1,398 research outputs found
Fig_Supplemental_v2 – Supplemental material for A Catalog of GAL4 Drivers for Labeling and Manipulating Circadian Clock Neurons in Drosophila melanogaster
No full textSupplemental material, Fig_Supplemental_v2 for A Catalog of GAL4 Drivers for Labeling and Manipulating Circadian Clock Neurons in Drosophila melanogaster by Manabu Sekiguchi, Kotaro Inoue, Tian Yang, Dong-Gen Luo and Taishi Yoshii in Journal of Biological Rhythms</p
Submucosal tunnel endoscopy: peroral endoscopic myotomy and peroral endoscopic tumor resection
No full textPeroral endoscopic myotomy (POEM) is an innovative, minimally invasive, endoscopic treatment for esophageal achalasia and other esophageal motility disorders, emerged from the natural orifice transluminal endoscopic surgery procedures, and since the first human case performed by Inoue in 2008, showed exciting results in international level, with more than 4000 cases globally up to now. POEM showed superior characteristics than the standard 100-year-old surgical or laparoscopic Heller myotomy (LHM), not only for all types of esophageal achalasia [classical (I), vigorous (II), spastic (III), Chicago Classification], but also for advanced sigmoid type achalasia (S1 and S2), failed LHM, or other esophageal motility disorders (diffuse esophageal spasm, nutcracker esophagus or Jackhammer esophagus). POEM starts with a mucosal incision, followed by submucosal tunnel creation crossing the esophagogastric junction (EGJ) and myotomy. Finally the mucosal entry is closed with endoscopic clip placement. POEM permitted relatively free choice of myotomy length and localization. Although it is technically demanding procedure, POEM can be performed safely and achieves very good control of dysphagia and chest pain. Gastroesophageal reflux is the most common troublesome side effect, and is well controllable with proton pump inhibitors. Furthermore, POEM opened the era of submucosal tunnel endoscopy, with many other applications. Based on the same principles with POEM, in combination with new technological developments, such as endoscopic suturing, peroral endoscopic tumor resection (POET), is safely and effectively applied for challenging submucosal esophageal, EGJ and gastric cardia tumors (submucosal tumors), emerged from muscularis propria. POET showed up to know promising results, however, it is restricted to specialized centers. The present article reviews the recent data of POEM and POET and discussed controversial issues that need further study and future perspectives
Training in peroral endoscopic myotomy (POEM) for esophageal achalasia
No full textNicholas Eleftheriadis, Haruhiro Inoue, Haruo Ikeda, Manabu Onimaru, Akira Yoshida, Toshihisa Hosoya, Roberta Maselli, Shin-ei KudoDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, JapanAbstract: Peroral endoscopic myotomy (POEM) has been developed in the context of natural orifice transluminal endoscopic surgery (NOTES) as a minimally invasive endoscopic treatment for symptomatic esophageal achalasia, which is a chronic progressive benign disease with severe morbidity and difficult management. Since September 2008, POEM has been successfully performed in more than 200 consecutive patients with symptomatic achalasia at the Digestive Disease Center of Showa University, Northern Yokohama Hospital, Yokohama, Japan, with excellent short- and long-term results and absence of serious complications. International experience of POEM within clinical studies is also promising. According to these results, POEM is considered as a safe procedure that can be applied to all achalasia patients. However, the low incidence of achalasia (0.3%&ndash;1% per 100,000 population), in combination with the potential serious complications related to the technically demanding POEM procedure, has made training difficult. There is therefore an urgent need for an animal model for training to decrease the learning curve. Further, there are other ethical and training issues to address. The pig is the most appropriate animal model for training in POEM due to its anatomy being similar to that of humans. The porcine esophagus has the advantage of easy mobilization due to absence of tight junctions to surrounding organs. A non-survival porcine model would be a simple, inexpensive, and reproducible animal model for training in POEM, without the need for concern about complications. A possible training process might first involve observation of POEM performed by specialists, then training on non-survival and survival porcine models, followed by training in humans under specialist guidance and finally, performance of POEM in humans.Keywords: porcine organ model, non-survival, porcine esophagus, Heller myotom
