1,721,100 research outputs found
Cardiovascular risk reduction throughout GLP-1 receptor agonist and SGLT2 inhibitor modulation of epicardial fat
No full textEpicardial adipose tissue is a novel cardiovascular risk factor. It plays a role in the progression of coronary artery disease, heart failure and atrial fibrillation. Given its rapid metabolism, clinical measurability, and modifiability, epicardial fat works well as therapeutic target of drugs modulating the adipose tissue. Epicardial fat responds to glucagon-like peptide 1 receptor agonists (GLP1A) and sodium glucose co-transporter 2 inhibitors (SGLT2i). GLP-1A and SGLT2i provide weight loss and cardiovascular protective effects beyond diabetes control, as recently demonstrated. The potential of modulating the epicardial fat morphology and genetic profile with targeted pharmacological agents can open new avenues in the pharmacotherapy of diabetes and obesity, with particular focus on cardiovascular risk reduction
Validation of an Urban Traffic Network Model using Colored Timed Petri Nets
No full textThis paper validates a colored timed Petri net (CTPN) model proposed to describe urban traffic networks. In particular, a CTPN models the dynamics of signalized traffic networks and timed Petri nets describe the traffic lights controlling the area. To this aim, the modeling framework is applied to a real intersection located in Bari, Italy. Discrete event simulations of the controlled intersection test the signal timing plan under different traffic scenarios and give a confirmation of the model capability to correctly predict the traffic performanc
Epicardial adipose tissue: anatomic, biomolecular and clinical relationships with the heart
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Comparing deadlock detection and avoidance policies in automated storage and retrieval systems
No full textThis paper focuses on real time control of automated storage and retrieval systems (AS/RS) that is in charge of making decisions on resource allocation and scheduling choices. In these systems deadlock conditions may occur when parts require a set of resources in a circular wait situation. We model a generic multi-product AS/RS serviced by rail guided vehicles as a discrete event system. Next, we compare two different real time deadlock solution strategies for AS/RS: a deadlock avoidance strategy previously proposed by one of the authors and a deadlock detection/recovery strategy, proposed in the related literature. The considered control strategies are compared by means of a simulation of a case study
Un modello per la valutazione delle prestazioni delle catene di produzione basato sulle reti di Petri colorate
No full textReducing the costs of public tenders: a modest proposal
No full textWhile in the private sector the buyer chooses the number of
potential suppliers to involve in an exchange, in the public sector the procedures
to follow usually oblige the purchasing manager to behave in a different way.
According to the European Directive 2004/18/EC, the Public Administration has
to consider all the bids belonging to all the suppliers willing, and able, to take
part into the trade. The main purpose of the law is to increase the
competitiveness among several bidders in order to reduce the public spending,
avoiding monopolistic or oligopolistic behaviours. However the legislator has
not taken into account the costs associated with participation in the single
tender. In the paper we underline that these costs are relevant and so by limiting
the number of bidders it is possible to save money both for the Public
Administration and the private sector
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Wormshaped thrombus mimicking Chiari's network in a cocaine user
Full text linkA 20 year old man, with a history of cocaine and amphetamine
abuse, was admitted to the coronary care unit with mild
exertional dyspnoea. His ECG and cardiac enzymes were
normal. A transthoracic echocardiogram showed a dilated and
hypokinetic left ventricle with a large sessile apical thrombus and the presence of a long and thin mass in the right atrium. The right ventricle was normal. A transoesophageal echocardiogram revealed a filiform, worm shaped type A thrombus (arrow) in the right atrium simulating Chiari’s network, the Eustachian’s valve embryonal residuum, floating freely in the cavity and coming from the inferior vena cava lumen. The patient was treated with a 10 mg intravenous bolus of recombinant tissue plasminogen activator (rt-PA) followed by a continuous infusion of 90 mg rt-PA over two hours. Following thrombolytic treatment the right atrial serpiginous thrombus and apical thrombus disappeared. The patient was discharged 10 days later in excellent general condition on oral anticoagulant treatment. Chronic abuse of cocaine can induce endothelial alterations allowing thrombus formation. Serpiginous and mobile thrombus can simulate Chiari’s network causing a difficult differential diagnosis
Vascular Endothelial Growth Factor and ventricular remodeling in patients with type 2 diabetes and hypertension.
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