405 research outputs found
Issei, "Manzanar, a photograph essay"
No full textA photograph of an Issei man, a Japanese immigrant, with chrysanthemums. Also includes an essay about the Issei. A page from: Manzanar, a photograph essay (csudh_uye_0001).The Chris S. Uyemura Manzanar Photograph Collection consists of a pictorial essay, “Manzanar, a photographic essay,” and additional loose photos, which were compiled and collected by Chris S. Uyemura. The essay contains photographs, texts, and newspaper clippings, and was submitted to Professor Donald T. Hata of the Department of History at CSU Dominguez Hills. The collection depicts the incarceration of people of Japanese ancestry in the Manzanar camp during World War II as well as reflects the events, contrasting with photographs of the Manznar National Historic Site, which illustrates what is left of the camp today. The collection was originally named as “Asian Pacific Studies Collection Box 14.
Identification of novel cancer-associated genes from genetic and epigenetic aberration in cancer cells detected by in-house BAC array-based approach
No full text第39回遺伝医学研究会 2006年10月6日（金） 東京女子医科大学 第二臨床講
Early Gardena Valley and the Issei
No full textBook about the development of the Gardena Valley and the Issei who moved there. Table of contents includes: "Acknowledgments," "Introduction," "Defining Geographical Locations," "Japanese Migration into Los Angeles and Southern California," "Historical Development of the South Bay," "Early Japanese Settlers in Gardena Valley," "Rise of the Strawberry Industry," "Moneta: The Formation of a Community," "Dispersion of Japanese Throughout the Gardena Valley," "Inter-Ethnic Perceptions in Gardena Valley, 1910-1925," "The 1930s," "1940-1941," "After the War," and "References."The Sakimoto Family papers contains correspondence, greeting cards, photographs, poems, booklets, and other material related to the Poston incarceration camp and Japanese Americans residing in California. The other photographs in the collection are related to a Japan tour group
A homozygous mutation of VWA3B causes cerebellar ataxia with intellectual disability
No full textBackground: Hereditary cerebellar ataxia constitutes a heterogeneous group of neurodegenerative disorders, occasionally accompanied by other neurological features. Genetic defects remain to be elucidated in approximately 40% of hereditary cerebellar ataxia cases in Japan. We attempted to identify the gene responsible for autosomal recessive cerebellar ataxia with intellectual disability. Methods: The present study involved three patients in a consanguineous Japanese family. Neurological examination and gene analyses were performed in all family members. We performed genome-wide linkage analysis including single nucleotide polymorphism arrays, copy-number variation analysis and whole exome sequencing. To clarify the functional alteration resulting from the identified mutation, we performed cell viability assay of cultured cells expressing mutant protein. Results: One homozygous region shared among the three patients on chromosomes 2p16.1-2q12.3 was identified. Using whole exome sequencing, six homozygous variants in genes in the region were detected. Only one variant, VWA3B c.A1865C, results in a change of a highly conserved amino acid (p.K622T) and was not present in control samples. VWA3B encodes a von Willebrand Factor A Domain-Containing Protein 3B with ubiquitous expression, including the cerebellum. The viability of cultured cells expressing the specific K622T mutation was proved to decrease through the activation of apoptotic pathway. Conclusions: Mutated VWA3B was found to be likely associated with cerebellar degeneration with intellectual disability. Although a rare cause of cerebellar degeneration, these findings indicate a critical role for VWA3B in the apoptosis pathway in neuronal tissues
Abstract 391: Identification of a novel tumor-suppressor gene through methylome analysis in smoking-associated lung adenocarcinoma
No full textAbstract 4274: The contribution of deleterious germ-line mutations of susceptibility genes to ovarian, fallopian tube, and peritoneal cancers in Japanese
No full textAbstract
Different ethnic groups present specific morphological features in ovarian cancer (OC). High-grade serous OC is more frequently found in Caucasian women, in contrast clear cell OC is more frequently found in East Asian women. Although inherited mutations of BRCA1 or BRCA2 (BRCA1/2) and other genes are known to predispose to OC, the contributions of these inherited mutations on disease burden is not well characterized in Japanese OC patients. Using a comprehensive genetic testing panel, the aim of our study was to identify the prevalence of pathogenic germ-line mutations of candidate genes associated with genetic predisposition to OC in Japanese patients with ovarian, fallopian tube, or peritoneal cancer.Samples from 236 individuals with unselected ovarian, fallopian tube, or peritoneal cancer, which were obtained from the Keio Women’s Health Biobank (KWB) from the School of Medicine at Keio University (Tokyo, Japan), were used for this study. Germ-line DNA was enriched using the SureSelect XT Target Enrichment System (Agilent Technologies) designed for 75 or 79 genes as a custom OC panel, followed by sequencing using MiSeq (Illumina). Detected variants, including point mutations, small indels, and a gross deletion, were classified according to the American College of Medical Genetics and Genomics (ACMG) recommendations. Furthermore, BRCA1/2 variants were interpreted using resources from Myriad Genetic Laboratories.Forty-two (17.8%) OC patients had germ-line mutations of cancer predisposition genes. BRCA1/2 pathological germ-line mutations were found in 27 cases (11.4%) while six cases (2.5%) had a mutation in a mismatch repair gene (MLH1, MSH2, MSH6, or PMS2). Furthermore, ten cases (4.2%) had germ-line mutations in the RAD51D, ATM, MRE11A, FANCC, or GABRA2 genes. Of patients with a BRCA1/2 mutation (n=27), we found that the most common histological subtype was high-grade serous OC, but we also found two cases with clear cell carcinoma. Of 42 cases with an inherited mutation, we found that 25% (6/24) had no family history of cancer, and 78% (31/41) were under 60 years old at diagnosis.We found that approximately 18% of unselected Japanese patients with ovarian, fallopian tube, or peritoneal cancer were associated with inherited mutations of cancer-predisposing genes. Our study demonstrates that comprehensive genetic testing is informative for all women with ovarian, fallopian tube, and peritoneal cancers to establish personalized clinical management and genetic counseling, irrespective of the patient's histological subtypes, ages or family histories.
