3,785 research outputs found
TACC3-ch-TOG track the growing tips of microtubules independently of clathrin and Aurora-A phosphorylation
No full textThe interaction between TACC3 (transforming acidic coiled coil protein 3) and the microtubule polymerase ch-TOG (colonic, hepatic tumor overexpressed gene) is evolutionarily conserved. Loading of TACC3–ch-TOG onto spindle microtubules requires the phosphorylation of TACC3 by Aurora-A kinase and the subsequent interaction of TACC3 with clathrin to form a microtubule binding surface. Whether there is a pool of TACC3–ch-TOG that is independent of clathrin in human cells, and what is the function of this pool, are open questions. Here, we report that TACC3 is recruited to the plus-ends of microtubules by its association with ch-TOG and that this pool is independent of phosphorylation and binding to clathrin. The plus-end binding of TACC3–ch-TOG persists in interphase and we propose that one cellular function of TACC3–ch-TOG is to modulate cell migration. We also describe the distinct subcellular pools of TACC3, ch-TOG and clathrin. TACC3 is often described as a centrosomal protein, but we show that there is no significant population of TACC3 at centrosomes. The delineation of distinct protein pools reveals a simplified view of how these proteins are organized and controlled by post-translational modification
"Closing the R&D Gap, Evaluating the Sources of R&D Spending"
No full textBoth spending and tax policies have been implemented in the United States with the goal of stimulating private sector research and development (R&D). Karier questions whether current R&D policy, especially the research and experimentation tax credit, can contribute to closing the gap between nondefense expenditures on R&D in the United States and such expenditures in other countries, such as Japan and Germany. He also explores possible changes to our current R&D policy to make it more effective.
Enriching people's experience at CH sites with IoT technology
No full textThe Internet of Things (IoT) technology is valuable for connecting physical objects to the digital world. IoT-based systems have the potential to enrich people's experiences with CH collections; indeed, sensors and other data-collecting devices embedded into tangible artifacts can capture real-time information about visitors' interactions with CH objects and permit the creation of customized narratives and experiences based on visitors' interests, preferences, and prior knowledge. To identify the strengths and weaknesses of IoT solutions and the factors that impact on the experiences of visitors of CH sites, we created an IoT-based game called Magic Torch and performed an experimental study involving a total of 18 visitors, in order to analyze whether and how this game affects the experience of museum visitors. Its results show that the use of IoT positively impacts visitors' emotions and overall experience; they also indicate some drawbacks
DIFFUSION MONTE CARLO CALCULATIONS OF MINIMUM ENERGY PATHS FOR THE ISOTOPIC VARIANTS OF THE CH + H CH CH + H REACTION
No full textAuthor Institution: Department of Chemistry, The Ohio State University, Columbus; Oh 43210Protonated methane is of interest to astrochemists due to its presumed importance as a reaction intermediate in the reaction involving CH + HD within the interstellar medium. However, within the interstellar medium there is a nonstatistical H/D isotopic abundance observed for the isotopologues of CH. Kinetic studies performed by Gerlich and co-workers determined that the reactions \begin{equation} \mathrm{CH_{3-n}D_{n}^{+} + HD \rightarrow CH_{4-n}D_{n+1}^{+} \rightarrow CH_{2-n}D_{n+1}^{+} + H_2} \end{equation} have identical net rate constants regardless of the value of n.{} We have calculated zero-point corrected energies and wave functions of the CH + H system{} and its deuterated analogs as functions of the center of mass separation between CH and H, . We can divide these simulations into distinct ranges of ; long-range interactions, complexation, and intermediate distances. Analysis of the wave functions associated with these three ranges of allows us to study how zero-point energy influences the approach geometries that are sampled during low-energy collisions
AND CH EMISSION FROM THE RED RECTANGLE
No full text S. P. Balm and M. Jura, A\&A 261 L25 (1992) F. R. Ornellas and F. B. C. Machado, J. Chem. Phys. 84 1296 (1986) H. Sun and K. F. Freed, J. Chem. Phys. 88 2659 (1988)Author Institution: Department of Astronomy and Astrophysics, The University of Chicago; Center for Astrophysics and Space Astronomy, University of Colorado; Center for Astrophysics and Space Astronomy, New Mexico State UniversityUsing the 3.5 meter telescope at the Apache Point Observatory, we have observed the , and bands of the transition (origin at ) of and the band of the transition of CH in emission from HD 44179, the central star of the Red Rectangle. The band emission of was reported but all other emission bands are new. The emission lines are observed up to the Q(7) and the P(6) lines demonstrating population of up to at least in the ground state. Since has a large dipole moment the spontaneous emission of the rotational transition at is fast (the Einstein coefficient . In order to populate up to the level, must be in an environment with a high density on the order of . It has to be a cloud of H atoms since will immediately react with to produce . Existence of such a high density H I cloud is remarkable. The observed CH emission, on the other hand, is limited to the and lines all of which can be reached from the lowest two levels in the ground state that are separated by only and spontaneous emission between them is slow. This clearly demonstrates that and CH exist in entirely different regions of the cloud surrounding HD 44179. A more detailed analysis will be given
ASTRONOMICAL DETECTIONS OF VACUUM ULTRAVIOLET TRANSITIONS OF CH
No full textAuthor Institution: Department of Physics and Astronomy, University of Toledo, Toledo, OH 43606In the 1990s, three unidentified absorption lines near 1370 \AA\ and another one near 1270 \AA\ were detected in {\it Hubble Space Telescope (HST)} spectra of diffuse interstellar sight lines. These features were suspected of belonging to molecular carriers; the widest one at 1369.13 \AA\ was hypothesized as being a vacuum ultraviolet (VUV) analogue of the ubiquitous diffuse interstellar bands seen in the visible. Eventually, all four features were assigned by Watson in 2001 to Rydberg transitions of CH, previously observed in laboratory spectra by Herzberg and Johns in 1969. Since all CH column densities to date have used optical CH transitions, especially the 4300 \AA\ doublet, we analyzed {\it HST} spectra of sight lines with optically-derived CH abundances to confirm Watson's assignment of the VUV lines by measuring consistent -values for them. In addition, we expanded the survey by searching for additional VUV transitions of interstellar CH. Two more CH bands were detected, near 1694 \AA\ and near 1549 \AA. Both measured -values and, for the wider lines, predissociation lifetimes are found to be in agreement with theoretical calculations by, e.g., van Dishoeck in 1987. The 1369.13 \AA\ transition from the (or ) band remains the strongest and widest VUV feature of CH
