132,297 research outputs found
[Letter from Chauncey D. Leake to Norman Isenberg - June 16, 1949]
No full textLetter from the vice president of The University of Texas Medical Branch, Chauncey D. Leake, to member of the Jewish Men's Club of Galveston, Norman Isenberg. The letter thanks Mr. Isenberg and the organization for their donation made to benefit the annual medical lectureship in honor of the late Meyer Brodansky
Noah Isenberg
No full textPhotograph of Noah Isenberg of Eugene Lang College with the Sigmund Freud statue on Clark University\u27s campus green. He was there as part of the Henry J. Leir Chair\u27s programming for the 2011-2012 season with a talk called “Revisiting \u27The Decent German\u27: Siegfried Kracauer\u27s Critique of Postwar German Film ”. Isenberg would go on to write claimed books on Austrian-born émigré turned prolific Poverty Row filmmaker Edgar G. Ulmer, and the canon classic Casablanca.
Robert Tobin was the inaugural Henry J. Leir Chair in Language, Literature, and Culture from 2008 until his passing in 2022.https://commons.clarku.edu/funwithfreud/1025/thumbnail.jp
Stable expression of a recombinant human antinucleosome antibody to investigate relationships between antibody sequence, binding properties, and pathogenicity
No full textWhen purified under rigorous conditions, some murine anti-double-stranded-DNA (anti-dsDNA) antibodies actually bind chromatin rather than dsDNA. This suggests that they may actually be antinucleosome antibodies that only appear to bind dsDNA when they are incompletely dissociated from nucleosomes. Experiments in murine models suggest that antibody - nucleosome complexes may play a crucial role in the pathogenesis of glomerulonephritis in systemic lupus erythematosus. Some human monoclonal anti- DNA antibodies are pathogenic when administered to mice with severe combined immunodeficiency (SCID). Our objective was to achieve stable expression of sequence-altered variants of one such antibody, B3, in Chinese hamster ovary (CHO) cells. Purified antibodies secreted by these cells were tested to investigate whether B3 is actually an antinucleosome antibody
Biologic treatments for idiopathic inflammatory myopathies
No full textThe idiopathic inflammatory myopathies are a group of acquired, heterogeneous, systemic diseases of skeletal muscle. As these conditions are uncommon, current treatment of myositis is based mainly on case reports and few randomised studies with small numbers of patients enrolled. Therefore, the current treatment paradigm is still relies primarily on clinical experience. High dose corticosteroids continue to be the first line therapy. In order to avoid side effects, the prednisolone dose should be reduced based on patient’s clinical response. Other immunosuppressive drugs are used in refractory cases, as well as steroid-sparing agents. Nevertheless, a Cochrane review concluded that there was insufficient evidence from the available studies to confirm the value of immunosuppressive agents in myositis. In patients with myositis resistant to conventional treatment, rituximab is a potential treatment option. Several agents could be of interest for future studies of myositis treatment; however more randomised controlled trials are needed to identify eligibility criteria, outcome predictors and the adequate regimen. The identification of responsive patients and specific therapies targeting the correct myositis subset may be cost-effective and potentially prevent incorrect use of biologics
Studying direct-touch interaction for 2D flow visualization
No full textTraditionally, scientific visualization research concentrates on the development and improvement of interactive techniques to support expert data analysis. While many scientific visualization tools have been developed for desktop environments and individual use, scenarios that go beyond mouse and keyboard interaction have received considerably less attention. We present a study that investigates how large-display direct-touch interaction affects data exploration and insight generation among groups of nonexperts exploring 2D vector data. In this study, pairs of participants used interaction techniques to customize and explore 2D vector visualizations and collaboratively discussed the process to develop their own understanding of the data sets
Information visualization on interactive tabletops in work vs. public settings
No full textDigital tabletop displays and other large interactive displays have recently become more affordable and commonplace. Due to their benefits for supporting collaborative work—when compared to current desktop-based setups—they will likely be integrated in tomorrow’s work and learning environments. In these environments the exploration of information is a common task. We describe design considerations that focus on digital tabletop collaborative visualization environments. We focus on two types of interfaces: those for information exploration and data analysis in the context of workplaces, and those for more casual information exploration in public settings such as museums. We contrast design considerations for both environments and outline differences and commonalities between them
Biologic therapies for systemic lupus erythematosus: where are we now?
