205,470 research outputs found
A model driven IDE for M-industries’ Alan
No full textWhile software is becoming increasingly important in our world, software development is also advancing with an increasing pace. One of the reasons is the increase in available information, which triggered the birth of a new programming paradigm: Model Driven Development (henceforth MDD). Though this can shorten the development time and make it easier, there is no real support for this method, and also no fully developed environment. This is where M-industries' Alan is key. A new MDD platform, but with no editor support. That was the initial scope of our project: create an editor capable of supporting Alan. This was no easy task, and so some preliminary research was done, which evaluates existing web-based editors based on the requirements set by us. The main development phase consisted of agile programming cycles where the targets and tasks were subject to changes. This enabled us to focus on creating an intrinsically correct system instead of a fully featured one that needs a lot of patching and cleaning. The result was a well rounded, integrated IDE that has powerful Alan specific features, but may lack some more basic editor features. The IDE was not only developed to aid in model driven development, but was actually developed itself in a model driven way, using M-industries' platform. This allowed for a deep integration with Alan, where the language definition became part of the IDE. To do this, the concept of an "editor state" was introduced, which proved to be an essential an powerful concept for creating an editor for model driven development.Software TechnologyElectrical Engineering, Mathematics and Computer Scienc
Adinda: A knowledgeable, browser-based IDE
No full textIn practice, many people have to work together to develop and maintain a software system. However, the programmer’s key tool, the Integrated Development Environment (IDE), is a solo-tool, serving to help individual programmers understand and modify the system. Such an IDE does not leverage the knowledge other team members may have of the design and implementation of the system. We propose to resolve this problem by exploring, experimentally, new ways of inferring knowledge from past IDE-interactions, and of maximizing collaboration among developers. Our approach, called ADINDA, revolves around transforming the IDE into a set of integrated services, accessible via a web browser, and enriched with Web 2.0 technologies. Such services will not only help developers perform traditional IDE tasks, but also facilitate the required informal communication and collaboration needs of software development projects. In this paper, we report on our vision, approach and challenges for building ADINDA, and initial results. Preprint accepted for publication in Proceedings of the ICSE New Ideas and Emerging Results Track, ACM Press, 2010.Software TechnologyElectrical Engineering, Mathematics and Computer Scienc
Ide Desain Rumah di Lahan 100 - 200 m²
No full textLahan dengan luas 100 – 200 m² kebanyakan dimiliki oleh masyarakat perkotaan. Di lahan ini agak sulit dirancang sebuah hunian yang nyaman dan sehat dengan tampilan yang srtistik. Namun, karena ingin memenuhi kebutuhan tersebut, berbagai cara pun dilakukan pemiliknya. Salah satunya dengan memanfaatkan jasa perancang bangunan untuk urusan ide bangunan. Melalui buku ini Anda akan diberikan 28 ide desain rumah yang artistik, nyaman, dan sehat
Nitrosylation of IDE by GSNO.
No full text<p>The nitrosylation of purified recombinant IDE by GSNO, but not GSNO(ox) is demonstrated using the biotin switch method. IDE was either not treated (lanes 2 and 6), treated with 10<sup>−4</sup> M GSNO(ox) (lanes 3 and 7) or 10<sup>−4</sup> M GSNO (lanes 4 and 8). Lanes 2 through 4 show controls without the biotin reagent. Lanes 6 through 8 show enzyme subjected to biotin labeling. Lanes 1 and 5 are molecular weight markers with indicated MW. IDE at approximately 110 K MW is indicated.</p
Glutathionylation of purified IDE by GSSG.
No full text<p>Post-translational modification of IDE by glutathionylation was measured by Western blotting with an anti-glutathione antibody (right panel). Anti-IDE blot is shown on the left. Partially-purified IDE was left untreated (lane 1) or treated with GSH [10<sup>−4</sup>, 10<sup>−3</sup>, or 10<sup>−2</sup> M, lanes 2 to 4 respectively] or GSSG [10<sup>−4</sup>, 10<sup>−3</sup>, or 10<sup>−2</sup> M, lanes 7 to 9, respectively]. Molecular weight markers, with their sizes indicated, are in lane 5. Lane 6 is a blank. GSSG dose-dependently increased glutathionylation of IDE, while GSH had no effect. Blot is representative of 4 similar experiments.</p
Dr. Duane M. Jackson, Morehouse College, July 2011
No full textThis video is a conversation with Dr. Duane M. Jackson. Dr. Jackson talks about his paper, "Recall and the Serial Position Effect: The Role of Primacy and Recency on Accounting Students' Performance." Jackie Daniel, AUC Woodruff Library, is the interviewer
Glutathionylation of IDE by GSNO(ox).
No full text<p>Post-translational modification of IDE by glutathionylation was measured by Western blotting with an anti-glutathione antibody (right panel). Anti-IDE blot of the same gel is shown in the left panel. Partially-purified IDE was left untreated (lane 1) or treated with GSNO [10<sup>−6</sup>, 10<sup>−5</sup>, or 10<sup>−4</sup> M, lanes 2 to 4 respectively] or GSNO(ox) [10<sup>−6</sup>, 10<sup>−5</sup>, or 10<sup>−4</sup> M, lanes 6–8, respectively]. Molecular weight markers, with their sizes indicated, are in lane 5. Lane 8 (right panel) shows increased glutathione staining with GSNO(ox), while GSNO had no effect. Blot is representative of 4 similar experiments.</p
Insulin-degrading enzyme (IDE): a novel heat shock-like protein.
No full textInsulin-degrading enzyme (IDE) is a highly conserved zinc metallopeptidase that is ubiquitously distributed in human tissues, and particularly abundant in the brain, liver, and muscles. IDE activity has been historically associated with insulin and beta-amyloid catabolism. However, over the last decade, several experimental findings have established that IDE is also involved in a wide variety of physiopathological processes, including ubiquitin clearance and Varicella Zoster Virus infection. In this study, we demonstrate that normal and malignant cells exposed to different stresses markedly up-regulate IDE in a heat shock protein (HSP)-like fashion. Additionally, we focused our attention on tumor cells and report that (i) IDE is overexpressed in vivo in tumors of the central nervous system (CNS); (ii) IDE-silencing inhibits neuroblastoma (SHSY5Y) cell proliferation and triggers cell death; (iii) IDE inhibition is accompanied by a decrease of the poly-ubiquitinated protein content and co-immunoprecipitates with proteasome and ubiquitin in SHSY5Y cells. In this work, we propose a novel role for IDE as a heat shock protein with implications in cell growth regulation and cancer progression, thus opening up an intriguing hypothesis of IDE as an anticancer target
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