224 research outputs found
Interview with Jean Francois Revel, author
No full textJean Francois Revel, the author of Without Marx or Jesus, has been quoted as saying, "The United States is now a microcosm for all of the problems man faces." In this interview with Meredith Watts, he discusses a new kind of revolution which could produce successful change without violent upheavalGrayscaleSoun
REVEL Is Better at Predicting Pathogenicity of Loss-of-Function than Gain-of-Function Variants
No full textIn silico predictive tools can help determine the pathogenicity of variants. The 2015 American College of Medical Genetics and Genomics (ACMG) guidelines recommended that scores from these tools can be used as supporting evidence of pathogenicity. A subsequent publication by the ClinGen Sequence Variant Interpretation Working Group suggested that high scores from some tools were sufficiently predictive to be used as moderate or strong evidence of pathogenicity. REVEL is a widely used metapredictor that uses the scores of 13 individual in silico tools to calculate the pathogenicity of missense variants. Its ability to predict missense pathogenicity has been assessed extensively; however, no study has previously tested whether its performance is affected by whether the missense variant acts via a loss-of-function (LoF) or gain-of-function (GoF) mechanism. We used a highly curated dataset of 66 confirmed LoF and 65 confirmed GoF variants to evaluate whether this affected the performance of REVEL. 98% of LoF and 100% of GoF variants met the author-recommended REVEL threshold of 0.5 for pathogenicity, while 89% of LoF and 88% of GoF variants exceeded the 0.75 threshold. However, while 55% of LoF variants met the threshold recommended for a REVEL score to count as strong evidence of pathogenicity from the ACMG guidelines (0.932), only 35% of GoF variants met this threshold (). GoF variants are therefore less likely to receive the highest REVEL scores which would enable the REVEL score to be used as strong evidence of pathogenicity. This has implications for classification with the ACMG guidelines as GoF variants are less likely to meet the criteria for pathogenicity.
P
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0.0352
). GoF variants are therefore less likely to receive the highest REVEL scores which would enable the REVEL score to be used as strong evidence of pathogenicity. This has implications for classification with the ACMG guidelines as GoF variants are less likely to meet the criteria for pathogenicity
Bio-Politics Today (1): Bio-Security
No full textFaculty of Arts – room 300 Biologization and naturalization of "threats" Who: Judith Revel What: Short Lecture When: 7 PM Language: English Live to Let Die: from Multitude to Pogrom Crowd in Capitalist Post-Modernization Who: Michał Kozłowski What: Short Lecture When: 8 PM Language: English Security and/or Rights and Liberties? Who: Ivan Buraj What: Short Lecture When: 8:30 PM Language: Slovak Fair Trade Palace – Studio Hridnů War and Violence Who: Pavel Barša, Étienne Fassin, Judith Revel, J..
Le ciel dans la photographie américaine. Remarques sur un absent
No full textThe sky is hardly ever "present" in photographs as it is in painting, and yet it constitutes a problem. By analyzing the work of American landscape photographers, from Ansel Adams to the New Topographers, as well as Stieglitz's seminal Equivalents, the author shows that the treatment of the sky points at the radicality of photography in the field of representation. The question of the sky as territory is indispensable to understanding photography.Le ciel est rarement aussi présent en photographie qu'en peinture, et pourtant il constitue un vrai problème théorique. En analysant les oeuvres de photographes américains de paysage, de Ansel Adams aux New Topographers, en passant par les "Equivalents" de Stieglitz, l'auteur montre que le traitement du ciel fait apparaître la radicalité de la photographie dans le domaine de la représentation. La question du ciel en tant que territoire est donc capitale pour une compréhension de l'histoire de la photographie
Effectiveness of policies and strategies to increase the capacity utilisation of intermittent renewable power plants
No full textEffectiveness of policies and strategies to increase the capacity utilisation of intermittent renewable power plants / David Benatia, Nick Johnstone & Ivan Haščič. Paris : OECD, May 2013, 50 p. http://www.oecd-ilibrary.org/environment/effectiveness-of-policies-and-strategies-to-increase-the-capacity-utilisation-of-intermittent-renewable-power-plants_5k46j0trlrnn-en Abstract (© OECD) : Intermittent renewable energy sources, such as wind and solar, will become increasingly important in the elec..
Effectiveness of policies and strategies to increase the capacity utilisation of intermittent renewable power plants
No full textEffectiveness of policies and strategies to increase the capacity utilisation of intermittent renewable power plants / David Benatia, Nick Johnstone & Ivan Haščič. Paris : OECD, May 2013, 50 p. http://www.oecd-ilibrary.org/environment/effectiveness-of-policies-and-strategies-to-increase-the-capacity-utilisation-of-intermittent-renewable-power-plants_5k46j0trlrnn-en Abstract (© OECD) : Intermittent renewable energy sources, such as wind and solar, will become increasingly important in the elec..
A rose is a rose is (not) a rose : De l’identification métaphorique ?
No full textInternational audienceThe author focuses his attention on the nature of the identification which is supposedly at the root of metaphorical enunciation, as well as on the nature of BE found in metaphorical utterances. Is it a marker of identification, of equivalence, or rather a locative or existential BE? He uses two cognitive linguistic theories (Conceptual Metaphor Theory and Blending Theory) and tries to give an answer on the linguistic and on the cognitive levels. He concludes by showing that there are few cases of identification during metaphorical enunciation as the metaphorization process is more often based on differences than on similarities.L’auteur s’interroge sur la nature de l’identification censée être à l’œuvre lors de l’énonciation métaphorique, ainsi que sur celle du BE apparaissant dans le cadre de l’énonciation métaphorique. Est-ce un BE d’identification, d’équivalence, un BE locatif, existentiel, etc. ? En convoquant les développements de la linguistique cognitive (Conceptual Metaphor Theory et Blending Theory), il essaie d’y donner une réponse aussi bien au niveau conceptuel qu’au niveau linguistique, pour conclure que les cas d’identification lors de l’énonciation métaphorique sont assez rares, le processus de métaphorisation se basant parfois plus sur les différences que sur les similarités
Revue des blogs - mardi 17 avril 2018
No full textWhy Markets Can’t Cool the Planet / Ivan Ascher, Project Syndicate, 16/04/2018 Among the most discussed climate-change remedies are those that would use market forces to make fossil fuels more expensive. But while free markets may have steered much of the world toward a wealthier, healthier future, placing our faith in Smith’s “invisible hand” to win the fight against climate change would be a tragic mistake... lire Justice climatique : en Colombie, une décision historique contre la déforesta..
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