MAU GCRIS Standard Database (Mardin Artuklu University)
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Ectoine-Loaded Solid Lipid Nanoparticles Enhance the Protection of Lacrimal Glands and Corneal Tissues in Dry Eye Disease Through Modulating NF-κB Mediated Signaling Pathway
No full textDry eye disease (DED) is a multifactorial disorder associated with tear film instability, inflammation, and ocular surface damage. This study aimed to develop and evaluate Ectoine-loaded solid lipid nanoparticles (Ect-SLNs) as a novel ocular drug delivery system to improve corneal penetration, retention, and therapeutic efficacy. Ect-SLNs were formulated using a Box-Behnken design and characterized for particle size, polydispersity index, zeta potential, and encapsulation efficiency. In vitro release kinetics were assessed. Ex vivo ocular retention studies were performed using bovine cornea. In vivo therapeutic efficacy was evaluated in a scopolamine-induced rat model of DED, with histological and immunohistochemical analyses of corneal and lacrimal gland tissues. The optimized Ect-SLN formulation exhibited a mean particle size, zeta potential and entrapment efficiency of 241.3 +/- 32.1 nm, -15.76 +/- -4.14 mV, and 32.84 + 3.15 % respectively. In vitro studies demonstrated that Ect-SLNs showed sustained release following Higuchi kinetics (r(2) = 0.991). Ex vivo studies confirmed 1.6-fold higher corneal retention compared to Ectoine solution. Animal studies showed that Ect-SLNs significantly improved glandular and corneal morphology, epithelial keratinization, apoptotic (Bax, Caspase-3) and pro-inflammatory (TNF-alpha, IL-1 beta) markers through NF-kappa B signaling pathway (p < 0.05). In addition, Ect-SLN formulation significantly inhibited the upregulated EGFR in corneal tissue, which is an important hallmark of neovascularization (p < 0.05). Ect-SLNs provided superior therapeutic benefits over conventional Ectoine solution by enhancing bioavailability, prolonging ocular residence, and modulating inflammatory and apoptotic responses. These findings suggest that Ect-SLNs constitute a promising nanocarrier platform for the clinical management of dry eye disease
Digital Engagement with Remote Architecture ‘Furthest from the Sea’: A Virtual Heritage Approach
No full textThis research addresses a computational analysis of the architectural heritage in Kashgar, the westernmost city in China and the easternmost part of Central Asia. Relevant to its culture and historical features, Kashgar is home to distinctive forms of mudbrick architecture that are furthest from the sea. Most historical mudbrick houses in the old town were replaced with replicas during a large-scale renewal project, initiated in 2009 and lasting for a decade. While the high risk of earthquakes made demolishing the original buildings seem like a practical solution for preserving local heritage, it also created a rare opportunity to digitally document the disappearing structures before their destruction. Based on an insightful review of methods used in 3D digital documentation and representation, this study provides new perspectives on computational studies of heritage sites. This study presents a set of 3D photogrammetric reconstructions of the narrow alleys in the old town, focusing on the role of user participation in the evaluation and interpretation of heritage. By investigating user-generated content in this unique cultural context, this research shows how novel research approaches are required to evaluate and interpret the inherent values of endangered heritage sites through participatory practices. © 2025 Elsevier B.V., All rights reserved
Unmanned Aerial Vehicles in Inventory Management: An Overview of Current Research and Applications
No full textThe University of Texas at Dallas, USA#Isparta University of Applied Sciences, Turkey#Prague University of Economics and Business, Czech Republic#Kent Business School, UK#University of LE HAVRE, France#University of Sfax, Tunisia#Manisa Celal Bayar University, Turkey#Healthcare Systems Group, TunisiaIndustry 4.0 refers to the integration of digital transformation and automation within production processes, offering the potential for significant improvements in productivity, cost optimization, and production flexibility. In this framework, inventory management is recognized as one of the fundamental applications of Industry 4.0. Intelligent inventory systems and automated stock tracking technologies facilitate the real-time monitoring and management of stock levels, thereby reducing the time lost and error rates typically associated with traditional inventory methods. The advent of big data analytics and sensor technologies has revolutionized inventory management, facilitating substantial cost savings and enabling more rapid and accurate responses to customer demands. Recently, Unmanned Aerial Vehicles (UAVs), commonly known as drones, have emerged as innovative tools for inventory counting. Drones equipped with advanced data collection capabilities are particularly effective in large warehouses and logistics centers, providing access to hard-to-reach areas and high-resolution imaging. This study presents a comprehensive literature review focusing on research conducted after 2018, aimed at examining current technologies for inventory counting. The review analyzes existing academic literature and industrial practices, revealing that drones significantly reduce error rates, shorten processing times, and facilitate real-time monitoring of stock levels. Consequently, UAV technology supports the implementation of inventory management strategies in a more dynamic and precise manner, thereby enhancing overall efficiency and accuracy. © 2025 Elsevier B.V., All rights reserved