Endoscopic Ex Vivo Evaluation of Bile Concentrations by Narrow Band Imaging: A Pilot Study
No full textBackground. Bile juice plays a major role in duodenogastroesophageal reflux (DGERD). Several devices to directly measure the bile concentration have been proposed. We aimed to ex-vivo evaluate the bile concentration by narrow band imaging (NBI). Method. From six surgical cholecystectomies, the content of the gallbladders was aspirated and the total biliary acid (TBA) concentration was evaluated. 2 mL was employed for serial twofold dilutions. Each dilution was scoped. Images on white light (WL) and NBI were captured and grouped accordingly to NBI-appearance and TBA-concentration. Results. Nondiluted bile had a TBA-concentration of 61965 ± 32989 μmol/L. Final dilution (1 : 4096) had 1.16 μmol/L. NBI and correspondent WL images were grouped into seven groups, and an NBI/Bile scale was created. Conclusion. The scale showed that not only NBI scale but also white light scale could be useful to predict the bile concentration. This initial study shows that NBI has a potential role in the detection of DGERD and further investigation is warranted to distinguish the presence and the concentration of bile, especially at very low TBA concentrations
Microvasculature of the esophagus and gastroesophageal junction: lesson learned from submucosal endoscopy
No full textAdvanced therapeutic endoscopy, in particular endoscopic mucosal resection, endoscopic submucosal dissection, per-oral endoscopic myotomy, submucosal endoscopic tumor resection opened a new era where direct esophageal visualization is possible. Combining these information with advanced diagnostic endoscopy, the esophagus is organized, from the luminal side to outside, into five layers (epithelium, lamina propria with lamina muscularis mucosa, submucosa, muscle layer, adventitia). A specific vascular system belonging to each layer is thus visible: Mucosa with the intra papillary capillary loop in the epithelium and the sub-epithelial capillary network in the lamina propria and, at the lower esophageal sphincter (LES) level with the palisade vessels; submucosa with the drainage vessels and the spindle veins at LES level; muscle layer with the perforating vessels; peri-esophageal veins in adventitia. These structures are particularly important to define endoscopic landmark for the gastro-esophageal junction, helpful in performing submucosal therapeutic endoscopy
sj-pdf-1-wso-10.1177_17474930211044635 - Supplemental material for Intensive blood pressure lowering with nicardipine and outcomes after intracerebral hemorrhage: An individual participant data systematic review
No full textSupplemental material, sj-pdf-1-wso-10.1177_17474930211044635 for Intensive blood pressure lowering with nicardipine and outcomes after intracerebral hemorrhage: An individual participant data systematic review by Kazunori Toyoda, Sohei Yoshimura, Mayumi Fukuda-Doi, Adnan I Qureshi, Renee’ Hebert Martin, Yuko Y Palesch, Masafumi Ihara, Jose I Suarez, Yasushi Okada, Chung Y Hsu, Ryo Itabashi, Yongjun Wang, Hiroshi Yamagami, Thorsten Steiner, Nobuyuki Sakai, Byung-Woo Yoon, Manabu Inoue, Kazuo Minematsu, Haruko Yamamoto, Masatoshi Koga and the ATACH Trial Investigators and the SAMURAI Investigators in International Journal of Stroke</p
Letter from children of Kihichi Sakamoto to Project Director [Raymond R. Best], February 14, 1944
No full textLetter from three of his children, Tatsuo, Manabu, and Osamu Sakamoto, requests the release of their father, Kihichi Sakamoto, from the Army Stockade, for the sake of their mother's "health and mind" stating that she has been ill since their stay in Heart Mountain the previous year and has suffered a relapse upon her husband's imprisonment in the stockade; the letter states that, according to her doctor, a lack of kindness and peace of mind regarding this request for release could prove lethal to her.The Willard Schmidt collection, documents some of the administrative duties of Willard Schmidt, the Chief of Internal Security for the War Relocation Authority and the Tule Lake incarceration/segregation