196,238 research outputs found

    Impaired endothelium-dependent vascular reactivity in patients with familial combined hyperlipidaemia.

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    1. Heart. 2007 Jan;93(1):78-81. Epub 2006 Jun 28. Impaired endothelium-dependent vascular reactivity in patients with familial combined hyperlipidaemia. De Michele M, Iannuzzi A, Salvato A, Pauciullo P, Gentile M, Iannuzzo G, Panico S, Pujia A, Bond GM, Rubba P. Division of Cardiology, Moscati Hospital, Aversa, Italy. BACKGROUND: Familial combined hyperlipidaemia (FCHL) is associated with a markedly increased risk of premature coronary artery disease. This study was designed to evaluate whether preclinical atherosclerotic functional abnormalities are detectable in the arteries of patients with FCHL. METHODS: 60 subjects were recruited for the study: 30 probands of families with FCHL (mean (standard deviation (SD)) age 48 (10) years, 77% men), defined by fasting total plasma cholesterol or triglyceride concentration >250 mg/dl (>6.5 mmol/l cholesterol, >2.8 mmol/l triglyceride) and by the occurrence of multiple lipoprotein phenotypes within a family, and 30 age-matched and sex-matched healthy controls. All subjects underwent high-resolution B-mode ultrasound examination and the brachial arterial reactivity, a marker of endothelial function, was measured by a semiautomated computerised program. Lipid profile, resting blood pressure, body mass index (BMI), smoking status, insulin and homocysteine levels were also determined. RESULTS: Compared with controls, patients with FCHL had significantly higher BMI, diastolic blood pressure and insulin levels. No difference was observed in baseline brachial diameter between the two groups (mean (SD) 3.45 (0.51) mm for FCHL v 3.60 (0.63) mm for controls; p = 0.17). In response to flow increase, the arteries of the controls dilated (mean (SD) 8.9% (4.9%), range 2.3-20.8%), whereas in the patients with FCHL, brachial arterial reactivity was significantly impaired (5.5% (2.5%), range 0-10.1%; p = 0.002). In multivariate linear regression analysis, apolipoprotein B and BMI were independent determinants of brachial artery response to reactive hyperaemia. CONCLUSIONS: The findings of our study suggest that vascular reactivity is impaired in the arteries of patients with FCHL. PMCID: PMC1861336 PMID: 16807271 [PubMed - indexed for MEDLINE

    Advanced power cycler with intelligent monitoring strategy of IGBT module under test

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    Power cycling (PC) test is one of the important test methods to assess the reliability performance of power device modules related to packaging technology, in respect to temperature stress. In this paper, an advanced power cycler with a real-time VCE_ON and VF measurement circuit for the IGBT and diode, which for the wear-out condition monitoring are presented. This advanced power cycler allows to perform power cycling test cost-effectively under conditions close to real power converter applications. In addition, an intelligent monitoring strategy for the separation of package-related wear-out failure mechanisms has been proposed. By means of the proposed method, the wear-out failure mechanisms of an IGBT module can be separated without any additional efforts during the power cycling tests. The validity and effectiveness of the proposed monitoring strategy are also verified by experiments

    An evaluation of the use of 4-methylumbelliferyl-beta-D-glucuronide (MUG) in different solid media for the detection and enumeration of Escherichia coli in foods

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    Abstract: The use of 4-methylumbelliferyl-beta-D-glucuronide (MUG) in different solid media for the detection and enumeration of Escherichia roll in foods was evaluated by; testing the effects of different substrate concentrations (50 or 100 mu g ml(-1)), incubation temperatures (37 or 41.5 degrees C) and incubation times (8, 12, 24 and 48 h). Different kinds of foods, both naturally and artificially contaminated, were analysed. The use of selective media without differential substances and an incubation time of 24 h Seem to be worthy of recommendation. In this case an incubation temperature of 37 degrees C would be preferred and the MUG concentration could be reduced to 50 mu g ml(-1). Incubation times: shorter than 24 h, which may cause a loss of sensitivity, require higher incubation temperatures (41.5 degrees C) and MUG concentration (100 mu g ml(-1))

    Editorial

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    This special issue of Microelectronics Reliability contains the papers presented at the 23rd European Symposium on the Reliability of Electron Devices, Failure Physics and Analysis, (ESREF 2012) which was held in Cagliari (Sardinia), Italy, from October 1 to 5, 2012. Since 1990, ESREF traditionally focuses on the latest research findings in Quality and Reliability of materials, devices, and circuits for microelectronics. It provides the annual European forum, where researchers coming from all over the world present the results of their researches related to the various aspects of the reliability management and define the state of the art in advanced analysis techniques for present and future semiconductor applications, with a particular attention to specification, technology and manufacturing, test, control and analysis

    Nonlinear dynamics of a wind turbine tower

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    The recent diffusion of wind turbines has evidenced problems about their vulnerability in different site conditions, as shown by recent collapse of wind towers after severe actions. The analysis of structures subjected to variable actions can be carried out by means of several methods with different levels of accuracy, among which the nonlinear dynamics is generally recognized as the most reliable one. This paper develops a numerical procedure to obtain approximate solutions for rigid-plastic response of structures subjected to base harmonic pulse. The model is applied to a wind turbine tower subjected to inertia forces generated by an harmonic ground acceleration, in which the failure is assumed depending on the formation of shear hinges. The approach presents the advantages of rigid-plastic procedures, in particular an efficient representation of the post-elastic behaviour of the structure, low computational competence and limited number of mechanical parameters
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