1,720,955 research outputs found
Uji Imunogenitas Protein Rekombinan Fusi Esat-6/Cfp-10 Mycobacterium Tuberculosis Terhadap Ekspresi Il-10 Dan Limfosit T Cd4+ Pada Kultur Peripheral Blood Mononuclear Cell (Pengembangan Vaksin Tuberkulosis)
Full text linkLatar Belakang : TB menjadi salah satu penyakit penyumbang kematian terbanyak di dunia. Vaksinasi menjadi salah satu metode pencegahan infeksi TB yang diharapkan menjadi alat yang menghemat biaya untuk eradikasi dan pengendalian TB. Vaksin BCG menjadi satu-satunya cara untuk mengontrol tuberculosis (TB) dimana efikasinya bervariasi, sehingga dibutuhkan perkembangan vaksin baru. Vaksin baru tersebut harus dapat menginduksi respon imun yang optimal dalam melawan infeksi Mtb meliputi aktivasi sel T CD4+ dan sel T CD8+. Tujuan dari penelitian ini adalah untuk meneliti apakah protein fusi rekombinan ESAT-6/CFP-10 Mycobacterium tuberculosis (M.tb) dapat menstimulasi respons imun seluler, khususnya prosentase IL-10 dan sel T CD4+ pada kultur PBMC.
Metode : Penelitian ini dilaksanakan melalui penelitian eksperimental pada kultur PBMC dari 3 kelompok ( pasien TB, Kontak TB, dan kontrol sehat endemis). Setiap kelompok terdiri dari 8 sampel. Setiap kelompok diinduksi dengan protein rekombinan fusi ESAT-6/CFP-10 M.tb. Penelitian berlangsung selama 3 bulan. Prosentase IL-10 dan sel T CD4+ diukur dengan flow cytometri.
Hasil : Protein rekombinan fusi ESAT-6/CFP-10 dapat menstimulasi prosentase IL-10 dan sel T CD4+ pada pasien TB, kontak dan sehat endemis. Hasil prosentase tertinggi dari IL-10 diperoleh dari pasien TB (44,196( 35,259)), yang berbeda bermakna dibandingkan sampel kontak (p= 0,028) dan sehat (p= 0, 028). Hasil prosentase tertinggi sel T CD4+ ditemukan pada pasien TB (27,863 (10,368)), yang tidak berbeda bermakna dengan sampel kontak dan sehat (p= 0,779).
Kesimpulan : Prosentase IL-10 yang meningkat pada pasien TB lebih menggambarkan progresivitas penyakit. Sedangkan prosentase sitokin IL-10 dari sel T CD4+ yang rendah pada kelompok kontak TB dan sehat endemik mendukung peran antigen fusi rESAT-6-CFP-10 sebagai kandidat vaksin Tb yang dominan menginduksi respons protektif Th1
Pengaruh Self Esteem, Self Efficacy Dan Kepuasan Kerja Terhadap Kinerja Karyawan (Studi Kasus Perawat RS Siloam Manado)
Full text linkPenelitian ini meneliti pengaruh self esteem, self efficacy, dan kepuasan kerja terhadap kinerja. Tujuan dari penelitian ini adalah untuk menemukan bukti empiris mengenai terdapat atau tidaknya a) pengaruh signifikan dari self esteem terhadap kepuasan kerja, b) pengaruh signifikan dari self efficacy terhadap kepuasan kerja, c) pengaruh signifikan dari self esteem terhadap kinerja, d) pengaruh signifikan dari self efficacy terhadap kinerja, e) pengaruh signifikan kepuasan kerja terhadap kinerja. Responden pada penelitian ini adalah perawat di RS Siloam Manado. Pengumpulan data menggunakan penyebaran kuesioner secara langsung. Data dianalisis menggunakan analisis jalur. Hasil dari penelitian ini diperoleh bahwa terdapat pengaruh signifikan dari self esteem terhadap kepuasan kerja, pengaruh yang signifikan dari self efficacy terhadap kepuasan kerja, pengaruh yang signifikan dari self efficacy terhadap kinerja perawat, pengaruh yang signifikan dari kepuasan kerja terhadap kinerja perawat, dan pengaruh yang tidak signifikan dari self esteem terhadap kinerja perawat. Kata kunci : Self Esteem, Self Efficacy, Kepuasan Kerja, dan Kinerj
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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