No full textAdvances in molecular biology have led to the development of biologic therapies. This is particularly relevant in systemic lupus erythematosus (SLE), which is a multisystem autoimmune rheumatic disease (ARD) associated with potentially life-threatening complications if not adequately treated. The availability of new biologic drugs has improved the prognosis of SLE in selected cases associated with unsatisfactory response to conventional therapies. Over the last decade, there have been developments in the availability of biologic agents for SLE treatment based upon the advances in the understanding of the disease pathogenesis. Even if the evidence of biologic treatment efficacy in SLE is weaker than in other autoimmune rheumatic diseases, such as rheumatoid arthritis (RA), significant progress was made, as the first biologic treatment for use in SLE patients received approval in 2011. These new biologic therapies for SLE range from anti-CD20/CD22 (clusters of differentiation characteristic to B cells), to anti-B cell activating factors and anti-interferon alpha (IFNα). This chapter reviews the various biologic agents used in SLE, their mechanism of action and safety profile. The most common side effects to biologic treatments include infection, tuberculosis (TB) reactivation and allergic reactions. Less common side effects include development of lymphoma and anti-drug or autoimmune antibody formation. Despite their toxicity profile, biologic agents are gaining ground in clinical practice due to the limited efficacy or increased toxicity of conventional disease modifying agents (DMARD’s). Biologic therapies targeting B cells, such as rituximab, and B cell activation factors, such as belimumab, are currently used in the treatment of refractory SLE. Furthermore, aggressive treatment, including the use of biologic agents, reduces long-term complications associated with prolonged use of steroids in SLE, such as cardiovascular disease and osteoporosis. In the short term, the biologic agents are expensive when compared to traditional DMARDs; however there is evidence that their use is associated with long term benefits for patients with SLE, such as reduced hospital admission and disease complications, and improved patient outcomes. This chapter provides a summary of most biologic agents tested in SLE patients, considering their efficacy and safety profile, as well as the health implications associated with their use. We also take a brief look at newer agents currently investigated in clinical trials
Autoimmune gastrointestinal complications in patients with Systemic Lupus Erythematosus: case series and literature review
No full textThe association of systemic lupus erythematosus (SLE) with gastrointestinal autoimmune diseases is rare, but has been described in the literature, mostly as case reports. However, some of these diseases may be very severe, thus a correct and early diagnosis with appropriate management are fundamental. We have analysed our data from the SLE patient cohort at University College Hospital London, established in 1978, identifying those patients with an associated autoimmune gastrointestinal disease. We have also undertaken a review of the literature describing the major autoimmune gastrointestinal pathologies which may be coincident with SLE, focusing on the incidence, clinical and laboratory (particularly antibody) findings, common aetiopathogenesis and complications
MeSH term explosion and author rank improve expert recommendations
No full textInformation overload is an often-cited phenomenon that reduces the productivity, efficiency and efficacy of scientists. One challenge for scientists is to find appropriate collaborators in their research. The literature describes various solutions to the problem of expertise location, but most current approaches do not appear to be very suitable for expert recommendations in biomedical research. In this study, we present the development and initial evaluation of a vector space model-based algorithm to calculate researcher similarity using four inputs: 1) MeSH terms of publications; 2) MeSH terms and author rank; 3) exploded MeSH terms; and 4) exploded MeSH terms and author rank. We developed and evaluated the algorithm using a data set of 17,525 authors and their 22,542 papers. On average, our algorithms correctly predicted 2.5 of the top 5/10 coauthors of individual scientists. Exploded MeSH and author rank outperformed all other algorithms in accuracy, followed closely by MeSH and author rank. Our results show that the accuracy of MeSH term-based matching can be enhanced with other metadata such as author rank
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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