102,872 research outputs found
Recent developments of the theory of tunneling. Dynamical symmetry breaking in curves spacetime : four-fermion interactions.
No full textOmslagtitel.Met lit. opg.Dynamical symmetry breaking in curves spacetime : four-fermion interactions / T. Inagaki, T. Muta and S.D. Odintsov.Recent developments of the theory of tunneling / H. Aoyama ... [et al.
Quantum level structure of molecular magnets, Fe12 and V15
No full textAjiro Y, Inagaki Y, Itoh H, et al. Quantum level structure of molecular magnets, Fe12 and V15. In: Iye Y, Maekawa S, eds. Proceedings of the 23rd International Conference on Low Temperature Physics (LT23). Physica B: Condensed Matter. Vol 329-333. ELSEVIER SCIENCE BV; 2003: 1138-1139.We review our recent work on molecular magnets, Fe12 and V15 with focus on the determination of low-lying quantum energy levels which have permanent importance in understanding their unique quantum magnetism. (C) 2003 Elsevier Science B.V. All rights reserved
Parametric authentication governed Inagaki by genetic algorithms
No full textПроведен краткий анализ существующих альтернатив классическому правилу объединения в теории Демпстера-Шафера. Предложен алгоритм параметрической идентификации правила Инагаки с помощью генетических алгоритмов.Проведений короткий аналіз існуючих альтернатив класичному правилу об'єднання в теорії Демпстера-Шафера. Запропонований алгоритм параметричної ідентифікації правила Інагаки за допомогою генетичних алгоритмів.The short analysis of existent alternatives is conducted to the classic rule of association in the theory of Dempster-Shafer. The algorithm of parametric authentication is offered Inagaki governed by genetic algorithms
IL-23 gene therapy for mouse bladder tumour cell lines.
No full textOBJECTIVES:
• To evaluate the antitumour effects of IL-23 gene transfer into mouse bladder carcinoma (MBT2) cells. • To investigate the mechanisms underlying the subsequent constitutive secrection of IL-23 by the MBT2 cells
MATERIALS AND METHODS:
• An expression vector containing IL-23 gene was introduced into MBT2 cells by liposome-mediated gene transfer, and secretion of IL-23 was confirmed by ELISA. • The in vivo antitumour effect of IL-23-secreting MBT2 cells (MBT2/IL-23) was examined by injecting the cells into syngeneic C3H mice. • A tumour vaccination study using mitomycin C (MMC)-treated IL-23-secreting MBT2 cells was carried out, and the usefulness of in vivo CD25 depletion for an additional vaccine effect was also investigated. • The mechanisms underlying the antitumour effects were investigated by antibody depletion of CD8 or CD4 T cells, or natural killer cells, and cells infiltrating the tumour sites in vivo were assessed using immunohistochemistry.
RESULTS:
• Stable transformants transduced with MBT2/IL-23 secreted IL-23 into the culture supernatant. • Genetically engineered IL-23-secreting MBT2 cells were rejected in syngeneic mice. • MBT2/IL-23-vaccinated mice inhibited the tumour growth of parental MBT2 cells injected at a distant site and this vaccine effect was enhanced by combination with in vivo CD25 depletion by an antibody. • The main effector cells for the direct antitumour effect of MBT2/IL-23 were CD8 T cells, which was shown by in vivo depletion and immunohistochemical study.
CONCLUSIONS:
• IL-23-secreting MBT2 cells were rejected in syngeneic mice by the activation of CD8 T cells. • MMC-treated MBT2/IL-23 can have a tumour vaccine effect for parental MBT2 cells, and this effect was enhanced by combination with in vivo CD25 depletion
Letter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
Supplemental material for Serum high-mobility group box 1 is correlated with interferon-α and may predict disease activity in patients with systemic lupus erythematosus
No full textSupplemental Material for Serum high-mobility group box 1 is correlated with interferon-α and may predict disease activity in patients with systemic lupus erythematosus by A Tanaka, T Ito, K Kibata, N Inagaki-Katashiba, H Amuro, T Nishizawa, Y Son, Y Ozaki and S Nomura in Lupus</p
High Field Magnetization Process in a Dodecanuclear Fe(III) Ring Cluster
No full textA high field magnetization technique is applied to study the field-dependent behaviors of the molecular magnet, dodecanuclear Iron(III) ring cluster [Fe(OCH3)(2)(dbm)](12), in which twelve numbers of Fe3+ (S = 5/2) ions form a finite chain ring, where dbm = dibenzoylmethane. The low-lying states of the spin manifold are dramatically revealed by the observation of magnetization process using pulsed high magnetic field up to 55 T at temperature down to 0.1 K. We observed four distinct magnetization steps with nearly equal field separation of 10T, arising from energy-level crossings for the discrete quantum states in the finite spin system. We discuss the structure of energy levels and the relaxation phenomena in the magnetization process around the level-crossing fields. It is found that the anomalous magnetization curve observed at 1.3 K, showing an unusual shape with characteristic hysteresis for increasing and decreasing field, is well reproduced by Phonon Bottleneck effect caused by the week heat exchange between sample and liquid-He bath during the fast field passage. Our results are compared and discussed with those obtained in the other iron magnets showing the step-like magnetization process due to quantum discrete energy levels
Arachidonic acid metabolism during antigen and ionophore activation of the mouse bone marrow derived mast cell.
No full textHandwritten biographical information on Paulina T. McClung Merritt
No full textA handwritten biography of Paulina T. McClung Merritt by an unknown author, 1892.
Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.
No full textIFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection has not been examined in detail. To address this, we have compared the effector T cell responses in wild-type and IFN-γ(-/-) mice during P. berghei ANKA infection. The expansion of splenic CD4(+) and CD8(+) T cells during P. berghei ANKA infection was unaffected by the absence of IFN-γ, but the contraction phase of the T cell response was significantly attenuated. Splenic T cell activation and effector function were essentially normal in IFN-γ(-/-) mice; however, the migration to, and accumulation of, effector CD4(+) and CD8(+) T cells in the lung, liver, and brain was altered in IFN-γ(-/-) mice. Interestingly, activation and accumulation of T cells in various nonlymphoid organs was differently affected by lack of IFN-γ, suggesting that IFN-γ influences T cell effector function to varying levels in different anatomical locations. Importantly, control of splenic T cell numbers during P. berghei ANKA infection depended on active IFN-γ-dependent environmental signals--leading to T cell apoptosis--rather than upon intrinsic alterations in T cell programming. To our knowledge, this is the first study to fully investigate the role of IFN-γ in modulating T cell function during P. berghei ANKA infection and reveals that IFN-γ is required for efficient contraction of the pool of activated T cells
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