260 research outputs found
Russian guidelines for the management of COPD: algorithm of pharmacologic treatment [Corrigendum]
No full textAisanov Z, Avdeev S, Arkhipov V, Belevskiy A, Chuchalin A, Leshchenko I, Ovcharenko S, Shmelev E, Miravitlles M. Int J Chron Obstruct Pulmon Dis. 2018;13:183–187.Page 186, Disclosure, the text “The authors report no conflicts of interest in this work” should read “SA has received speaker/consultancy fees from Boehringer Ingelheim, AstraZeneca, Chiesi, Teva and Novartis; non-financial support from Boehringer Ingelheim, Chiesi and Novartis; and research grants from AstraZeneca, GlaxoSmithKline and Novartis. MM has received speaker fees from Boehringer Ingelheim, Chiesi, Cipla, Menarini, Rovi, Bial, CSL Behring, Grifols and Novartis; consultancy fees from Boehringer Ingelheim, Chiesi, GlaxoSmithKline, Bial, Gebro Pharma, CSL Behring, Laboratories Esteve, Mereo BioPharm, Verona Pharma, pH Pharma, Novartis and Grifols; and research grants from GlaxoSmithKline and Grifols. ZA has received speaker/consultancy fees from Boehringer Ingelheim, AstraZeneca, Chiesi, Teva and Novartis, GlaxoSmithKline; non-financial support from Boehringer Ingelheim, GSK and Novartis; and research grants from AstraZeneca, GlaxoSmithKline and Novartis. The authors report no other conflicts of interest in this work”.Read the original articl
Фінансові установи як учасники ринку фінансових послуг
No full textСтаттю присвячено дослідженню окремих проблем правового статусу фінансових установ на ринку фінансових послуг. Теоретичну базу дослідження, на яку спирався автор, обґрунтовуючи зроблені висновки, склали праці таких учених у сфері господарського та цивільного права, як К. Ю. Баранов, М. Г. Делягін, В. В. Долинська, Г. В. Жуков, Н. В. Козлова, К. О. Кочергіна, І. М. Кучеренко, А. В. Майфат, Г. Б. Леонова, Д. С. Лещенко, В. І. Полюхович, О. С. Янкова та ін. // The article is devoted to the study of separate problems of the legal status of financial institutions in the financial services market. The theoretical base of the study, which was released by the author, substantiated the conclusions made, consisted of such scientists in the field of economic and civil law, as K. Yu Baranov, M. G. Delagin, V. V. Dolinskaya, G.V. Zhukov, V. Kozlova, K. O. Kocherig, I. M. Kucherenko, A. V. MaFat, G. B. Leonov, D. S. Leshchenko, V. I. Polukhovich, O. S. Yankova and others
The influence of technological methods of growing corn with legumes on the nutritional value of silage raw materials
No full textВ статті представлена теза доповіді учасників V міжнародної наукової інтернет-конференції «Тенденції та виклики сучасної аграрної науки в умовах війни: теорія і практика», яка присвячена 125-річчю кафедри рослинництва НУБІП України. Висвітлено теоретичні і практичні питання сучасної аграрної науки, напрями їх вирішення та впровадження у виробництво
Fixed dose long-acting bronchodilator combinations in chronic obstructive pulmonary disease: safety, effectiveness and cardiovascular system
No full textAt present time, long-acting bronchodilators are the main class of drugs for basis therapy of chronic obstructive pulmonary disease (COPD). COPD is characterized not only by a decrease in pulmonary function parameters, but also by a decline in cardiac contractility. The article presents the results of studies of four approved fixed long-acting anticholinergic drugs/long-acting beta2-agonists in the Russian Federation, according their effect on the cardiovascular system. The safety of LAMA/ LABA was proved in terms of relation to the cardiovascular system, additionally the positive effect on the pumping function of the heart was shown in patients with COPD, which confirms the value of dual bronchodilators for COPD treatment
Community-acquired pneumonia in adults: diagnostic strategy and outpatient treatment
No full textCommunity-acquired pneumonia (CAP) is a common disease but it is often poorly diagnosed in outpatient departments. Diagnosis CAP is certain (Evidence A) if there is a new lung shadowing at chest radiograph and a patient has at least two clinical signs of list: abrupt onset with fever (t0> 38,0 eC); productive cough; physical findings conformed to consolidation (focal signs -end-inspiratory crackles and/or fine crackles, bronchial breathing, dullness of percussion sound); raised peripheral blood white cell count (> 10.0*109 /I and/or stab shift (> 10%). Severity assessment is important to deciding place of care (in outpatient department or hospital admission). This should be done through clinical judgment guided by CRB-65 score and criteria of Systemic Inflammatory Response Syndrome (SIRS). Empiric choice of antibacterial therapy is based on national CAP recommendations and includes such tablet formulations as amoxicillin, macrolides II type, protected penicillin, respiratory fluoroquinolones.Внебольничная пневмония (ВП) - распространенное и, в тоже время, плохо диагностируемое в амбулаторных условиях заболевание. Диагноз ВП является определенным (категория доказательств А) при наличии у больного рентгенологически подтвержденной очаговой инфильтрации легочной ткани и, по крайней мере, двух клинических признаков из числа следующих: острая лихорадка в начале заболевания (Ю тела > 38,0°С); кашель с мокротой; физические признаки пневмонической инфильтрации (фокус крепитации и/или мелкопузырчатые хрипы, жесткое бронхиальное дыхание, укорочение перкуторного звука); лейкоцитоз > 10,0-109/л и/или палочкоядерный сдвиг (> 10%). При принятии решения о лечении в амбулаторных условиях или в условиях круглосуточного стационара для всех пациентов рекомендуется клиническая оценка по шкале CRB-65 и критериям синдрома системной воспалительной реакции. Эмпирический выбор антибиотикотерапии основан на национальных рекомендациях по ВП и включают следующие таблетированные препараты: амоксициллин, макролиды I! типа, защищенные пенициллины, респираторные фторхинолоны
