1,017 research outputs found
The Fichtner Family
No full textI will present a brief introduction of my immediate family which lives in Rock Island, Washington
Markt- und Kostenentwicklung der Stromerzeugung aus Biomasse Gutachten
No full textVor dem Hintergrund dieser Ausgangsituation beauftragte die Bundesinitiative BioEnergie (BBE) in Kooperation mit den vorgenannten BBE-Mitgliedsverbaenden und -firmen Fichtner mit der Erstellung eines Gutachtens zur Untersuchung des Stands der Markteinfuehrung und der Kostenentwicklung von Anlagen zur Stromerzeugung aus Biomasse. Ziel der Untersuchung ist die Erarbeitung fundierter Aussagen zur aktuellen Markt- und Kostenentwicklung der Bioenergienutzung zur Stromerzeugung. Die Ergebnisse dienen der Verifizierung des zum 30.06.02 vorzulegenden Erfahrungsberichts des Bundeswirtschaftsministeriums sowie als Faktenbasis zur Formulierung von Handlungsempfehlungen fuer die Politik bezueglich der Weiterentwicklung des Erneuerbare-Energien-Gesetzes in Verbindung mit der Biomasseverordnung. (orig.)Starting from this situation, the Federal Initiative ''BioEnergie'' (BBE), in cooperation with its member associations and companies, asked Fichtner to prepare an expertise for investigating the situation of the market launch and the cost development of systems used for generating power from biomass. The investigation aims at obtaining sound statements on the current market and cost development of generating power from biomass. The results help to verify the experience report issued by the Federal Ministry of Economical Affairs which was to be presented on 30 June 2002; they also form a basis of facts which can be used to set up recommendations on how to proceed in politics regarding the further development of the act on regenerative energies in connection with the biomass regulation.SIGLEAvailable from TIB Hannover / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman
Die Entwicklung zukünftiger körpernaher Sensorsysteme für die autarke und mobile Trainingsunterstützung
No full textHesse M, Christ P, Hörmann T, Adams M, Rückert U. Die Entwicklung zukünftiger körpernaher Sensorsysteme für die autarke und mobile Trainingsunterstützung. In: Fichtner I, ed. Technologien im Leistungssport. Schriftenreihe Angewandte Trainingswissenschaft. Vol 4. Aachen: Meyer & Meyer; 2016: 152-161
Pathogenesis and pathobiology of testicular germ cell tumours: a view from a developmental biological perspective with guidelines for pathological diagnostics
No full textTesticular germ cell tumours (GCT) are divided into three different subtypes (types I–III) regarding to their developmental origin, histological differences and molecular features. Type I GCT develop from disturbed primordial germ cells and most commonly occur in children and young adolescents, which is why they are referred to as prepubertal GCT. Type II GCT develop from a non‐invasive germ cell neoplasia in situ (GCNIS) and show an isochromosome 12p (i12p) or gain of 12p material as a common and characteristic molecular alteration. Type III GCT originate from distorted postpubertal germ cells (e.g. spermatogonia) in adult patients and have changes on chromosome 9 with amplification of the DMRT1 gene. Type I GCT encompass prepubertal‐type teratomas and yolk‐sac tumours (YST). Type II GCT include seminoma, embryonal carcinoma, choriocarcinoma, postpubertal‐type teratoma and postpubertal‐type YST. Types I and II GCT both show similar morphology, but are separated from each other by the detection of a GCNIS and an i12p in type II GCT. For type II GCT it is especially important to detect non‐seminomatous elements, as these tumours have a worse biological behaviour and need a different treatment to seminomas. In contrast to types I and II GCT, type III tumours are equivalent to spermatocytic tumours and usually occur in elderly men, with few exceptions in young adults. The development of types I and II GCT seems to depend not upon driver mutations, but rather on changes in the epigenetic landscape. Furthermore, different pluripotency associated factors (e.g. OCT3/4, SOX2, SOX17) play a crucial role in GCT development and can be used as immunohistochemical markers allowing to distinguish the different subtypes from each other in morphologically challenging tissue specimens. Especially in metastatic sites, a morphological and immunohistochemical diagnostic algorithm is important to detect small subpopulations of each non‐seminomatous GCT subtype, which are associated with a poorer prognosis and need a different treatment. Furthermore, primary extragonadal GCT of the retroperitoneum or mediastinum develop from misguided germ cells during embryonic development, and might be challenging to detect in small tissue biopsies due to their rarity at corresponding sites. This review article summarises the pathobiological and developmental aspects of the three different types of testicular GCT that can be helpful in the histopathological examination of tumour specimens by pathologists.Wilhelm Sander-Stiftung https://doi.org/10.13039/10000867
Visuelles Sensorsystem für die Trainings- und Spielunterstützung im Leistungshandball
No full textAdams M, Hesse M, Hörmann T, Rückert U. Visuelles Sensorsystem für die Trainings- und Spielunterstützung im Leistungshandball. In: Fichtner I, ed. Technologien im Leistungssport 3. Tagungsband zur 19. Frühjahrsschule am 14./15. Mai 2018 in Leipzig. Schriftenreihe für angewandte Trainingswissenschaft . Vol 13. Meyer & Meyer Verlag; 2018: 106-115
Histopathologische Befundung von Keimzelltumoren – worauf ist zu achten?
