169,920 research outputs found
Viaţa şi domnia lui Constantin-Vodă Brîncoveanu
Full text linkIorga, Nicolae
Viaţa şi domnia lui Constantin-Vodă Brîncoveanu / de N. Iorga. - Bucureşti : [s.n.] (Vălenii de Munte ; Atelierele de Tipografie şi Legătorie de cărţi "Neamul Romănesc", 1914. - 215 p. : il., portr. ; 24 c
N. Iorga, Istoria bisericii româneşti şi a vieţii religioase a Românilor.
No full textA. C. N. Iorga, Istoria bisericii româneşti şi a vieţii religioase a Românilor.. In: Échos d'Orient, tome 12, n°78, 1909. p. 318
Investigation of the contribution of emission sources to atmospheric particulate matter concentration (PM) and to its redox properties
Full text linkIn the last few years, various epidemiological studies were conducted to estimate the health effects of particulate matter (PM) on human population, placing at the core the association between exposure to PM and several adverse outcomes, especially on cardiovascular and respiratory systems. PM mass concentration is typically used to estimate population exposure. However, this indicator misestimate the overall impact of PM, since it does not consider the multiple toxicological effects of the different pollutants that constitute and determine the intrinsic properties of PM. In fact, the complexity and variability of PM can lead to different responses in biological systems. The hypothesis of the mechanisms of PM-related diseases include oxidative stress, inflammatory responses, and genotoxicity. All of them can be mediated by PM-related reactive oxygen species (ROS).
To assess the particles’ oxidative capacity, several acellular methods, defined as oxidative potential (OP) assays, have been developed and proposed as relevant and valid metric for addressing biological exposure to PM. There is still no agreement regarding the most representative assay to measure the OP of PM, but methods mostly used on the PM filter extracts are the dithiothreitol (OPDTT), the 2′,7′-dichlorofluorescin (OPDCFH), and the ascorbic acid (OPAA) assays. Each assay gives different results and probably simulates just a small part of the many potential mechanisms of oxidative stress induction. Therefore, the synergic application of the three assays on the same PM samples is strongly recommended to have a complete characterization of their redox properties. The study of PM composition and toxicity represents a particularly interesting field of research, aimed to a better understanding of the existing relationships between the chemical composition and sources of PM and its adverse effects on human health and environment, useful to plan the appropriate mitigation measures. It is also worth considering the heterogeneity of emission sources and the role that they play on PM physical and chemical properties. The analysis of PM coming from different sources could allow associating specific chemical composition, which depends on the pollutant origin, with a given biological response. In fact, the role of each chemical component on PM toxicity is still to be fully defined.
One of the goals of this PhD thesis is to improve the knowledge about the existing relationships between PM chemical composition and sources and, therefore, to attempt to estimate PM adverse effects on health and environment through the investigation of PM redox properties.
To this aim, a multidisciplinary study based on the synergic application of traditional and innovative approaches to PM was carried out in this PhD research.
PM field samples were collected at monitoring sites differently impacted by anthropic activities by using different techniques, such as traditional monitoring equipment, cascade impactors, biomonitoring methods and very-low volume samplers allowing spatially-resolved determination of PM chemical components. Furthermore, widespread components of PM produced by specific emission sources and characterized by very different chemical compositions were used to compare different experimental procedures on PM from defined emission sources.
Chemical characterization of PM samples was obtained by applying advanced and robust analytical procedures for the determination of inorganic ions, water-soluble and insoluble elements, water-soluble organic carbon (WSOC) and levoglucosan (LVG). PM water-soluble and insoluble fraction were separately analyzed through a well-established fractionation procedure to increase the selectivity of elements as source tracers and to estimate the environmental mobility and bio-accessibility of toxic elements.
Much of the PhD experimental research has focused on the investigation of redox properties of PM since in the last few years, the oxidative potential appears to be the central paradigm in the assessment of PM toxicity. However, there are still operative criticisms affecting its relevance as effective realistic metric to quantify the effects of ambient particles on human health, such as the influence of multiple operative conditions on OP obtained results, as well the lack of standardized operative conditions, which make a challenge to representatively compare inter-laboratory data. Therefore, one of the goals of this research was to explore in depth redox equilibria between PM reactive species.
During the PhD research various monitoring campaigns aimed to improve knowledge about the existing relationships between sources of PM and its related chemical composition were conducted under different conditions and in different geographical areas (i.e. during the national lockdown imposed by Italian government to counter the Covid-19 pandemic). Valuable information for PM source apportionment through a chemical/size fractionation procedure and OP measurements were obtained.
Potential effects of PM composition on biological systems were studied by using an in vitro approach based on the cytotoxic, genotoxic, oxidative, and inflammatory response of bronchial epithelial cell line BEAS-2B after the exposure to PM coming from different sources.
In parallel with the described activity, the reliability of PM biomonitoring techniques for the assessment of atmospheric element concentrations was estimated. To this aim, leaf deposition on riparian species (Arundo donax (L.)) and lichen transplants (Evernia prunastri (L.) Ach.) were used. Furthermore, an integrated approach to assess the effects of PM on functional traits of Quercus ilex (L.) in an urban area was carried out comparing results from OP assays when applied on PM deposited on Q. ilex leaves, and on filters (traditional monitoring system).
Another line of research was the analysis of PM samples in indoor environments of private dwellings and University classrooms, to study the concentration, the chemical composition, and the OP of indoor and outdoor PM to obtain information about the main indoor and outdoor PM emission sources and exposure of occupants.
