1,721,094 research outputs found
Trifluoromethyl derivatives of canonical nucleosides: synthesis and bioactivity studies
No full textThe use of the system CF3SO2Na/tert-butyl-hydroperoxide (tert-ButOOH), recently reported for the efficient
trifluoromethylation of a variety of heterocyclic aromatic compounds, has been here profitably exploited
for the synthesis of 5-CF3-2'-deoxycytidine, 8-CF3-2'-deoxyadenosine, 8-CF3-2'-deoxyguanosine and 8-CF3-
inosine, regioselectively obtained in good to acceptable yields following a very simple protocol. The
bioactivity of these modified nucleosides, and particularly of the novel 8-CF3-20-deoxyguanosine and 8-
CF3-inosine, has been evaluated on a panel of tumour and non-tumour cell lines in preliminary in vitro
cytotoxicity assays
L-carnosine dipeptide overcomes acquired resistance to 5-fluorouracil in HT29 human colon cancer cells via downregulation of HIF1-alpha and induction of apoptosis
No full textPerspectives and Potential Applications of Ruthenium-Based Nanocarriers for Cancer Therapy
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