No full textZusammenfassung Die Keimzelltumoren machen den Großteil der Hodentumoren aus und bilden eine heterogene Gruppe an Tumoren, die sich biologisch unterschiedlich verhalten. Aufgrund des Auftretens in unterschiedlichen Altersgruppen, ihrer morphologischen Charakteristika und der molekularen Veränderungen werden sie in 3 verschiedene Gruppen (Typ I–III) unterteilt. Die genaue histopathologische Analyse eines Orchiektomieresektats, die Zuordnung in die genannten 3 Gruppen und die genaue Benennung aller Subtypen mit prozentualer Verteilung ist für die Therapie und Prognose eines Patienten mit Keimzelltumor sehr wichtig. In diesem Artikel wird die Vorgehensweise bei der Aufarbeitung eines Orchiektomieresektats und die histopathologische Analyse des Hodentumorgewebes geschildert und dargestellt, in welchen Situationen Hilfsmittel wie immunhistochemische oder molekularpathologische Untersuchungen notwendig sind. Ferner wird die aktuelle Einteilung der Keimzelltumoren des Hodens anhand der gültigen WHO-Klassifikation geschildert und diskutiert
Vescicole extracellulari nel contesto dell'aterosclerosi = Extracellular vesicles in atherothrombosis
No full textLe vescicole extracellulari (VEs) sono una popolazione eterogenea di nano-particelle rilasciate nella maggior part
dei fluidi biologici da quasi tutti i tipi cellulari, sia in condizioni fisiologiche che di malattia. Essendo in grado di
trasportare un contenuto molecolare (tra cui proteine, acidi nucleici, e persino organuli interi e/o frammentati) da
una cellula donatrice a una ricevente, le VEs non solo svolgono un ruolo fondamentale nella comunicazione paracrina
ed endocrina tra cellule, ma rappresentano una fonte importante di informazioni di tipo molecolare. Queste caratteristiche
rendono le VEs particolarmente interessanti nell’ambito dei processi fisiopatologici in ambito cardiovascolare.
Difatti, alterazioni significative nella quantità, nella dimensione e nel contenuto proteico potrebbero associarsi
con specifiche caratteristiche fisiopatologiche, tra cui, ad esempio, la severità del grado di danno endoteliale.
Di conseguenza, le VEs godono di un potenziale clinico di notevole importanza e rappresentano un’impronta
molecolare specifica utile sia in termini diagnostici che prognostici. Monitorando le caratteristiche delle VEs è
possibile valutare l’insorgenza e l’andamento di determinate patologie ‘silenti’, come ad esempio l’aterosclerosi. In
determinati contesti cardiovascolari, le VEs svolgono anche ruoli rigenerativi e riparatori. Ovviamente saranno
necessari ulteriori studi e l’applicazione di nuove tecnologie per far sì che le VEs possano essere considerate veri e
propri strumenti sia di diagnosi che di prognosi nell’ambito delle patologie a eziologia aterosclerotica.Extracellular vesicles (EVs) are a heterogeneous group of nanoparticles released by almost all cell types into most
biological fluids, under both physiological and pathological conditions. Given their ability of transporting molecular
content (including proteins, nucleic acids, lipids, and even whole and/or fragmented organelles) from a donor cell
to a recipient cell, EVs not only play a key role in paracrine and endocrine intercellular communication, but also
represent an important source of molecular information that would otherwise be difficult to obtain. These charac-
teristics render EVs particularly interesting in the context of the pathophysiological processes of cardiovascular
diseases. Indeed, numerous studies demonstrate how significant alterations of certain EV aspects, such as circulat-
ing concentration, size, and protein content, associate with specific features of disease, including, for example, se-
verity. Consequently, EVs yield significant clinical potential as tools that may assist on a molecular level in the diag-
nosis and monitoring of various diseases. In addition to their potential diagnostic role, EVs also represent promis-
ing fingerprints in the clinical setting from a prognostic point of view. By monitoring the phenotypic characteristics
of EVs, it is possible to assess the onset and progression of certain ‘silent’ diseases, such as for instance atheroscle-
rosis. In certain cardiovascular settings, EVs also play regenerative and reparative roles. Extensive further studies
and development of new technologies will be essential to establish EVs as practical tools for a routinely diagnostic
clinical use
Fichtner On Density-Gradient Modeling of Tunneling Through Insulators
