287 research outputs found
Rewilding Victoria: remembering and restoring nature in the city
No full textTo know what is, you must know what was. This is the simple truth that J.B. MacKinnon explores in his new book The once and future world: nature as it is, as it was, as it could be. The natural world, he argues, has been lost not only to human rapaciousness, but also through a great forgetting. MacKinnon calls on us to examine the nature of the past in order to "rewild" the earth in the future, "The history of nature is not only a lament," he writes."It is also an invitation to envision another world." MacKinnon is the author or co-author of four books of nonfiction, including The 100-mile diet (with Alisa Smith), a bestseller widely recognized as a catalyst of the local foods movement, His writing in print and online has won more than a dozen national and international awards, including Canada's highest prize for literary nonfiction. MacKinnon lives in Vancouver, Canada.Lansdowne Lecture SeriesFacultyUnreviewe
Mediation Analysis with Survival Outcomes: Accelerated Failure Time Versus Proportional Hazards Models
No full textObjective: Survival time is an important type of outcome variable in treatment research. Currently, limited guidance is available regarding performing mediation analyses with survival outcomes, which generally do not have normally distributed errors, and contain unobserved (censored) events. We present considerations for choosing an approach, using a comparison of semi-parametric proportional hazards (PH) and fully parametric accelerated failure time (AFT) approaches for illustration.Method: We compare PH and AFT models and procedures in their integration into mediation models and review their ability to produce coefficients that estimate causal effects. Using simulation studies modeling Weibull-distributed survival times, we compare statistical properties of mediation analyses incorporating PH and AFT approaches (employing SAS procedures PHREG and LIFEREG, respectively) under varied data conditions, some including censoring. A simulated data set illustrates the findings.Results: AFT models integrate more easily than PH models into mediation models. Furthermore, mediation analyses incorporating LIFEREG produce coefficients that can estimate causal effects, and demonstrate superior statistical properties. Censoring introduces bias in the coefficient estimate representing the treatment effect on outcome – underestimation in LIFEREG, and overestimation in PHREG. With LIFEREG, this bias can be addressed using an alternative estimate obtained from combining other coefficients, whereas this is not possible with PHREG.Conclusions: When Weibull assumptions are not violated, there are compelling advantages to using LIFEREG over PHREG for mediation analyses involving survival-time outcomes. Irrespective of the procedures used, the interpretation of coefficients, effects of censoring on coefficient estimates, and statistical properties should be taken into account when reporting results
Friends of the Library lecture: "Reflections on the Utah War after sixty years: conclusions and surprises," William MacKinnon, author of, "At Sword\u27s Point, Part 2," Sunday November 13, 2016, 3:00 PM, J. Willard Marriott Library, Gould Auditorium
No full textPoster created in the Marriott Library to publicize the Friends of the Library lecture by William MacKinnon, "Reflections on the Utah War after sixty years: conclusions and surprises," held November 13, 2016, in the Library\u27s Gould Auditorium
Predicting the past: the Utah War's twenty-first century future
No full textSeptember 25, 2008.Includes bibliographical references.The first ten lectures in Leonard J. Arrington Mormon History Lecture Series are here collected in one volume. The series, established by one of the twentieth-century West's most distinguished historians, Leonard Arrington, has become a leading forum for prominent historians to address topics related to Mormon history
Lessons from Uganda on strategies to fight poverty
No full textCountries receiving debt relief under the Heavily Indebted Poor Countries initiative will be among the first to benefit from the new World Bank -- International Monetary Fund approach to strengthening the impact on poverty of concessional assistance in low-income countries. The new approach features a more inclusive and participatory process for helping recipient countries develop poverty reduction strategies. From these strategies, joint Poverty Reduction Strategy Papers (PRSPs) will bring together the country's own priorities and Bank-Fund assistance to the country. In Uganda, such a strategy has existed for several years. Uganda was one of the first low-income countries to prepare a comprehensive national strategy for poverty reduction using a participatory approach. Indeed, its experience contributed substantially to the design of the PRSPs. Uganda's top leadership is heavily committed to poverty reduction. Formulation of Uganda's Poverty Eradication Action Plan (PEAP) in 1996-97 was the executive branch's effort to make that commitment and vision operational.The authors draw lessons from the drafting of Uganda's PEAP. First, the plan made extensive use of existing data and research about Uganda to refocus a range of public policies and interventions relevant to poverty reduction. Second, the government's approach was highly participatory, with central and local governments, the donor community, nongovernmental organizations and civil society, and academics invited to contribute. Third, the government was quick to translate the plan into its budget and medium-term spending framework. Public expenditures on basic services were significantly increased after adoption of the PEAP in 1997. The authors discuss the general characteristics of a poverty reduction action plan, drawing on Uganda's experience; discuss what is known about poverty in Uganda and identify shortcomings in the data; examine the macroeconomic and fiscal policies that were considered most important to poverty reduction during the participatory process; discuss the delivery of public services, especially those that directly affect the poor; and highlight problems associated with land issues, including problems with access to credit and financial services and with the security of productive assets.Health Monitoring&Evaluation,Environmental Economics&Policies,Public Health Promotion,Health Economics&Finance,Services&Transfers to Poor,Poverty Assessment,Environmental Economics&Policies,Achieving Shared Growth,Governance Indicators,Health Economics&Finance
Transmission experiment in Atlantic salmon (Salmo salar) with an Atlantic Canadian isolate of Moritella viscosa
No full textInternet initiated relationships: Associations between age and involvement in online dating
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Erythrocyte complement receptor 1 (CR1) expression level is not associated with polymorphisms in the promoter or 3' untranslated regions of the CR1 gene
No full textComplement receptor 1 (CR1) expression level on erythrocytes is genetically determined and is associated with high (H) and low (L) expression alleles identified by a HindIII restriction fragment-length polymorphism (RFLP) in intron 27 of the CR1 gene. The L allele confers protection against severe malaria in Papua New Guinea, probably because erythrocytes with low CR1 expression, are less able to form pathogenic rosettes with Plasmodium falciparum-infected erythrocytes. Despite the biological importance of erythrocyte CR1, the genetic mutation controlling CR1 expression level remains unknown. We investigated the possibility that mutations in the upstream or 3' untranslated regions of the CR1 gene could control erythrocyte CR1 level. We identified several novel polymorphisms; however, the mutations did not segregate with erythrocyte CR1 expression level or the H and L alleles. Therefore, high and low erythrocyte CR1 levels cannot be explained by polymorphisms in transcriptional control elements in the upstream or 3' untranslated regions of the CR1 gene
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