4,966 research outputs found
FT-infrared spectroscopic studies of lymphoma, lymphoid and myeloid leukaemia cell lines
No full textThis paper presents a novel method to characterise spectral differences that
distinguish leukaemia and lymphoma cell lines. This is based on objective
spectral measurements of major cellular biochemical constituents and
multivariate spectral processing. Fourier transform infrared (FT-IR) maps of the
lymphoma, lymphoid and myeloid leukaemia cell samples were obtained using a
Perkin-Elmer Spotlight 300 FT-IR imaging spectrometer. Multivariate statistical
techniques incorporating principal component analysis (PCA) and linear
discriminant analysis (LDA) were used to construct a mathematical model. This
model was validated for reproducibility. Multivariate statistical analysis of
FTIR spectra collected for each cell sample permit a combination of unsupervised
and supervised methods of distinguishing cell line types. This resulted in the
clustering of cell line populations, indicating distinct bio-molecular
differences. Major spectral differences were observed in the 4000 to 800 cm-
1 spectral region. Bands in the averaged spectra for the cell line were assigned
to the major biochemical constituents including; proteins, fatty acids,
carbohydrates and nucleic acids. The combination of FT-IR spectroscopy and
multivariate statistical analysis provides an important insight into the
fundamental spectral differences between the cell lines, which differ according
to the cellular biochemical composition. These spectral differences can serve as
potential biomarkers for the differentiation of leukaemia and lymphoma cells.
Consequently these differences could be used as the basis for developing a
spectral method for the detection and identification of haematological
malignancies
From Canon Road, 900 ft. above river, S.E. to Upper Falls (109 ft. high), Yellowstone Park, U.S.A.
No full textFrom Canon Road, 900 ft. above river, S.E. to Upper Falls (109 ft. high), Yellowstone Park, U.S.A
Electric Peak (11155 ft.), highest elevation in Yellowstone Park, U.S.A.
No full textElectric Peak (11155 ft.), highest elevation in Yellowstone Park, U.S.A
Synthesis, Crystal Structure, and Photoluminescent Properties of a Series of LnIII–CuI Heterometallic Coordination Polymers Based on Cu4I3 Clusters and Ln–ina Rod Units
No full text
A novel series of LnIII–CuI heterometallic coordination polymers (HCPs) {[Ln2Cu4I3(ina)7(DMA)2]n·nDMA, Ln = La (1), Ce (2), Pr (3) Nd (4), Sm (5), Eu (6), Gd (7), Tb (8), Dy (9) Ho (10), Er (11), Yb (12), Hina = isonicotinic acid, DMA = N,N-dimethylacetamide} were synthesised by a solvothermal reaction. The structures of compounds 1–12 were characterised by elemental analysis, FT-IR spectroscopy, thermogravimetric analysis, and powder X-ray diffraction. Single crystal X-ray diffraction studies revealed that 1–12 are isomorphous and are 3D heterometallic coordination polymers based on inorganic Cu4I3 clusters and Ln2(ina)7(DMA) rod units. In addition, the luminescent properties of compounds 5–9 have been investigated in detail. All of them exhibited green light emission due to the synergistic effects of characteristic emissions of lanthanide ions and iodide-to-copper charge transfer.
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Old Faithful in action (150 ft.), the chief attraction of the Upper Geyser Basin, Yellowstone Park, U.S.A.
No full textOld Faithful in action (150 ft.), the chief attraction of the Upper Geyser Basin, Yellowstone Park, U.S.A
Most famous sight in Yellowstone Park - "Old Faithful" Geyser in action (height, 180 ft. 1,500,000 gallons each eruption), U.S.A., The
No full textMost famous sight in Yellowstone Park - "Old Faithful" Geyser in action (height, 180 ft. 1,500,000 gallons each eruption), U.S.A., Th
FT-IR, FT-Raman, NMR spectra and DFT simulations of 4-(4-fluoro-phenyl)-1H-imidazole
No full textWOS: 000317987400006The FT-IR, FT-Raman and FT-NMR spectra of the compound 4-(4-Fluoro-phenyl)-1H-imidazole (4-FPI) were recorded and analyzed. Density functional method (B3LYP level with the 6-311G(d, p) and 6-311++G(d, p) and cc-pVQZ as basis sets) has been used to compute optimized geometry, vibrational wavenumbers of the 4-FPI. Only one tautomeric form was found most stable by using DFT/B3LYP. The detailed interpretation of the vibrational spectra was carried out with the aid of total energy distribution following the scaled quantum mechanical force field methodology. Potential Energy Surface scan studies has also been carried out by ab initio calculations with the same basis sets.Ahi Evran UniversityAhi Evran UniversityThe author (Y. Erdogdu) would like to thank Ahi Evran University Research Fund for its financial support. We would like to thank the central laboratory of METU (ODTU) for recording FT-Raman spectra, Gazi University Art and Science Faculty Department of Chemistry for recording FT-IR spectra
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[Roundtable Writer's Breakfast, A Sailor's Perspective Series 2 of 2, "My Golden Nuggets: Life Changing Devotions and Meditations" ft. author Ronnie C. King.]
No full textVideo recording from The Black Academy of Arts and Letters recorded during their Roundtable Writer's Breakfast, A Sailor's Perspective Series 2 of 2, "My Golden Nuggets: Life Changing Devotions and Meditations" ft. author and Navy Captain and Chaplain Ronnie C. King. King talks about his time and career with the US Military
[Roundtable Writer's Breakfast, A Sailor's Perspective Series 2 of 2, "My Golden Nuggets: Life Changing Devotions and Meditations" ft. author Ronnie C. King.]
