53 research outputs found
Lettere mercantili in volgare parmense: il carteggio dei Garso
No full textIl lavoro presenta l’edizione di un corpus di lettere mercantili in volgare, risalenti all’ultimo ventennio del Trecento, inviate da alcuni esponenti della famiglia parmense dei Garso al fondaco di Francesco di Marco Datini a Pisa, oggi conservate presso il fondo Datini dell’Archivio di Stato di Prato. L’edizione dei 64 testi (finora inediti, ad eccezione di uno) è accompagnata da un commento linguistico che si propone di individuare, accanto ai fenomeni genericamente settentrionali da una parte e alle tracce di contaminazione linguistica con il toscano dall’altra, alcuni tratti caratteristici del volgare parmense. Conclude il lavoro un glossario selettivo che raccoglie il materiale lessicale di uso locale, così come gli elementi riconducibili al formulario mercantile medievale
Leptospira spp. infection in wild ruminants: a survey in Central Italian Alps
No full textLeptospirosis is an important zoonotic disease diffused worldwide, and wildlife species are commonly considered to be important epidemiological carriers. Four-hundred and forty‑one serological and 198 renal samples from red deer, roe deer and chamois collected in the Province of Sondrio were analysed using the microscopic agglutination test and histopathologic examination. Positive serological findings were found only in 15 red deer and 19 positive serologic reactions were recorded. The most frequent serovars were Bratislava and Grippotyphosa, followed by Pomona, Hardjo and Copenhagheni. Twenty-two per cent of renal samples from seropositive red deer were affected by mild to moderate multifocal chronic lymphoplasmacytic and fibrosing tubulo-interstitial nephritis, mainly involving the cortical parenchyma. In this study, antibodies to Leptospira spp. were infrequent in wild ruminants, and only red deer seemed to be sensitive to the infection. Given the low presence and the fact that there was no record of Leptospira spp. infections in cattle, sheep, goats and also hunters in area during the study period, wild ruminants in Alpine environments cannot be considered as reservoirs or important sources of Leptospira spp. infection for humans or domestic animals
Tick-Borne Encephalitis, Lombardy, Italy
No full textTick-borne encephalitis was limited to northeast portions of Italy. We report in Lombardy, a populous region in the northwest, a chamois displaying clinical signs of tickborne encephalitis virus that had multiple virus-positive ticks attached, as well as a symptomatic man. Further, we show serologic evidence of viral circulation in the are
Transient restoration of anti-viral T cell responses induced by lamivudine therapy in chronic hepatitis B
No full textLamivudine therapy in patients with chronic hepatitis B can induce the recovery of antiviral T cell responses. It is unknown whether the recovery of T cell responsiveness is long-lasting and persists throughout the treatment and whether the elevation of viremia which follows therapy withdrawal can restore a condition of T cell unresponsiveness
Molecular and Serological Detection of Bovine Coronaviruses in Marmots (Marmota marmota) in the Alpine Region
No full text: In this study, virological surveillance focused on coronaviruses in marmots in the Alpine region in 2022, captured as part of a population control reduction program in the Livigno area. Seventy-six faecal samples were randomly collected from marmots at the time of capture and release and tested for genome detection of pan-coronavirus, pan-pestivirus, canine distemper virus, and influenza A and D virus. Nine faecal samples were positive in the Pan-CoV RT-PCR, while all were negative for the other viruses. Pan-coronavirus positives were further identified using Illumina's complete genome sequencing, which showed the highest homology with Bovine Coronavirus previously detected in roe deer in the Alps. Blood samples (n.35) were collected randomly from animals at release and tested for bovine coronavirus (BCoV) antibodies using competitive ELISA and VNT. Serological analyses revealed that 8/35 sera were positive for BCoV antibodies in both serological tests. This study provides molecular and serological evidence of the presence of BCoV in an alpine marmot population due to a likely spillover event. Marmots share areas and pastures with roe deer and other wild ruminants, and environmental transmission is a concrete possibility
A disponibilidade das fontes sobre o Brasil existentes nos arquivos e instituições francesas
No full textRESUMO
O artigo aborda inicialmente, a história do Projeto Resgate Barão do Rio Branco e como foi elaborado o Guia de Fontes do projeto, do qual a autora participa como Coordenadora Técnica. Na sequência, refere-se à microfilmagem dos documentos dispersos existentes em mais de dez cidades francesas e a redação dos respectivos verbetes. Referindo-se ao espírito democrático do projeto, conforme preconizado pela Unesco, lembra que o mesmo tem acompanhado também a pesquisa na História da Imprensa, na qual se estudam os temas voltados à influência da imprensa de diversos países, em particular da influência francesa.
PALAVRAS-CHAVE: Microfilmagem. Documentos. Influência francesa.
ABSTRACT
This paper analyse the Rescue Project of Rio Branco history and how it was prepared the Guide of Source of the project, which the author is a technical coordinator. In sequence, it refers to microfilm of documents that are spreaded in more than ten French cities. Regard to democratic spirit of the project as enforced by Unesco, it also has followed the research about the History of Press, in which studies issues about the influence of the press several countries, focousing on the French influence.