Turkish Validity and Reliability of the Parental Competence Questionnaire in the Paediatric Hospital Emergency Setting (ECP-U)
No full textAim: The aim of this study is to conduct Turkish validity and reliability study of the parental competence questionnaire in the paediatric hospital emergency setting. Methods: This study is a descriptive, cross-sectional, correlational and methodological study. Participants were 624 parents with children aged 0-14 who presented to the paediatric emergency department between December 2023 and July 2024. The study was carried out in the emergency department of three hospitals in three different regions of Turkey. The data were collected by using the "demographic information form" and "parental competence questionnaire in the paediatric hospital emergency setting", "state and trait anxiety inventory", and "parental stress questionnaire". Explanatory and confirmatory factor analysis, Horn's parallel analysis, Catell's scree test, Cronbach's ordinal alpha coefficients and Pearson correlation were used in the data analysis. Results: The mean age of the mothers included in the study was 34.63 +/- 6.94, and the mean age of the fathers was 37.88 +/- 7.83. The scale consisted of 18 items and three sub-dimensions: emotional management and expression, social support, and parental agency, explaining 60 % of the total variance. It was determined that the Cronbach's ordinal alpha coefficients of the scale factors were greater than 0.745. There is a negative correlation between the parental stress questionnaire, the state and trait anxiety inventory, and the parental competence questionnaire in the paediatric hospital emergency setting. Conclusions: According to the results of this study, the parental competence questionnaire in the paediatric hospital emergency setting is a valid and reliable measurement tool for the Turkish population
Etiology of Postharvest Fungal Decay in Kumquat: A Polyphasic Approach Integrating Aggressiveness, IPBS and SCOT Fingerprinting, and Multilocus Phylogeny
No full textAs the global popularity of kumquat (Fortunella spp.; syn. Citrus japonica) continues to rise, knowledge of the pathogens responsible for postharvest losses remains limited. This study presents the first etiological investigation of postharvest fungal decay in kumquat, using a multi-regional survey and polyphasic characterization. A pathogenic complex responsible for postharvest decay was identified on this host for the first time, consisting of Alternaria alternata (n = 23), Geotrichum citri-aurantii (n =17), Penicillium digitatum (n = 30), P. italicum (n = 8), and P. expansum (n = 4). Identification combined morphological characterization with high-resolution molecular fingerprinting using start codon targeted (SCoT 32) and inter-primer binding site (iPBS 2395) markers, yielding polymorphic profiles that provided clear species-level discrimination consistent with multilocus phylogenetic analysis. In vitro assays identified distinct thermal optima for each pathogen. Geotrichum citri-aurantii growth was maximal at 30 degrees C, whereas P. expansum grew optimally at 20 degrees C. The remaining species-P. digitatum, P. italicum, and A. alternata-all achieved maximum growth at 25 degrees C, although P. italicum demonstrated a broad optimal range spanning from 20 to 25 degrees C. Aggressiveness varied among the pathogens, with P. digitatum and A. alternata being the most aggressive, followed by G. citri-aurantii and P. expansum, while P. italicum was the least aggressive. This study establishes the first pathogenic profile for kumquat decay, providing a framework for evidence-based postharvest management. The demonstrated efficiency of SCoT 32 and iPBS 2395 markers highlights their value as powerful, rapid, and cost-effective tools for pathogen surveillance and taxonomic resolution in postharvest pathology.The Scientific and Technological Research Council of Turkiye (TUBITAK) The authors would like to thank The Scientific and Technological Research Council of Turkiye (TUBITAK) for their financial support
Short-Term Resistance Training Enhances Functional and Physiological Markers in Older Women: Implications for Biomechanical and Health Interventions in Aging
