170,315 research outputs found
R. N. Ironside and I. R. C. Batchelor, Aviation neuro-psychiatry
No full textNuttin J. R. N. Ironside and I. R. C. Batchelor, Aviation neuro-psychiatry. In: Revue Philosophique de Louvain. Troisième série, tome 44, n°1, 1946. p. 180
R. N. Ironside and I. R. C. Batchelor, Aviation neuro-psychiatry
No full textNuttin J. R. N. Ironside and I. R. C. Batchelor, Aviation neuro-psychiatry. In: Revue Philosophique de Louvain. Troisième série, tome 44, n°1, 1946. p. 180
A liénard oscillator resonant tunnelling diode-laser diode hybrid integrated circuit: model and experiment
No full textWe report on a hybrid optoelectronic integrated circuit based on a resonant tunnelling diode driving an optical communications laser diode. This circuit can act as a voltage controlled oscillator with optical and electrical outputs. We show that the oscillator operation can be described by Liénard's equation, a second order nonlinear differential equation, which is a generalization of the Van der Pol equation. This treatment gives considerable insight into the potential of a monolithic version of the circuit for optical communication functions including clock recovery and chaotic source applications
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Mitomycin C in highly myopic eyes - Author reply
No full textOphthalmology. 2005 Feb;112(2):208-18; discussion 219.
Mitomycin C modulation of corneal wound healing after photorefractive keratectomy in highly myopic eyes.
Gambato C, Ghirlando A, Moretto E, Busato F, Midena E.
SourceRefractive Surgery Service and Antimetabolite Therapy Research Unit, Department of Ophthalmology, University of Padova, Padova, Italy.
Abstract
PURPOSE: To evaluate the role of topical mitomycin C in corneal wound healing (CWH) after photorefractive keratectomy (PRK) in highly myopic eyes.
DESIGN: Prospective, double-masked, randomized clinical trial.
PARTICIPANTS: Seventy-two eyes of 36 patients affected by high (>7 diopters) myopia.
METHODS: In each patient, one eye was randomly assigned to PRK with intraoperative topical 0.02% mitomycin C application, and the fellow eye was treated with a placebo. Postoperatively, mitomycin C-treated eyes received artificial tears (3 times daily, tapered in 3 months), whereas the fellow eye was treated with fluorometholone sodium 2% and artificial tears (3 times daily, tapered in 3 months).
MAIN OUTCOME MEASURES: Uncorrected visual acuity (UCVA) and best-corrected visual acuity (BCVA), contrast sensitivity, manifest refraction, and biomicroscopy. Contrast sensitivity was determined using the Pelli-Robson chart. Corneal confocal microscopy documented CWH.
RESULTS: Mean follow-up was 18 months (range, 12-36). No side effects or toxic effects were documented. At 12-month follow-up examination, UCVAs (logarithm of the minimum angle of resolution) were 0.4+/-0.48 and 0.5+/-0.53 (P = .03) in mitomycin C-treated eyes and corticosteroid-treated eyes, respectively. At 1 year, corneal haze developed in 20% of corticosteroid-treated eyes, versus 0% of mitomycin C-treated eyes. At 12, 24, and 36 months, corneal confocal microscopy showed activated keratocytes and extracellular matrix significantly more evident in untreated eyes (Ps = 0.004, 0.024, and 0.046, respectively).
CONCLUSION: Topical intraoperative application of 0.02% mitomycin C can reduce haze formation in highly myopic eyes undergoing PRK.
Comment in
Ophthalmology. 2006 Feb;113(2):357; author reply 357-8
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Investigation into the integration of a resonant tunnelling diode and an optical communications laser: model and experiment
No full textA resonant tunnelling diode has been monolithically integrated with an optical communications laser [the resonant tunnelling diode (RTD-LD)] to form a simple optoelectronic integrated circuit (OEIC) that is a novel bistable device suitable for an optical communications system. The RTD-LD was based on a ridge-waveguide laser structure and was fabricated from an InAlGaAs-InP epi-wafer grown by molecular beam epitaxy; it emitted at around 1500 nm. Voltage controlled optical-electrical switching and bistability were observed during the characterisation of the RTD-LD - useful features for a fibre-optic communications laser. Optical and electrical simulations of the RTD-LD were carried out using the circuit simulation tool PSPICE. In addition, a discrete component version of the RTD-LD was constructed which exhibited optical power oscillations, and along with the results of the simulations, gave insight into the operating principles of the monolithically integrated RTD-LD
Neuropathology and molecular biology of iatrogenic Creutzfeldt-Jakob disease in UK human growth hormone recipients
No full textCreutzfeldt-Jakob disease (CJD) is the commonest form of human prion disease and
occurs in sporadic, genetic and acquired forms. The causative agents (prions) appear
to be composed entirely of a modified host protein, the prion protein, which
undergoes misfolding to a disease-associated isoform closely associated with
infectivity that is resistant to conventional methods of decontamination. Prions can
be transmitted from one individual to another by medical and surgical procedures,
resulting in iatrogenic CJD (iCJD). The commonest cause of iCJD is the inoculation
of cadaveric pituitary-derived human growth hormone (hGH) to treat growth
hormone deficiency in children; this form of treatment was abandoned in 1985 after
the first UK case of iCJD in a hGH recipient was identified. Seventy-eight cases of
iCJD have since occurred in the UK cohort of 1849 hGH recipients, including a case
in 2016.
This thesis describes a comprehensive tissue-based and molecular genetic analysis of
the largest series (35 cases) of UK hGH-iCJD cases reported to date, including in
vitro kinetic molecular modelling of genotypic factors influencing prion
transmission. The results show that the polymorphism at codon 129 of the prion
protein gene strongly influences the disease incubation period in hGH-iCJD (from
7.8-32.3 years in this series) and interacts with the infectious prion strain to govern
the molecular and pathological characteristics of iCJD. The findings are consistent
with the hypothesis that the UK hGH-iCJD epidemic resulted from transmission of
the V2 human prion strain, which is found in the second most common form of
sporadic CJD.
The investigation also found accumulation of the amyloid beta (Aβ) protein
associated with Alzheimer’s disease (AD) in the brains and cerebral blood vessels in
18/35 hGH-iCJD patients and 5/12 control patients who had been treated with hGH,
but died from causes other than iCJD. In contrast, Aβ accumulation was markedly
less prevalent in age-matched patients who died from sporadic CJD (1/15 cases) and
variant CJD (2/33 cases). These results are consistent with the hypothesis that Aβ,
which can accumulate in the pituitary gland, was present in the inoculated hGH
preparations and seeded into the brains of around 50% of all hGH recipients,
producing AD-like neuropathology and cerebral amyloid angiopathy (CAA). This
provides further evidence of the prion-like properties of Aβ and gives insight into the
potential for possible transmission of AD/CAA. It is uncertain whether any Aβ
seeding within the brains of surviving patients in the UK hGH recipient cohort will
ultimately result in clinical AD; however, the CAA in these patients may be
complicated by intracerebral haemorrhage resulting from rupture of the blood vessels
damaged by Aβ accumulation within their walls
A Multi-Language Comparison of Influences on Author Verification using Character N-Grams
No full textWe create a new multi-language corpus for author verification based on Wikipedia talkpages, and evaluate the influence that differences in topic and time have on character n-gram author profiles. Topic alignment between two texts is found to increase author verification precision, and an authors writing style is found to change over time, but not more significantly after 3 years than after 1 year.Information ArchitectureWISElectrical Engineering, Mathematics and Computer Scienc
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