16 research outputs found
Hyperuricemia in Destabilization of Endothelial Function in Adolescents with Arterial Hypertension
No full textThe objective of this work was to study the correlation of uric acid level in blood serum and parameters of endothelial function and non-specific inflammation in adolescents with arterial hypertension considering their body weight. In the most of patients with arterial hypertension endothelial dysfunction was detected; endothelium-dependent vasodilation was more altered in the patients with obesity and especially in those with hyperuricemia. An increase in C-reactive protein serum level was mainly associated with obesity; a decrease in systolic-diastolic ratio — with hyperuricemia
ECOLOGICAL-ECONOMIC ESTIMATION OF INFLUENCE OF AN OIL-AND-GAS COMPLEX ON TERRITORY HANTI-MANSIYSKIY AUTONOMOUS OKRUG – UGRA
No full textResearches show presence of interrelations between a condition of ecological system and a level of economy in the present and the future. The author marks, that in system «the nature - a society - the person» is observed an aggravation of ýêîëîãî-economic, social and economic, economic-demographic and other contradictions. This circumstance forces to search for ways of improvement of a condition of an environment. In work the ýêîëîãî-economic estimation of influence of an oil-and-gas complex on territory Hanti-Mansiyskiy autonomous okrug - Ugra is given
Biochemical markers of the functional disorders of the liver in patients with systemic lupus erythematosus
No full textBackground. Systemic lupus erythematosus (SLE) in the basis of the pathogenesis has generalized autoimmune inflammation, which leads to the development of a wide range of immune-inflammatory organ disorders. Among them, the liver deserves special attention, since its functional state can reflect not only the severity of the pathological process, but also the response on aggressive treatment. The purpose of the work was studying the biochemical markers of the functional state of the liver in children with initial stages of SLE. Materials and methods. Features of the lipid, carbohydrate spectrum of the blood, indicators of pigment exchange, markers of cytolysis, cholestasis, fibrosis and protein-synthetic function of the liver were studied in children and adolescents with SLE. Twenty six patients aged 7–18 years were examined. Two groups were formed: 10 patients (38.4 %) with the duration of the disease of 1–3 years and 16 people (61.5 %) with duration of more than 3 years. Results. The average blood lipids levels did not exceed the reference values and did not have statistical differences among the patients of the selected groups. The levels of total cholesterol and triglycerides in both groups of patients significantly exceeded the control values (p < 0.05). Indicators of low density lipoprotein cholesterol increased already in the early stages of the disease (p < 0.05) and reached the maximum values in individuals with a course of SLE over 3 years (p < 0.05). Concentration of high density lipoprotein cholesterol in patients of the second group decreased somewhat (p < 0.1). There was an increase in the average values of atherogenic index by 1.7 times among patients in the first group (p < 0.05) and 2.25 times in persons from the second group (p < 0.05). Studies of other metabolic links showed that the average values of glycaemia and immunoreactive insulin (IRI) were consistent with the physiological norm. However, half of patients with SLE had hyperinsulinaemia (an increase in IRI of more than 25 μM/ml). There is a tendency to disturbance of pigmentary metabolism. The average total bilirubin values increased with an increase in the duration of the disease (p < 0.05) and depending on the activity of the disease (r = 0.632; p < 0.05). With the duration of SLE over 3 years, the concentration of haptoglobin significantly decreased (1.1 ± 0.1 g/l against 1.6 ± 0.2 g/l, p < 0.05), and there were high concentrations of AST (in 12.5 % of the surveyed persons). The growth in the parameters of fibrosis formation has been established; p < 0.05. Conclusions. In children suffering from SLE, already in the early stages there are significant changes in the functional state of the liver. The presence of atherogenic dyslipidemia was detected, which deepened with increasing duration and activity of the disease. 50.0 % of the subjects have a violation of carbohydrate metabolism in the form of hyperinsulinemia. A decrease in the concentration of hapthoglobin, as well as the association of liver fibrosis indeces AST/PYP and ALT/PYR, depended on the duration and activity of the disease
Біохімічні маркери функціональних порушень печінки хворих на системний червоний вовчак