No full textAbstract — The density gradient model (DG) is tested for its ability to describe tunneling currents through thin insulating barriers. Simulations of single barriers (MOS diodes, MOS-FETs) and double barriers show the limitations of the DG model. As a reference the Schrödinger-Bardeen method is taken. ‘Resonant tunneling ’ in the density gradient model turns out to be an artifact related to large density differences in the semiconductor regions. I
citizen of Vechigen BE accepted on the recommendation of
No full textI would like to thank my advisor, Prof. Wolfgang Fichtner, for his overall support and for his confidence in me and my work. I would also like to thank Prof. Lothar Thiele for reading and co-examining the thesis. I am greatly indebted in Hubert Kaeslin and Norbert Felber for their encouragement and support during the work as well as for proofreading and commenting on my thesis. I also want to express my gratitude to all colleagues at the Integrated Systems Laboratory who contributed to the perfect working environment. In particular, I want to thank the secretaries for keeping the administration, Hanspeter Mathys and Hansjörg Gisler the installations, Christoph Wicki and Adam Feigin the computers, and Andreas Wieland the VLSI design tools running. I want to thank Hanspeter Kunz and Patrick Müller for the valuable contributions during their student projects. Also, I am grateful to Rajiv Gupta, Duncan Fisher, and all other people who supported me during my internship at Rockwell Semiconductor Systems in Newport Beach, CA. I acknowledge the financial support of MicroSwiss, a Microelectronics Program of the Swiss Government. Finally my special thanks go to my parents for their support during my education and for their understanding and tolerance during the last couple of years. i ii Acknowledgment
Molecular pathology of testicular germ cell tumours: an update for practicing pathologists
No full textTesticular tumours are a diverse group of tumours, but most cases fall into the category of testicular germ cell tumours (TGCT). TGCTs are classified as either derived from a germ cell neoplasia in situ (GCNIS) or unrelated to GCNIS. Based on the development, molecular alterations and onset of development, TGCTs can further be divided into three groups. Type I TGCTs include prepubertal‐type teratoma and yolk‐sac tumour. Type II TGCTs are the only GCNIS‐related tumours in this classification and include seminomas, embryonal carcinoma, choriocarcinoma, yolk‐sac tumour and teratoma of postpubertal type. Type III TGCTs only include spermatocytic tumours. While genetic alterations are helpful in the diagnostic routine, they have not yet been useful in determining treatment options, as targetable alterations are very rare. Type I TGCTs most commonly exhibit chromosomal aberrations and rarely display alterations related to the Wnt signalling pathway. A common molecular alteration in type II TGCTs is the presence of an isochromosome 12p or gain of 12p material. It is thought that the isochromosome 12p develops during the progression of a GCNIS to an invasive TGCT. Seminomas can also exhibit c‐Kit mutations or KRAS mutations. Alterations associated with the formation of a somatic‐type malignancy and/or the development of cisplatin resistance include TP53 mutations or MDM2 gene amplifications as well as epigenetic alterations. In advanced cases, some of these genes might be useful as targeted therapies (e.g. KRAS G12C or BRAF V600E), but as these mutations are rare, studies on larger groups of patients are not possible. Amplification of chromosome 9 including the DMRT1 gene, or Ras mutations is common in spermatocytic tumours. Overlapping molecular alterations, including those on chromosome 12, have recently been discovered in some type III TGCT. Tumour serum markers (e.g. alpha‐fetoprotein, beta‐subunit of human gonadotropin and microRNAs) are helpful in the diagnosis and for follow‐up analysis to detect recurrent disease or disease progression. This review article provides an overview of the current classification of testicular tumours and their molecular classification. Furthermore, it provides information on biomarkers that are helpful in the diagnostic setting. Additionally, we will provide guidance on how to examine a testicular tumour specimen histopathologically to reach an accurate diagnosis. Finally, we will outline the importance of the content of a histopathological report for the urologists and oncologists
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