camp. This collection contains administrative records and photos documenting the Tule Lake camp, the largest incarceration camp with a peak population of 18,789 and with the most turbulent history. In 1943, the camp was turned into a segregation center to house "disloyal" Japanese Americans relocated from other camps based on their answers to a confusing loyalty questionnaire. The camp endured martial law from November 1943- Jan 1944 after escalating protests and unrest. The hostile environment of the camp lead to many incarcerees renouncing their American citizenship upon the end of incarceration, a process which took 14 years to reverse if they did not wish to be deported to Japan
From the plate to the brain: associations between dietary patterns and reduced dementia prevalence and white matter lesions in older Japanese adults
No full textPreKURA:1124*Japan Prospective Studies Collaboration for Aging, Dementia (JPSC-AD) study group:
Jun Hata, Mao Shibata, Takanori Honda, Tomoyuki Ohara, Masato Akiyama, Koichi Murashita, Tatsuya Mikami, Songee Jung, Mina Misawa, Naoki Ishizuka, Hiroshi Akasaka, Yasuo Terayama, Hisashi Yonezawa, Junko Takahashi, Masahito Yamada, Kazuo Iwasa, Sohshi Yuki-Nozaki, Shogyoku Bun, Hidehito Niimura, Ryo Shikimoto, Hisashi Kida, Yasuyo Fukada, Hisanori Kowa, Kenji Wada, Masafumi Kishi, Takaaki Mori, Yuta Yoshino, Hideaki Shimizu, Ayumi Tachibana, Shu-ichi Ueno, Tomohisa Ishikawa, Ryuji Fukuhara, Asuka Koyama, Mamoru Hashimoto, Manabu Ikeda, Yoshihiro Kokubo, Midori Esaki, Yuji Takano, Koji Yonemoto, Hisako Yoshida, Kaori Muto, Yusuke Inoue, Yukihide Momozawa, Chikashi Terao, Michiaki Kubo & Yutaka Kiyoharajournal articl
A case of multiple renal leiomyoma located at renal sinus and hilus
No full textA case of multiple renal leiomyoma of the right kidney in a 60-year-old woman, complaining of lower abdominal pain of two months duration, is presented. Ultrasonography, intravenous pyelography and CT scan showed the masses at the right renal sinus and hilus. Selective right renal angiography demonstrated very hypovascular tumors. Right radical nephrectomy was performed. There were two lobulated tumors with no connections, which were elastic hard in consistency and smooth in surface; one was 4 x 2 x 2 cm in size and located at the renal sinus between the upper and middle calyces, the other was 6.5 x 5 x 4 cm in size and located at the renal hilus, apart from the renal parenchyma, pelvis, artery and vein. Histological examination revealed these tumors to be benign leiomyoma. Both were covered with the Gerota's fascia, but not the renal capsule. The renal parenchyma was completely covered with the renal capsule histologically, although these tumors were closely attached to the parenchyma on gross examination. The tumor at renal sinus was considered to arise from the outer layer of the renal pelvis or from the blood vessel in the connective tissues at renal sinus. The tumor at renal hilus was considered to arise from the blood vessel in the connective tissues at renal hilus. This appears to be the first reported case as multiple renal leiomyoma in both Japanese and English literatures
8516KAWADA
No full textAbstract. Insulin-like growth factor-I (IGF- I Solid tumors are composed of tumor cells, as well as the surrounding stroma, including the extracellular matrix, fibroblasts, macrophages and endothelial cells (1). Because the growth of tumor cells is regulated by the stromal cells through their diffusible factors and adhesion (2-5), tumorstromal cell interactions significantly contribute to the development of some carcinomas, such as those of the breast and prostate (6, 7). Many growth factors and cytokines are known to be involved in the regulation of tumor-stromal cell interactions (2, 8). The various lines of evidence have suggested the involvement of the insulin-like growth factor (IGF) axis in prostate cancer development (9, 10). The IGF axis consists of two major ligands (IGF-I and IGF-II), two cell surface receptors (IGF-IR and IGF-IIR), and six binding proteins (IGFBP-1 to 6) that regulate IGF availability to the receptors and a group of IGFBP proteases that cleave IGFBP and modulate the action of IGFs (11-13). IGF-I binds to IGF-IR, and the tyrosine kinase of the cytoplasmic domain of IGF-IR transduces IGF-I signals into cells 721 Correspondence to: Manabu Kawada, Drug Development Unit
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