3,457 research outputs found
Novel derivatives of 4,4’-dithiobis-(3-aminobutane-sulfonates) and compositions comprising the same. B.P. Roques, C. Llorens Cortes, P. Corvol, N. Inguimbert
No full textNovel derivatives of 4,4’-dithiobis-(3-aminobutane-sulfonates) and compositions comprising the same. B.P. Roques, C. Llorens Cortes, P. Corvol, N. Inguimbert
No full textThe North is another country. by Nicolas Rothwell
No full texttag=1 data=The North is another country. by Nicolas Rothwell
tag=2 data=Rothwell, Nicolas
tag=3 data=Australian Magazine,
tag=6 data=16/17 November 1996
tag=7 data=20-33.
tag=8 data=NT%TOURISM
tag=10 data=Worse, better, stranger, wilder, but above all different from the rest of the country. Continuing his journey of discovery across Australia's Top half the author stops over in Darwin to hear all the truths and whispers about the North.
tag=11 data=1996/2/8
tag=12 data=96/0316
tag=13 data=CABWorse, better, stranger, wilder, but above all different from the rest of the country. Continuing his journey of discovery across Australia's Top half the author stops over in Darwin to hear all the truths and whispers about the North
Investigating Cone Snail Venoms through Proteotranscriptomic Analyses : Application to the Molluskhunter, Cylinder Canonicus
No full textInternational audienceCone snails are carnivorous marine mollusks, which use a potent neurotoxic venom, for predatory and defensive purposes in their environment [1]. Some cone snails prey on fish (piscivorous), worms (vermivorous) or mollusks (molluscivorous) [2].The main constituents of a cone snail venom are highly structured cysteine-rich peptides known as conotoxins. Remarkably, a subset of conotoxins are specifically selected for predation or for defense in some species [1,3]. Yet, characterizing the entire venom content of cone snails is essential, not only to have a better understanding of the cone snails’ biology, but also to discover new therapeutic leads, such as the FDA-approved analgesic Ziconotide (Prialt®) [4].Here we describe the venom characterization of the mollusk-hunting cone snail Cylinder canonicus, using a proteo-transcriptomics approach. This approach first consists in profiling the venom by standard mass spectrometry technologies such as LC-MS and MALDI-TOF-MS, second, by sequencing a library of all the expressed mRNA in the whole venom gland, and finally, by matching MS/MS spectra with transcriptomics data. Analysis of the predatory milked venom compared to different sections of the duct revealed a distal origin.1. Dutertre, S. et al., Nat. Commun. 2014, 5, 3521, doi:10.1038/ncomms4521.2. Puillandre, N. et al., J. Molluscan Stud. 2015, 81, 1e23, doi:10.1093/mollus/eyu055.3. Ratibou, Z.; Inguimbert, N.; Dutertre, S. Toxins 2024, 16, 94. doi.org/10.3390/ toxins160200944. Safavi-Hemami, H. et al., J. Proteomics 2019, 190, 12e20. doi:10.1016/j.jprot.2018.05.009
Grace S. Fong, Herself an Author : Gender, Agency, and Writing in Late Imperial China, 2008
No full textZufferey Nicolas. Grace S. Fong, Herself an Author : Gender, Agency, and Writing in Late Imperial China, 2008. In: Études chinoises, n°28, 2009. Numéro spécial sur le droit chinois. pp. 243-247
New Necklaces: 400 Designs in Contemporary Jewellery
