47 research outputs found
sj-docx-3-tam-10.1177_17588359221081075 – Supplemental material for Influence of probenecid on endoxifen systemic exposure in breast cancer patients on adjuvant tamoxifen treatment
No full textSupplemental material, sj-docx-3-tam-10.1177_17588359221081075 for Influence of probenecid on endoxifen systemic exposure in breast cancer patients on adjuvant tamoxifen treatment by Stefan A. J. Buck, C. Louwrens Braal, Maaike M. Hofman, Esther Oomen-de Hoop, Peter de Bruijn, Inge M. Ghobadi Moghaddam-Helmantel, Koen G. A. M. Hussaarts, Mijntje B. Vastbinder, Quirine C. van Rossum-Schornagel, Ron H. N. van Schaik, Agnes Jager, Stijn L. W. Koolen and Ron H. J. Mathijssen in Therapeutic Advances in Medical Oncology</p
sj-docx-1-tam-10.1177_17588359221081075 – Supplemental material for Influence of probenecid on endoxifen systemic exposure in breast cancer patients on adjuvant tamoxifen treatment
No full textSupplemental material, sj-docx-1-tam-10.1177_17588359221081075 for Influence of probenecid on endoxifen systemic exposure in breast cancer patients on adjuvant tamoxifen treatment by Stefan A. J. Buck, C. Louwrens Braal, Maaike M. Hofman, Esther Oomen-de Hoop, Peter de Bruijn, Inge M. Ghobadi Moghaddam-Helmantel, Koen G. A. M. Hussaarts, Mijntje B. Vastbinder, Quirine C. van Rossum-Schornagel, Ron H. N. van Schaik, Agnes Jager, Stijn L. W. Koolen and Ron H. J. Mathijssen in Therapeutic Advances in Medical Oncology</p
sj-docx-2-tam-10.1177_17588359221081075 – Supplemental material for Influence of probenecid on endoxifen systemic exposure in breast cancer patients on adjuvant tamoxifen treatment
No full textSupplemental material, sj-docx-2-tam-10.1177_17588359221081075 for Influence of probenecid on endoxifen systemic exposure in breast cancer patients on adjuvant tamoxifen treatment by Stefan A. J. Buck, C. Louwrens Braal, Maaike M. Hofman, Esther Oomen-de Hoop, Peter de Bruijn, Inge M. Ghobadi Moghaddam-Helmantel, Koen G. A. M. Hussaarts, Mijntje B. Vastbinder, Quirine C. van Rossum-Schornagel, Ron H. N. van Schaik, Agnes Jager, Stijn L. W. Koolen and Ron H. J. Mathijssen in Therapeutic Advances in Medical Oncology</p
Genetically isolated populations: Implications for genetic care
No full textGenetically isolated populations exist worldwide. They provide unique opportunities for genetic studies that may eventually lead to useful clinical applications. This thesis concerns such genetic studies in a young genetically isolated population in the Netherlands. We identified the genetic causes of two autosomal recessive disorders (fetal akinesia deformation sequence and XX female gonadal dysgenesis) and studied the phenotypic variation of another autosomal recessive disorder (retinitis pigmentosa type 12). Furthermore, we implemented a preconception outpatient clinic offering carrier screening for multiple severe recessive disorders in this population. Approximately one-third of the individuals visiting the clinic turned out to be a carrier of at least one of the disorders and 1 in 25 couples were a carrier couple with a 1-in-4 risk of affected offspring. We evaluated the carrier screening offer by taking questionnaires and conducting interviews. Attendees were highly familiar with the disorders, demonstrated no major psychological outcomes, experienced no stigmatization, and were very satisfied after testing. All identified carrier couples made reproductive decisions based on their test results. Although genetically isolated populations may differ in various aspects from other populations and not all research findings may be representative for an outbred population, investigations in isolated populations are helpful in understanding causes of genetic disorders and provide important lessons for further successful and responsible implementation of preconception (expanded) carrier screening and other genetic services in the general population
Fast Starters, Slow Starters, and Late Dippers: Trajectories of Patient-Reported Outcomes After Total Hip Arthroplasty: Results from a Dutch Nationwide Database