No full textBackground: The impact of resistance training extends beyond the enhancement of muscle strength, encompassing improvements in physical performance, postural stability, and overall functional capacity. This study aimed to investigate the effects of a 4-week resistance training program on functional capacity, respiratory muscle strength, diaphragm thickness, and liver density in healthy older women. Methods: The study included 30 healthy women aged 60-80 years and was designed as a randomized controlled experimental trial. Participants were randomly assigned to a resistance training (RT) group or a control (CON) group. Each participant attended the laboratory on three occasions: during the initial visit, the study procedures were explained; the second visit involved baseline assessments (6MWT, diaphragm thickness and liver fat via ultrasound, and respiratory muscle strength); and final measurements were conducted after the 4-week training programme during the third visit. Results: When pre- and post-training measurements were compared, the resistance training (RT) group demonstrated a significantly greater improvement (8.02%) in the Six-Minute Walk Test (6MWT) distance compared to the control group (p < 0.001). In terms of diaphragm thickness (DT), the RT group showed a 16.66% increase, whereas the control group exhibited a 1.13% decrease (p < 0.001). Maximal inspiratory pressure (MIP) increased by 12.30% in the RT group, while it decreased by 7.25% in the control group, indicating a 19.55% greater improvement in the RT group (p < 0.001). Regarding maximal expiratory pressure (MEP), a significant improvement of 21.48% was observed in the RT group, whereas a 0.75% decrease was recorded in the control group, resulting in a 22.23% greater enhancement in the RT group (p < 0.001). Finally, liver density (LD) increased by 12.30% in the RT group, while it decreased by 7.25% in the control group (p < 0.001). Conclusion: As a result of resistance training, greater improvement was observed in functional capacity, respiratory muscle strength, diaphragm thickness and liver density in the training group compared to the control group.The author(s) declare that no financial support was received for the research and/or publication of this article
Validity and Reliability Study of the Turkish Version of the Questionnaire on Best Practices for Short Peripheral Intravenous Catheter Maintenance: A Methodological Study
No full textAim: This study aimed to evaluate the validity and reliability of the Turkish version of the Questionnaire on Best Practices for Short Peripheral Intravenous Catheter Maintenance.Methods: A methodological design was employed between February and May 2025, involving a sample of 276 nurses. Participants were drawn from emergency departments, internal medicine units, surgical wards, and intensive care units across hospitals in two provinces in eastern Turkey. Data were collected using two instruments: the Nurses' Information Form and the Questionnaire on Best Practices for Short Peripheral Intravenous Catheter Maintenance. Descriptive statistics, including frequencies, percentages, means, standard deviations, medians, and minimum and maximum values, were used to describe participant characteristics. Content validity was assessed through expert review, and the Content Validity Index was calculated using the Davis technique. Item discrimination and difficulty indices were computed using Microsoft Excel. Reliability analysis involved calculation of the Kuder-Richardson Formula 20 (KR-20) coefficient, alongside item-total score correlation analysis.Results: The KR-20 coefficient for the Questionnaire on Best Practices for Short Peripheral Intravenous Catheter Maintenance was 0.974. Analysis of the test mean scores revealed that the items were generally easy but exhibited high discriminatory power.Conclusion: The Turkish version of the Questionnaire on Best Practices for Short Peripheral Intravenous Catheter Maintenance demonstrated high reliability, as evidenced by its KR-20 value. The use of this questionnaire enables the identification of knowledge gaps among nursing professionals regarding best practices in short peripheral catheter care
Investigation of the Relationship Between University Students' Religious Attitudes and Their Attitudes Towards Spiritual Counseling and Guidance in Terms of Some Variables
No full textBu araştırmada, Mardin Artuklu Üniversitesi öğrencilerinin dini tutumları ile manevî danışmanlığa yönelik tutumları arasındaki ilişkinin ve bu tutumların cinsiyet, yaş fakülte ve sınıf düzeyine göre farklılaşıp farklılaşmadığının incelenmesi amaçlanmaktadır. Araştırmanın evrenini Mardin Artuklu Üniversitesinde eğitim gören tüm lisans öğrencileri oluşturmaktadır. Örneklem ise kolayda örnekleme yöntemiyle belirlenen 344 öğrenciyle sınırlandırılmıştır. Veri toplama aracı olarak katılımcıların demografik özelliklerini belirlemeye yönelik Demografik Bilgi Formu, Ok (2024) tarafından geliştirilen 26 maddelik Dini Tutum Ölçeği ve Altundağ (2022) tarafından geliştirilen 17 maddelik Manevî Danışmanlığa Yönelik Tutum Ölçeği kullanılmıştır. Ölçeklerin iç tutarlılığı Cronbach's α ile sırasıyla .91 ve .89 olarak tespit edilmiştir. Bulgular, dini tutum ile manevî danışmanlığa yönelik tutum arasında pozitif ve anlamlı bir ilişkinin varlığını göstermektedir (r = .280, p .05), yaş grupları bakımından yalnızca danışmanlık tutum puanlarında anlamlı farklılıklar saptanmıştır (p = .043). Sınıf düzeyi açısından ise danışmanlığa yönelik tutum puanlarında anlamlı farklılıklar mevcutken (p=.003), dini tutum puanları sınıf etkisinden etkilenmemektedir (p> .05). Sonuç olarak, öğrencilerin dini inanç düzeyleri yükseldikçe manevî danışmanlık hizmetlerine yönelik olumlu tutumlarında da artış görülmüş ve öğrenim ilerledikçe danışmanlığa yönelik kabullerin güçlendiği belirlenmiştir. Araştırmanın sınırlılıkları arasında tek bir üniversite ile sınırlandırılmış örneklem ve kesitsel tasarım yer almakta olup, elde edilen bulguların genellenebilirliği bu