No full textAfter the successful New Rings and New Earrings, New Necklaces is the third book curated by jeweller and author Nicolas Estrada, from classic forms and materials to the most daring, experimental and surprising ideas, each of the 500 necklaces included in this book has something that makes it unique and relates strongly to today's social, cultural and artistic reality. With prefaces by German jeweller Julia Wild and Leo Caballero, owner of the Barcelona gallery Klimt 02, specialised in contemporary jewellers
Investigating Cone Snail Venoms through Proteotranscriptomic Analyses : Application to the Molluskhunter, Cylinder Canonicus
No full textInternational audienceCone snails are carnivorous marine mollusks, which use a potent neurotoxic venom, for predatory and defensive purposes in their environment [1]. Some cone snails prey on fish (piscivorous), worms (vermivorous) or mollusks (molluscivorous) [2].The main constituents of a cone snail venom are highly structured cysteine-rich peptides known as conotoxins. Remarkably, a subset of conotoxins are specifically selected for predation or for defense in some species [1,3]. Yet, characterizing the entire venom content of cone snails is essential, not only to have a better understanding of the cone snails’ biology, but also to discover new therapeutic leads, such as the FDA-approved analgesic Ziconotide (Prialt®) [4].Here we describe the venom characterization of the mollusk-hunting cone snail Cylinder canonicus, using a proteo-transcriptomics approach. This approach first consists in profiling the venom by standard mass spectrometry technologies such as LC-MS and MALDI-TOF-MS, second, by sequencing a library of all the expressed mRNA in the whole venom gland, and finally, by matching MS/MS spectra with transcriptomics data. Analysis of the predatory milked venom compared to different sections of the duct revealed a distal origin.1. Dutertre, S. et al., Nat. Commun. 2014, 5, 3521, doi:10.1038/ncomms4521.2. Puillandre, N. et al., J. Molluscan Stud. 2015, 81, 1e23, doi:10.1093/mollus/eyu055.3. Ratibou, Z.; Inguimbert, N.; Dutertre, S. Toxins 2024, 16, 94. doi.org/10.3390/ toxins160200944. Safavi-Hemami, H. et al., J. Proteomics 2019, 190, 12e20. doi:10.1016/j.jprot.2018.05.009
How Did I Get to Princess Margaret? (And How Did I Get Her to the World Wide Web?)
No full textThe paper explores the growing use of
tools from the arts and humanities for investigation
and dissemination of social science research.
Emerging spaces for knowledge transfer, such as
the World Wide Web, are explored as outlets for
"performative social science". Questions of ethnics
and questions of evaluation which emerge from
performative social science and the use of new
technologies are discussed. Contemporary thinking
in aesthetics is explored to answer questions
of evaluation. The use of the Internet for productions
is proposed as supporting the collective
elaboration of meaning supported by Relational
Aesthetics.
One solution to the ethical problem of performing
the narrations of others is the use of the writer's
own story as autoethnography. The author queries
autoethnography's tendency to tell "sad" stories and
proposes an amusing story, exemplified by "The
One about Princess Margaret" (see Appendix).
The conclusion is reached that the free and open
environment of the Internet sidelines the usual
tediousness of academic publishing and begins to
explore new answers to questions posed about
the evaluation and ethics of performative social
science
Développement méthodologique en synthèse peptidique pour l'obtention de composés antifongiques et antibactériens dérivés de peptides marins.