Lastly, another important study included in the PhD research was related to the project Redox-activity and Health-effects of Atmospheric Primary and Secondary aerosol (PRIN 2017-RHAPS project) in which our groups participated with OP measurements and elemental analysis of PM samples. RHAPS aims to identify specific properties of PM from anthropogenic sources that are responsible for toxicological effects and can be used as new metrics for health-related outdoor pollution studies. The main goal of RHAPS project was to provide a new assessment of the sources and nature of PM components responsible for adverse health
effects in real-world conditions. The experimental field monitoring campaigns have been recently completed and data elaboration is still ongoing.
Supplementary research activities were focused on the evaluation of the capability of food waste materials as low-cost adsorbents for the removal of Volatile Organic Compounds (VOC) from wastewater, and on the analytical characterization of biological matrices (i.e. bees and beehive products, olive oil) to evaluate their potential of accumulating toxic elements, allowing the monitoring of this kind of pollutants concentrations in the environment for integrated measurements. Rapid analytical methods for routinely analyzing a significant number of biological samples were developed and validated
A built-in technique for measuring substrate and power supply digital switching noise using PMOS-based differential sensors and a waveform sampler in system-on-chip applications
No full textDocumente şi regeste din colecţii de familie ; Inscripţii şi însemnări
No full text[Documente şi regeste din colecţii de familie] ; [Inscripţii şi însemnări] / publicate de N. Iorga. - Bucureşti : Atelierele Grafice Socec & Co, 1909. - IX, 453 p. ; 24 cm. - (Studii şi documente cu privire la istoria romînilor ; 16 )
oclc. - RC2013. - Index. - Cuprinde: Chemarea lui Constantin-Vodă Mavrocordat către olteni ; Trei scrisori privitoare la Ienăchiţă Văcărescu ; Un manuscript de leacuri ; Două acte privitoare la Unire ; O moşie a lui Mihai Viteazul : Bîrca din Dolj ; Un memoriu de advocat al lui Mihail Kogălniceanu (1847) ; Mărunţişuri istorice ; Documente amestecate ; Acte botuşănene şi dorohoiene privitoare mai mult la familia Cananău ; Alte mărunţişuri istorice ; Documente comunicate de d. Simionescu-Rîmniceanu ; Din actele expuse la exposiţia istorică din Iaşi ; Documente ale familiei Palade ; Un catastif de dajde al oraşului Galaţi (c. 1683) ; Pomelnicul romănesc al mănăstirii Bisericani ; Inscripţii şi însemnări ; Documente amestecate ; Varia ; Miscellane
Figuri revoluţionare române : cinci conferinţe ale Universităţii Libere
No full textBucureşti : Cartea Românească, 1937. - 126 p. ; 24 cm. - (Aşezământul Cultural Ion C. Brătianu ; 36 ). - Cuprinde: Horea, Cloşca şi Crişan / N Iorga ; Avram Iancu / P. P. Panaitescu ; Tudor Vladimirescu / D. Bodin ; Ion Câmpineanu / Al. Lapedatu ; Fraţii Brătianu / N. Bănesc
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Mitomycin C in highly myopic eyes - Author reply
No full textOphthalmology. 2005 Feb;112(2):208-18; discussion 219.
Mitomycin C modulation of corneal wound healing after photorefractive keratectomy in highly myopic eyes.
Gambato C, Ghirlando A, Moretto E, Busato F, Midena E.
SourceRefractive Surgery Service and Antimetabolite Therapy Research Unit, Department of Ophthalmology, University of Padova, Padova, Italy.
Abstract
PURPOSE: To evaluate the role of topical mitomycin C in corneal wound healing (CWH) after photorefractive keratectomy (PRK) in highly myopic eyes.
DESIGN: Prospective, double-masked, randomized clinical trial.
PARTICIPANTS: Seventy-two eyes of 36 patients affected by high (>7 diopters) myopia.
METHODS: In each patient, one eye was randomly assigned to PRK with intraoperative topical 0.02% mitomycin C application, and the fellow eye was treated with a placebo. Postoperatively, mitomycin C-treated eyes received artificial tears (3 times daily, tapered in 3 months), whereas the fellow eye was treated with fluorometholone sodium 2% and artificial tears (3 times daily, tapered in 3 months).
MAIN OUTCOME MEASURES: Uncorrected visual acuity (UCVA) and best-corrected visual acuity (BCVA), contrast sensitivity, manifest refraction, and biomicroscopy. Contrast sensitivity was determined using the Pelli-Robson chart. Corneal confocal microscopy documented CWH.
RESULTS: Mean follow-up was 18 months (range, 12-36). No side effects or toxic effects were documented. At 12-month follow-up examination, UCVAs (logarithm of the minimum angle of resolution) were 0.4+/-0.48 and 0.5+/-0.53 (P = .03) in mitomycin C-treated eyes and corticosteroid-treated eyes, respectively. At 1 year, corneal haze developed in 20% of corticosteroid-treated eyes, versus 0% of mitomycin C-treated eyes. At 12, 24, and 36 months, corneal confocal microscopy showed activated keratocytes and extracellular matrix significantly more evident in untreated eyes (Ps = 0.004, 0.024, and 0.046, respectively).
CONCLUSION: Topical intraoperative application of 0.02% mitomycin C can reduce haze formation in highly myopic eyes undergoing PRK.
Comment in
Ophthalmology. 2006 Feb;113(2):357; author reply 357-8
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
A Multi-Language Comparison of Influences on Author Verification using Character N-Grams
No full textWe create a new multi-language corpus for author verification based on Wikipedia talkpages, and evaluate the influence that differences in topic and time have on character n-gram author profiles. Topic alignment between two texts is found to increase author verification precision, and an authors writing style is found to change over time, but not more significantly after 3 years than after 1 year.Information ArchitectureWISElectrical Engineering, Mathematics and Computer Scienc
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