Ekologické vlastnosti nivikolních hlenek s ohledem na změnu klimatu
No full textThis diploma thesis focuses on nivicolous myxomycetes, a group of amoeboid protists widely distributed in terrestrial ecosystems, particularly in alpine, subalpine, and arctic zones. The main objective is to distinguish whether subgroups of nivicolous myxomycetes have distinct spatial requirements and to identify the key environmental factors influencing their distribution. I employed species distribution modelling (SDM) using three methods (MaxEnt, BIOCLIM, and Random Forest) to predict the habitat suitability of these subgroups. Three taxon experts validated the model predictions. This diploma thesis also explores the potential impact of climate change on their distribution using future climate projection scenarios. The results suggest that SDMs may not fully capture the complexity of habitat requirements for nivicolous myxomycetes in the European part of the Palearctic, however key bioclimatic variables for the study group were distinguished: temperature seasonality, precipitation of the warmest quarter, the maximum temperature of the warmest month. The evaluation by experts reveals some limitations regarding the research design, such as the need for accurate species categorization and consideration of fine-scale environmental variations in the study region. Keywords: nivicolous myxomycetes,...Tato diplomová práce se zaměřuje na nivicolne hlenek, skupinu amoeboidních prvoků široce rozšířených v terestrických ekosystémech, zejména v alpinských, subalpinských a arktických oblastech. Hlavním cílem je rozlišit, zda podskupiny nivicolných hlenek mají odlišné prostorové požadavky, a identifikovat klíčové environmentální faktory ovlivňující jejich rozšíření. K predikci vhodnosti prostředí těchto podskupin ja používá modelování rozšíření druhů (SDM) pomocí tří metod (MaxEnt, BIOCLIM a Fandom Forest). Tři odborníci na taxony hlenek ověřili predikce modelů. Tato diplomová práce také zkoumá potenciální dopad změny klimatu na jejich rozšíření pomocí scénářů budoucího klimatu. Výsledky naznačují, že SDM možná plně nezachycují složitost požadavků na prostředí nivicolných hlenek v evropské části palearktické oblasti. Byly však rozpoznány klíčové bioklimatické proměnné pro studijní skupinu: sezónnost teploty, srážky nejteplejšího čtvrtletí a maximální teplota nejteplejšího měsíce. Hodnocení odborníky odhaluje některá omezení týkající se výzkumného designu, jako je potřeba přesné kategorizace druhů a zohlednění jemnoškálových environmentálních variací v oblasti studia. Klíčová slova: nivikolní hlenky, Lamproderma, environmentální nika, modelování distribuce druhů, suchozemské ekosystémy.Department of EcologyKatedra ekologieFaculty of SciencePřírodovědecká fakult
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Whole and quality grits yield of emmer wheat grain depending on endosperm consistency and water-heat treatment
No full textThe article is devoted to the determining of the effect of water-heat treatment regimes (moistening and softening) and hulling during the production of whole grits of emmer wheat with different vitreous endosperm. A comparative analysis of grits products yield was made, depending on the studied factors, and the optimal regimes are determined taking into account the culinary assessment of the finished product. During the production of whole grits of emmer wheat, the optimal to hull vitreous grain of moisture content 12.0–13.0%. The duration of hulling of such grain should be 40–120 s (grits yield 92–97%) to production high quality cereals and 120–140 s (grits yield 86–90%) – with very high
Character features of community-acquired pneumonia during the pandemic influenza A / N1N1 / 2009
No full textArchaeological Wood from Medieval Monuments of Primorye in the Russian Far East
No full textThe article considers the archaeological wood from Primorye medieval sites of the time of Bohai state (698–926) and post-Bohai period. Materials from collections of open complexes are used: Nikolayevka-II, Kraskino settlements, Konstantinovka-I unfortified settlement, as well as the closed – Kraskino burial ground. The wood was extracted both from archaeological objects, structures (well shafts, fences, details of a platform in a tiled chamber, boarding the walls of granaries, wooden columns, structural elements of burials), and objects made of wood (knife handles, tools, combs, dishes, horse trapping parts) were studied. The methods and techniques of surface treatment, as well as the tools used, are considered. Definitions of wood species have been made. Paleoxylotonic analysis of wood remains from the barrow No. 1 of the Kraskino burial ground was conducted. A spore-pollen analysis of samples from sections of this object was made. The results of analyses of samples, produced during microscopic section of wood are given. For the first time sources on the problem of interest have been collected together. Photoanalytical and trace evidence methods were applied in treatment of materials. Andonstar A1 long-focus digital USB microscope with 500x magnification and 2 MP sensor was used in the work
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