No full textLa chimie de clic est devenue indispensable dans les nombreux domaines de chimie associée à la conception de médicament. Dans ce contexte, comme nous savons(connaissons) l'étude concernant l'impact d'insertion triazole sur la conformation de peptaibol est limitée, nous avons conduit l'étude pour examiner l'impact et l'adaptabilité de 1, 1 4-disubstituted, 2, l'insertion 3-triazole dans peptaibols différent. Selon le résultat de cette expérience touchant à l'activité réduite et la conformation perturbée de l'analogue peptaibol, le substitut dipeptide décoré du fragment triazole portant substituents hydrophobe divers a été inséré à très N-ter la partie du peptaibol. L'amélioration du bioactivity et de la restauration de la conformation pour les analogues peptaibol a été observée et le fait a été aussi soutenu par les résultats obtenus de l'étude biophysique des analogues choisis d'ALM F50/5. Nous avons plus loin prolongé notre étude pour employer notre stratégie à être appliqué sur le peptide P42 thérapeutique qui souffre de la limitation de manque de perméabilité et de stabilité. Le peptide P42 est impliqué dans le pathophysiology de la maladie d'Huntington neurodégénératif. Un total de 12 analogues de peptide de P42-camelote a été synthétisé par SPPS par notre protocole optimize. Dans la deuxième partie, nous avons développé une stratégie pour synthétiser lipopeptide cyclique produit de l'espèce cynaobacterial marine. Notre objectif principal était de synthétiser Hormothamnin A, undecapeptide cyclique consistant de plusieurs acides aminés artificiels incluant dehydroamino acide (Dhaa) qui fait la synthèse de ce peptide compliqué. En raison de cette raison, premièrement, nous avons voulu appliquer notre stratégie de synthétiser Trichormamide A, une sorte relativement plus simple de cylic lipopeptide. Après l'accomplissement de cette tâche, une première tentative a été faite pour synthétiser Hormothamnin A. Le résultat préliminaire de ceci est présenté dans cette section. Enfin, nous avons essayé de développer une méthodologie robuste pour synthétiser Fmoc-Dhaa dans la phase de solution et son insertion dans l'ordre peptaibol par une norme(un standard) SPPS le protocole. Les résultats préliminaires que nous avons concernant la synthèse Dhaa et son insertion dans peptaibol sont aussi discutés ici de plus avec la synthèse de phase solide de Bergofungin naturel D.The click chemistry has become indispensible in the many areas of chemistry associated with drug design. In this context, as we know the study concerning the impact of triazole insertion on the conformation of peptaibol is limited, we have conducted the study to investigate the impact and adaptability of the 1, 4-disubstituted 1, 2, 3-triazole insertion into different peptaibols. Depending on the outcome of this experiment relating to reduced activity and perturbed conformation of the peptaibol analogue, the dipeptide surrogate decorated with the triazole moiety bearing various hydrophobic substituents was inserted at the very N-ter part of the peptaibol. The improvement of the bioactivity and restoration of the conformation for the peptaibol analogues was observed and the fact was also supported by the results obtained from the biophysical study of the selected analogues of ALM F50/5. We have further extended our study to employ our strategy to be applied on the therapeutic P42 peptide which suffers from the limitation of lack of permeability and stability. P42 peptide is involved in the pathophysiology of neurodegenerative Huntington’s disease. A total of 12 analogues of P42-TAT peptide were synthesized through SPPS by our optimized protocol. In the second part, we have developed a strategy for synthesizing the cyclic lipopeptide originated from marine cynaobacterial species. Our main objective was to synthesize Hormothamnin A, a cyclic undecapeptide consisting of several unnatural amino acids including dehydroamino acid (Dhaa) which makes the synthesis of this peptide complicated. Due to this reason, firstly, we have chosen to apply our strategy to synthesize Trichormamide A, a relatively simpler kind of cylic lipopeptide. After accomplishing this task, a first attempt was made to synthesize Hormothamnin A. The preliminary result of this is presented in this section. At last, we have tried to develop a robust methodology to synthesize Fmoc-Dhaa in solution phase and its insertion into the peptaibol sequence through a standard SPPS protocol. The preliminary results we have got concerning the Dhaa synthesis and its insertion into peptaibol are also discussed here in addition with the solid phase synthesis of natural Bergofungin
Identification of author profiles through social networks
No full textThe aim of this paper is to compile dictionaries of slang words, abbreviations, contractions, and emoticons to help the pre-processing of texts published in social networks. The use of these dictionaries is intended to improve the results of the tasks related to data obtained from these platforms. Therefore, a hypothesis was evaluated in the task of identifying author profiles (author profiling).Silva, JesúsMaria Santodomingo, Nicolas EliasRomero, LigiaJorge, MarisolHerrera, MaritzaPineda Lezama, Omar Bonerg
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