No full textBackground:The purpose of this study was to explore whether subgroups of patients with different functional recovery trajectories after total hip arthroplasty can be discerned, as well as their predictors, using data from the Dutch Arthroplasty Register (Landelijke Registratie Orthopedische Implantaten [LROI]).Methods:We retrospectively reviewed prospectively collected Oxford Hip Scores (OHS) up to 1 year postoperatively for patients who had undergone a primary total hip arthroplasty. Latent class growth modeling was used to classify subgroups of patients according to the trajectory of functional recovery represented by the patients' OHS. We used multivariable multinomial logistic regression analysis to explore factors associated with class membership.Results:A total of 6,030 patients were analyzed. Latent class growth modeling identified fast starters (fast initial improvement, high 12-month scores; 87.7%), slow starters (no initial change and subsequent improvement; 4.6%), and late dippers (initial improvement and subsequent deterioration; 7.7%). Factors associated with slow starters were female sex (odds ratio [OR], 1.63 [95% confidence interval (CI), 1.14 to 2.33]) and smoking (OR, 1.95 [95% CI, 1.26 to 3.03]); an anterior approach (OR, 0.47 [95% CI, 0.29 to 0.78]) had a protective effect against a less favorable response. Factors associated with late dippers were age of >75 years (OR, 1.62 [95% CI, 1.22 to 2.15]), smoking (OR, 1.68 [95% CI, 1.17 to 2.42]), American Society of Anesthesiologists (ASA) grade of III or IV (OR, 1.41 [95% CI, 1.05 to 1.91]), obesity (OR, 1.96 [95% CI, 1.43 to 2.69]), poorer EuroQol-5 Dimensions (EQ-5D) Self-Care (OR, 1.41 [95% CI, 1.09 to 1.82] for "some problems" and OR, 2.90 [95% CI, 1.39 to 6.03] for "unable"), poorer EQ-5D Anxiety/Depression (OR, 1.31 [95% CI, 1.00 to 1.71] for "moderately" and OR, 1.86 [95% CI, 1.06 to 3.24] for "extremely"), poorer EQ-5D visual analog scale (OR, 0.91 [95% CI, 0.86 to 0.97] per 10 points), direct lateral approach (OR, 2.18 [95% CI, 1.58 to 3.02]), and hybrid fixation with a cemented acetabular implant (OR, 1.79 [95% CI, 1.00 to 3.21]).Conclusions:We discerned fast starters, slow starters, and late dippers after total hip arthroplasty. Female sex, older age, obesity, higher ASA grades, and worse EQ-5D scores were associated with a less favorable response to total hip arthroplasty, as well as hybrid fixation (cemented acetabular implant) and direct lateral approach. Anterior approach had a protective effect against a less favorable response. However, all subgroups experienced functional improvement following total hip arthroplasty.Accepted Author ManuscriptApplied Ergonomics and Desig
Operating room ventilation systems: recovery degree, cleanliness recovery rate and air change effectiveness in an ultra-clean area
No full textBackground: Entrainment test methods are described in most European standards and guidelines to determine the protected area for ultra-clean ventilation (UCV) systems. New UCV systems, such as temperature-controlled airflow (TcAF) and controlled dilution ventilation (cDV) systems, claim the whole operating room (OR) to be ultra-clean. However, current test standards were not developed to assess ventilation effectiveness outside the standard protected area. Aim: To assess and compare the ventilation effectiveness of four types of OR ventilation systems in the ultra-clean area using a uniform test grid.Methods: Ventilation effectiveness of four ventilation systems was evaluated for three different ultra-clean (protected) areas: the standard protected area (A); the area outside the standard protected area (B); and a large protected area (AB). Ventilation effectiveness was assessed using recovery degree (RD), cleanliness recovery rate (CRR) and air change effectiveness (ACE). Findings: RD, CRR and ACE were significantly higher for the unidirectional air flow (UDAF) system compared with the other systems in area A. In area B, the UDAF and cDV systems were comparable for RD and CRR, and the UDAF and conventional ventilation (CV) systems were comparable for ACE. In area AB, the UDAF and cDV systems were comparable for CRR and ACE, but significant differences were found in RD.Conclusion: In area A, the ventilation effectiveness of the UDAF system outperformed other ventilation systems. In area B, the cDV system was best, followed by the UDAF, TcAF and CV systems. In area AB, the UDAF system was best, followed by the cDV, TcAF and CV systems.Building ServicesMedical Instruments & Bio-Inspired TechnologySupport Biomechanical Engineerin
Iris heterochromia: A variable feature in Verloes-Koulischer-oral-acral syndrome [6]