KEYWORDS: Microfilm. Documents. French Influence
As marcas de oralidade nas crônicas de Luis Fernando Verissimo
No full textO presente trabalho objetiva demonstrar as marcas da oralidade na modalidade escrita dentro de uma perspectiva sociointeracionista entendendo a fala e a escrita não como um fenômeno dicotômico, mas como um continuum. Para tanto, fez-se pesquisa bibliográfica dentro da área de Análise da Conversação, Análise do Discurso e Gêneros Textuais para embasar a posterior análise do corpus utilizado. Após leitura e construção do embasamento teórico, pretendeu-se demonstrar algumas marcas de oralidade, mais especificamente os turnos conversacionais, as repetições e os marcadores conversacionais, nos diálogos construídos que formam as crônicas analisadas de Luis Fernando Verissimo. Foi verificada nas crônicas a presença dessas marcas orais como estratégias de interação e aproximação do leitor, para que este aceite o diálogo construído como se fosse uma interação natural.The present paper intends to present the oral marks in a written modality under a sociointeracionist approach understanding speaking and writing not as a dichotomy phenomena but a continuum. To enhance that, a biographical research on Conversation Analysis, Discourse Analysis and Textual Genre was done to base the corpus analysis. After the readings and theoretical base, it was intended to show how the author uses spoken language, more specifically turns-talking, repetitions and conversation markers, on constructed dialogues, which form the Luis Fernando Verissimo analyzed chronicles. It was found out on the chronicles the presence of oral marks as interaction strategy to bring the reader near, making him/her accept that dialogue as a natural on
A common HLA-DPA1 variant is associated with hepatitis B virus infection but fails to distinguish active from inactive Caucasian carriers
No full textBackground and Aims: Chronic infection with the hepatitis B virus (HBV) is a major health issue worldwide. Recently, single nucleotide polymorphisms (SNPs) within the human leukocyte antigen (HLA)-DP locus were identified to be associated with HBV infection in Asian populations. Most significant associations were observed for the A alleles of HLA-DPA1 rs3077 and HLA-DPB1 rs9277535, which conferred a decreased risk for HBV infection. We assessed the implications of these variants for HBV infection in Caucasians.
Methods: Two HLA-DP gene variants (rs3077 and rs9277535) were analyzed for associations with persistent HBV infection and with different clinical outcomes, i.e., inactive HBsAg carrier status versus progressive chronic HBV (CHB) infection in Caucasian patients (n = 201) and HBsAg negative controls (n = 235).
Results: The HLA-DPA1 rs3077 C allele was significantly associated with HBV infection (odds ratio, OR = 5.1, 95% confidence interval, CI: 1.9–13.7; p = 0.00093). However, no significant association was seen for rs3077 with progressive CHB infection versus inactive HBsAg carrier status (OR = 2.7, 95% CI: 0.6–11.1; p = 0.31). In contrast, HLA-DPB1 rs9277535 was not associated with HBV infection in Caucasians (OR = 0.8, 95% CI: 0.4–1.9; p = 1).
Conclusions: A highly significant association of HLA-DPA1 rs3077 with HBV infection was observed in Caucasians. However, as a differentiation between different clinical courses of HBV infection was not possible, knowledge of the HLA-DPA1 genotype cannot be translated into personalized anti-HBV therapy approaches
Expansion of anti-AFP Th1 and Tc1 responses in hepatocellular carcinoma occur in different stages of disease
No full textCopyright @ 2010 Cancer Research UK. This work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License.
To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/.Background: α-Fetoprotein (AFP) is a tumour-associated antigen in hepatocellular carcinoma (HCC) and is a target for immunotherapy. However, there is little information on the pattern of CD4 (Th1) and CD8 (Tc1) T-cell response to AFP in patients with HCC and their association with the clinical characteristics of patients.
Methods: We therefore analysed CD4 and CD8 T-cell responses to a panel of AFP-derived peptides in a total of 31 HCC patients and 14 controls, using an intracellular cytokine assay for IFN-γ.
Results: Anti-AFP Tc1 responses were detected in 28.5% of controls, as well as in 25% of HCC patients with Okuda I (early tumour stage) and in 31.6% of HCC patients with stage II or III (late tumour stages). An anti-AFP Th1 response was detected only in HCC patients (58.3% with Okuda stage I tumours and 15.8% with Okuda stage II or III tumours). Anti-AFP Th1 response was mainly detected in HCC patients who had normal or mildly elevated serum AFP concentrations (P=0.00188), whereas there was no significant difference between serum AFP concentrations in these patients and the presence of an anti-AFP Tc1 response. A Th1 response was detected in 44% of HCC patients with a Child–Pugh A score (early stage of cirrhosis), whereas this was detected in only 15% with a B or C score (late-stage cirrhosis). In contrast, a Tc1 response was detected in 17% of HCC patients with a Child–Pugh A score and in 46% with a B or C score.
Conclusion: These results suggest that anti-AFP Th1 responses are more likely to be present in patients who are in an early stage of disease (for both tumour stage and liver cirrhosis), whereas anti-AFP Tc1 responses are more likely to be present in patients with late-stage liver cirrhosis. Therefore, these data provide valuable information for the design of vaccination strategies against HCC.Association for International Cancer Research and Polkemmet Fund, London
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