120 research outputs found
Some Inequalities for Normal Operators in Hilbert Spaces
No full textSome inequalities for normal operators in Hilbert spaces are given. For this purpose, some results for vectors in inner product spaces due to Buzano, Dunkl-Williams, Hile, Goldstein-Ryff-Clarke, Dragomir-S´andor and the author are employed
The Perturbed Median Principle for Integral Inequalities with Applications
Full text linkIn this paper a perturbed version of the Median Principle introduced
by the author in 'The median principle for inequalities and applications' is developed. Applications for various Riemann-
Stieltjes integral and Lebesgue integral inequalities are also provided
New Reverse Inequalities for Normal Operators in Hilbert Spaces
No full textIn this paper, more reverse inequalities for the class of normal
operators, are established. Some of the obtained results are based on recent
reverse results for the Schwarz inequality in Hilbert spaces due to the author
Upper Bounds for the Euclidean Operator Radius and Applications
No full textThe main aim of the present paper is to establish various sharp
upper bounds for the Euclidean operator radius of an n−tuple of bounded
linear operators on a Hilbert space. The tools used are provided by several
generalisations of Bessel inequality due to Boas-Bellman, Bombieri and the
author. Natural applications for the norm and the numerical radius of bounded
linear operators on Hilbert spaces are also given
Inequalities for some Functionals Associated with Bounded Linear Operators in Hilbert Spaces
No full textSome inequalities between the operator norm, numerical radius
and functional are established. New upper bounds for the nonnegative
quantity that complement some recent results of the author are given as well
Između ambicija i iluzija : nuklearna politika Jugoslavije : 1945-1990: nuklearna politika Jugoslavije : 1945-1990
No full textPublishe
Mechanisms mediating macrophage activation during acetaminophen-induced hepatotoxicity: role of high mobility group box-1 and galectin-3
No full textClassically and alternatively activated macrophages and inflammatory mediators they release play a key role in the pathogenesis of acetaminophen (APAP)-induced hepatotoxicity. In the present studies, we investigated the role of the DNA-binding protein, high mobility group box-1 (HMGB1), and the β-galactoside binding lectin, galectin-3 (Gal-3), in regulating the phenotype of activated macrophages in the liver following APAP intoxication. Culture medium collected from hepatocytes treated for 24 h with 5 mM APAP (CM-AA) stimulated macrophage production of reactive oxygen species and upregulated expression of the antioxidant enzymes catalase and heme oxygenase-1 (HO-1). CM-AA also upregulated expression of the proinflammatory chemokines MIP-1α (CCL3) and MIP-2 (CXCL2), and the eicosanoid biosynthetic enzymes, COX-2 and 12/15-LOX, effects dependent on the p44/42 MAP kinase. Treatment of hepatocytes with ethyl pyruvate (EP) prior to APAP blunted the effects of CM-AA on macrophage ROS production, expression of antioxidant proteins, and COX-2, suggesting that part of the activity in CM-AA was HMGB1. Further studies demonstrated that APAP-induced hepatotoxicity was associated with upregulation of Gal-3 mRNA and protein expression. Loss of Gal-3 resulted in reduced hepatotoxicity in response to APAP. This correlated with decreases in APAP-induced expression of the inflammatory proteins lipocalin 2 (24p3), inducible nitric oxide synthase (iNOS), interleukin-12 (IL-12), tumor necrosis factor- (TNF-), macrophage inflammatory protein-3 (MIP-3α), CD98, the macrophage Gal-3 receptor, and TNF-α receptor 1 (TNFR1). In contrast, APAP-induced expression of the alternative activation markers Ym1 and Fizz-1, as well as tissue repair, was increased in Gal-3-/- mice. These results suggest that Gal-3 contributes to inflammatory mediator production and hepatotoxicity after APAP. We next investigated the role of Gal-3 in regulating macrophage proinflammatory phenotype. Following APAP intoxication, increased numbers of proinflammatory CD11b+/Ly6Chi macrophages accumulated in necrotic regions of the liver. These cells were distinct from resident Kupffer cells and expressed Gal-3. Loss of Gal-3 resulted in reduced accumulation of CD11b+/Ly6Chi macrophages in response to APAP and increased accumulation of anti-inflammatory CD11b+/Ly6Clo macrophages. These results suggest that Gal-3 promotes a proinflammatory, classically activated macrophage phenotype in the liver during APAP-induced hepatotoxicity. Taken together, these studies indicate that multiple mechanisms contribute to proinflammatory macrophage activation following APAP intoxication.Ph. D.Includes bibliographical referencesIncludes vitaby Ana-Cristina Dragomi
K-loops: Loop Transformations for Reconfigurable Architectures
No full textThe focus of this dissertation is on kernel loops (K-loops), which are loop nests that contain hardware mapped kernels in the loop body. In this thesis, we propose methods for improving the performance of such K-loops, by using standard loop transformations for exposing and exploiting the coarse grain loop level parallelism. We target a reconfigurable architecture that is a heterogeneous system consisting of a general purpose processor and a field programmable gate array (FPGA). Research projects targeting reconfigurable architectures are trying to give answers to several problems: how to partition the application -- decide which parts to be accelerated on the FPGA, how to optimize these parts (the kernels), what is the performance gain. However, only few try to exploit the coarse grain loop level parallelism. This work goes towards automatically deciding the number of kernel instances to place into the reconfigurable hardware, in a flexible way that can balance between area and performance. In this dissertation, we propose a general framework that helps determine the optimal degree of parallelism for each hardware mapped kernel within a K-loop, taking into account area, memory size and bandwidth, and performance considerations. In the future it can also take into account power. Furthermore, we present algorithms and mathematical models for several loop transformations in the context of K-loops. The algorithms are used to determine the best degree of parallelism for a given K-loop, while the mathematical models are used to determine the corresponding performance improvement. The algorithms are validated with experimental results. The loop transformations that we analyze in this thesis are loop unrolling, loop shifting, K-pipelining, loop distribution, and loop skewing. An algorithm that decides which transformations to use for a given K-loop is also provided. Finally, we also present an analysis of possible situations and justifications of when and why the loop transformations have or have not a significant impact on the K-loop performance.Microelectronics & Computer EngineeringElectrical Engineering, Mathematics and Computer Scienc
Experimental investigation on hydrazinium nitroformate (HNF) combustion and its modification
No full textApplied Science
Upper Bounds for the Euclidean Operator Radius and Applications
Full text linkThe main aim of the present paper is to establish various sharp upper bounds for the Euclidean
operator radius of an n-tuple of bounded linear operators on a Hilbert space. The tools used are
provided by several generalizations of Bessel inequality due to Boas-Bellman, Bombieri, and the
author. Natural applications for the norm and the numerical radius of bounded linear operators
on Hilbert spaces are also given
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