2,861 research outputs found
Gioco, guerra e diritto nel De ludo scacchorum in legali methodo tractatus (1583) di Tommaso Azzi
No full textThe De ludo scacchorum in legale methodo tractatus (1583) of Tommaso Azzi, is not really a treatise on the game of chess, but a work that addresses various legal issues. In De ludo the theme of war is relevant. The aim of my essay is to show how the close connection between war, game of chess and law established by Azzi is functional to the idea of just war based on the game theory. According to Azzi the war has affinities to the game: strict rules, a limited and orderly space in which to take place, a position of equality between the parties. In this treaty the author underlines similarities between war and gaming and he represents war as a regulated phenomenon, within a path of “civilisation”.Il De ludo scacchorum in legali methodo tractatus (1583) del giurista Tommaso Azzi non è realmente un trattato sul gioco degli scacchi, ma un’opera che affronta varie questioni giuridiche. Tra i temi ricorrenti del De ludo troviamo il tema della guerra. La tesi di questo saggio è mostrare come la stretta connessione tra guerra, gioco degli scacchi e diritto stabilita da Azzi sia funzionale all’affermazione di una idea di guerra giusta ricalcata sul gioco. Tale guerra deve quindi possedere le caratteristiche proprie del gioco: regole severe, uno spazio limitato e ordinato in cui svolgersi, una posizione di uguaglianza tra le parti. Il trattato si inserisce così all’interno di una tradizione che, sottolineando le similitudini tra guerra e gioco, rappresenta la guerra come un fenomeno regolato, all’interno di un percorso di “civilizzazione”
Effects of vitamin E on extracellular matrix components of the vascular wall: Non-antioxidant roles in the prevention of cardiovascular diseases.
No full textSARS-CoV-2 Pandemic and the Need for Transplant-Oriented Trials
No full textIn this letter to the editor the authors highlight the important role of the scientific community in the SARS-CoV-2 pandemic and the urgent need of clinical trial specific in transplant patients
A novel human tocopherol-associated protein: cloning, in vitro expression, and characterization.
No full textVitamin E (alpha-tocopherol) is an essential dietary nutrient for humans and animals. The mechanisms involved in cellular regulation as well as in the preferential cellular and tissue accumulation of alpha-tocopherol are not yet well established. We previously reported (Stocker, A., Zimmer, S., Spycher, S. E., and Azzi, A. (1999) IUBMB Life 48, 49-55) the identification of a novel 46-kDa tocopherol-associated protein (TAP) in the cytosol of bovine liver. Here, we describe the identification, the molecular cloning into Escherichia coli, and the in vitro expression of the human homologue of bovine TAP, hTAP. This protein appears to belong to a family of hydrophobic ligand binding proteins, which have the CRAL (cis-retinal binding motif) sequence in common. By using a biotinylated alpha-tocopherol derivative and the IASys resonant mirror biosensor, the purified recombinant protein was shown to bind tocopherol at a specific binding site with K(d) 4.6 x 10(-7) m. Northern analyses showed that hTAP mRNA has a size of approximately 2800 base pairs and is ubiquitously expressed. The highest amounts of hTAP message are found in liver, brain, and prostate. In conclusion, hTAP has sequence homology to proteins containing the CRAL_TRIO structural motif. TAP binds to alpha-tocopherol and biotinylated tocopherol, suggesting the existence of a hydrophobic pocket, possibly analogous to that of SEC14
Molecular events of the inflammation process that are affected by alpha-tocopherol. Antioxidant and gene expression in the process of inflammation and wound repair.
No full textMolecular basis of alpha-tocopherol action and its protective role against diabetic complications
No full textα-Tocopherol binding to human serum albumin
No full textGiven the ability of human serum albumin (HSA) to bind hydrophobic ligands, the binding mode of α-tocopherol, the most representative member of the vitamin E family, is reported. α-Tocopherol binds to HSA with K = (7.0 ± 3.0) × 10-6 M (pH 7.2, 25.0°C). Competitive and allosteric modulation of α-tocopherol binding to full-length and truncated (Asp1-Glu382) HSA by endogenous and exogenous ligands suggests that it accommodates preferentially in the FA3-FA4 site. As HSA is taken up into cells, colocalizes with the α-tocopherol transfer protein, and contributes to ligand secretion via ABCA1, it might participate in the distribution of α-tocopherol between plasma, cells, and tissues
Reaction mechanism of the reconstituted aspartate / glutamate carrier from mitochondria. Reversible switching to uniport function
No full textDierks T, Krämer R. Reaction mechanism of the reconstituted aspartate / glutamate carrier from mitochondria. Reversible switching to uniport function. In: Azzi A, Nalecz KA, Nalecz MJ, Wojtczak L, eds. Anion Carriers of Mitochondrial Membranes. Berlin: Springer; 1989: 99-110
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