2,453 research outputs found
MEMORIAL STATEMENTS BY ANDERSON, JUDGE, PRESS, AIGNER, ALLENBY, AND PALM
No full textThis collection presents memorial statements by Theodore W. Anderson, George G. Judge, S. James Press, Dennis J. Aigner, Greg M. Allenby, and Franz C. Palm
Lost conversations: finding new ways for black and white Australians to lead together
No full textIt\u27s time for a game-changer in how black and white Australians relate.
The difficulties we have in coming together—to talk, to work, to lead change—are core to our challenge to reconcile, as a country. But if we want to shift the status quo, if we want to lead change on entrenched Indigenous disadvantage, we don\u27t need another program, initiative or money to try and \u27fix\u27 the problem. We need to start having a different conversation.
The result of two years experience working together as part of a Social Leadership Australia initiative, Lost Conversations brings together the diverse perspectives and personal stories of five Aboriginal and four non-Indigenous authors, all with first-hand knowledge of what happens when black and white Australians come together to try and work on change.
Lost Conversations asks the questions and starts the conversations that we daren\u27t have in Australia ... until now:
What is \u27black\u27 power?
What is \u27white\u27 power?
What qualifies someone to lead in this cross-cultural space?
Why is this so hard to talk about?
Can we start to name these things and try to shift the status quo?
Can we change?
Should we?
 
AUT791817_Lay_Abstract – Supplemental material for Prevalence of overweight and obesity among US youth with autism spectrum disorder
No full textSupplemental material, AUT791817_Lay_Abstract for Prevalence of overweight and obesity among US youth with autism spectrum disorder by Seán Healy, Carrie J Aigner and Justin A Haegele in Autism</p
Adult mesenchymal stem cell therapy for myelin repair in Multiple Sclerosis
No full textMultiple sclerosis (MS) is a demyelinating immune-mediated disease of the central nervous system (CNS). It is the most frequent neurological disease in young adults and affects over 2 million people worldwide. Current treatments reduce the relapse rate and the formation of inflammatory lesions in the CNS, but with only temporary and limited success. Despite the presence of endogenous oligodendroglial progenitors (OPCs) and of spontaneous remyelination, at least in early MS its levels and its qualities are apparently insufficient for a sustained endogenous functional repair. Therefore, novel MS therapies should consider not only immunemodulatory but also myelin repair activities. Mesenchymal stem cells (MSCs) represent an attractive alternative to develop a cell-based therapy for MS. MSCs display stromal features and exert bystander immunemodulatory and neuroprotective activities. Importantly, MSCs induce oligodendrocyte fate decision and differentiation/maturation of adult neural progenitors, suggesting the existence of MSC-derived remyelination activity. Moreover, transplanted MSCs promote functional recovery and myelin repair in different MS animal models. Here, we summarize the current knowledge on endogenous mechanisms for remyelination and proposed autologous MSC therapy as a promising strategy for MS treatment
Pathobiology of osteoarthritis: pathomechanisms and potential therapeutic targets
No full textOsteoarthritis, a degenerative joint disease, is the most disabling condition of the Western world. It affects first and foremost the articular cartilages and leads to a molecular and supramolecular destruction of the extracellular cartilage matrix. In addition, the cells, the chondrocytes, show severe alterations of their phenotype: they get anabolically and catabolically activated, change accordingly their gene expression pattern, lose their differentiated phenotype, and undergo focally cell death and cell degeneration. All these processes represent potential targets for therapeutic intervention and drug development. Apart from the cartilage itself, however, other joint tissues are also involved in the disease: thus, the synovial capsule and membrane as well as the subchondral bone account not only for most of the symptoms of the disease, but are also presumably involved in the progression of the degenerative process. Both, inflammation and stiffening within the joint capsule accelerate joint destruction. Stiffening of the subchondral bone increases the mechanical stress over the overlying cartilage during physiological movement. Altogether, there is a plethora of tissues, disease processes and targets for treating osteoarthritic joint degeneration, which will need to be followed up systematically in the future
