1,721,235 research outputs found
Correction: Microbiological diagnosis of pulmonary invasive aspergillosis in critically ill patients with severe SARS-CoV-2 pneumonia: a bronchoalveolar study (Annals of Clinical Microbiology and Antimicrobials, (2023), 22, 1, (90), 10.1186/s12941-023-00626-7)
No full textCorrection to: Annals of Clinical Microbiology and Antimicrobials (2023) 22:90 Following publication of the original article [1], the author name “Ignacio Martín-Loeches” was incorrectly written as “Ignacio Martin Loeches”. This has now been corrected with this erratum. The original article has been corrected.1 págin
Supplemental Material, Supplementary_File - Lower Respiratory Tract Infection and Short-Term Outcome in Patients With Acute Respiratory Distress Syndrome
No full textSupplemental Material, Supplementary_File for Lower Respiratory Tract Infection and Short-Term Outcome in Patients With Acute Respiratory Distress Syndrome by Fernando G. Zampieri, Pedro Póvoa, Jorge I. Salluh, Alejandro Rodriguez, Sandrine Valade, José Andrade Gomes, Jean Reignier, Elena Molinos, Jordi Almirall, Nicolas Boussekey, Lorenzo Socias, Paula Ramirez, William N. Viana, Anahita Rouzé, Saad Nseir, and Ignacio Martin-Loeches; on behalf of the TAVeM study group in Journal of Intensive Care Medicine</p
Appropriate antimicrobial therapy in critically ill patients
No full textAppropriate antibiotic therapy in the critically ill requires more specialised considerations than just selecting the most suitable antibiotic and adhering to traditional dosing guidelines. Unfortunately, most of the guideline recommendations are based on research that either underrepresent or exclude critically ill patients. The pathophysiology of critical illness, as in the case of intraabdominal sepsis, has many unique features unseen in noncritically ill patients. These include inconsistent changes in important physiological phenomena that govern drug disposition. It follows that the disposition of several antimicrobials is markedly different and variable in the critically ill relative to that described by the drug development clinical trials often conducted on healthy volunteers or noncritically ill patients. Drug disposition determines how much of a dose to administer; thus altered disposition simply means that the dose required for critically ill patients to ensure optimal effects is likely to be different. Indeed several clinical studies have illustrated that standard doses of antimicrobials such as beta-lactam antibiotics, vancomycin, aminoglycosides, fluoroquinolones and fluconazole are largely inadequate in critically ill patients due to high variability of changes in disposition. Therefore, dosing regimens should be tailored to the unique dosing requirements of individual patients. This chapter presents a discussion on the current understandings of special dosing considerations for appropriate antimicrobials therapy of critically ill patients with intraabdominal sepsis
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Current Concepts in Community and Ventilator Associated Lower Respiratory Tract Infections in ICU Patients
No full textIt is widely known that pneumonia (either community acquired or hospital acquired, as like ventilator associated pneumonia (VAP)), is the most frequent type of severe infection and continues to pose a significant burden on healthcare services worldwide. Despite new diagnostic developments, most pneumonia cases continue to be difficult to diagnose clinically, partly due to acquired antibiotic resistance and the lack of a ‘gold standard’ method of diagnosis. In other words, the lack of a rapid, accurate diagnostic test, as well as the uncertainty of the initial etiologic diagnosis and the risk stratification, results in empirical antibiotic treatments. There are significant changes in the aetiology of patients with ventilator associated lower respiratory tract infections (VA-LRTI), which are characterised by a higher incidence of multi drug resistant organisms. Evidence suggests that when patients with VA-LRTI develop organ failure, the associated mortality can be exceptionally high with frequent complications, including acute respiratory distress syndrome, acute kidney injury, and septic shock. Appropriate antibiotic treatments must consider that the present cardiovascular failure seen in patients has a different association with the patient’s mortality. Unlike patients with less severe clinical presentations, who have a higher chance of survival when the appropriate antibiotics are administered promptly, for patients with a severe subtype of the disease, the appropriateness of antibiotic treatment will impact the patient’s outcome to a lesser extent. The present review highlights certain factors detectable at the time of admission that could indicate patients who are at a high risk of bacteraemia and who, therefore, merit more intense therapy and stratified care
Faculty Opinions recommendation of Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial.
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