital transfer or requiring critical care between 1 January 1996 and 31 December 2006. Main Outcome Measures Daily counts of adult and paediatric trauma admissions. Results Multivariate regression analysis indicated that there were strong seasonal trends in paediatric (χ2 likelihood ratio test p<0.001), and adult (p=0.016) trauma admissions. For adults, each rise of 5°C in the maximum daily temperature and each additional 2 h of sunshine caused increases in trauma admissions of 1.8% and 1.9%. Effects in the paediatric group were considerably larger, with similar increases in temperature and hours of sunshine causing increases in trauma admissions of 10% and 6%. Each drop of 5°C in the minimum daily temperature, eg, due to a severe night time frost, caused adult trauma admissions to increase by 3.2%. Also the presence of snow increased adult trauma admissions by 7.9%. Conclusion This is the largest study of its kind to investigate and quantify the relationship between trauma admissions and the weather. The results show clear associations that have direct application for planning and resource management in UK ED

    Epidemiology, transmission dynamics and control of SARS: the 2002-2003 epidemic

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    This paper reviews current understanding of the epidemiology, transmission dynamics and control of the aetiological agent of severe acute respiratory syndrome (SARS). We present analyses of data on key parameters and distributions and discuss the processes of data capture, analysis and public health policy formulation during the SARS epidemic are discussed. The low transmissibility of the virus, combined with the onset of peak infectiousness following the onset of clinical symptoms of disease, transpired to make simple public health measures, such as isolating patients and quarantining their contacts, very effective in the control of the SARS epidemic. We conclude that we were lucky this time round, but may not be so with the next epidemic outbreak of a novel aetiological agent. We present analyses that help to further understanding of what intervention measures are likely to work best with infectious agents of defined biological and epidemiological properties. These lessons learnt from the SARS experience are presented in an epidemiological and public health context

    Intraarticular Adeno-Associated Virus Serotype AAV-PHP.S–Mediated Chemogenetic Targeting of Knee-Innervating Dorsal Root Ganglion Neurons Alleviates Inflammatory Pain in Mice

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    Objective: Joint pain is the major clinical symptom of arthritis that affects millions of people. Controlling the excitability of knee-innervating dorsal root ganglion (DRG) neurons (knee neurons) could potentially provide pain relief. We undertook this study to evaluate whether the newly engineered adeno-associated virus (AAV) serotype, AAV-PHP.S, can deliver functional artificial receptors to control knee neuron excitability following intraarticular knee injection. Methods: The AAV-PHP.S virus, packaged with dTomato fluorescent protein and either excitatory (Gq) or inhibitory (Gi) designer receptors exclusively activated by designer drugs (DREADDs), was injected into the knee joints of adult mice. Labeling of DRG neurons with AAV-PHP.S from the knee was evaluated using immunohistochemistry. The functionality of Gq- and Gi-DREADDs was evaluated using whole-cell patch clamp electrophysiology on acutely cultured DRG neurons. Pain behavior in mice was assessed using a digging assay, dynamic weight bearing, and rotarod performance, before and after intraperitoneal administration of the DREADD activator, Compound 21. Results: We showed that AAV-PHP.S can deliver functional genes into ~7% of lumbar DRG neurons when injected into the knee joint in a similar manner to the well-established retrograde tracer, fast blue. Short-term activation of AAV-PHP.S–delivered Gq-DREADD increased excitability of knee neurons in vitro (P = 0.02 by unpaired t-test), without inducing overt pain in mice when activated in vivo. By contrast, in vivo Gi-DREADD activation alleviated digging deficits induced by Freund's complete adjuvant–mediated knee inflammation (P = 0.0002 by repeated-measures analysis of variance [ANOVA] followed by Holm-Sidak multiple comparisons test). A concomitant decrease in knee neuron excitability was observed in vitro (P = 0.005 by ANOVA followed by Holm-Sidak multiple comparisons test). Conclusion: We describe an AAV-mediated chemogenetic approach to specifically control joint pain, which may be utilized in translational arthritic pain research
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