ENERGY TRANSFER PATHWAYS FOR CH IN AN ATMOSPHERIC PRESSURE
No full text Supported by the U.S. Army Research Office, Contract No. DAAG29-80-K-0049.Author Institution: Molecular Physics Department, SRI InternationalVibrational energy transfer (V) and rotational energy transfer (R) within the state of CH has been studied in an atmospheric pressure flame at . A laser pumps specific levels in and fluorescence in the (1,0) and (0,0) bands is monitored. Excitation of shows a partially rotationally relaxed distribution within and very little emission ; excitation of produces considerable transfer to but less rotational redistribution than for the low rotational level. A more extensive map of relative R, V, and electronic quenching routes as a function of is in progress
A framework for the effective management of collaborative R&D projects : executive summary
No full textThere is a growing trend toward collaboration, both between companies, and between
academia and industry. Studies have linked the use of external sources of information
and expertise to the enhanced generation of innovation. Innovative companies, in turn,
have been shown to out-perform non-innovating companies in terms of both growth
and profit. Therefore, against a background of increasing international competition
and rapid technological change, governments are actively encouraging collaboration as
a means of improving innovation efficiency and thereby enhancing wealth creation.
Collaboration provides companies with the means by which to advance technologically,
at lower cost and with less inherent risk. Collaboration also provides access to a
greater breadth and depth of knowledge and technologies than would normally be
possible through internal development. For universities the benefits include additional
public and private funding, and increasingly, licensing and patenting income, as a result
of technology transfer activities.
However, these considerable potential benefits are often not realised in practice. The
major reason is that collaborations between, often diverse, organisations, need
considerable management effort in order to be successful. To this end, considerable
research (reported in the literature) has been devoted to identifying management
"success" factors, factors which where present, enhance the probability that a
collaboration will be successful. This information was used by the author to develop a
best practice model for collaboration management that is more comprehensive than has
previously been reported in the literature. To date however, the literature provides no
guidance as to how the full range of these success factors could be applied in the every
day context of managing a collaboration.
The Framework presented here provides a mechanism for achieving more effective
collaboration management in the form of a simple-to-apply management tool. The
Framework was developed on the basis of case study research and disparate sources of
relevant published research. Essentially, it provides a means of applying the current
body of knowledge in a way that does not assume prior experience of collaboration
management on the part of the user. Through the provision of reference material and
diagnostic features, the Framework encourages an awareness of the key issues
affecting the success of collaborations and prompts the manager to take appropriate
and timely action to prevent the occurrence of problems later on. The main feature of
the Framework's feedback mechanism, the Collaboration Chart, enables the user to
identify quickly, specific areas where problems could arise. The concept of the
Framework is new to the collaboration field and as such it constitutes the main
innovation to result from this research.
Furthermore, while ihe Framework was originally conceived as a specific aid to
collaboration between WMG and its industrial partners, this research indicates that it is
potentially much more widely applicable. The Framework is certainly shown to be
applicable to other university-industry collaborations, and with some modification,
could also be applied to industry-industry collaborations. In addition, the Framework
would lend itself to development into an evaluation tool that funding bodies could use
to assess research proposals. The potential value of the Framework therefore extends
beyond industry and academia, to ensuring the efficient use of public funds
Cellular Communications Using Aerial Platforms
No full textThis paper is devoted to the study of cellular communications using aerial platforms (APs). A set of key equations is derived that quantify the coverage area on the ground as a function of AP elevation, the operation of the adaptive multibeam antenna on the AP, and the formulation of contiguous terrestrial cells and their shapes. Specifically, we consider the deployment of an AP to provide terrestrial mobile radio communications using the universal mobile telecommunication system operating in its wide-band code-division multiple-access mode. Calculations are made of the number of users versus Eb/No for different service rates. Multi-tiered cellular structures having cells of different size that are steerable with the offered teletraffic are examined. The array structure to achieve this is identified. The preliminary results shows that an AP at a height of 21 km covers an area of radius 517 km. Up to 21 users per cell with a service rate of 8 kb/s can be accommodated in the 2.2-GHz band. These services can be provided within an area of radius 70 km with transmitted powers of less than 1 W. High system capacity is proved to be possible by constructing cells of radius as small as 100 m using square planar arrays with dimensions of less than 12 m x 12 m. The AP system provides high capacity and Doppler frequency shifts that only originate from roving mobiles
Determining the need for an expanded fitness component in the Fire Science Program at Milwaukee Area Technical College
No full textIncludes bibliographical references
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