koşullar ışığında yorumlanmalıdır.This study aims to examine the relationship between the religious attitudes of Mardin Artuklu University students and their attitudes toward spiritual counseling. It also explores whether these attitudes differ according to gender, age, and grade level. The population of the study consists of all undergraduate students studying at Mardin Artuklu University. The sample was limited to 344 students selected through convenience sampling. The data collection tools used in the study were the Demographic Information Form, the 26-item Religious Attitude Scale developed by Ok (2024), and the 17-item Attitude Toward Spiritual Counseling Scale developed by Altundağ (2022). The internal consistency of the scales was determined to be 0.91 for the Religious Attitude Scale and 0.89 for the Attitude Toward Spiritual Counseling Scale, with Cronbach's α. The findings showed the existence of a positive and significant relationship between religious attitude and attitude toward spiritual counseling (r = .280, p .05), significant differences were found in counseling attitude scores across age groups (p = .043). Additionally, significant differences were found in attitude scores toward counseling by grade level (p = .003), but religious attitude scores were not affected by grade level (p > .05). Consequently, as students' religious belief levels increased, their positive attitudes toward spiritual counseling services also increased. Moreover, their acceptance of counseling strengthened as their education progressed. Limitations of the study include the sample size being limited to a single university and the cross-sectional design. Therefore, the generalizability of the findings should be interpreted in light of these factors
The Spatial and Functional Transformation of Aziz Önen Girls' Anatolian High School in Midyat
No full textEğitim yapıları, bilgi birikiminin kuşaktan kuşağa aktarılmasında temel rol oynayan mekânlardır. Bireylerin erken yaşlardan itibaren önemli bir zaman dilimini geçirdiği bu yapılar, eğitim-öğretim süreçleriyle uyumlu biçimde tasarlandığında, eğitimin niteliği üzerinde doğrudan etkili olmaktadır. Eğitim yapılarının tasarım ölçütleri; dönemin gereksinimleri, coğrafi koşullar, uygulanan eğitim modeli ve öğrenci sayıları gibi çok boyutlu faktörlerden etkilenmekte, bu değişkenlerdeki dönüşüm, mekânsal ihtiyaçların yeniden tanımlanmasına yol açmaktadır. Bu çalışma, Mardin ili Midyat ilçesinde ortaokul olarak inşa edilen ancak zamanla artan öğrenci sayısı nedeniyle lise işlevini de üstlenen bir eğitim yapısının mekânsal dönüşümünü incelemektedir. Söz konusu yapının seçilme nedeni, Midyat ilçesinde inşa edilen ilk ortaokul ve lise binası olması dolayısıyla tarihsel bir öneme sahip olmasıdır. Araştırma kapsamında nitel ve nicel yöntemler birlikte kullanılmış; sınırlı literatür verisi nedeniyle ilgili kurumlarla ve kullanıcılarla görüşmeler gerçekleştirilmiştir. Ayrıca yerinde gözlemler yapılmış, mimari çizimler (vaziyet planı, kat planları, kesitler, görünüşler) hazırlanmış ve fotoğraflama çalışmaları yürütülmüştür. Elde edilen bulgular doğrultusunda yapının geçirdiği mekânsal dönüşümler analiz edilmiştir. Sonuç olarak literatürde yeterince ele alınmamış olan bu yapıya yönelik gerçekleştirilen çalışma, eğitim yapılarının işlevsel dönüşümleri bağlamında özgün bir katkı sunacak ve yapılacak olan bilimsel çalışmalar için önemli bir kaynak olacaktır. Anahtar Kelimeler: Midyat, Mekân, Mekânsal Dönüşüm, Eğitim Yapısı, Mimari, İşlevEducational buildings are spaces that play a fundamental role in the transmission of knowledge from one generation to the next. These structures, where individuals spend a significant portion of their time from an early age, have a direct impact on the quality of education when designed in harmony with educational processes. The design criteria of educational buildings are influenced by multidimensional factors such as the needs of the period, geographical conditions, the implemented educational model, and student population. Transformations in these variables lead to a redefinition of spatial requirements. This study examines the spatial transformation of an educational structure in the Midyat district of Mardin province, which was originally built as a middle school but later assumed the function of a high school due to the increasing number of students over time. The reason for selecting this particular building is its historical significance, as it was the first middle and high school building constructed in the Midyat district. Both qualitative and quantitative methods were employed in the research. Due to limited literature data, interviews were conducted with relevant institutions and users. In addition, on-site observations were made, architectural drawings (site plan, floor plans, sections, elevations) were prepared, and photographic documentation was carried out. Based on the findings, the spatial transformations the building underwent were analyzed. As a result, this study on a structure that has not been sufficiently addressed in the literature offers a unique contribution in the context of the functional transformations of educational buildings and will serve as a valuable resource for future scientific research. Key Words: Midyat, Space, Spatial Transformation, Educational Building, Architecture, Functio