49 research outputs found
Therapeutic Plasma Exchange and Conservative Treatment Comparison in Patients With Hypertriglyceridemia-Induced Acute Pancreatitis
No full textVatansever, Sezgin/0000-0002-8413-5353; Taskiran, Ismail/0000-0001-5450-5133Objective: Hypertriglyceridemia is the third most common cause of acute pancreatitis. Immediate triglyceride level lowering is beneficial in patients with severe hypertriglyceridemia [triglyceride (TG) >1,000 mg/dL]. This study aimed to compare the severity of acute pancreatitis, in-hospital mortality, and local and systemic complications, as well as hospitalization duration between patients with hypertriglyceridemia-induced acute pancreatitis treated with conservative treatment only and with therapeutic plasma exchange (TPE) in addition to conservative treatment. Materials and Methods: A total of 120 patients diagnosed with hypertriglyceridemia-induced acute pancreatitis treated with TPE in addition to conservative treatment (group 1) or conservative treatment only (group 2) participated in the study. Results: Group 1 consisted of 38 patients (9 females and 29 males) and group 2 had 82 patients (29 females and 53 males). No difference was found between the two groups regarding patient characteristics. The TG levels in group 1 decreased by 56.8% in one treatment session. The rate of patients with moderately severe acute pancreatitis + severe acute pancreatitis in group 1 was 36.8%, whereas 59.8% in group 2 (p=0.029). The local complication rate was 34.2% and 57.3% in group 1 and group 2, respectively (p=0.031). No significant difference was found between the groups regarding organ failure, systemic complication, hospitalization duration, and in-hospital mortality rates. Conclusion: Our study revealed that TPE treatment is effective in reducing local complications (especially pancreatic pseudocyst)
Clinical and biochemical characteristics of Sjögren’s syndrome and its differences from keratoconjunctivitis sicca
No full textObjective: In this study we aimed to compare the clinical and biochemical characteristics of primary Sjogren's syndrome patients with that of keratoconjunctivitis sicca, secondary Sjogren syndrome and undifferentiated disease
An unsaturated-soils approach to the bearing capacity of foundation structures
Get PDFUnsaturated soils are maintaining their importance for researchers and there is still much need to investigate the many engineering aspects of these soils. A new technique is proposed here to predict the variation of the bearing capacity of unsaturated soils with matric suction. The proposed method is an extension of conventional bearing-capacity theories and conceptually based on the logarithmic model of the shear strength of unsaturated soils, which only include one unknown, unsaturated parameter (the airentry value, AEV). The possibility of predicting the unsaturated bearing capacity of soils is shown by the saturated effective shear-strength parameters c\u27 and Ø\u27 and the AEV from the soil-water retention curve (SWRC). Considering the necessity of validating new methods with other researchers’ data, the proposed equation is tested using the published unsaturated experimental study by the author, in addition to some reported experimental studies on the shear strength for unsaturated soils and also a model footing loading on unsaturated sand under controlled suction conditions. The results of the study indicate that there is a good comparison between the “unsaturated bearing capacities” obtained via predicted and measured unsaturated strength parameters (ctotal , Ø) and also between the measured/ calculated bearing values of a model footing loading. Consequently, it is shown that, without needing complex unsaturated testing facilities, the proposed equation is capable of predicting the unsaturated bearing capacity for both fine-grained and sandy soils, requiring only one unsaturated parameter, which can be obtained from the SWRC or predicted using the basic soil-index properties
Diverticulum With Papillae: Does Position of Papilla Affect Technical Success?
No full textBasis and Purpose:The presence of peripapillary diverticulum (PPD) can cause some biliary diseases, especially common bile duct stones, and also, literally, can change the technique of endoscopic retrograde cholangiopancreatography (ERCP) and affect the complication ratio of this procedure. In this study, we investigate the effect of localization and position of the papilla according to the diverticulum on the success of therapeutic ERCP procedures.Materials and Methods:The study was conducted prospectively in the patients with naive papillae, who underwent ERCP for a period of 16 months. In all patients, the position of papillae according to the diverticulum (the periphery of the diverticulum is thought as the clock circumference, and the position of papillae is defined as the dials of clock), the success rate of biliary cannulation, total procedure time, overall treatment success rate of ERCP, and the complications are investigated.Results:During this period, 222 (18.5%) of the 1205 enrolled patients who underwent ERCP had PPD. Of the patients with PPD, 123 (55.4%) were female and 99 (44.6%) were male, and the median age was 68.910.1 years. According to the position of the papilla by the diverticulum, 90 (40.5%) patients have it on 7 o'clock position, 64 (28.8%) patients have on 6 o'clock position, 63 (28.3%) patients have on 5 o'clock position, and 5 (2.3%) patients have on 1 o'clock position. In the cases of the papilla on 1 o'clock position according to the diverticulum, cannulation procedures were found to be more difficult than other patients (P<0.05). The presence of the diverticulum did not affect the success of therapeutic procedures and did not increase the ratio of complications.Conclusions:In the presence of PPD, additional cannulation techniques may be required for the procedure. Particularly, the aid of percutaneous techniques may be needed for the papilla on 1 o'clock position
The Prevalence of Barrett Esophagus Diagnosed in the Second Endoscopy A Retrospective, Observational Study at a Tertiary Center
No full textOur study showed that in patients receiving no diagnosis of BE on their first endoscopic examination performed for any reason, the prevalence of BE on their second endoscopy within 6 years was very low (0.66%)
Simplified Technique for Sealing Corneal Perforations Using a Fibrin Glue-Assisted Amniotic Membrane Transplant-Plug
Get PDFPurpose. To describe a surgical technique using amniotic membrane transplant (AMT) with fibrin glue (FG) for treating smaller corneal perforations more practically and appropriately filling the defect. Method. A patient with noninfectious central corneal perforation, in 1 mm in diameter, was treated with FG-assisted AMT-plug. An AMT was folded in on itself twice by using FG then a small piece of this FG-AMT mixture was cut to maintain an appropriate plug for the site of the corneal perforation. The FG-assisted AMT-plug was placed in the perforation area by using FG. An amniotic membrane patch was placed over the plug, which was then secured by a bandage contact lens. Result. Surgery to restore corneal stromal thickness without recurrence of perforation. Conclusion. The FG-assisted AMT-plug allowed a successful repair of 1 mm in diameter corneal perforation. This technique was easily performed, thus seeming to be a good alternative to treat corneal perforations with restoring corneal thickness
Is Outpatient ERCP Safe for Choledocholithiasis?
