1,721,165 research outputs found
Premessa
No full textPresentazione del volume e cenni storici ai contenuti e all'interesse del carteggio tra Clara Maffei e Carlo Tenca, due tra i maggiori protagonisti della letteratura italiana in età risorgimentale
A study of the role of different forms of chronic rhinitis in the development of otitis media with effusion in children affected by adenoid hypertrophy.
No full textOBJECTIVE: The aim of the present study was to evaluate the role of the different
forms of chronic rhinitis in the pathogenesis of otitis media with effusion in
children affected by obstructive adenoid hypertrophy.
METHODS: 81 patients, aged between 4 and 15 years (mean age of 6.9 years),
affected by obstructive adenoid hypertrophy were evaluated. All patients
underwent accurate history taking, physical examination with endoscopy of the
nasopharynx, skin prick test, nasal cytology and hearing evaluation.
RESULTS: Nasal citology showed that 21% of patients had a non-allergic rhinitis
(NAR) subtype, 17.4% NAR overlapping with infectious rhinitis (IR), 29.6% IR,
4.9% allergic rhinitis (AR), 2.5% AR overlapping with IR and the remaining 24.6%
a negative cytology. The presence of OME was positively correlated with
neutrophils (p = 0.01) and mast cells (p = 0.022), while it was negatively
correlated with the presence of eosinophils (p = 0.02) and bacteria (p = 0.02).
CONCLUSIONS: A chronic rhinitis was present in more than 70% of children with AH
and 60% of them showed OME. Nasal cytology together with SPT showed that AR was
rarely present in this group of children, while the mast-cells and neutrophils
positively correlated with OME
Does the type of rhinitis influence development of otitis media with effusion in children?
No full textOtitis media with effusion (OME) is characterized by the presence of fluid in the middle ear cavity behind an intact eardrum and is considered a multifactorial condition with Eustachian tube dysfunction as the underlying pathophysiologic condition. One of the most debated causes of OME is allergy, in particular allergic rhinitis. The aim of this paper is to review the role of rhinitis in the development of OME and in particular the role of both allergic (AR) and non-allergic rhinitis (NAR). Most of the recent literature confirms the role of AR in the development of OME, while there are few reports on the role of NAR. In non-allergic children affected by obstructive adenoid hypertrophy, the presence of mast cells in the nasal smear was associated with a high risk of developing a chronic OME
Intranasal sodium hyaluronate on the nasal cytology of patients with allergic and nonallergic rhinitis.
No full textBACKGROUND: Rhinitis is an extremely common medical problem characterized by
nasal congestion, clear rhinorrhea, sneezing, and itching. Hyaluronate is an
endogenous compound that has an important role in mucociliary clearance by the
epithelial surface of the nasal passages and in mucosal surface healing and
repair. The objective of this work was to determine the effects of intranasal
administration of sodium hyaluronate on nasal cytology in patients with allergic
and nonallergic rhinitis.
METHODS: In a single-center, randomized, blinded trial, 78 patients received
intranasal mometasone and oral desloratadine plus either intranasal sodium
hyaluronate or saline for 1 month. Nasal cytology was performed and the change
from baseline in the numbers of neutrophils, eosinophils, mast cells,
lymphocytes, and infective species was determined. Other outcomes included
changes in symptoms and the endoscopic appearance of the nasal mucosa, and
tolerability.
RESULTS: Patients receiving sodium hyaluronate experienced a significant decrease
in the median neutrophil count seen on nasal cytology compared with controls (p =
0.001). Sodium hyaluronate was associated with significant improvements in
sneezing, rhinorrhea, and nasal congestion, and on exudate seen on endoscopy at 1
month compared with baseline. Intranasal sodium hyaluronate received better
tolerability scores than saline over the 1-month treatment period.
CONCLUSION: The addition of sodium hyaluronate to intranasal corticosteroid and
systemic antihistamine reduced the neutrophil count seen on nasal cytology in
patients with allergic and nonallergic rhinitis and improved several clinical and
endoscopic parameters while being well tolerated. These data provide encouraging
evidence of the efficacy of sodium hyaluronate in the treatment of this common
disease
Characterization, conservation and sustainability of endangered animal breeds in Campania (Southern Italy).
No full textSix bovine cosmid-derived microsatellites mapping different syntenic groups are fluorescence in situ hybridization-mapped to six river buffalo chromosomes.
No full textSix bovine cosmid-derived microsatellites (IDVGA53, BTA3/U6; IDVGA61, U13; IDVGA41, BTA12/U27; IDVGA32, BTA15/U19; IDVGA59, BTA26/U26 and IDVGA71, U8), previously assigned to cattle chromosomes, were FISH-mapped to river buffalo chromosomes (BBU) 6q15, 8q34, 13q15, 16q25, 23q22 and 24q13 respectively. Sequential FISH/RBA-banding allowed the precise identification of chromosomes and localization of probe-signals on chromosome bands. These localizations allowed us to assign indirectly, for the first time, six bovine syntenic groups to river buffalo chromosomes, thereby extending its physical map. The localization of IDV-GA71 (bovine U8) to the marker BBU24 adds further information to resolve definitively cattle chromosome ambiguities involving cattle chromosomes 25, 27 and 29
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
The β-casein in camels: molecular characterization of the CSN2 gene, promoter analysis and genetic variability.
No full textThe β-casein is the most abundant protein in camel milk and its encoding gene (CSN2) is considered in other species a 'major' gene for the presence of alleles associated to different level of expression. In the present paper, we report for the first time the characterization of the nucleotide sequence of the whole β-casein-encoding gene (CSN2) plus 2,141 bp at the 5'-flanking region in Camelus dromedarius. The promoter region and the complete cDNA are also provided for the first time in Camelus bactrianus. The gene is spread over 7.8 kb and consists of 9 exons varying in length from 24 bp (exon 5) to 519 bp (exon 7), and 8 introns from 95 bp (intron 5) to 1,950 bp (intron 1). The composite response element (CoRE) region was identified in the promoter, whereas the presence of mature microRNA sequences improves the knowledge on the factors putatively involved in the gene regulation. A total of 46 polymorphic sites have been detected. The transition g.2126A>G falls within the TATA-box of dromedary CSN2 promoter with a putative influence on the transcription factor binding activity. The frequency of the G allele is 0.35 in a population of 180 she-camels belonging to 4 different ecotypes. In the same population, a conservative SNP (g.4175C>A) was found at the codon 7 of the signal peptide, whereas a comparative analysis with a cDNA sequence available in the database evidenced a missense SNP (g.4180T(Leu)>G(Arg)) at exon 2. Four SNPs were found in the bactrian camel. The SNP c.666G>A is responsible for the amino acid change Met(201)→Ile and it represents the first missense allele at the β-casein in camels. Finally, five interspersed repeated elements were identified at intronic level, whereas the presence of putative bio-functional peptides belonging to ACE-inhibitor and anti-oxidative families confirms the potential protective role of the camel milk for the human nutrition
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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