Citation Format: Akira Hirasawa, Issei Imoto, Takuya Naruto, Tomoko Akahane, Wataru Yamagami, Nobuyuki Susumu, Hitoshi Tsuda, Daisuke Aoki. The contribution of deleterious germ-line mutations of susceptibility genes to ovarian, fallopian tube, and peritoneal cancers in Japanese [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 4274. doi:10.1158/1538-7445.AM2017-4274</jats:p
Ancestral Y-linked genes were maintained by translocation to the X and Y chromosomes fused to an autosomal pair in the Okinawa spiny rat Tokudaia muenninki
No full textTwo species of the genus Tokudaia lack the Y chromosome and SRY, but several Y-linked genes have been rescued by translocation or transposition to other chromosomes. Tokudaia muenninki is the only species in the genus that maintains the Y owing to sex chromosome-autosome fusions. According to previous studies, many SRY pseudocopies and other Y-linked genes have evolved by excess duplication in this species. Using RNA-seq and RT-PCR, we found that ZFY, EIF2S3Y, TSPY, UTY, DDX3Y, USP9Y, and RBMY, but not UBA1Y, had high deduced amino acid sequence similarity and similar expression patterns with other rodents, suggesting that these genes were functional. Based on FISH and quantitative real-time PCR, all of the genes except for UTY and DDX3Y were amplified on the X and Y chromosomes with approximately 10-66 copies in the male genome. In a comparative analysis of the 372.4-kb BAC sequence and Y-linked gene transcripts from T. muenninki with the mouse Y genomic sequence, we observed that multiple-copy genes in the ancestral Y genome were nonfunctional, indicating that the gene functions were assumed by amplified copies. We also found a LTR sequence at the distal end of a SRY duplication unit, suggesting that unequal sister chromatid exchange mediated by retrotransposable elements could have been involved in SRY amplification. Our results revealed that the Y-linked genes were rescued from degeneration via translocations to other sex chromosomal regions and amplification events in T. muenninki
New Year's greeting card from Mamoru and Tsuru Yamauchi to the Okine family, January 1, 1946 [in Japanese]
No full textA new year's greeting card from Mamoru and Tsuru Yamauchi in Gardena, California to the Okine family.The Okine Collection contains materials collected by Seiichi and Tomeyo Okine who were Issei flower growers in Whittier, California. It includes correspondence, photographs, financial documents, and a photo album. A large portion of the collection consists of family correspondence with Seiichi and Tomeyo Okine, including letters from their Nisei children, Masao and Makoto Okine, both soldiers overseas during World War II, to their Issei parents incarcerated in the Rohwer incarceration camp in McGehee, Arkansas. The correspondence also includes letters from their relatives and friends who are former incarcerees in the camps during the war and have “resettled” in Chicago, Illinois as well as letters from the Okines’ family members in Hiroshima, Japan during the Allied occupation of Japan. In addition, the collection includes a family photo album compiled by Dorothy Ai Aoki, a Nisei daughter to the Okines
[Daily life notes], Issei, Nisei, Kibei, Sansei
No full textStraight from the personal notebook of Pollock, there is a plethora of notes that were recorded on a daily basis, documenting the life and culture of the Fresno Assembly Center.Walter E. Pollock was the head of the service division at the Fresno Assembly Center. He was deeply affected by his time working at the center and was working on a memoir of his experiences there, but unfortunately passed away before it could be completed. The collection contains his research and draft chapters
Letter from W. Freitas to Mr. and Mrs. Seiichi Okine, October 19, [1947?]
No full textA thank you letter from Mr. Freitas to Seiichi and Tomeyo Okine for their visit and flowers.The Okine Collection contains materials collected by Seiichi and Tomeyo Okine who were Issei flower growers in Whittier, California. It includes correspondence, photographs, financial documents, and a photo album. A large portion of the collection consists of family correspondence with Seiichi and Tomeyo Okine, including letters from their Nisei children, Masao and Makoto Okine, both soldiers overseas during World War II, to their Issei parents incarcerated in the Rohwer incarceration camp in McGehee, Arkansas. The correspondence also includes letters from their relatives and friends who are former incarcerees in the camps during the war and have “resettled” in Chicago, Illinois as well as letters from the Okines’ family members in Hiroshima, Japan during the Allied occupation of Japan. In addition, the collection includes a family photo album compiled by Dorothy Ai Aoki, a Nisei daughter to the Okines
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