No full textАктуальність. Системний червоний вовчак (СЧВ) в основі патогенезу має генералізоване автоімунне запалення, що призводить до розвитку широкого спектра імунозапальних органних порушень. Серед них на особливу увагу заслуговує печінка, оскільки її функціональний стан може відбивати не тільки тяжкість патологічного процесу, а й відповідь на агресивне лікування. Мета роботи полягала в дослідженні біохімічних маркерів функціонального стану печінки у дітей із початковими стадіями СЧВ. Матеріали та методи. Вивчено особливості ліпідного, вуглеводного спектра крові, показники пігментного обміну, маркерів цитолізу, холестазу, фіброзу та білковосинтетичної функції печінки дітей і підлітків, хворих на СЧВ. Обстежено 26 хворих віком від 7 до 18 років. Сформовано дві групи: 10 пацієнтів (38,4 %) із терміном перебігу хвороби 1–3 роки та 16 (61,5 %) — з її тривалістю понад 3 роки. Результати. Середні показники ліпідного спектра крові хворих не перевищували референтних значень і не мали статистичних відмінностей серед пацієнтів виділених груп. Рівні загального холестерину (ХС) та тригліцеридів в обох групах пацієнтів значно перевищували контрольні значення (р < 0,05). Показники ХС ліпопротеїдів низької щільності зростали вже на ранніх стадіях хвороби (р < 0,05) і досягали максимальних значень в осіб із перебігом СЧВ понад 3 роки (р < 0,05). Концентрація ХС ліпопротеїдів високої щільності пацієнтів другої групи дещо зменшувалась (р < 0,1). Відбувалось підвищення середніх показників коефіцієнта атерогенності в 1,7 раза серед пацієнтів першої групи (р < 0,05) та в 2,25 раза — в осіб другої групи (р < 0,05). Дослідження інших ланок метаболізму показали, що середні значення глікемії та імунореактивного інсуліну (ІРІ) натще відповідали фізіологічній нормі. Однак у половини пацієнтів із СЧВ мала місце гіперінсулінемія (підвищення рівня ІРІ понад 25 мкМО/мл). Встановлено тенденцію до порушення пігментного обміну. Середні показники загального білірубіну збільшувались при збільшенні тривалості хвороби (р < 0,05) та залежно від активності захворювання (r = 0,632; р < 0,05). Із тривалістю СЧВ понад 3 роки суттєво зменшувалась концентрація гаптоглобіну (1,1 ± 0,1 г/л проти 1,6 ± 0,2 г/л; р < 0,05) та визначались високі концентрації аспартатамінотрансферази (у 12,5 % обстежених). Встановлено зростання показників фіброзоутворення (р < 0,05). Висновки. У дітей, хворих на СЧВ, вже на ранніх етапах відбуваються суттєві зміни у функціональному стані печінки. Встановлено наявність дисліпідемії атерогенної спрямованості, яка поглиблювалась при зростанні тривалості й активності хвороби, порушення вуглеводного обміну у вигляді гіперінсулінемії у 50,0 % обстежених, зниження концентрації гаптоглобіну, а також асоціація показників фіброзу печінки АСТ/PYP та АЛТ/РYР з тривалістю та активністю захворювання.</jats:p
Analysing ocean wave data for improved planning of future offshore renewable energy
No full textClimate change is impacting people, industries and economies to ever greater degrees. One of the rapidly growing industries impacted by climate change is offshore wind energy. Numerous studies have shown a wide range of climate change impacts on the offshore wind resource. However, other potential impacts of climate change are less understood. This thesis investigated climate change impacts on installation and maintenance of offshore wind farms. Installation and maintenance each account for 20-25% of offshore wind farm lifecycle costs, and these activities significantly depend on ocean wave conditions. Wave reanalysis datasets, like ERA5, are often used to assess long-term wave climate. This thesis assessed the accuracy of the ERA5 wave dataset as a source of global ground-truth significant wave height data. The author showed that ERA5 tends to underestimate significant wave height above 5 m. The ERA5 accuracy increases with the increasing distance to shore, and is higher in more recent years. These findings informed the use of the ERA5 wave data in combination with atmospheric data from eight CMIP6 climate models to train a neural network to produce wave climate projections. The large size of the dataset, which included global 3-hour data for five variables (including significant wave height), hindered learning of the feed-forward neural network. Since the neural network failed to produce acceptable wave climate projections, an ensemble of existing numerical projections was used to quantify impacts of climate change on accessibility - the fraction of time when the weather does not impede installation and maintenance of offshore structures. This ensemble consisted of 11 wave simulations from the COWCLIP project, where wave models were forced with atmospheric data from seven CMIP5 climate models. This study found that accessibility is projected to increase in the North Atlantic and Asia, but decrease in Central America and in some cases in Australia and on the western North American coast. Most of the accessibility increase in the North Atlantic comes in the winter months, suggesting lengthening of the traditional maintenance season
Analysing ocean wave data for improved planning of future offshore renewable energy