No full textSCOPUS: le.jinfo:eu-repo/semantics/publishe
Advances in Propulsive Bionic Feet and Their Actuation Principles
No full textIn the past decades, researchers have deeply studied pathological and nonpathological gait to understand the human ankle function during walking. These efforts resulted in the development of new lower limb prosthetic devices aiming at raising the 3C-level (control, comfort, and cosmetics) of amputees. Thanks to the technological advances in engineering and mechatronics, challenges in the field of prosthetics have become an important source of interest for roboticists. Currently, most of the bionic feet are still on a research level but show promising results and a preview of tomorrow's commercial prosthetic devices. In this paper, the authors present the current state-of-the-art and the latest advances in propulsive bionic feet with its actuation principles. The context of this review study is outlined followed by a brief description of the basics in human biomechanics and criteria for new prosthetic designs. A new categorization based on the actuation principle of propulsive ankle-foot prostheses is proposed. Based on simulations, the general principles and benefits of each actuation method are explained. The corresponding latest advances in propulsive bionic feet are presented together with their main characteristics and scientific outcomes. The authors also propose to the reader a comparison analysis of the presented devices with a discussion of the general tendencies in new prosthetic feet
How will new genetic technologies, such as gene editing, change reproductive decision-making? Views of high-risk couples
No full textCouples at increased risk of having offspring with a specific genetic disorder who want to avoid having an affected child have several reproductive options including prenatal diagnosis (PND) and preimplantation genetic testing (PGT). In the future, non-invasive prenatal diagnosis (NIPD), germline gene editing (GGE) and somatic gene editing (SGE) might become available. This study explores if, and how, availability of new genetic technologies, including NIPD, GGE, SGE, would change reproductive decision-making of high-risk couples. In 2018, semi-structured interviews were conducted with 25 genetically at-risk couples. Couples previously had received genetic counselling for PND and PGT, and in most cases opted for (one of) these techniques, at one Dutch Clinical Genetics Center between 2013 and 2017. Considerations participants mentioned regarding the hypothetical use of NIPD, GGE and SGE, seem similar to considerations regarding PND and PGT and are reflected in underlying concepts. These include safety and burden for mother and child, and moral considerations. Couples generally favoured NIPD over PND as this would be safe and enables earlier diagnosis. Increased opportunities of having a ‘healthy’ embryo and less embryo disposal were considerations in favour of GGE. Some regarded GGE as unsafe and feared slippery slope scenarios. Couples were least favourable towards SGE compared to choosing for a genetic reproductive technology, because of the perceived burden for the affected offspring. With the possibly growing number of technological options, understanding high risk couples’ perspectives can assist in navigating the reproductive decision-making process. Counsellors should be prepared to counsel on more and complex reproductive options
Testicular cancer in a patient with Primrose syndrome
No full textA mentally retarded, adult man was found to have joint contractures, sparse body hair, hearing loss, dysmorphic facial features, large calcified pinnae and a huge torus palatinus. All features are similar to those earlier described in patients with Primrose syndrome. In addition he developed a germ cell tumour of his right testicle at age 27 years. A comparison is provided between the main findings in the four previously reported cases with Primrose syndrome and the current patient. Calcification of the pinnae is an infrequent symptom in the general population, and a torus palatinus of limited size is commonly found but a torus of the size reported here is extremely unusual. Both symptoms are excellent handles for diagnosing this entity. It remains as yet uncertain whether an increased risk to malignancies forms part of this syndrome or is only a consequence of cryptorchidism in this patien
