1,040 research outputs found
The role of Plasmodium falciparum var genes in malaria in pregnancy
No full textSequestration of Plasmodium falciparum-infected erythrocytes in the placenta is responsible for many of the harmful effects of malaria during pregnancy. Sequestration occurs as a result of parasite adhesion molecules expressed on the surface of infected erythrocytes binding to host receptors in the placenta such as chondroitin sulphate A (CSA). Identification of the parasite ligand(s) responsible for placental adhesion could lead to the development of a vaccine to induce antibodies to prevent placental sequestration. Such a vaccine would reduce the maternal anaemia and infant deaths that are associated with malaria in pregnancy. Current research indicates that the parasite ligands mediating placental adhesion may be members of the P. falciparum variant surface antigen family PfEMP1, encoded by var genes. Two relatively well-conserved subfamilies of var genes have been implicated in placental adhesion, however, their role remains controversial. This review examines the evidence for and against the involvement of var genes in placental adhesion, and considers whether the most appropriate vaccine candidates have yet been identified
Introduction. Shakespeare: Overlapping Mediascapes in the Mind
No full textIntroduction to the issue 'Shakespeare in the Media. Old and New', Anglistica aion, 15.2, 2011, co-edited with co-author Katherine Rowe, discussing the place of Shakespeare in the media today and the 'state of the art' of Shakespeare studies on the topic
Letter from Sanford Rowe and W. W. Bass to Carl Hayden
No full textLetter from Sanford Rowe and W. W. Bass to Carl Hayden requesting a re-examination on the proposed park boundaries as they are disadvantageous to current land owners surrounding the canyon
Centralization of care for rare genetic syndromes associated with cancer: improving outcomes and advancing research on VHL disease
No full textVon Hippel–Lindau (VHL) disease is a rare genetic syndrome caused by a germline pathogenic variant in one VHL allele. Any somatic event disrupting the other allele induces VHL protein (pVHL) loss of function, ultimately leading to patients developing multiple tumours in multiple organs at multiple timepoints, and reducing life expectancy. Treatment of this complex, rare disease is often fragmented, as patients visit specialist clinicians in isolation at different medical centres. Consequently, patients can receive sub-optimal treatment that results in decreased quality of life and a poor experience of health care systems. In 2021, we established a comprehensive clinical centre at San Raffaele Hospital, Milan, devoted to VHL disease. The centre provides a structured programme for the diagnosis, surveillance and treatment of patients alongside research into VHL disease and involves a multidisciplinary team of dedicated physicians. This programme demonstrates the benefits of care centralization, including concentration of knowledge and services, synergy and multidisciplinary management, improved networking and patient resources, reducing health care costs, and fostering research and innovation. VHL disease provides an ideal model to assess the advantages of centralizing care for rare disease and represents an unparalleled opportunity to broaden our understanding of cancer biology in general
1920-12-31 (December 31, 1920 - Rowe, L.S.): Correspondence From L.S. Rowe, Pan American Union, to Manoel de Oliveira Lima
No full text1921-04-28 (April 28, 1921 - Rowe, L.S.): Correspondence From L.S. Rowe, Pan American Union, to Manoel de Oliveira Lima
No full text1924-10-13 (October 13, 1924 - Rowe, L.S.): Correspondence From L.S. Rowe, Pan American Union, to Manoel de Oliveira Lima
No full text1924-02-26 (February 26, 1924 - Rowe, L.S.): Correspondence From L.S. Rowe, Pan American Union, to Manoel de Oliveira Lima
No full text1921-11-10 (November 10, 1921 - Rowe, L.S.): Correspondence From L.S. Rowe, Pan American Union, to Manoel de Oliveira Lima
No full text1921-06-08 (June 08, 1921 - Rowe, L.S.): Correspondence From L.S. Rowe, Pan American Union, to Manoel de Oliveira Lima
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