68 research outputs found
Erratum: Immunogenicity, antigenicity and epitope mapping of Salmonella InvH protein: An in silico study
No full textThere was an error in the author list of the published article.
Two authors (T Hashempour, Z Hasanshahi) requested to remove from the authors lists. After obtaining the agreement of the authors and the corresponding author, Editor-in-Chief accept the corrections as listed below.
The correct author list is:
Behzad Dehghani, Iraj Rasooli
We apologize for any inconvenience this may have caused.
Erratum for:
Immunogenicity, antigenicity and epitope mapping of Salmonella InvH protein: An in silico study
B Dehghani, T Hashempour, Z Hasanshahi, I Rasooli
J Curr Biomed Rep. 2020; 1(1): 9-16
Bioactive Compounds in Phytomedicine
No full textThere are significant concerns regarding the potential side effects from the chronic use of conventional drugs such as corticosteroids, especially in children. Herbal therapy is less expensive, more readily available, and increasingly becoming common practice all over the world. Such practices have both their benefits and risks. However, herbal self-therapy might have serious health consequences due to incorrect self-diagnosis, inappropriate choice of herbal remedy or adulterated herbal product. In addition, absence of clinical trials and other traditional safety mechanisms before medicines are introduced to the wider market results in questionable safe dosage ranges which may produce adverse and unexpected outcomes. Therefore, the use of herbal remedies requires sufficient knowledge about the efficacy, safety and proper use of such products. Hence, it is necessary to have baseline data regarding the use of herbal remedies and to educate future health professionals about various aspects of herbal remedies
Phytochemicals
No full textAmong the thousands of naturally occurring constituents so far identified in plants and exhibiting a long history of safe use, there are none that pose - or reasonably might be expected to pose - a significant risk to human health at current low levels of intake when used as flavoring substances. Due to their natural origin, environmental and genetic factors will influence the chemical composition of the plant essential oils. Factors such as species and subspecies, geographical location, harvest time, plant part used and method of isolation all affect chemical composition of the crude material separated from the plant. The screening of plant extracts and natural products for antioxidative and antimicrobial activity has revealed the potential of higher plants as a source of new agents, to serve the processing of natural products
Anti-trypanosomal activity and cytotoxicity of some compounds and extracts from Nigerian medicinal plants
No full textThis chapter explores the anti-trypanosomal activity and cytotoxicity of some compounds and extracts from Nigerian medicinal plant
Phytochemicals and cancer chemoprevention: epigenetic friends or foe?
No full textCancer, as one of the non-communicable diseases, remains one of the leading causes of death around the world. Since immune cells that infiltrate tumors engage in an extensive and dynamic crosstalk with cancer cells, inflammatory responses play decisive roles at different stages of tumor development, including initiation, promotion, malignant conversion, invasion, and metastasis. Inflammation also affects immune surveillance and therapy sensitivity. Recent successes of therapeutic interventions in cancer and inflammatory diseases using epigenetic modifiers such as histone deacetylase inhibitors and inhibitors of DNA methylation suggest that epigenetic reprogramming plays an important role in the aetiology of these diseases. Epigenetic changes in DNA methylation patterns at CpG sites (epimutations) or corrupt chromatin states of tumor promoting genes and noncoding RNAs, recently emerged as major governing factors in tumor progression and cancer drug sensitivity. Epigenetic defects (epimutations) are thought to be more easily reversible (when compared with genetic defects) and, as such, have inspired efforts to identify novel compounds that correct epimutations or prevent disease progression. Given the fact that epigenetic modifications occur early in carcinogenesis and represent potentially initiating events in cancer development, they have been identified as promising new targets for chemoprevention strategies. Numerous clinical, epidemiological and laboratory studies have identified various promising nutritional anti-inflammatory compounds as chemopreventive agents, which affect carcinogenic epigenetic marks in the body and the host immune system, and protect against aggressive cancer malignancies. This has recently launched reexploration of chemopreventive phytochemicals for identification of epigenetic targets which allow epigenetic (re)programming of cancer stem cells, prevent metastasis or sensitize for drug sensitivity. This review will discuss mechanisms of epigenome plasticity by cancer-inflammation and chemopreventive phytochemicals
Immunogenicity, antigenicity and epitope mapping of Salmonella InvH protein: An in silico study
No full textInvH is an indispensable part of T3SS-I and has a significant role in SPI-I mediated effector protein translocation. The InvH mutations have significant effects including reduced secretory and inflammatory responses that result from preventing the normal secretion of several proteins. Our team previous studies showed the capable ability of InvH to induce the humoral immune system to prevent almost all Salmonella strains infections. The current study aimed to determine all aspects of this protein using several bioinformatics tools and find the differences among all Salmonella strains. This data could pave the way for further studies about InvH protein and the production of an effective vaccine against Salmonella infections. InvH sequences for all Salmonella strains were obtained from GenBank and analyzed to determine physicochemical properties, B-Cell and T-Cell epitopes, and reliable structures. Results showed some minimal differences among Salmonella strains. B-Cell and T-Cell epitopes predicted by numerous software approved the ability of this protein to induce both humoral and cellular immune systems remarkably. This study provided a comprehensive data to determine all features of InvH protein and our results showed the ability of this protein to design a capable vaccine and the effect of amino acid changes on structure and physico-chemical properties, and epitopes.
Erratum in:
Erratum: Immunogenicity, antigenicity and epitope mapping of Salmonella InvH protein: An in silico study
B Dehghani, I Rasooli
J Curr Biomed Rep. 2020; 1(2): 81
In-Situ Determination of Buildings’ Thermo-Physical Characteristics
No full textAccurate determination of building’s critical thermo-physical characteristics such as the walls’ thermal resistance, thermal conductivity, and volumetric heat capacity is essential to indicate effective and efficient energy conservation strategies at building level. In practice, the values of these parameters, which determine not only possible energy savings, but also related costs, are rarely available because the current determination methods are time-and-effort-expensive, and consequently seldom used.This thesis combines theories, simulations, computations, and experiments to develop and improve methods and approaches for determination of a number of buildings’ most important thermophysical characteristics. First, a modification to the existing standard method, “ISO 9869 Average Method” is proposed to measure the walls’ thermal resistance. Two current problems are solved: long measurement duration (weeks) and imprecision. To further shorten the measurement period to a few hours, a new transient in-situ method, Excitation Pulse Method, EPM (Patent No. 2014467), is then developed and tested. This method allows the determination of the walls’ response factors which can be applied directly in dynamic models. More importantly, it is used to extract critical construction information including walls’ thermal resistance, thermal conductivity, volumetric heat capacity, and the possible layer composition. Finally, in an attempt to reduce the hassle, cost, and intrusion associated with locally-conducted experiments, the use of data from smart meters and home automation systems is explored. Building’s global characteristics including heat loss coefficient, global heat capacitance and daily air change rates are accordingly determined.A+BE I Architecture and the Built Environment No 7 (2020)Building Energy Epidemiolog
- …
