169,765 research outputs found
A screening of antineoplastic drugs for acute myeloid leukemia reveals contrasting immunogenic effects of etoposide and fludarabine
No full textBackground: Recent evidence demonstrated that the treatment of acute myeloid leukemia (AML) cells with daunorubicin (DNR) but not cytarabine (Ara-C) results in immunogenic cell death (ICD). In the clinical setting, chemotherapy including anthracyclines and Ara-C remains a gold standard for AML treatment. In the last decade, etoposide (Eto) and fludarabine (Flu) have been added to the standard treatment for AML to potentiate its therapeutic effect and have been tested in many trials. Very little data are available about the ability of these drugs to induce ICD. Methods: AML cells were treated with all four drugs. Calreticulin and heat shock protein 70/90 translocation, non-histone chromatin-binding protein high mobility group box 1 and adenosine triphosphate release were evaluated. The treated cells were pulsed into dendritic cells (DCs) and used for in vitro immunological tests. Results: Flu and Ara-C had no capacity to induce ICD-related events. Interestingly, Eto was comparable to DNR in inducing all ICD events, resulting in DC maturation. Moreover, Flu was significantly more potent in inducing suppressive T regulatory cells compared to other drugs. Conclusions: Our results indicate a novel and until now poorly investigated feature of antineoplastic drugs commonly used for AML treatment, based on their different immunogenic potential
Variazioni della temperatura corporea rilevata a diversi livelli durante interventi di Chirurgia Addominale Maggiore
No full textGli autori espongono brevemente i meccanismi della termoregolazione e ricordano che già da molti anni è noto durante interventi in anestesia generale i pazienti si raffreddano di 1-2 C°.Gli autori poi espongono i risultati dei controlli eseguiti in due tipi di chirurgia addominale maggiore ponendo un accento particolare sul controllo della temperatura vescicale
Variazioni di alcune componenti del quadro lipidico dopo infusione endovenosa di Diprivan
No full textLa nuova formulazione del Diprivan ha consentito una nuova generalizzazione del suo impiego in anestesia.Gli autori hanno voluto controllare eventuali variazioni del quadro lipidico dopo infusione e.v. continua del farmaco per interventi di media e piccola chirurgia
Caspase-3 overexpression is correlated with apoptotic death of PBMC in ICU patients with sepsis
No full textMuch work has raised the view that septic patients are undergoing accelerated poptotic process that results in the depletion of lymphocyte population. Caspases are crucial mediators of apoptosis and among them caspase-3 appears to be a frequently activated death protease
Modificazioni Cardiocircolatorie e Respiratorie indotte dal Salbutamolo durante Anestesia inalatoria condotta con Alotano ed Etrano
No full textDopo aver brevemente ricordato i vari tipi di recettori adrenergici,gli autori espongono i risultati ottenuti somministrando per via e.v. 0,1mg di salbutamolo,farmaco beta 2 stimolante durante anestesie inalatorie condotte con alotano o etrano in respiro spontaneo
[Total intravenous anesthesia (TIVA): clinical comparison of 2 pharmacologic combinations: flunitrazepam-droperidol-fentanyl and propofol-droperidol-fentanyl].
No full textAssociazione[Diprivan-FANS] in corso di litotrissia extracorporea per il trattamento in Day- hospital
No full textGoing Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Midazolam e Remifentanil in infusione continua negli interventi di adenomectomia trans-vescicale
No full textLe peculiari caratteristiche farmacocinetiche e farmacodinamiche di composti a breve durata d'azione come il midazolam ed il remifentanil producono come risultato il raggiungimento di un adeguato piano di anestesia,il suo stabile mantenimento ed un rapido recupero al termine dell'atto chirurgico
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