No full textVideo recording from The Black Academy of Arts and Letters recorded during their Roundtable Writer's Breakfast, A Sailor's Perspective Series 2 of 2, "My Golden Nuggets: Life Changing Devotions and Meditations" ft. author and Navy Captain and Chaplain Ronnie C. King. King talks about his time and career with the US Military
Retrospektivna analiza utjecaja funkcionalnih parametara štitnjače na tromboembolijske događaje
No full textObjectives: Thyroid hormones are known to have numerous actions on body systems and functions, but their influence on blood coagulation and thrombus formation and therefore being a risk factor for developing a stroke, is less commonly discussed. The aim of this study is to observe if there could be a possible connection between thyroid functional parameters and the occurrence of a stroke, by investigating numerous laboratory parameters. We hypothesize that patients that experienced a stroke differ from their thyroid functional and coagulation parameters to patients that did not experience a stroke.
Materials and methods: This study was conducted in the form of retrospective case-control study. There are 134 patients in the stroke group, whereas the non-stroke group consists of 139 patients. All of them are older than 18 years and were admitted and diagnosed at the hospital of Coburg at the time between 2020 and 2023. Only patients with obtained thyroid functional and coagulation parameters were included into this study. The blood test that was the first one obtained in the hospital, was used for further analysis.
Results: When comparing the stroke and non-stroke groups, FT₃, TSH, PTT, Quick values, and the FT₃/FT₄ ratio were significantly different. FT₃ correlated with FT₄ in both groups, and with TSH, PTT, and Quick in the non-stroke group. FT₄ only showed a correlation with FT₃ and TSH in both groups, and TSH correlated with FT₃ in the non-stroke group and TSH in both groups. Among patients taking anticoagulants, FT₃, TSH, PTT, and Quick values were significantly different, while only Quick differed in those not taking anticoagulants. Patients taking thyroid medication showed no significant differences between the stroke and non-stroke groups, but those not on thyroid medication had significantly different TSH and PTT values.
Conclusion: It was confirmed that patients that experienced a stroke show higher FT₃ and lower TSH values compared to patients that did not suffer from stroke. Patients with a stroke show a different relation of FT₃/FT₄ in comparison to the non-stroke group. It was verified that patients that suffered from a stroke display lower PTT and higher Quick values than patients that did not experience a stroke. The sole correlation between thyroid function and coagulation parameters was observed with FT₃, which is related to PTT and Quick in the non-stroke group. Anticoagulants seem to influence FT₃ and TSH values in the blood, whereas thyroid medication affects PTT values.Ciljevi: Poznato je da tiroidni hormoni imaju brojne učinke na tjelesne sustave i funkcije, ali njihov utjecaj na zgrušavanje krvi i stvaranje tromba, te time kao faktor rizika za razvoj moždanog udara, rjeđe se raspravlja. Cilj ovog istraživanja je promatrati može li postojati moguća povezanost između funkcionalnih parametara štitnjače i pojave moždanog udara, istražujući brojne laboratorijske parametre. Pretpostavljamo da se pacijenti koji su doživjeli moždani udar razlikuju od svojih tiroidnih funkcionalnih i koagulacijskih parametara u odnosu na pacijente koji nisu doživjeli moždani udar.
Materijali i metode: Ovo istraživanje provedeno je u obliku retrospektivne studije slučaj-kontrola. U grupi s moždanim udarom nalazi se 134 pacijenata, dok u grupi bez moždanog udara ima 139 pacijenata. Svi su stariji od 18 godina i bili su primljeni i dijagnosticirani u bolnici u Coburgu u razdoblju između 2020. i 2023. godine. U istraživanje su uključeni samo pacijenti s dobivenim funkcionalnim i koagulacijskim parametrima štitnjače. Krvni test koji je prvi dobiven u bolnici korišten je za daljnju analizu.
Rezultati: Pri usporedbi grupa s moždanim udarom i bez moždanog udara, vrijednosti FT₃, TSH, PTT, Quick te omjer FT₃/FT₄ značajno su se razlikovale. FT₃ je korelirao s FT₄ u obje grupe, te s TSH, PTT i Quick u grupi bez moždanog udara. FT₄ je pokazao korelaciju samo s FT₃ i TSH u obje grupe, dok je TSH korelirao s FT₃ u grupi bez moždanog udara i TSH u obje grupe. Među pacijentima koji uzimaju antikoagulanse, vrijednosti FT₃, TSH, PTT i Quick bile su značajno različite, dok se samo Quick razlikovao kod onih koji nisu uzimali antikoagulanse. Pacijenti koji su uzimali lijekove za štitnjaču nisu pokazali značajne razlike između grupa s moždanim udarom i bez moždanog udara, ali oni koji nisu uzimali lijekove za štitnjaču imali su značajno različite vrijednosti TSH i PTT.
Zaključci: Potvrđeno je da pacijenti koji su doživjeli moždani udar imaju više vrijednosti FT₃ i niže vrijednosti TSH u usporedbi s pacijentima koji nisu imali moždani udar. Pacijenti s moždanim udarom pokazuju drugačiji omjer FT₃/FT₄ u usporedbi sa skupinom bez moždanog udara. Verificirano je da pacijenti koji su pretrpjeli moždani udar imaju niže vrijednosti PTT i više vrijednosti Quick u usporedbi s pacijentima koji nisu doživjeli moždani udar. Jedina korelacija između funkcije štitnjače i parametara koagulacije uočena je s FT₃, koji je povezan s PTT i Quick u skupini bez moždanog udara. Čini se da antikoagulansi utječu na vrijednosti FT₃ i TSH u krvi, dok lijekovi za štitnjaču utječu na vrijednosti PTT
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