No full textClimate change is impacting people, industries and economies to ever greater degrees. One of the rapidly growing industries impacted by climate change is offshore wind energy. Numerous studies have shown a wide range of climate change impacts on the offshore wind resource. However, other potential impacts of climate change are less understood. This thesis investigated climate change impacts on installation and maintenance of offshore wind farms. Installation and maintenance each account for 20-25% of offshore wind farm lifecycle costs, and these activities significantly depend on ocean wave conditions. Wave reanalysis datasets, like ERA5, are often used to assess long-term wave climate. This thesis assessed the accuracy of the ERA5 wave dataset as a source of global ground-truth significant wave height data. The author showed that ERA5 tends to underestimate significant wave height above 5 m. The ERA5 accuracy increases with the increasing distance to shore, and is higher in more recent years. These findings informed the use of the ERA5 wave data in combination with atmospheric data from eight CMIP6 climate models to train a neural network to produce wave climate projections. The large size of the dataset, which included global 3-hour data for five variables (including significant wave height), hindered learning of the feed-forward neural network. Since the neural network failed to produce acceptable wave climate projections, an ensemble of existing numerical projections was used to quantify impacts of climate change on accessibility - the fraction of time when the weather does not impede installation and maintenance of offshore structures. This ensemble consisted of 11 wave simulations from the COWCLIP project, where wave models were forced with atmospheric data from seven CMIP5 climate models. This study found that accessibility is projected to increase in the North Atlantic and Asia, but decrease in Central America and in some cases in Australia and on the western North American coast. Most of the accessibility increase in the North Atlantic comes in the winter months, suggesting lengthening of the traditional maintenance season
ECOLOGICAL-ECONOMIC ESTIMATION OF INFLUENCE OF AN OIL-AND-GAS COMPLEX ON TERRITORY HANTI-MANSIYSKIY AUTONOMOUS OKRUG – UGRA
No full textResearches show presence of interrelations between a condition of ecological system and a level of economy in the present and the future. The author marks, that in system «the nature - a society - the person» is observed an aggravation of эколого-economic, social and economic, economic-demographic and other contradictions. This circumstance forces to search for ways of improvement of a condition of an environment. In work the эколого-economic estimation of influence of an oil-and-gas complex on territory Hanti-Mansiyskiy autonomous okrug - Ugra is given
Aesthetic development of children of younger school age by means of fiction
No full textВ статье рассматривается эстетическое развитие детей младшего школьного возраста средствами художественной литературы. Автор называет источники эстетических впечатлений младших школьников: книга, природа, события общественной жизни. Описываются два направления процесса обучения чтению и различные подходы к выделению уровней восприятия художественного произведения.The article discusses the aesthetic development of children of younger school age by means of fiction. The author refers to the sources of aesthetic experiences of younger students: book, nature, events of public life. Describes two areas of learning reading and different approaches to the allocation of levels of perception artwork
Aesthetic development of children of younger school age by means of fiction
No full textВ статье рассматривается эстетическое развитие детей младшего школьного возраста средствами художественной литературы. Автор называет источники эстетических впечатлений младших школьников: книга, природа, события общественной жизни. Описываются два направления процесса обучения чтению и различные подходы к выделению уровней восприятия художественного произведения.The article discusses the aesthetic development of children of younger school age by means of fiction. The author refers to the sources of aesthetic experiences of younger students: book, nature, events of public life. Describes two areas of learning reading and different approaches to the allocation of levels of perception artwork
Conflicting patterns of thought in the Russian debate on transition: 2003-2007
No full textThis article is a continuation of two essays by the same author on Soviet/Russian economic debates between 1987 and 2002 published in Europe-Asia Studies in 2006 and 2007, so now the series of articles covers 20 years of Soviet/Russian discussions on economic reforms. Should Russia strive to become a 'Western' country marked by democracy and a market economy serving the individual interests of its citizens, or was it more important to become a great power again? Are Western patterns of political and economic life suitable for Russia or is the attempt to import foreign institutional structures doomed for failure, making it necessary for Russia to find her own way? This type of question, going far beyond the realm of economics, was and still is at the heart of the debate among Russian economists, which shall be discussed here, on the basis of a qualitative content analysis of the most important economic journals and selected monographs. --
