1,354,434 research outputs found
Giulio Ieni (1943-2003). Il senso dell'architettura e la maestria della parola
No full textIl volume miscellaneo, ripartito in quattro sezioni, offre uno spaccato – si spera non banale, ma certo amichevolmente memore – dell’amplissima produzione scientica di Giulio Ieni, in una sorta di prima guida alla consultazione della ricca documentazione che, con spontanea e accorta disponibilità, il fratello ha legato alla Biblioteca Civica di Alessandria. I curatori, parte del comitato scientico dello stesso Fondo Giulio Ieni, si sono fatti (forse indegni, ma spronati dall’affetto) latori della sua eredità culturale, con il prezioso appoggio di una folta schiera di amici, che ha voluto, con alcuni brevi contributi, onorare la sua memoria, tracciando un prolo vivo e umanissimo di un ricercatore di eccezionale competenza e di riconosciuta autorevolezza, anche sul piano internazionale. Venti testimonianze di lavoro comune si affiancano così alla riedizione di alcuni suoi testi,non sempre di facile reperimento, ma citatissimi, e una ridotta serie di “saggi d’occasione”, di piccoli xenia, che vanno a fare da corollario alla ricostruzione della sua estrema varietà di interessi, testimoniata dal regesto completo degli scritti, vero palinsesto per l’interpretazione della sua biblioteca e del suo archivio, degni, nella loro completezza e versatilità, di un vero “gentiluomo delle scienze e delle arti”
A retroperitoneal cyst with unusual urinary histogenesis: clinical and immunomorphological characteristics
No full textPrimary retroperitoneal cysts are rare benign lesions which often present as an incidental radiological finding and also cause abdominal symptoms. A 47-year-old woman was admitted to the surgery unit because of right-sided abdominal pain. Computed tomographic scan investigation confirmed a circumscribed, oval, dishomogeneous mass in the right anterior pararenal space. The final diagnosis was obtained after laparotomy excision and pathological evaluation. Immunohistochemical profile was characterized by positive expression of epithelial cystic cells for CKAE1/AE3, CK7, CK8, and CK18, with EMA sustaining the diagnosis of a benign retroperitoneal cyst of urinary system origin
Aquaporin-1 expression in fluoro-edenite-induced mesothelioma effusions: An approach by cell-block procedure
No full textObjective: Aquaporin 1 (AQP-1) is a water channel protein found in cell membranes, whose expression has been considered an independent favourable prognostic factor in pleural malignant mesothelioma (MM). The aim of this study was to evaluate the expression of AQP-1 and its prognostic value in a series of pleural MM effusions, from a geographical area with high concentrations of fluoro-edenite (FE). Methods: We selected 25 MM cases from Biancavilla (Italy), an area with high environmental concentrations of FE. Cytological samples, cell-blocks (CB), clinical and follow-up data were available for all cases. Immunohistochemistry for calretinin, CK5/6, WT1, CK7 and TTF1 was used on CB sections to confirm the cytological diagnosis of MM. Immunohistochemistry for AQP-1 was performed and high expression was defined when ≥50% of tumour cells showed linear and circumferential membranous staining. Results: The cohort included 16 men and nine women (median age: 67.5 years; range: 49-88 years). The median survival was 14 months (range 1.5-60 months), with a significant value (P = 0.006). All cases have been histologically confirmed and classified as epithelioid (16 cases), biphasic (seven cases) and sarcomatoid (two cases). AQP-1 high expression has been observed in 16 cases. Comparing AQP-1 high expression to the survival of corresponding patients, a significant association with a slight increased overall survival of 12 months has been demonstrated. Nine patients with a AQP-1 score less than 50% showed a shorter median overall survival (7 months). Conclusions: AQP-1 high expression is detectable on cytological samples of FE-induced MM with a prognostic value
Clear cell colorectal carcinoma: a case report with analysis of neo-angiogenesis
No full textNo abstract availabl
Letter to the Editor regarding the paper by Park et al., Extra-gain of HER2-positive cases through HER2 reassessment in primary and metastatic sites in advanced gastric cancer with initially HER2-negative primary tumours: Results of GASTric cancer HER2 reassessment study 1 (GASTHER1)
No full textLymph node fine-needle cytology: Beyond flow cytometry
No full textLymph node (LN) fine-needle cytology (FNC) coupled with flow cytometry immunophenotyping provides relevant information for the diagnosis of non-Hodgkin lymphoma (NHL). Numerous studies have shown FNC samples to be suitable for different molecular procedures; in this review, some of the molecular procedures most commonly employed for NHL are briefly described and evaluated in this perspective. Fluorescence in situ hybridization and chromogenic in situ hybridization are briefly described. Polymerase chain reaction (PCR)-based assays are used to identify and quantify mutations and translocations, namely immunoglobulin (IGH) and T-cell receptor rearrangements by clonality testing and IGVH somatic hypermutations either by Sanger sequencing, single-strand conformational polymorphisms or RT-PCR strategies. High-Throughput technologies (HTT) encompass numerous and different diagnostic tools that share the capacity of multiple molecular investigation and sample processing in a fast and reproducible manner. HTT includes gene expression profiling, comparative genomic hybridization, single-nucleotide polymorphism arrays and next-generation sequencing technologies. A brief description of these tools and their potential application to LN FNC is reported. The challenge for FNC will be to achieve new knowledge and apply new technologies to FNC, exploiting its own basic qualities
Immunohistochemical expression of glypican-3 in adrenocortical carcinoma: A potential cause of diagnostic pitfalls
No full textno abstract availabl
HER2 status in unusual histological variants of gastric adenocarcinomas
No full textAim To investigate HER2 status in a cohort of 109 gastric adenocarcinomas also including unusual variants, such as 14 hepatoid (HAS) and 9 mitochondrion-rich (MRC), characterised by an opposing clinical behaviour.Methods and Results Using HercepTest (DAKO) and FISH test (pharmDx DAKO), HER2 overexpression/amplification was encountered in 23 of 109 (21.10%) of all gastric adenocarcinomas. A progressive increase in HER2 overexpression was observed moving from the poorly cohesive histotype to MRC, tubular adenocarcinomas and HAS. A statistically significant difference was found between poorly cohesive carcinomas and the others; a similar significant difference was encountered between HAS and all other variants of adenocarcinoma. HER2 overexpression was significantly associated with high grade, advanced stage, high Ki-67 labelling index value and death from gastric cancer. Multivariate analysis identified HER2 overexpression as an independent unfavourable prognostic variable for adenocarcinomas as a whole and also for the HAS variant.Conclusions Trastuzumab has been confirmed as an additional useful therapeutic standard option for patients with HER2-positive advanced gastric cancers, and also in aggressive variants of adenocarcinomas such as HAS
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