No full textObjective: This study aimed to compare the complications of outpatient and inpatient endoscopic retrograde cholangiopancreatography (ERCP) procedures in patients with bile duct stones and to investigate whether it is a safe approach to perform outpatient ERCP or not
A Cross-Sectional Study of the Relationship Between Missed Nursing Care and Conscientious Intelligence in Hospital Nurses
No full textAim: To examine the relationship between missed nursing care and conscientious intelligence. Background: Missed nursing care is a globally common patient safety issue that threatens quality nursing care. Current studies mainly focus on the relationship between missed nursing care and external factors such as nurse, unit and hospital characteristics. However, internal factors, such as the conscientious intelligence of nurses, are also very important for missed nursing care. Moreover, the relationship between missed nursing care and conscientious intelligence has not been examined so far. This study will contribute to filling this gap in the literature. Methods: This is a descriptive correlational study. The study sample consisted of 514 nurses working in a city in the southeastern region of Türkiye, reached by convenience sampling method. Study data were collected between 30 January and 30 June 2021. Descriptive statistics, difference statistics, Pearson correlation analysis and multiple regression analysis were performed. Results: Nurses missed nursing care at an occasional level (1.66 ± 0.63), and their conscientious intelligence score was high (131.26 ± 19.24). Conscientious intelligence alone accounted for 10.6% of the variance in missed nursing care. As nurses’ conscientious intelligence levels increase, the level of missed nursing care decreases. Gender, education level, satisfaction with being a nurse and patient-to-nurse ratios had a statistically significant effect on missed nursing care scores. Conclusion: Missed nursing care decreased as nurses’ conscientious intelligence increased. Although nurses need to be knowledgeable and competent in caregiving, it is also necessary to consider their conscientious intelligence in patient care. Implications for nursing and health policy: Organizations and nurse managers could improve nursing care by implementing strategies to increase nurses’ conscientious intelligence. For this, they would need to encourage nurses to receive training on sensitivity, awareness, ethical decision-making and ethical sensitivity. Moreover, nurse managers should be role models and leaders in compliance with personal and professional values and ethical standards to improve nursing care. © 2024 The Author(s). International Nursing Review published by John Wiley & Sons Ltd on behalf of International Council of Nurses
A rare case of ovarian cancer in a pregnant woman with metastatic non-small cell lung cancer
No full textEffect of ovarian stimulation on the expression of piRNA pathway proteins.
Get PDFPIWI-interacting RNAs (piRNAs) play an important role in gametogenesis, fertility and embryonic development. The current study investigated the effect of different doses of pregnant mare serum gonadotrophin/human chorionic gonadotrophin (PMSG/hCG) and repeated ovarian stimulation (OS) on the expression of the Mili, Miwi, Mael, Tdrd1, Tdrd9, qnd Mitopld genes, which have crucial roles in the biogenesis and function of piRNAs. Here, we found that after treatment with 7.5 I.U. PMSG/hCG and two repeated rounds of OS, both the mRNA and protein levels of Tdrd9, Tdrd1 and Mael showed the greatest decrease in the ovarian tissue, but the plasma E2 levels showed the strongest increases (p<0.05). However, we found that the Mitopld, Miwi and Mili gene levels were decreased significantly after treatment with 12.5 I.U. PMSG/hCG. Our results suggested that exogenous gonadotropin administration leads to a significant decrease in the expression of the Mili, Miwi, Mael, Tdrd1, Tdrd9 and Mitopld genes, which are critically important in the piRNA pathway, and the changes in the expression levels of Tdrd9, Tdrd1 and Mael may be associated with plasma E2 levels. New comprehensive studies are needed to reduce the potential effects of OS on the piRNA pathway, which silences transposable elements and maintains genome integrity, and to contribute to the safety of OS