Efficiency and Input - and Output - Substitutability in English Higher Education 1996/97 to 2007/08: A Parametric Distance Function Approach
No full textHEIs are likely to face tight fiscal constraints in the future. This paper uses random effects and stochastic frontier techniques to estimate an output distance function over the period 1997/97 to 2007/08 in order to investigate the efficiency of higher education institutions (HEIs) and to examine the opportunities for substitution between inputs. Mean efficiency across the whole sector is estimated to be 70%, and further investigation reveals that the pattern of production in the typical institution in the highest efficiency quartile is closest to the pattern of production of the average pre-1992 university. The Morishima elasticities calculated from the parameter estimates suggest that the main possibilities for substitution are out of undergraduates into other inputs and from administration into other inputs (except academic services). Opportunities for substitution are generally much more limited from postgraduate inputs, staff and academic services. A simple examination of the effects of merger activity reveals that it takes place amongst institutions which are typically performing at the same level as non-merging HEIs, and that it has beneficial effects in terms of efficiency
Mesenchymal Stem Cells Promote Oligodendroglial Differentiation in Hippocampal Slice Cultures
No full textWe have previously shown that soluble factors derived from mesenchymal stem cells (MSCs) induce oligodendrogenic fate and differentiation in adult rat neural progenitors (NPCs) in vitro. Here, we investigated if this pro-oligodendrogenic effect is maintained after cells have been transplanted onto rat hippocampal slice cultures, a CNS-organotypic environment. We first tested whether NPCs, that were pre-differentiated in vitro by MSC-derived conditioned medium, would generate oligodendrocytes after transplantation. This approach resulted in the loss of grafted NPCs, suggesting that oligodendroglial pre-differentiated cells could not integrate in the tissue and therefore did not survive grafting. However, when NPCs together with MSCs were transplanted in situ into hippocampal slice cultures, the grafted NPCs survived and the majority of them differentiated into oligodendrocytes. In contrast to the prevalent oligodendroglial differentiation in case of the NPC/MSC co-transplantation, naive NPCs transplanted in the absence of MSCs differentiated predominantly into astrocytes. In summary, the pro-oligodendrogenic activity of MSCs was maintained only after co-transplantation into hippocampal slice cultures. Therefore, in the otherwise astrogenic milieu, MSCs established an oligodendrogenic niche for transplanted NPCs, and thus, co-transplantation of MSCs with NPCs might provide an attractive approach to re-myelinate the various regions of the diseased CNS. Copyright (C) 2009 S. Karger AG, Base
2018_Supplement_table_I – Supplemental material for Impulsivity predicts illness severity in long-term course of bipolar disorder: A prospective approach
No full textSupplemental material, 2018_Supplement_table_I for Impulsivity predicts illness severity in long-term course of bipolar disorder: A prospective approach by Jonas Rote, Alice-Mai-Ly Dingelstadt, Annette Aigner, Michael Bauer, Jana Fiebig, Barbara König, Johanna Kunze, Steffi Pfeiffer, Andrea Pfennig, Esther Quinlivan, Christian Simhandl and Thomas J Stamm in Australian & New Zealand Journal of Psychiatry</p
2018_Supplement_table_IV – Supplemental material for Impulsivity predicts illness severity in long-term course of bipolar disorder: A prospective approach
No full textSupplemental material, 2018_Supplement_table_IV for Impulsivity predicts illness severity in long-term course of bipolar disorder: A prospective approach by Jonas Rote, Alice-Mai-Ly Dingelstadt, Annette Aigner, Michael Bauer, Jana Fiebig, Barbara König, Johanna Kunze, Steffi Pfeiffer, Andrea Pfennig, Esther Quinlivan, Christian Simhandl and Thomas J Stamm in Australian & New Zealand Journal of Psychiatry</p
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